-
1
-
-
44249098800
-
Natural products to drugs: Natural product-derived compounds in clinical trials
-
Butler MS. 2008. Natural products to drugs: natural product-derived compounds in clinical trials. Nat. Prod. Rep. 25:475-516
-
(2008)
Nat. Prod. Rep.
, vol.25
, pp. 475-516
-
-
Butler, M.S.1
-
2
-
-
69249202590
-
The biosynthetic logic of polyketide diversity
-
Hertweck C. 2009. The biosynthetic logic of polyketide diversity. Angew. Chem. Int. Ed. 48:4688-716
-
(2009)
Angew. Chem. Int. Ed.
, vol.48
, pp. 4688-4716
-
-
Hertweck, C.1
-
3
-
-
67650436176
-
Drug discovery and natural products: End of an era or an endless frontier
-
Li JWH, Vederas JC. 2009. Drug discovery and natural products: End of an era or an endless frontier Science 325:161-65
-
(2009)
Science
, vol.325
, pp. 161-165
-
-
Li, J.W.H.1
Vederas, J.C.2
-
4
-
-
84858308226
-
Natural products as sources of new drugs over the 30 years from 1981 to 2010
-
Newman DJ, Cragg GM. 2012. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 75:311-35
-
(2012)
J. Nat. Prod.
, vol.75
, pp. 311-335
-
-
Newman, D.J.1
Cragg, G.M.2
-
5
-
-
0037436563
-
Dispelling the myths: Biocatalysis in industrial synthesis
-
Schoemaker HE,MinkD, WubboltsMG.2003. Dispelling the myths: biocatalysis in industrial synthesis. Science 299:1694-97
-
(2003)
Science
, vol.299
, pp. 1694-1697
-
-
Schoemaker, H.E.1
Mink, D.2
Wubbolts, M.G.3
-
6
-
-
84876710917
-
On the development of new biocatalytic processes for practical pharmaceutical synthesis
-
Huisman GW, Collier SJ. 2013. On the development of new biocatalytic processes for practical pharmaceutical synthesis. Curr. Opin. Chem. Biol. 17:284-92
-
(2013)
Curr. Opin. Chem. Biol.
, vol.17
, pp. 284-292
-
-
Huisman, G.W.1
Collier, S.J.2
-
7
-
-
84860741240
-
Engineering the third wave of biocatalysis
-
Bornscheuer UT, Huisman GW, Kazlauskas RJ, Lutz S, Moore JC, Robins K. 2012. Engineering the third wave of biocatalysis. Nature 485:185-94
-
(2012)
Nature
, vol.485
, pp. 185-194
-
-
Bornscheuer, U.T.1
Huisman, G.W.2
Kazlauskas, R.J.3
Lutz, S.4
Moore, J.C.5
Robins, K.6
-
8
-
-
77954797329
-
Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture
-
Savile CK, Janey JM, Mundorff EC,Moore JC, Tam S, et al. 2010. Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture. Science 329:305-9
-
(2010)
Science
, vol.329
, pp. 305-309
-
-
Savile, C.K.1
Janey, J.M.2
Mundorff, E.C.3
Moore, J.C.4
Tam, S.5
-
9
-
-
84857633496
-
Protein engineering towards natural product synthesis and diversification
-
Zabala AO, Cacho RA, Tang Y. 2012. Protein engineering towards natural product synthesis and diversification. J. Ind. Microbiol. Biotechnol. 39:227-41
-
(2012)
J. Ind. Microbiol. Biotechnol.
, vol.39
, pp. 227-241
-
-
Zabala, A.O.1
Cacho, R.A.2
Tang, Y.3
-
10
-
-
84891396350
-
Engineering the acyltransferase substrate specificity of assembly line polyketide synthases
-
DunnBJ,KhoslaC. 2013. Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J. R. Soc. Interface 10:20130297
-
(2013)
J. R. Soc. Interface
, vol.10
, pp. 20130297
-
-
Dunn, B.J.1
Khosla, C.2
-
11
-
-
33744512606
-
Directed evolution of enzymes and biosynthetic pathways
-
Johannes TW, Zhao HM. 2006. Directed evolution of enzymes and biosynthetic pathways. Curr. Opin. Microbiol. 9:261-67
-
(2006)
Curr. Opin. Microbiol.
, vol.9
, pp. 261-267
-
-
Johannes, T.W.1
Zhao, H.M.2
-
12
-
-
78649323531
-
Engineered polyketide biosynthesis and biocatalysis in Escherichia coli
-
Gao X, Wang P, Tang Y. 2010. Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. Appl. Microbiol. Biotechnol. 88:1233-42
-
(2010)
Appl. Microbiol. Biotechnol.
, vol.88
, pp. 1233-1242
-
-
Gao, X.1
Wang, P.2
Tang, Y.3
-
13
-
-
34848843433
-
The type i fatty acid and polyketide synthases: A tale of two megasynthases
-
Smith S, Tsai SC. 2007. The type I fatty acid and polyketide synthases: a tale of two megasynthases. Nat. Prod. Rep. 24:1041-72
-
(2007)
Nat. Prod. Rep.
, vol.24
, pp. 1041-1072
-
-
Smith, S.1
Tsai, S.C.2
-
14
-
-
64049116611
-
Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways
-
Cronan JE, Thomas J. 2009. Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways. Method Enzymol. 459:395-433
-
(2009)
Method Enzymol.
, vol.459
, pp. 395-433
-
-
Cronan, J.E.1
Thomas, J.2
-
15
-
-
59349116977
-
Heterologous expression systems for polyketide synthases
-
Fujii I. 2009. Heterologous expression systems for polyketide synthases. Nat. Prod. Rep. 26:155-69
-
(2009)
Nat. Prod. Rep.
, vol.26
, pp. 155-169
-
-
Fujii, I.1
-
16
-
-
64049111007
-
Introduction to polyketide biosynthesis
-
Weissman KJ. 2009. Introduction to polyketide biosynthesis. Method Enzymol. 459:3-16
-
(2009)
Method Enzymol.
, vol.459
, pp. 3-16
-
-
Weissman, K.J.1
-
17
-
-
33748631825
-
Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms
-
Fischbach MA, Walsh CT. 2006. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem. Rev. 106:3468-96
-
(2006)
Chem. Rev.
, vol.106
, pp. 3468-3496
-
-
Fischbach, M.A.1
Walsh, C.T.2
-
18
-
-
0034957814
-
Type i polyketide biosynthesis in bacteria (part B)
-
Rawlings BJ. 2001. Type I polyketide biosynthesis in bacteria (part B). Nat. Prod. Rep. 18:231-81
-
(2001)
Nat. Prod. Rep.
, vol.18
, pp. 231-281
-
-
Rawlings, B.J.1
-
19
-
-
70350493673
-
Complete reconstitution of a highly reducing iterative polyketide synthase
-
Ma SM, Li JWH, Choi JW, Zhou H, Lee KKM, et al. 2009. Complete reconstitution of a highly reducing iterative polyketide synthase. Science 326:589-92
-
(2009)
Science
, vol.326
, pp. 589-592
-
-
Ma, S.M.1
Li, J.W.H.2
Choi, J.W.3
Zhou, H.4
Lee, K.K.M.5
-
20
-
-
34547930907
-
Structure and mechanism of the 6-deoxyerythronolide B synthase
-
Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE. 2007. Structure and mechanism of the 6-deoxyerythronolide B synthase. Annu. Rev. Biochem. 76:195-221
-
(2007)
Annu. Rev. Biochem.
, vol.76
, pp. 195-221
-
-
Khosla, C.1
Tang, Y.2
Chen, A.Y.3
Schnarr, N.A.4
Cane, D.E.5
-
21
-
-
78449290452
-
New insights into the formation of fungal aromatic polyketides
-
Crawford JM, Townsend CA. 2010. New insights into the formation of fungal aromatic polyketides. Nat. Rev. Microbiol. 8:879-89
-
(2010)
Nat. Rev. Microbiol.
, vol.8
, pp. 879-889
-
-
Crawford, J.M.1
Townsend, C.A.2
-
22
-
-
77954652490
-
Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes
-
Campbell CD, Vederas JC. 2010. Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. Biopolymers 93:755-63
-
(2010)
Biopolymers
, vol.93
, pp. 755-763
-
-
Campbell, C.D.1
Vederas, J.C.2
-
23
-
-
84869169169
-
Navigating the fungal polyketide chemical space: From genes to molecules
-
Chooi YH, Tang Y. 2012. Navigating the fungal polyketide chemical space: from genes to molecules. J. Org. Chem. 77:9933-53
-
(2012)
J. Org. Chem.
, vol.77
, pp. 9933-9953
-
-
Chooi, Y.H.1
Tang, Y.2
-
24
-
-
33846923183
-
Type II polyketide synthases: Gaining a deeper insight into enzymatic teamwork
-
Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A. 2007. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat. Prod. Rep. 24:162-90
-
(2007)
Nat. Prod. Rep.
, vol.24
, pp. 162-190
-
-
Hertweck, C.1
Luzhetskyy, A.2
Rebets, Y.3
Bechthold, A.4
-
25
-
-
84859083398
-
Type III polyketide synthases in natural product biosynthesis
-
Yu DY, Xu FC, Zeng J, Zhan JX. 2012. Type III polyketide synthases in natural product biosynthesis. IUBMB Life 64:285-95
-
(2012)
IUBMB Life
, vol.64
, pp. 285-295
-
-
Yu, D.Y.1
Xu, F.C.2
Zeng, J.3
Zhan, J.X.4
-
26
-
-
79851505835
-
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues
-
Mo S, KimDH, Lee JH, Park JW, BasnetDB, et al. 2011. Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. J. Am. Chem. Soc. 133:976-85
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 976-985
-
-
Mo, S.1
Kim, D.H.2
Lee, J.H.3
Park, J.W.4
Basnet, D.B.5
-
27
-
-
20044397059
-
Structure-Activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor
-
Macherla VR,Mitchell SS, Manam RR, Reed KA, Chao T-H, et al. 2005. Structure-Activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J. Med. Chem. 48:3684-87
-
(2005)
J. Med. Chem.
, vol.48
, pp. 3684-3687
-
-
MacHerla, V.R.1
Mitchell, S.S.2
Manam, R.R.3
Reed, K.A.4
Chao, T.-H.5
-
28
-
-
0032532250
-
A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii
-
An JH, Kim YS. 1998. A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii. Eur. J. Biochem. 257:395-402
-
(1998)
Eur. J. Biochem.
, vol.257
, pp. 395-402
-
-
An, J.H.1
Kim, Y.S.2
-
29
-
-
0034801511
-
Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors
-
Pohl NL, Hans M, Lee HY, Kim YS, Cane DE, Khosla C. 2001. Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors. J. Am. Chem. Soc. 123:5822-23
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 5822-5823
-
-
Pohl, N.L.1
Hans, M.2
Lee, H.Y.3
Kim, Y.S.4
Cane, D.E.5
Khosla, C.6
-
30
-
-
79951841094
-
Enzymatic extender unit generation for in vitro polyketide synthase reactions: Structural and functional showcasing of Streptomyces coelicolor
-
Hughes AJ, Keatinge-Clay A. 2011. Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor Mat B. Chem. Biol. 18:165-76
-
(2011)
Mat B. Chem. Biol.
, vol.18
, pp. 165-176
-
-
Hughes, A.J.1
Keatinge-Clay, A.2
-
31
-
-
84883484875
-
Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways
-
Walker MC, Thuronyi BW, Charkoudian LK, Lowry B, Khosla C, Chang MC. 2013. Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Science 341:1089-94
-
(2013)
Science
, vol.341
, pp. 1089-1094
-
-
Walker, M.C.1
Thuronyi, B.W.2
Charkoudian, L.K.3
Lowry, B.4
Khosla, C.5
Chang, M.C.6
-
32
-
-
80053608537
-
Mutant malonyl-CoA synthetases with altered specificity for polyketide synthase extender unit generation
-
Koryakina I, Williams GJ. 2011. Mutant malonyl-CoA synthetases with altered specificity for polyketide synthase extender unit generation. Chem Bio Chem 12:2289-93
-
(2011)
Chem Bio Chem
, vol.12
, pp. 2289-2293
-
-
Koryakina, I.1
Williams, G.J.2
-
33
-
-
0033079834
-
Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase
-
Gokhale RS, Hunziker D, Cane DE, Khosla C. 1999. Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase. Chem. Biol. 6:117-25
-
(1999)
Chem. Biol.
, vol.6
, pp. 117-125
-
-
Gokhale, R.S.1
Hunziker, D.2
Cane, D.E.3
Khosla, C.4
-
34
-
-
84872518753
-
Poly specific transacyltransferase machinery revealed via engineered Acyl-CoA synthetases
-
Koryakina I, McArthur J, Randall S, Draelos MM, Musiol EM, et al. 2012. Poly specific transacyltransferase machinery revealed via engineered Acyl-CoA synthetases. ACS Chem. Biol. 8:200-8
-
(2012)
ACS Chem. Biol.
, vol.8
, pp. 200-208
-
-
Koryakina, I.1
McArthur, J.2
Randall, S.3
Draelos, M.M.4
Musiol, E.M.5
-
35
-
-
83455210375
-
Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity
-
Wilson MC,Moore BS. 2012. Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. Nat. Prod. Rep. 29:72-86
-
(2012)
Nat. Prod. Rep.
, vol.29
, pp. 72-86
-
-
Wilson, M.C.1
Moore, B.S.2
-
36
-
-
34547542453
-
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway
-
Erb TJ, Berg IA, Brecht V,M̈ ullerM, Fuchs G, Alber BE. 2007. Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway. Proc. Natl. Acad. Sci. USA 104:10631-36
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 10631-10636
-
-
Erb, T.J.1
Berg, I.A.2
Brecht, V.3
M̈uller, M.4
Fuchs, G.5
Alber, B.E.6
-
37
-
-
67049132524
-
Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase
-
Erb TJ, Brecht V, Fuchs G, M̈ uller M, Alber BE. 2009. Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase. Proc. Natl. Acad. Sci. USA 106:8871-76
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 8871-8876
-
-
Erb, T.J.1
Brecht, V.2
Fuchs, G.3
M̈uller, M.4
Alber, B.E.5
-
38
-
-
79953692091
-
Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors
-
Rachid S, Huo L,Herrmann J, Stadler M, K̈ opcke B, et al. 2011. Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors. Chem Bio Chem 12:922-31
-
(2011)
Chem Bio Chem
, vol.12
, pp. 922-931
-
-
Rachid, S.1
Huo Lherrmann, J.2
Stadler, M.3
K̈opcke, B.4
-
39
-
-
83655163980
-
Unusual carbon fixation gives rise to diverse polyketide extender units
-
Quade N, Huo LJ, Rachid S, Heinz DW, M̈ uller R. 2012. Unusual carbon fixation gives rise to diverse polyketide extender units. Nat. Chem. Biol. 8:117-24
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 117-124
-
-
Quade, N.1
Huo, L.J.2
Rachid, S.3
Heinz, D.W.4
M̈uller, R.5
-
40
-
-
84879996598
-
Promiscuity of a modular polyketide synthase towards natural and non-natural extender units
-
Koryakina I, McArthur JB, Draelos MM, Williams GJ. 2013. Promiscuity of a modular polyketide synthase towards natural and non-natural extender units. Org. Biomol. Chem. 11:4449-58
-
(2013)
Org. Biomol. Chem.
, vol.11
, pp. 4449-4458
-
-
Koryakina, I.1
McArthur, J.B.2
Draelos, M.M.3
Williams, G.J.4
-
41
-
-
0032501971
-
Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases
-
Quadri LEN, Weinreb PH, Lei M, Nakano MM, Zuber P, Walsh CT. 1998. Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. Biochemistry 37:1585-95
-
(1998)
Biochemistry
, vol.37
, pp. 1585-1595
-
-
Quadri, L.E.N.1
Weinreb, P.H.2
Lei, M.3
Nakano, M.M.4
Zuber, P.5
Walsh, C.T.6
-
42
-
-
84878653692
-
Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase
-
Yuzawa S, Eng CH, Katz L, Keasling JD. 2013. Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase. Biochemistry 52:3791-93
-
(2013)
Biochemistry
, vol.52
, pp. 3791-3793
-
-
Yuzawa, S.1
Eng, C.H.2
Katz, L.3
Keasling, J.D.4
-
43
-
-
0036007875
-
Biosynthesis and attachment of novel bacterial polyketide synthase starter units
-
Moore BS, Hertweck C. 2002. Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Nat. Prod. Rep. 19:70-99
-
(2002)
Nat. Prod. Rep.
, vol.19
, pp. 70-99
-
-
Moore, B.S.1
Hertweck, C.2
-
44
-
-
34248586053
-
Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids
-
Xu Z, Schenk A, Hertweck C. 2007. Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids. J. Am. Chem. Soc. 129:6022-30
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 6022-6030
-
-
Xu, Z.1
Schenk, A.2
Hertweck, C.3
-
45
-
-
61649116145
-
Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives
-
Xu Z, Mets̈a-Ketel̈aM,Hertweck C. 2009. Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives. J. Biotechnol. 140:107-13
-
(2009)
J. Biotechnol.
, vol.140
, pp. 107-113
-
-
Xu, Z.1
Mets̈a-Ketel̈a, M.2
Hertweck, C.3
-
46
-
-
0036848668
-
Crystal structure of the priming β-ketosynthase from the R1128 polyketide biosynthetic pathway
-
Pan H, Tsai SC, Meadows ES, Miercke LJW, Keatinge-Clay AT, et al. 2002. Crystal structure of the priming β-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure 10:1559-68
-
(2002)
Structure
, vol.10
, pp. 1559-1568
-
-
Pan, H.1
Tsai, S.C.2
Meadows, E.S.3
Miercke, L.J.W.4
Keatinge-Clay, A.T.5
-
47
-
-
84856111131
-
A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis
-
Bretschneider T, Zocher G, Unger M, Scherlach K, Stehle T, Hertweck C. 2012. A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat. Chem. Biol. 8:154-61
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 154-161
-
-
Bretschneider, T.1
Zocher, G.2
Unger, M.3
Scherlach, K.4
Stehle, T.5
Hertweck, C.6
-
49
-
-
72249105298
-
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575
-
Pickens LB, KimW,Wang P, ZhouH,WatanabeK, et al. 2009. Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. J. Am. Chem. Soc. 131:17677-89
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 17677-17689
-
-
Pickens, L.B.1
Kim, W.2
Wang, P.3
Zhou, H.4
Watanabe, K.5
-
50
-
-
84871757755
-
The status of type i polyketide synthase ketoreductases
-
Zheng JT, Keatinge-Clay AT. 2013. The status of type I polyketide synthase ketoreductases. Med. Chem. Commun. 4:34-40
-
(2013)
Med. Chem. Commun.
, vol.4
, pp. 34-40
-
-
Zheng, J.T.1
Keatinge-Clay, A.T.2
-
51
-
-
39749093400
-
Synthesis of chiral pharmaceutical intermediates by biocatalysis
-
Patel RN. 2008. Synthesis of chiral pharmaceutical intermediates by biocatalysis. Coord. Chem. Rev. 252:659-701
-
(2008)
Coord. Chem. Rev.
, vol.252
, pp. 659-701
-
-
Patel, R.N.1
-
52
-
-
33646115667
-
High-throughput mutagenesis to evaluatemodels of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase
-
O'Hare HM, Baerga-Ortiz A, Popovic B, Spencer JB, Leadlay PF. 2006. High-throughput mutagenesis to evaluatemodels of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase. Chem. Biol. 13:287-96
-
(2006)
Chem. Biol.
, vol.13
, pp. 287-296
-
-
O'Hare, H.M.1
Baerga-Ortiz, A.2
Popovic, B.3
Spencer, J.B.4
Leadlay, P.F.5
-
53
-
-
36048958284
-
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase
-
Castonguay R, He W, Chen AY, Khosla C, Cane DE. 2007. Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. J. Am. Chem. Soc. 129:13758-69
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 13758-13769
-
-
Castonguay, R.1
He, W.2
Chen, A.Y.3
Khosla, C.4
Cane, D.E.5
-
54
-
-
34547945950
-
A tylosin ketoreductase reveals how chirality is determined in polyketides
-
Keatinge-Clay AT. 2007. A tylosin ketoreductase reveals how chirality is determined in polyketides. Chem. Biol. 14:898-908
-
(2007)
Chem. Biol.
, vol.14
, pp. 898-908
-
-
Keatinge-Clay, A.T.1
-
55
-
-
77955477986
-
Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase
-
Zheng J, Taylor CA, Piasecki SK, Keatinge-Clay AT. 2010. Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase. Structure 18:913-22
-
(2010)
Structure
, vol.18
, pp. 913-922
-
-
Zheng, J.1
Taylor, C.A.2
Piasecki, S.K.3
Keatinge-Clay, A.T.4
-
56
-
-
33644905256
-
Broad substrate specificity of ketoreductases derived from modular polyketide synthases
-
Bali S, O'Hare HM, Weissman KJ. 2006. Broad substrate specificity of ketoreductases derived from modular polyketide synthases. Chem Bio Chem 7:478-84
-
(2006)
Chem Bio Chem
, vol.7
, pp. 478-484
-
-
Bali, S.1
O'Hare, H.M.2
Weissman, K.J.3
-
57
-
-
80055086082
-
Employingmodular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks
-
Piasecki SK, Taylor CA, Detelich JF, Liu J, Zheng J, et al. 2011. Employingmodular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks. Chem. Biol. 18:1331-40
-
(2011)
Chem. Biol.
, vol.18
, pp. 1331-1340
-
-
Piasecki, S.K.1
Taylor, C.A.2
Detelich, J.F.3
Liu, J.4
Zheng, J.5
-
58
-
-
84867206986
-
Preparative, in vitro biocatalysis of triketide lactone chiral building blocks
-
Harper AD, Bailey CB, Edwards AD, Detelich JF, Keatinge-Clay AT. 2012. Preparative, in vitro biocatalysis of triketide lactone chiral building blocks. Chem Bio Chem 13:2200-3
-
(2012)
Chem Bio Chem
, vol.13
, pp. 2200-2203
-
-
Harper, A.D.1
Bailey, C.B.2
Edwards, A.D.3
Detelich, J.F.4
Keatinge-Clay, A.T.5
-
59
-
-
56049125010
-
A polylinker approach to reductive loop swaps in modular polyketide synthases
-
Kellenberger L, Galloway IS, Sauter G, B̈ohm G, Hanefeld U, et al. 2008. A polylinker approach to reductive loop swaps in modular polyketide synthases. Chem Bio Chem 9:2740-49
-
(2008)
Chem Bio Chem
, vol.9
, pp. 2740-2749
-
-
Kellenberger, L.1
Galloway, I.S.2
Sauter, G.3
B̈ohm, G.4
Hanefeld, U.5
-
60
-
-
77954203515
-
Insights into bacterial 6-methylsalicylic acid synthase and its engineering to orsellinic acid synthase for spirotetronate generation
-
Ding W, Lei C, He QL, Zhang QL, Bi YR, Liu W. 2010. Insights into bacterial 6-methylsalicylic acid synthase and its engineering to orsellinic acid synthase for spirotetronate generation. Chem. Biol. 17:495-503
-
(2010)
Chem. Biol.
, vol.17
, pp. 495-503
-
-
Ding, W.1
Lei, C.2
He, Q.L.3
Zhang, Q.L.4
Bi, Y.R.5
Liu, W.6
-
61
-
-
77950127253
-
Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis
-
Olano C, Ḿendez C, Salas JA. 2010. Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. Nat. Prod. Rep. 27:571-616
-
(2010)
Nat. Prod. Rep.
, vol.27
, pp. 571-616
-
-
Olano, C.1
Ḿendez, C.2
Salas, J.A.3
-
62
-
-
0030875774
-
Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase
-
Jacobsen JR, Hutchinson CR, Cane DE, Khosla C. 1997. Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. Science 277:367-69
-
(1997)
Science
, vol.277
, pp. 367-369
-
-
Jacobsen, J.R.1
Hutchinson, C.R.2
Cane, D.E.3
Khosla, C.4
-
63
-
-
84870925950
-
Flavoenzymes: Versatile catalysts in biosynthetic pathways
-
Walsh CT, Wencewicz TA. 2013. Flavoenzymes: versatile catalysts in biosynthetic pathways. Nat. Prod. Rep. 30:175-200
-
(2013)
Nat. Prod. Rep.
, vol.30
, pp. 175-200
-
-
Walsh, C.T.1
Wencewicz, T.A.2
-
64
-
-
84868318849
-
Diversity of P450 enzymes in the biosynthesis of natural products
-
Podust LM, Sherman DH. 2012. Diversity of P450 enzymes in the biosynthesis of natural products. Nat. Prod. Rep. 29:1251-66
-
(2012)
Nat. Prod. Rep.
, vol.29
, pp. 1251-1266
-
-
Podust, L.M.1
Sherman, D.H.2
-
65
-
-
84855990581
-
Angucyclines: Biosyn thesis, mode-of-Action, new natural products, and synthesis
-
Kharel MK, Pahari P, Shepherd MD, Tibrewal N, Nybo SE, et al. 2012. Angucyclines: biosynthesis, mode-of-Action, new natural products, and synthesis. Nat. Prod. Rep. 29:264-325
-
(2012)
Nat. Prod. Rep.
, vol.29
, pp. 264-325
-
-
Kharel, M.K.1
Pahari, P.2
Shepherd, M.D.3
Tibrewal, N.4
Nybo, S.E.5
-
66
-
-
33751092257
-
Biosynthesis of lovastatin analogs with a broadly specific acyltransferase
-
Xie X, Watanabe K,WojcickiWA, Wang CC, Tang Y. 2006. Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chem. Biol. 13:1161-69
-
(2006)
Chem. Biol.
, vol.13
, pp. 1161-1169
-
-
Xie, X.1
Watanabe, K.2
Wojcicki, W.A.3
Wang, C.C.4
Tang, Y.5
-
67
-
-
34247474300
-
Efficient synthesis of simvastatin by use of whole-cell biocatalysis
-
Xie XK, Tang Y. 2007. Efficient synthesis of simvastatin by use of whole-cell biocatalysis. Appl. Environ. Microbiol. 73:2054-60
-
(2007)
Appl. Environ. Microbiol.
, vol.73
, pp. 2054-2060
-
-
Xie, X.K.1
Tang, Y.2
-
68
-
-
71149114259
-
Directed evolution and structural characterization of a simvastatin synthase
-
Gao X, Xie X, Pashkov I, Sawaya MR, Laidman J, et al. 2009. Directed evolution and structural characterization of a simvastatin synthase. Chem. Biol. 16:1064-74
-
(2009)
Chem. Biol.
, vol.16
, pp. 1064-1074
-
-
Gao, X.1
Xie, X.2
Pashkov, I.3
Sawaya, M.R.4
Laidman, J.5
-
69
-
-
0030716357
-
Analysis of a commercially improved Penicillium chrysogenum strain series: Involvement of recombinogenic regions in amplification and deletion of the penicillin biosynthesis gene cluster
-
Newbert RW, Barton B, Greaves P, Harper J, Turner G. 1997. Analysis of a commercially improved Penicillium chrysogenum strain series: involvement of recombinogenic regions in amplification and deletion of the penicillin biosynthesis gene cluster. J. Ind. Microbiol. Biotechnol. 19:18-27
-
(1997)
J. Ind. Microbiol. Biotechnol.
, vol.19
, pp. 18-27
-
-
Newbert, R.W.1
Barton, B.2
Greaves, P.3
Harper, J.4
Turner, G.5
-
70
-
-
0028998750
-
The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences
-
Fierro F, Barredo JL, D́ez B, Gutierrez S, Ferńandez FJ, Mart́n JF. 1995. The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences. Proc. Natl. Acad. Sci. USA 92:6200-4
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 6200-6204
-
-
Fierro, F.1
Barredo, J.L.2
D́ez, B.3
Gutierrez, S.4
Ferńandez, F.J.5
Mart́n, J.F.6
-
71
-
-
78149428283
-
Biosynthetic gene cluster dose effect on penicillin production by Penicillium chrysogenum
-
Nijland JG, Ebbendorf B, Woszczynska M, Boer R, Bovenberg RAL, Driessen AJM. 2010. Nonlinear biosynthetic gene cluster dose effect on penicillin production by Penicillium chrysogenum. Appl. Environ. Microbiol. 76:7109-15
-
(2010)
Appl. Environ. Microbiol.
, vol.76
, pp. 7109-7115
-
-
Nijland, J.G.1
Ebbendorf, B.2
Woszczynska, M.3
Boer, R.4
Bovenberg, R.A.L.5
Driessen, A.J.M.6
-
72
-
-
84868332788
-
Increased penicillin production in Penicillium chrysogenum production strains via balanced overexpression of isopenicillinNacyltransferase
-
Weber SS, Polli F, Boer R, Bovenberg RAL, Driessen AJM. 2012. Increased penicillin production in Penicillium chrysogenum production strains via balanced overexpression of isopenicillinNacyltransferase. Appl. Environ. Microbiol. 78:7107-13
-
(2012)
Appl. Environ. Microbiol.
, vol.78
, pp. 7107-7113
-
-
Weber, S.S.1
Polli, F.2
Boer, R.3
Bovenberg, R.A.L.4
Driessen, A.J.M.5
-
73
-
-
33646086963
-
Profiling a taxol pathway 10β-Acetyltransferase: Assessment of the specificity and the production of baccatin III by in vivo acetylation
-
Loncaric C, Merriweather E,Walker KD. 2006. Profiling a taxol pathway 10β-Acetyltransferase: assessment of the specificity and the production of baccatin III by in vivo acetylation. E. coli. Chem. Biol. 13:309-17
-
(2006)
E. Coli. Chem. Biol.
, vol.13
, pp. 309-317
-
-
Loncaric, C.1
Merriweather, E.2
Walker, K.D.3
-
74
-
-
58049202807
-
The taxol pathway 10-O-Acetyltransferase shows regioselective promiscuity with the oxetane hydroxyl of 4-deacetyltaxanes
-
Ondari ME,Walker KD. 2008. The taxol pathway 10-O-Acetyltransferase shows regioselective promiscuity with the oxetane hydroxyl of 4-deacetyltaxanes. J. Am. Chem. Soc. 130:17187-94
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 17187-17194
-
-
Ondari, M.E.1
Walker, K.D.2
-
75
-
-
79951815138
-
The chromomycin CmmA acetyltransferase: A membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin
-
Garća B, Gonźalez-Sab́n J, Meńendez N, Brãna AF, Nu ̃ nez LE, et al. 2011. The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin. Microbiol. Biotechnol. 4:226-38
-
(2011)
Microbiol. Biotechnol.
, vol.4
, pp. 226-238
-
-
Garća, B.1
Gonźalez-Sab́n, J.2
Meńendez, N.3
Brãna, A.F.4
Nũnez, L.E.5
-
76
-
-
3843111327
-
Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A3 by Streptomyces griseus ssp. Griseus
-
Meńendez N, Nur-e-Alam M, Bra ̃ na AF, Rohr J, Salas JA, Ḿendez C. 2004. Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A3 by Streptomyces griseus ssp. griseus. Mol. Microbiol. 53:903-15
-
(2004)
Mol. Microbiol.
, vol.53
, pp. 903-915
-
-
Meńendez, N.1
Nur-E-Alam, M.2
Brãna, A.F.3
Rohr, J.4
Salas, J.A.5
Ḿendez, C.6
-
77
-
-
0035501490
-
Altering the glycosylation pattern of bioactive compounds
-
Ḿendez C, Salas JA. 2001. Altering the glycosylation pattern of bioactive compounds. Trends Biotechnol. 19:449-56
-
(2001)
Trends Biotechnol.
, vol.19
, pp. 449-456
-
-
Ḿendez, C.1
Salas, J.A.2
-
78
-
-
0031127564
-
The role of carbohydrates in biologically active natural products
-
Weymouth-Wilson AC. 1997. The role of carbohydrates in biologically active natural products. Nat. Prod. Rep. 14:99-110
-
(1997)
Nat. Prod. Rep.
, vol.14
, pp. 99-110
-
-
Weymouth-Wilson, A.C.1
-
79
-
-
33750712392
-
Colchicine glycorandomization influences cytotoxicity and mechanism of action
-
Ahmed A, Peters NR, Fitzgerald MK, Watson JA, Hoffmann FM, Thorson JS. 2006. Colchicine glycorandomization influences cytotoxicity and mechanism of action. J. Am. Chem. Soc. 128:14224-25
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 14224-14225
-
-
Ahmed, A.1
Peters, N.R.2
Fitzgerald, M.K.3
Watson, J.A.4
Hoffmann, F.M.5
Thorson, J.S.6
-
80
-
-
57549105096
-
Natural-product sugar biosynthesis and enzymatic glycodiversification
-
Thibodeaux CJ, Melançon CE, Liu H-W. 2008. Natural-product sugar biosynthesis and enzymatic glycodiversification. Angew. Chem. Int. Ed. 47:9814-59
-
(2008)
Angew. Chem. Int. Ed.
, vol.47
, pp. 9814-9859
-
-
Thibodeaux, C.J.1
Melançon, C.E.2
Liu, H.-W.3
-
81
-
-
34548685673
-
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution
-
Williams GJ, Zhang C, Thorson JS. 2007. Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution. Nat. Chem. Biol. 3:657-62
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 657-662
-
-
Williams, G.J.1
Zhang, C.2
Thorson, J.S.3
-
82
-
-
40649092405
-
A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution
-
Williams GJ, Thorson JS. 2008. A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution. Nat. Protoc. 3:357-62
-
(2008)
Nat. Protoc.
, vol.3
, pp. 357-362
-
-
Williams, G.J.1
Thorson, J.S.2
-
83
-
-
41949101106
-
Optimizing glycosyltransferase specificity via hot spot saturation mutagenesis presents a catalyst for novobiocin glycorandomization
-
Williams GJ, Goff RD, Zhang CS, Thorson JS. 2008. Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization. Chem. Biol. 15:393-401
-
(2008)
Chem. Biol.
, vol.15
, pp. 393-401
-
-
Williams, G.J.1
Goff, R.D.2
Zhang, C.S.3
Thorson, J.S.4
-
84
-
-
67349254960
-
Reconstitution of antibiotics glycosylation by domain exchanged chimeric glycosyltransferase
-
Park S-H, Park H-Y, Cho B-K, Yang Y-H, Sohng JK, et al. 2009. Reconstitution of antibiotics glycosylation by domain exchanged chimeric glycosyltransferase. J. Mol. Catal. B 60:29-35
-
(2009)
J. Mol. Catal. B
, vol.60
, pp. 29-35
-
-
Park, S.-H.1
Park, H.-Y.2
Cho, B.-K.3
Yang, Y.-H.4
Sohng, J.K.5
-
85
-
-
58549088752
-
Engineering a function into a glycosyltransferase
-
Krauth C, Fedoryshyn M, Schleberger C, Luzhetskyy A, Bechthold A. 2009. Engineering a function into a glycosyltransferase. Chem. Biol. 16:28-35
-
(2009)
Chem. Biol.
, vol.16
, pp. 28-35
-
-
Krauth, C.1
Fedoryshyn, M.2
Schleberger, C.3
Luzhetskyy, A.4
Bechthold, A.5
-
86
-
-
47049087906
-
A kinetic analysis of regiospecific glucosylation by two glycosyltransferases of Arabidopsis thaliana: Domain swapping to introduce new activities
-
Cartwright AM, Lim E-K, Kleanthous C, Bowles DJ. 2008. A kinetic analysis of regiospecific glucosylation by two glycosyltransferases of Arabidopsis thaliana: domain swapping to introduce new activities. J. Biol. Chem. 283:15724-31
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 15724-15731
-
-
Cartwright, A.M.1
Lim, E.-K.2
Kleanthous, C.3
Bowles, D.J.4
-
87
-
-
0041422391
-
Structure of the TDPepi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway
-
Mulichak AM, Losey HC, Lu W, Wawrzak Z, Walsh CT, Garavito RM. 2003. Structure of the TDPepi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway. Proc. Natl. Acad. Sci. USA 100:9238-43
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 9238-9243
-
-
Mulichak, A.M.1
Losey, H.C.2
Lu, W.3
Wawrzak, Z.4
Walsh, C.T.5
Garavito, R.M.6
-
88
-
-
0037417869
-
Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases
-
Hu Y, Chen L, Ha S, Gross B, Falcone B, et al. 2003. Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases. Proc. Natl. Acad. Sci. USA 100:845-49
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 845-849
-
-
Hu, Y.1
Chen, L.2
Ha, S.3
Gross, B.4
Falcone, B.5
-
89
-
-
67649563070
-
Chimeric glycosyltransferases for the generation of hybrid glycopeptides
-
Truman AW, Dias MVB, Wu S, Blundell TL, Huang FL, Spencer JB. 2009. Chimeric glycosyltransferases for the generation of hybrid glycopeptides. Chem. Biol. 16:676-85
-
(2009)
Chem. Biol.
, vol.16
, pp. 676-685
-
-
Truman, A.W.1
Dias, M.V.B.2
Wu, S.3
Blundell, T.L.4
Huang, F.L.5
Spencer, J.B.6
-
90
-
-
33748302743
-
Exploiting the reversibility of natural product glycosyltransferase- catalyzed reactions
-
Zhang CS, Griffith BR, Fu Q, Albermann C, Fu X, et al. 2006. Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions. Science 313:1291-94
-
(2006)
Science
, vol.313
, pp. 1291-1294
-
-
Zhang, C.S.1
Griffith, B.R.2
Fu, Q.3
Albermann, C.4
Fu, X.5
-
91
-
-
80052968314
-
Using simple donors to drive the equilibria of glycosyltransferase- catalyzed reactions
-
GanttRW, Peltier-Pain P, Cournoyer WJ, Thorson JS. 2011. Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions. Nat. Chem. Biol. 7:685-91
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 685-691
-
-
Gantt, R.W.1
Peltier-Pain, P.2
Cournoyer, W.J.3
Thorson, J.S.4
-
92
-
-
79251501973
-
Recombinant E. Coli prototype strains for in vivo glycorandomization
-
Williams GJ, Yang J, Zhang C, Thorson JS. 2010. Recombinant E. coli prototype strains for in vivo glycorandomization. ACS Chem. Biol. 6:95-100
-
(2010)
ACS Chem. Biol.
, vol.6
, pp. 95-100
-
-
Williams, G.J.1
Yang, J.2
Zhang, C.3
Thorson, J.S.4
-
94
-
-
84867364541
-
Natural product disaccharide engineering through tandem glycosyltransferase catalysis reversibility and neoglycosylation
-
Peltier-Pain P, Marchillo K, Zhou MQ, Andes DR, Thorson JS. 2012. Natural product disaccharide engineering through tandem glycosyltransferase catalysis reversibility and neoglycosylation. Org. Lett. 14:5086-89
-
(2012)
Org. Lett.
, vol.14
, pp. 5086-5089
-
-
Peltier-Pain, P.1
Marchillo, K.2
Zhou, M.Q.3
Andes, D.R.4
Thorson, J.S.5
-
95
-
-
84877359433
-
Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis
-
Gantt RW, Peltier-Pain P, Singh S, Zhou MQ, Thorson JS. 2013. Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis. Proc. Natl. Acad. Sci. USA 110:7648-53
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 7648-7653
-
-
Gantt, R.W.1
Peltier-Pain, P.2
Singh, S.3
Zhou, M.Q.4
Thorson, J.S.5
-
96
-
-
84883122189
-
Characterizing amosamine biosynthesis in amicetin reveals AmiG as a reversible retaining glycosyltransferase
-
Chen R, Zhang H, Zhang G, Li S, Zhang G, et al. 2013. Characterizing amosamine biosynthesis in amicetin reveals AmiG as a reversible retaining glycosyltransferase. J. Am. Chem. Soc. 135:12152-55
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 12152-12155
-
-
Chen, R.1
Zhang, H.2
Zhang, G.3
Li, S.4
Zhang, G.5
-
97
-
-
33748588122
-
Nature's inventory of halogenation catalysts: Oxidative strategies predominate
-
Vaillancourt FH, Yeh E, Vosburg DA, Garneau-Tsodikova S, Walsh CT. 2006. Nature's inventory of halogenation catalysts: oxidative strategies predominate. Chem. Rev. 106:3364-78
-
(2006)
Chem. Rev.
, vol.106
, pp. 3364-3378
-
-
Vaillancourt, F.H.1
Yeh, E.2
Vosburg, D.A.3
Garneau-Tsodikova, S.4
Walsh, C.T.5
-
98
-
-
77950789591
-
Halogen atoms in the modern medicinal chemistry: Hints for the drug design
-
HernandesMZ, Cavalcanti SMT, Moreira DRM, de Azevedo WF, Leite ACL. 2010. Halogen atoms in the modern medicinal chemistry: hints for the drug design. Curr. Drug Targets 11:303-14
-
(2010)
Curr. Drug Targets
, vol.11
, pp. 303-314
-
-
Hernandes, M.Z.1
Cavalcanti, S.M.T.2
Moreira, D.R.M.3
De Azevedo, W.F.4
Leite, A.C.L.5
-
99
-
-
33745963527
-
Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH
-
Yeh E, Cole LJ, Barr EW, Bollinger JM, Ballou DP, Walsh CT. 2006. Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH. Biochemistry 45:7904-12
-
(2006)
Biochemistry
, vol.45
, pp. 7904-7912
-
-
Yeh, E.1
Cole, L.J.2
Barr, E.W.3
Bollinger, J.M.4
Ballou, D.P.5
Walsh, C.T.6
-
100
-
-
82555168471
-
Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor
-
Glenn WS, Nims E, O'Connor SE. 2011. Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor. J. Am. Chem. Soc. 133:19346-49
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 19346-19349
-
-
Glenn, W.S.1
Nims, E.2
O'Connor, S.E.3
-
101
-
-
84877258549
-
Regioselective arene halogenation using the FAD-dependent halogenase RebH
-
Payne JT, Andorfer MC, Lewis JC. 2013. Regioselective arene halogenation using the FAD-dependent halogenase RebH. Angew. Chem. Int. Ed. 52:5271-74
-
(2013)
Angew. Chem. Int. Ed.
, vol.52
, pp. 5271-5274
-
-
Payne, J.T.1
Andorfer, M.C.2
Lewis, J.C.3
-
102
-
-
78651445383
-
A novel fungal flavin-dependent halogenase for natural product biosynthesis
-
Zeng J, Zhan J. 2010. A novel fungal flavin-dependent halogenase for natural product biosynthesis. Chem Bio Chem 11:2119-23
-
(2010)
Chem Bio Chem
, vol.11
, pp. 2119-2123
-
-
Zeng, J.1
Zhan, J.2
-
103
-
-
84880606744
-
Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens
-
Zhu T, Cheng X, Liu Y,Deng Z, You D. 2013. Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens. Metab. Eng. 19:69-78
-
(2013)
Metab. Eng.
, vol.19
, pp. 69-78
-
-
Zhu, T.1
Cheng, X.2
Liu Ydeng, Z.3
You, D.4
-
104
-
-
1142310932
-
Crystal structure and mechanism of a bacterial fluorinating enzyme
-
Dong CJ, Huang FL, Deng H, Schaffrath C, Spencer JB, et al. 2004. Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature 427:561-65
-
(2004)
Nature
, vol.427
, pp. 561-565
-
-
Dong, C.J.1
Huang, F.L.2
Deng, H.3
Schaffrath, C.4
Spencer, J.B.5
-
105
-
-
39149099787
-
Halogenation strategies in natural product biosynthesis
-
Neumann CS, Fujimori DG, Walsh CT. 2008. Halogenation strategies in natural product biosynthesis. Chem. Biol. 15:99-109
-
(2008)
Chem. Biol.
, vol.15
, pp. 99-109
-
-
Neumann, C.S.1
Fujimori, D.G.2
Walsh, C.T.3
-
106
-
-
37249024344
-
Discovery and characterization of a marine bacterial SAM-dependent chlorinase
-
Eustaquio AS, Pojer F, Noe JP, Moore BS. 2008. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat. Chem. Biol. 4:69-74
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 69-74
-
-
Eustaquio, A.S.1
Pojer, F.2
Noe, J.P.3
Moore, B.S.4
-
107
-
-
45749125659
-
Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome
-
EustaquioAS, MooreBS. 2008. Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew. Chem. Int. Ed. 47:3936-38
-
(2008)
Angew. Chem. Int. Ed.
, vol.47
, pp. 3936-3938
-
-
Eustaquio, A.S.1
Moore, B.S.2
-
108
-
-
79955963713
-
Natural products via enzymatic reactions
-
Piel J. 2010. Natural products via enzymatic reactions. Preface. Top. Curr. Chem. 297:ix-x
-
(2010)
Preface. Top. Curr. Chem.
, vol.297
, pp. 9-10
-
-
Piel, J.1
-
109
-
-
48249137414
-
Total biosyn thesis: In vitro reconstitution of polyketide and nonribosomal peptide pathways
-
Sattely ES, Fischbach MA, Walsh CT. 2008. Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways. Nat. Prod. Rep. 25:757-93
-
(2008)
Nat. Prod. Rep.
, vol.25
, pp. 757-793
-
-
Sattely, E.S.1
Fischbach, M.A.2
Walsh, C.T.3
-
110
-
-
8144227951
-
EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions
-
Xiang L, Kalaitzis JA, Moore BS. 2004. EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions. Proc. Natl. Acad. Sci. USA 101:15609-14
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15609-15614
-
-
Xiang, L.1
Kalaitzis, J.A.2
Moore, B.S.3
-
111
-
-
34548089959
-
Enzymatic total synthesis of enterocin polyketides
-
Cheng Q, Xiang L, Izumikawa M, Meluzzi D, Moore BS. 2007. Enzymatic total synthesis of enterocin polyketides. Nat. Chem. Biol. 3:557-58
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 557-558
-
-
Cheng, Q.1
Xiang, L.2
Izumikawa, M.3
Meluzzi, D.4
Moore, B.S.5
-
112
-
-
65249168100
-
In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides
-
Kalaitzis JA, Cheng Q, Thomas PM, Kelleher NL, Moore BS. 2009. In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides. J. Nat. Prod. 72:469-72
-
(2009)
J. Nat. Prod.
, vol.72
, pp. 469-472
-
-
Kalaitzis, J.A.1
Cheng, Q.2
Thomas, P.M.3
Kelleher, N.L.4
Moore, B.S.5
-
113
-
-
84856179567
-
Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis
-
Pahari P, Kharel MK, Shepherd MD, van Lanen SG, Rohr J. 2012. Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis. Angew. Chem. Int. Ed. 51:1216-20
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 1216-1220
-
-
Pahari, P.1
Kharel, M.K.2
Shepherd, M.D.3
Van Lanen, S.G.4
Rohr, J.5
-
114
-
-
84881058964
-
Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin
-
Hansen DA, Rath CM, Eisman EB, Narayan AR, Kittendorf JD, et al. 2013. Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin. J. Am. Chem. Soc. 135:11232-38
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 11232-11238
-
-
Hansen, D.A.1
Rath, C.M.2
Eisman, E.B.3
Narayan, A.R.4
Kittendorf, J.D.5
-
115
-
-
70350639418
-
Synthesis and biochemical analysis of complex chainelongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases
-
Mortison JD, Kittendorf JD, Sherman DH. 2009. Synthesis and biochemical analysis of complex chainelongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases. J. Am. Chem. Soc. 131:15784-93
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 15784-15793
-
-
Mortison, J.D.1
Kittendorf, J.D.2
Sherman, D.H.3
-
116
-
-
79953727021
-
Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics
-
Zhang W, Ntai I, Bolla ML, Malcolmson SJ, Kahne D, et al. 2011. Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. J. Am. Chem. Soc. 133:5240-43
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 5240-5243
-
-
Zhang, W.1
Ntai, I.2
Bolla, M.L.3
Malcolmson, S.J.4
Kahne, D.5
-
117
-
-
84886495241
-
Complexity generation in fungal polyketide biosyn thesis: A spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin
-
Cacho RA, Chooi YH, ZhouH, Tang Y. 2013. Complexity generation in fungal polyketide biosynthesis: a spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin. ACS Chem. Biol. 8:2322-30
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 2322-2330
-
-
Cacho, R.A.1
Chooi, Y.H.2
Zhou, H.3
Tang, Y.4
|