High-Throughput Mutagenesis to Evaluate Models of Stereochemical Control in Ketoreductase Domains from the Erythromycin Polyketide Synthase

Chemistry and Biology

Volumn 13, Issue 3, 2006, Pages 287-296

  O'Hare, Helen M ^a   Baerga Ortiz, Abel ^a   Popovic, Bojana ^a   Spencer, Jonathan B ^a   Leadlay, Peter F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CHEMBIO

Indexed keywords

OXIDOREDUCTASE; POLYKETIDE SYNTHASE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CHEMISTRY; CONFORMATION; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; OXIDATION REDUCTION REACTION; PROTEIN TERTIARY STRUCTURE; STEREOISOMERISM;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OXIDATION-REDUCTION; OXIDOREDUCTASES; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 33646115667     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2006.01.003     Document Type: Article

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