Nonlinear biosynthetic gene cluster dose effect on penicillin production by Penicillium chrysogenum

Applied and Environmental Microbiology

Volumn 76, Issue 21, 2010, Pages 7109-7115

  Nijland, Jeroen G ^a   Ebbendorf, Bjorg ^a   Woszczynska, Marta ^a   Boer, Rémon ^b   Bovenberg, Roel A L ^a,b   Driessen, Arnold J M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b DSM RESOLVE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHETIC GENE; BIOSYNTHETIC GENE CLUSTER; BIOSYNTHETIC PATHWAY; COENZYME A; COPY NUMBER; D-VALINE; DOSE EFFECTS; FILAMENTOUS FUNGI; GENE CLUSTERS; INTRACELLULAR LEVELS; ISOPENICILLIN N SYNTHASE; KEY ENZYMES; LIMITING STEP; PENICILLIN PRODUCTION; PENICILLIN V; PENICILLIUM CHRYSOGENUM; PROTEIN LEVEL; SIDE CHAINS; STRAIN IMPROVEMENT; SYNTHETASES; TRANSCRIPT LEVEL;

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CYTOLOGY; ENZYME ACTIVITY; PLANTS (BOTANY); STRAIN;

GENES;

ACYL COA 6 AMINOPENICILLANIC ACID ACYLTRANSFERASE; ACYL-COA-6-AMINOPENICILLANIC ACID ACYLTRANSFERASE; ACYLTRANSFERASE; ADICILLIN; ALPHA AMINOADIPYL CYSTEINYL VALINE SYNTHETASE; ALPHA-AMINOADIPYL-CYSTEINYL-VALINE SYNTHETASE; ISOPENICILLIN N SYNTHETASE; OXIDOREDUCTASE; PENICILLIN BINDING PROTEIN; PENICILLIN DERIVATIVE; PENICILLIN V; PEPTIDE SYNTHASE;

ANTIBIOTICS; CLUSTER ANALYSIS; ENZYME ACTIVITY; EXPERIMENTAL STUDY; FUNGUS;

ARTICLE; BIOSYNTHESIS; GENE DOSAGE; GENE EXPRESSION; GENETICS; METABOLISM; MULTIGENE FAMILY; PENICILLIUM CHRYSOGENUM; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ACYLTRANSFERASES; GENE DOSAGE; GENE EXPRESSION; MULTIGENE FAMILY; OXIDOREDUCTASES; PENICILLIN V; PENICILLIN-BINDING PROTEINS; PENICILLINS; PENICILLIUM CHRYSOGENUM; PEPTIDE SYNTHASES; POLYMERASE CHAIN REACTION;

FUNGI; PENICILLIUM CHRYSOGENUM;

EID: 78149428283     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.01702-10     Document Type: Article

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