SCOPUS 정보 검색 플랫폼

Journal of the American Chemical Society

Volumn 133, Issue 48, 2011, Pages 19346-19349

Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor

(3) Glenn, Weslee S a,b Nims, Ezekiel b,d O'Connor, Sarah E a,c

a JOHN INNES CENTRE (United Kingdom)

b MASSACHUSETTS INSTITUTE OF TECHNOLOGY (United States)

c UNIVERSITY OF EAST ANGLIA (United Kingdom)

d Ra Pharmaceuticals Inc (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHARANTHUS ROSEUS; DE NOVO PRODUCTION; ENZYMATIC HALOGENATION; FLAVIN-DEPENDENT; IN-VIVO; MADAGASCAR; METABOLIC ENGINEERING; MONOTERPENE INDOLE ALKALOIDS; NATURAL PRODUCTS; POTENTIAL UTILITY; SUBSTRATE SPECIFICITY; TRYPTAMINES; TRYPTOPHAN DECARBOXYLASE; TRYPTOPHAN HALOGENASE; WILD TYPES;

AMINO ACIDS; CHLORINE; ENZYMES; HALOGENATION; METABOLISM; METABOLITES; NITROGEN COMPOUNDS; TISSUE; TISSUE CULTURE; TISSUE ENGINEERING;

SUBSTRATES;

12 CHLORO 19,20 DIHYDROAKUAMMICINE; 7 CHLOROTRYPTOPHAN; AROMATIC LEVO AMINO ACID DECARBOXYLASE; CHLORINE; ENZYME REBH; INDOLE ALKALOID; TRYPTAMINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CATHARANTHUS ROSEUS; CHLORINATION; ENZYME ENGINEERING; NONHUMAN; WILD TYPE;

ALKALOIDS; CATHARANTHUS; HALOGENATION; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; METABOLIC ENGINEERING; MUTATION; OXIDOREDUCTASES; PROTEIN ENGINEERING; TRYPTAMINES; TRYPTOPHAN;

EID: 82555168471 PISSN: 00027863 EISSN: 15205126 Source Type: Journal
DOI: 10.1021/ja2089348 Document Type: Article

Times cited : (99)

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