-
1
-
-
77953053139
-
Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases
-
1:CAS:528:DC%2BC3cXmsFSltLo%3D 10.1039/b909988n
-
I Abe H Morita 2010 Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases Nat Prod Rep 27 6 809 838 1:CAS:528:DC%2BC3cXmsFSltLo%3D 10.1039/b909988n
-
(2010)
Nat Prod Rep
, vol.27
, Issue.6
, pp. 809-838
-
-
Abe, I.1
Morita, H.2
-
2
-
-
13144258781
-
Biosynthesis of the ansamycin antibiotic rifamycin: Deductions from the molecular analysis of the rif biosynthetic gene cluster of amycolatopsis mediterranei s699
-
1:CAS:528:DyaK1cXhsl2ntr0%3D 10.1016/S1074-5521(98)90141-7
-
PR August L Tang YJ Yoon S Ning R Muller TW Yu M Taylor D Hoffmann CG Kim XH Zhang CR Hutchinson HG Floss 1998 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of amycolatopsis mediterranei s699 Chem Biol 5 2 69 79 1:CAS:528:DyaK1cXhsl2ntr0%3D 10.1016/S1074-5521(98)90141-7
-
(1998)
Chem Biol
, vol.5
, Issue.2
, pp. 69-79
-
-
August, P.R.1
Tang, L.2
Yoon, Y.J.3
Ning, S.4
Muller, R.5
Yu, T.W.6
Taylor, M.7
Hoffmann, D.8
Kim, C.G.9
Zhang, X.H.10
Hutchinson, C.R.11
Floss, H.G.12
-
3
-
-
0037319699
-
The chalcone synthase superfamily of type III polyketide synthases
-
DOI 10.1039/b100917f
-
MB Austin AJP Noel 2003 The chalcone synthase superfamily of type III polyketide synthases Nat Prod Rep 20 1 79 110 1:CAS:528:DC%2BD3sXisVKls7s%3D 10.1039/b100917f (Pubitemid 36219433)
-
(2003)
Natural Product Reports
, vol.20
, Issue.1
, pp. 79-110
-
-
Austin, M.B.1
Noel, J.P.2
-
4
-
-
4644270018
-
An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases
-
DOI 10.1016/j.chembiol.2004.05.024, PII S1074552104002248
-
MB Austin ME Bowman JL Ferrer J Schroder JP Noel 2004 An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases Chem Biol 11 9 1179 1194 1:CAS:528:DC%2BD2cXnslGnurg%3D 10.1016/j.chembiol.2004.05.024 (Pubitemid 39282794)
-
(2004)
Chemistry and Biology
, vol.11
, Issue.9
, pp. 1179-1194
-
-
Austin, M.B.1
Bowman, M.E.2
Ferrer, J.-L.3
Schroder, J.4
Noel, J.P.5
-
5
-
-
33845709126
-
Molecular engineering approaches to peptide, polyketide and other antibiotics
-
DOI 10.1038/nbt1265, PII NBT1265
-
RH Baltz 2006 Molecular engineering approaches to peptide, polyketide and other antibiotics Nat Biotechnol 24 12 1533 1540 1:CAS:528:DC%2BD28Xht12gtbrE 10.1038/nbt1265 (Pubitemid 44967477)
-
(2006)
Nature Biotechnology
, vol.24
, Issue.12
, pp. 1533-1540
-
-
Baltz, R.H.1
-
7
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
-
1:CAS:528:DyaK2MXlvFeqsr0%3D
-
DM Bollag PA McQueney J Zhu O Hensens L Koupal J Liesch M Goetz E Lazarides CM Woods 1995 Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action Cancer Res 55 11 2325 2333 1:CAS:528:DyaK2MXlvFeqsr0%3D
-
(1995)
Cancer Res
, vol.55
, Issue.11
, pp. 2325-2333
-
-
Bollag, D.M.1
McQueney, P.A.2
Zhu, J.3
Hensens, O.4
Koupal, L.5
Liesch, J.6
Goetz, M.7
Lazarides, E.8
Woods, C.M.9
-
8
-
-
77956261727
-
Programming of erythromycin biosynthesis by a modular polyketide synthase
-
1:CAS:528:DC%2BC3cXhtVOns7fF 10.1074/jbc.R110.144618
-
DE Cane 2010 Programming of erythromycin biosynthesis by a modular polyketide synthase J Biol Chem 285 27517 27523 1:CAS:528:DC%2BC3cXhtVOns7fF 10.1074/jbc.R110.144618
-
(2010)
J Biol Chem
, vol.285
, pp. 27517-27523
-
-
Cane, D.E.1
-
9
-
-
0032475992
-
Harnessing the biosynthetic code: Combinations, permutations, and mutations
-
DOI 10.1126/science.282.5386.63
-
DE Cane CT Walsh C Khosla 1998 Harnessing the biosynthetic code: combinations, permutations, and mutations Science 282 5386 63 68 1:CAS:528:DyaK1cXmsFKru74%3D 10.1126/science.282.5386.63 (Pubitemid 28471127)
-
(1998)
Science
, vol.282
, Issue.5386
, pp. 63-68
-
-
Cane, D.E.1
Walsh, C.T.2
Khosla, C.3
-
10
-
-
0025081416
-
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
-
DOI 10.1038/348176a0
-
J Cortes SF Haydock GA Roberts DJ Bevitt PF Leadlay 1990 An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea Nature 348 6297 176 178 1:CAS:528:DyaK3MXit1ahtb4%3D 10.1038/348176a0 (Pubitemid 20368921)
-
(1990)
Nature
, vol.348
, Issue.6297
, pp. 176-178
-
-
Cortes, J.1
Haydock, S.F.2
Roberts, G.A.3
Bevitt, D.J.4
Leadlay, P.F.5
-
11
-
-
0037161282
-
Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli
-
DOI 10.1021/bi015593k
-
LC Dayem JR Carney DV Santi BA Pfeifer C Khosla JT Kealey 2002 Metabolic engineering of a methylmalonyl-coa mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli Biochemistry 41 16 5193 5201 1:CAS:528:DC%2BD38XitlOlu7k%3D 10.1021/bi015593k (Pubitemid 34411674)
-
(2002)
Biochemistry
, vol.41
, Issue.16
, pp. 5193-5201
-
-
Dayem, L.C.1
Carney, J.R.2
Santi, D.V.3
Pfeifer, B.A.4
Khosla, C.5
Kealey, J.T.6
-
12
-
-
0026559262
-
Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea
-
1:CAS:528:DyaK38XltVOitLw%3D 10.1016/0378-1119(92)90602-L
-
S Donadio L Katz 1992 Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea Gene 111 1 51 60 1:CAS:528:DyaK38XltVOitLw%3D 10.1016/0378-1119(92)90602-L
-
(1992)
Gene
, vol.111
, Issue.1
, pp. 51-60
-
-
Donadio, S.1
Katz, L.2
-
13
-
-
0026415106
-
Modular organization of genes required for complex polyketide biosynthesis
-
1:CAS:528:DyaK3MXkt1entb8%3D 10.1126/science.2024119
-
S Donadio MJ Staver JB McAlpine SJ Swanson L Katz 1991 Modular organization of genes required for complex polyketide biosynthesis Science 252 5006 675 679 1:CAS:528:DyaK3MXkt1entb8%3D 10.1126/science.2024119
-
(1991)
Science
, vol.252
, Issue.5006
, pp. 675-679
-
-
Donadio, S.1
Staver, M.J.2
McAlpine, J.B.3
Swanson, S.J.4
Katz, L.5
-
14
-
-
33644889050
-
Statins, cholesterol, and the prevention of coronary heart disease
-
DOI 10.1096/fj.06-0202ufm
-
MW Freeman 2006 Statins, cholesterol, and the prevention of coronary heart disease FASEB J 20 2 200 201 1:CAS:528:DC%2BD28XhsFOmur8%3D 10.1096/fj.06-0202ufm (Pubitemid 44933165)
-
(2006)
FASEB Journal
, vol.20
, Issue.2
, pp. 200-201
-
-
Freeman, M.W.1
-
15
-
-
71149114259
-
Directed evolution and structural characterization of a simvastatin synthase
-
1:CAS:528:DC%2BD1MXhtlCnt7fM 10.1016/j.chembiol.2009.09.017
-
X Gao XK Xie I Pashkov MR Sawaya J Laidman WJ Zhang R Cacho TO Yeates Y Tang 2009 Directed evolution and structural characterization of a simvastatin synthase Chem Biol 16 10 1064 1074 1:CAS:528:DC%2BD1MXhtlCnt7fM 10.1016/j.chembiol.2009.09.017
-
(2009)
Chem Biol
, vol.16
, Issue.10
, pp. 1064-1074
-
-
Gao, X.1
Xie, X.K.2
Pashkov, I.3
Sawaya, M.R.4
Laidman, J.5
Zhang, W.J.6
Cacho, R.7
Yeates, T.O.8
Tang, Y.9
-
16
-
-
0033168682
-
Lovastatin biosynthesis in Aspergillus terreus: Characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene
-
DOI 10.1016/S1074-5521(99)80061-1
-
L Hendrickson CR Davis C Roach DK Nguyen T Aldrich PC McAda CD Reeves 1999 Lavastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene Chem Biol 6 7 429 439 1:CAS:528:DyaK1MXksFKrt78%3D 10.1016/S1074-5521(99)80061-1 (Pubitemid 29311480)
-
(1999)
Chemistry and Biology
, vol.6
, Issue.7
, pp. 429-439
-
-
Hendrickson, L.1
Davis, C.R.2
Roach, C.3
Nguyen, D.K.4
Aldrich, T.5
McAda, P.C.6
Reeves, C.D.7
-
17
-
-
33846923183
-
Type II polyketide synthases: Gaining a deeper insight into enzymatic teamwork
-
DOI 10.1039/b507395m
-
C Hertweck A Luzhetskyy Y Rebets A Bechthold 2007 Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork Nat Prod Rep 24 1 162 190 1:CAS:528:DC%2BD2sXislygtLc%3D 10.1039/b507395m (Pubitemid 46238594)
-
(2007)
Natural Product Reports
, vol.24
, Issue.1
, pp. 162-190
-
-
Hertweck, C.1
Luzhetskyy, A.2
Rebets, Y.3
Bechthold, A.4
-
18
-
-
0001716655
-
Biosynthetic studies of daunorubicin and tetracenomycin c
-
1:CAS:528:DyaK2sXmvFCgsbY%3D 10.1021/cr960022x
-
CR Hutchinson 1997 Biosynthetic studies of daunorubicin and tetracenomycin c Chem Rev 97 7 2525 2535 1:CAS:528:DyaK2sXmvFCgsbY%3D 10.1021/cr960022x
-
(1997)
Chem Rev
, vol.97
, Issue.7
, pp. 2525-2535
-
-
Hutchinson, C.R.1
-
19
-
-
0037545559
-
Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster
-
DOI 10.1128/AEM.69.5.2699-2706.2003
-
EI Hwang M Kaneko Y Ohnishi S Horinouchi 2003 Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster Appl Environ Microbiol 69 5 2699 2706 1:CAS:528:DC%2BD3sXjslOlsLY%3D 10.1128/AEM.69.5.2699-2706.2003 (Pubitemid 36560347)
-
(2003)
Applied and Environmental Microbiology
, vol.69
, Issue.5
, pp. 2699-2706
-
-
Hwang, E.I.1
Kaneko, M.2
Ohnishi, Y.3
Horinouchi, S.4
-
20
-
-
0034673927
-
Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum
-
DOI 10.1016/S0378-1119(00)00149-9, PII S0378111900001499
-
B Julien S Shah R Ziermann R Goldman L Katz C Khosla 2000 Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum Gene 249 1-2 153 160 1:CAS:528:DC%2BD3cXjsVeltLY%3D 10.1016/S0378-1119(00)00149-9 (Pubitemid 30265497)
-
(2000)
Gene
, vol.249
, Issue.1-2
, pp. 153-160
-
-
Julien, B.1
Shah, S.2
Ziermann, R.3
Goldman, R.4
Katz, L.5
Khosla, C.6
-
21
-
-
0027932534
-
Engineered biosynthesis of a complete macrolactone in a heterologous host
-
1:CAS:528:DyaK2cXmtVens7c%3D 10.1126/science.8036492
-
CM Kao L Katz C Khosla 1994 Engineered biosynthesis of a complete macrolactone in a heterologous host Science 265 5171 509 512 1:CAS:528:DyaK2cXmtVens7c%3D 10.1126/science.8036492
-
(1994)
Science
, vol.265
, Issue.5171
, pp. 509-512
-
-
Kao, C.M.1
Katz, L.2
Khosla, C.3
-
22
-
-
35748972666
-
Precursor-directed biosynthesis of stilbene methyl ethers in Escherichia coli
-
DOI 10.1002/biot.200700098
-
Y Katsuyama N Funa S Horinouchi 2007 Precursor-directed biosynthesis of stilbene methyl ethers in Escherichia coli Biotechnol J 2 10 1286 1293 1:CAS:528:DC%2BD2sXhtlSlu7vN 10.1002/biot.200700098 (Pubitemid 350047846)
-
(2007)
Biotechnology Journal
, vol.2
, Issue.10
, pp. 1286-1293
-
-
Katsuyama, Y.1
Funa, N.2
Horinouchi, S.3
-
23
-
-
34250304606
-
Synthesis of Unnatural Flavonoids and Stilbenes by Exploiting the Plant Biosynthetic Pathway in Escherichia coli
-
DOI 10.1016/j.chembiol.2007.05.004, PII S1074552107001500
-
Y Katsuyama N Funa I Miyahisa S Horinouchi 2007 Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli Chem Biol 14 6 613 621 1:CAS:528:DC%2BD2sXmvVOgt74%3D 10.1016/j.chembiol.2007.05.004 (Pubitemid 46920981)
-
(2007)
Chemistry and Biology
, vol.14
, Issue.6
, pp. 613-621
-
-
Katsuyama, Y.1
Funa, N.2
Miyahisa, I.3
Horinouchi, S.4
-
24
-
-
53449086128
-
Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway
-
1:CAS:528:DC%2BD1cXhtF2gtb3M 10.1099/mic.0.2008/018721-0
-
Y Katsuyama M Matsuzawa N Funa S Horinouch 2008 Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway Microbiology 154 2620 2628 1:CAS:528:DC%2BD1cXhtF2gtb3M 10.1099/mic.0.2008/ 018721-0
-
(2008)
Microbiology
, vol.154
, pp. 2620-2628
-
-
Katsuyama, Y.1
Matsuzawa, M.2
Funa, N.3
Horinouch, S.4
-
25
-
-
77950183811
-
Precursor-directed biosynthesis of curcumin analogs in Escherichia coli
-
1:CAS:528:DC%2BC3cXks1Cnu7Y%3D 10.1271/bbb.90866
-
Y Katsuyama Y Hirose N Funa Y Ohnishi S Horinouchi 2010 Precursor-directed biosynthesis of curcumin analogs in Escherichia coli Biosci Biotechnol Biochem 74 3 641 645 1:CAS:528:DC%2BC3cXks1Cnu7Y%3D 10.1271/bbb.90866
-
(2010)
Biosci Biotechnol Biochem
, vol.74
, Issue.3
, pp. 641-645
-
-
Katsuyama, Y.1
Hirose, Y.2
Funa, N.3
Ohnishi, Y.4
Horinouchi, S.5
-
26
-
-
0033591447
-
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis
-
DOI 10.1126/science.284.5418.1368
-
J Kennedy K Auclair SG Kendrew C Park JC Vederas CR Hutchinson 1999 Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis Science 284 5418 1368 1372 1:CAS:528:DyaK1MXjs1WhtLg%3D 10.1126/science.284.5418.1368 (Pubitemid 29289665)
-
(1999)
Science
, vol.284
, Issue.5418
, pp. 1368-1372
-
-
Kennedy, J.1
Auclair, K.2
Kendrew, S.G.3
Park, C.4
Vederas, J.C.5
Hutchinson, C.R.6
-
27
-
-
0345060483
-
6-Deoxyerythronolide B Analogue Production in Escherichia coli through Metabolic Pathway Engineering
-
DOI 10.1021/bi035157t
-
J Kennedy S Murli JT Kealey 2003 6-deoxyerythronolide b analogue production in Escherichia coli through metabolic pathway engineering Biochemistry 42 48 14342 14348 1:CAS:528:DC%2BD3sXovVOiur8%3D 10.1021/bi035157t (Pubitemid 37499432)
-
(2003)
Biochemistry
, vol.42
, Issue.48
, pp. 14342-14348
-
-
Kennedy, J.1
Murli, S.2
Kealey, J.T.3
-
28
-
-
34547930907
-
Structure and mechanism of the 6-deoxyerythronolide b synthase
-
1:CAS:528:DC%2BD2sXhtVehtb7L 10.1146/annurev.biochem.76.053105.093515
-
C Khosla Y Tang AY Chen NA Schnarr DE Cane 2007 Structure and mechanism of the 6-deoxyerythronolide b synthase Annu Rev Biochem 76 195 221 1:CAS:528:DC%2BD2sXhtVehtb7L 10.1146/annurev.biochem.76.053105.093515
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 195-221
-
-
Khosla, C.1
Tang, Y.2
Chen, A.Y.3
Schnarr, N.A.4
Cane, D.E.5
-
29
-
-
0031047160
-
Rational design and engineered biosynthesis of a novel 18-carbon aromatic polyketide
-
DOI 10.1021/ja962888q, PII S0002786396028880
-
PJ Kramer RJX Zawada R McDaniel CR Hutchinson DA Hopwood C Khosla 1997 Rational design and engineered biosynthesis of a novel 18-carbon aromatic polyketide J Am Chem Soc 119 4 635 639 1:CAS:528:DyaK2sXitFejsg%3D%3D 10.1021/ja962888q (Pubitemid 27101227)
-
(1997)
Journal of the American Chemical Society
, vol.119
, Issue.4
, pp. 635-639
-
-
Kramer, P.J.1
Zawada, R.J.X.2
McDaniel, R.3
Hutchinson, C.R.4
Hopwood, D.A.5
Khosla, C.6
-
30
-
-
0030294470
-
A new enzyme superfamily - The phosphopantetheinyl transferases
-
1:CAS:528:DyaK28XntlGgt7g%3D 10.1016/S1074-5521(96)90181-7
-
RH Lambalot AM Gehring RS Flugel P Zuber M LaCelle MA Marahiel R Reid C Khosla CT Walsh 1996 A new enzyme superfamily-the phosphopantetheinyl transferases Chem Biol 3 11 923 936 1:CAS:528:DyaK28XntlGgt7g%3D 10.1016/S1074-5521(96)90181-7
-
(1996)
Chem Biol
, vol.3
, Issue.11
, pp. 923-936
-
-
Lambalot, R.H.1
Gehring, A.M.2
Flugel, R.S.3
Zuber, P.4
Lacelle, M.5
Marahiel, M.A.6
Reid, R.7
Khosla, C.8
Walsh, C.T.9
-
31
-
-
1942455740
-
Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli
-
DOI 10.1016/j.jbiotec.2004.02.001, PII S0168165604000641
-
J Lau C Tran P Licari J Galazzo 2004 Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide b in Escherichia coli J Biotechnol 110 1 95 103 1:CAS:528:DC%2BD2cXjtF2rur8%3D 10.1016/j.jbiotec.2004.02.001 (Pubitemid 38510257)
-
(2004)
Journal of Biotechnology
, vol.110
, Issue.1
, pp. 95-103
-
-
Lau, J.1
Tran, C.2
Licari, P.3
Galazzo, J.4
-
32
-
-
33644816925
-
Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli
-
DOI 10.1016/j.ymben.2005.11.001, PII S1096717605000972
-
E Leonard Y Yan MA Koffas 2006 Functional expression of a p450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli Metab Eng 8 2 172 181 1:CAS:528:DC%2BD28XhvVWrtLY%3D 10.1016/j.ymben.2005.11.001 (Pubitemid 43356399)
-
(2006)
Metabolic Engineering
, vol.8
, Issue.2
, pp. 172-181
-
-
Leonard, E.1
Yan, Y.2
Koffas, M.A.G.3
-
33
-
-
34250849659
-
Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli
-
DOI 10.1128/AEM.00200-07
-
E Leonard KH Lim PN Saw MAG Koffas 2007 Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli Appl Environ Microbiol 73 12 3877 3886 1:CAS:528:DC%2BD2sXntVOgtro%3D 10.1128/AEM.00200-07 (Pubitemid 46983235)
-
(2007)
Applied and Environmental Microbiology
, vol.73
, Issue.12
, pp. 3877-3886
-
-
Leonard, E.1
Lim, K.-H.2
Saw, P.-N.3
Koffas, M.A.G.4
-
34
-
-
42549160614
-
Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids
-
DOI 10.1021/mp7001472
-
E Leonard Y Yan ZL Fowler Z Li CG Lim KH Lim MAG Koffas 2008 Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids Mol Pharm 5 2 257 265 1:CAS:528:DC%2BD1cXjt1Wru7k%3D 10.1021/mp7001472 (Pubitemid 351579129)
-
(2008)
Molecular Pharmaceutics
, vol.5
, Issue.2
, pp. 257-265
-
-
Leonard, E.1
Yan, Y.2
Fowler, Z.L.3
Li, Z.4
Lim, C.-G.5
Lim, K.-H.6
Koffas, M.A.G.7
-
35
-
-
0036431904
-
The polyketide synthase gene pks4 from Gibberella fujikuroi encodes a key enzyme in the biosynthesis of the red pigment bikaverin
-
DOI 10.1016/S1087-1845(02)00501-7, PII S1087184502005017
-
P Linnemannstons J Schulte PM del Mar RH Proctor J Avalos B Tudzynski 2002 The polyketide synthase gene pks4 from Gibberella fujikuroi encodes a key enzyme in the biosynthesis of the red pigment bikaverin Fungal Genet Biol 37 2 134 148 1:CAS:528:DC%2BD38XotFGgsLw%3D 10.1016/S1087-1845(02)00501-7 (Pubitemid 35333771)
-
(2002)
Fungal Genetics and Biology
, vol.37
, Issue.2
, pp. 134-148
-
-
Linnemannstons, P.1
Schulte, J.2
Del Mar Prado, M.3
Proctor, R.H.4
Avalos, J.5
Tudzynski, B.6
-
36
-
-
34848890676
-
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi
-
DOI 10.1021/ja074865p
-
SM Ma J Zhan K Watanabe X Xie W Zhang CC Wang Y Tang 2007 Enzymatic synthesis of aromatic polyketides using pks4 from Gibberella fujikuroi J Am Chem Soc 129 35 10642 10643 1:CAS:528:DC%2BD2sXovF2ltr8%3D 10.1021/ja074865p (Pubitemid 350067459)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.35
, pp. 10642-10643
-
-
Ma, S.M.1
Zhan, J.2
Watanabe, K.3
Xie, X.4
Zhang, W.5
Wang, C.C.6
Tang, Y.7
-
37
-
-
0036222207
-
Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs
-
1:CAS:528:DC%2BD38Xjs12ktL0%3D
-
M Manzoni N Rollini 2002 Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs Appl Environ Microbiol 58 5 555 564 1:CAS:528:DC%2BD38Xjs12ktL0%3D
-
(2002)
Appl Environ Microbiol
, vol.58
, Issue.5
, pp. 555-564
-
-
Manzoni, M.1
Rollini, N.2
-
38
-
-
0032498205
-
Engineering broader specificity into an antibiotic-producing polyketide synthase
-
DOI 10.1126/science.279.5348.199
-
AFA Marsden B Wilkinson J Cortes NJ Dunster J Staunton PF Leadlay 1998 Engineering broader specificity into an antibiotic-producing polyketide synthase Science 279 5348 199 202 1:CAS:528:DyaK1cXkvV2ktA%3D%3D 10.1126/science.279. 5348.199 (Pubitemid 28103871)
-
(1998)
Science
, vol.279
, Issue.5348
, pp. 199-202
-
-
Marsden, A.F.A.1
Wilkinson, B.2
Cortes, J.3
Dunster, N.J.4
Staunton, J.5
Leadlay, P.F.6
-
39
-
-
0027908014
-
Engineered biosynthesis of novel polyketides
-
1:CAS:528:DyaK2cXhtVWms78%3D 10.1126/science.8248802
-
R McDaniel S Ebertkhosla DA Hopwood C Khosla 1993 Engineered biosynthesis of novel polyketides Science 262 5139 1546 1550 1:CAS:528:DyaK2cXhtVWms78%3D 10.1126/science.8248802
-
(1993)
Science
, vol.262
, Issue.5139
, pp. 1546-1550
-
-
McDaniel, R.1
Ebertkhosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
40
-
-
0029064652
-
Rational design of aromatic polyketide natural-products by recombinant assembly of enzymatic subunits
-
1:CAS:528:DyaK2MXmtlajsLc%3D 10.1038/375549a0
-
R McDaniel S Ebertkhosla DA Hopwood C Khosla 1995 Rational design of aromatic polyketide natural-products by recombinant assembly of enzymatic subunits Nature 375 6532 549 554 1:CAS:528:DyaK2MXmtlajsLc%3D 10.1038/375549a0
-
(1995)
Nature
, vol.375
, Issue.6532
, pp. 549-554
-
-
McDaniel, R.1
Ebertkhosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
41
-
-
27644520003
-
Efficient production of (2s)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster
-
1:CAS:528:DC%2BD2MXhtFansL7K
-
I Miyahisa M Kaneko N Funa H Kawasaki H Kojima Y Ohnishi S Horinouchi 2005 Efficient production of (2s)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster Appl Environ Microbiol 68 4 498 504 1:CAS:528:DC%2BD2MXhtFansL7K
-
(2005)
Appl Environ Microbiol
, vol.68
, Issue.4
, pp. 498-504
-
-
Miyahisa, I.1
Kaneko, M.2
Funa, N.3
Kawasaki, H.4
Kojima, H.5
Ohnishi, Y.6
Horinouchi, S.7
-
44
-
-
23744444815
-
Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1
-
DOI 10.1128/AEM.71.8.4503-4509.2005
-
S Murli KS MacMillan ZH Hu GW Ashley SD Dong JT Kealey CD Reeves J Kennedy 2005 Chemobiosynthesis of novel 6-deoxyerythronolide b analogues by mutation of the loading module of 6-deoxyerythronolide b synthase 1 Appl Environ Microbiol 71 8 4503 4509 1:CAS:528:DC%2BD2MXoslGiurw%3D 10.1128/AEM.71.8.4503- 4509.2005 (Pubitemid 41129505)
-
(2005)
Applied and Environmental Microbiology
, vol.71
, Issue.8
, pp. 4503-4509
-
-
Murli, S.1
MacMillan, K.S.2
Hu, Z.3
Ashley, G.W.4
Dong, S.D.5
Kealey, J.T.6
Reeves, C.D.7
Kennedy, J.8
-
45
-
-
31544449418
-
Heterologous production of epothilone C and D in Escherichia coli
-
DOI 10.1021/bi052075r
-
SC Mutka JR Carney YQ Liu J Kennedy 2006 Heterologous production of epothilone c and d in Escherichia coli Biochemistry 45 4 1321 1330 1:CAS:528:DC%2BD28XitV2iug%3D%3D 10.1021/bi052075r (Pubitemid 43167199)
-
(2006)
Biochemistry
, vol.45
, Issue.4
, pp. 1321-1330
-
-
Mutka, S.C.1
Carney, J.R.2
Liu, Y.3
Kennedy, J.4
-
46
-
-
65349093437
-
Antitumor compounds from actinomycetes: From gene clusters to new derivatives by combinatorial biosynthesis
-
1:CAS:528:DC%2BD1MXkvVals7w%3D 10.1039/b822528a
-
C Olano C Mendez JA Salas 2009 Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis Nat Prod Rep 26 5 628 660 1:CAS:528:DC%2BD1MXkvVals7w%3D 10.1039/b822528a
-
(2009)
Nat Prod Rep
, vol.26
, Issue.5
, pp. 628-660
-
-
Olano, C.1
Mendez, C.2
Salas, J.A.3
-
47
-
-
77950127253
-
Post-pks tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis
-
1:CAS:528:DC%2BC3cXjslGntb8%3D 10.1039/b911956f
-
C Olano C Mendez JA Salas 2010 Post-pks tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis Nat Prod Rep 27 4 571 616 1:CAS:528:DC%2BC3cXjslGntb8%3D 10.1039/b911956f
-
(2010)
Nat Prod Rep
, vol.27
, Issue.4
, pp. 571-616
-
-
Olano, C.1
Mendez, C.2
Salas, J.A.3
-
48
-
-
18444395871
-
Production of the potent antibacterial polyketide erythromycin C in Escherichia coli
-
DOI 10.1128/AEM.71.5.2539-2547.2005
-
S Peiru HG Menzella E Rodriguez J Carney H Gramajo 2005 Production of the potent antibacterial polyketide erythromycin c in Escherichia coli Appl Environ Microbiol 71 5 2539 2547 1:CAS:528:DC%2BD2MXktFKmurs%3D 10.1128/AEM.71.5.2539- 2547.2005 (Pubitemid 40646999)
-
(2005)
Applied and Environmental Microbiology
, vol.71
, Issue.5
, pp. 2539-2547
-
-
Peiru, S.1
Menzella, H.G.2
Rodriguez, E.3
Carney, J.4
Gramajo, H.5
-
49
-
-
0035102454
-
Biosynthesis of polyketides in heterologous hosts
-
DOI 10.1128/MMBR.65.1.106-118.2001
-
BA Pfeifer C Khosla 2001 Biosynthesis of polyketides in heterologous hosts Microbiol Mol Biol Rev 65 1 106 118 1:CAS:528:DC%2BD3MXisFyms70%3D 10.1128/MMBR.65.1.106-118.2001 (Pubitemid 32204289)
-
(2001)
Microbiology and Molecular Biology Reviews
, vol.65
, Issue.1
, pp. 106-118
-
-
Pfeifer, B.A.1
Khosla, C.2
-
50
-
-
0035793858
-
Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
-
DOI 10.1126/science.1058092
-
BA Pfeifer SJ Admiraal H Gramajo DE Cane C Khosla 2001 Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli Science 291 5509 1790 1792 1:CAS:528:DC%2BD3MXhslSku7c%3D 10.1126/science.1058092 (Pubitemid 32198984)
-
(2001)
Science
, vol.291
, Issue.5509
, pp. 1790-1792
-
-
Pfeifer, B.A.1
Admiraal, S.J.2
Gramajo, H.3
Cane, D.E.4
Khosla, C.5
-
51
-
-
0036306047
-
Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B
-
DOI 10.1128/AEM.68.7.3287-3292.2002
-
B Pfeifer ZH Hu P Licari C Khosla 2002 Process and metabolic strategies for improved production of escherichia coli-derived 6-deoxyetythronolide b Appl Environ Microbiol 68 7 3287 3292 1:CAS:528:DC%2BD38Xlt1Sntro%3D 10.1128/AEM.68.7.3287-3292.2002 (Pubitemid 34734022)
-
(2002)
Applied and Environmental Microbiology
, vol.68
, Issue.7
, pp. 3287-3292
-
-
Pfeifer, B.1
Hu, Z.2
Licari, P.3
Khosla, C.4
-
52
-
-
0032501971
-
Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carder protein domains in peptide synthetases
-
DOI 10.1021/bi9719861
-
LE Quadri PH Weinreb M Lei MM Nakano P Zuber CT Walsh 1998 Characterization of sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases Biochemistry 37 6 1585 1595 1:CAS:528:DyaK1cXlt1ahug%3D%3D 10.1021/bi9719861 (Pubitemid 28093674)
-
(1998)
Biochemistry
, vol.37
, Issue.6
, pp. 1585-1595
-
-
Quadri, L.E.N.1
Weinreb, P.H.2
Lei, M.3
Nakano, M.M.4
Zuber, P.5
Walsh, C.T.6
-
53
-
-
0038168191
-
Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli
-
DOI 10.1074/jbc.M303867200
-
R Sanishvili AF Yakunin RA Laskowski T Skarina E Evdokimova A Doherty-Kirby GA Lajoie JM Thornton CH Arrowsmith A Savchenko A Joachimiak AM Edwards 2003 Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli J Biol Chem 278 28 26039 26045 1:CAS:528:DC%2BD3sXlt1Clt74%3D 10.1074/jbc.M303867200 (Pubitemid 36835371)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.28
, pp. 26039-26045
-
-
Sanishvili, R.1
Yakunin, A.F.2
Laskowski, R.A.3
Skarina, T.4
Evdokimova, E.5
Doherty-Kirby, A.6
Lajoie, G.A.7
Thornton, J.M.8
Arrowsmith, C.H.9
Savchenko, A.10
Joachimiak, A.11
Edwards, A.M.12
-
54
-
-
0032519914
-
Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei
-
1:CAS:528:DyaK1cXht1Wgt7c%3D 10.1111/j.1574-6968.1998.tb12861.x
-
T Schupp C Toupet N Engel S Goff 1998 Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei FEMS Microbiol Lett 159 2 201 207 1:CAS:528:DyaK1cXht1Wgt7c%3D 10.1111/j.1574-6968.1998.tb12861.x
-
(1998)
FEMS Microbiol Lett
, vol.159
, Issue.2
, pp. 201-207
-
-
Schupp, T.1
Toupet, C.2
Engel, N.3
Goff, S.4
-
55
-
-
0034887171
-
Polyketide biosynthesis: A millennium review
-
DOI 10.1039/a909079g
-
J Staunton KJ Weissman 2001 Polyketide biosynthesis: a millennium review Nat Prod Rep 18 4 380 416 1:CAS:528:DC%2BD3MXltlyqsbo%3D 10.1039/a909079g (Pubitemid 32773840)
-
(2001)
Natural Product Reports
, vol.18
, Issue.4
, pp. 380-416
-
-
Staunton, J.1
Weissman, K.J.2
-
56
-
-
0034723333
-
Cloning and heterologous expression of the epothilone gene cluster
-
DOI 10.1126/science.287.5453.640
-
L Tang S Shah L Chung J Carney L Katz C Khosla B Julien 2000 Cloning and heterologous expression of the epothilone gene cluster Science 287 5453 640 642 1:CAS:528:DC%2BD3cXovVOrtQ%3D%3D 10.1126/science.287.5453.640 (Pubitemid 30070909)
-
(2000)
Science
, vol.287
, Issue.5453
, pp. 640-642
-
-
Tang, L.1
Shah, S.2
Chung, L.3
Carney, J.4
Katz, L.5
Khosla, C.6
Julien, B.7
-
57
-
-
0142135988
-
Polyketide Chain Length Control by Chain Length Factor
-
DOI 10.1021/ja0378759
-
Y Tang SC Tsai C Khosla 2003 Polyketide chain length control by chain length factor J Am Chem Soc 125 42 12708 12709 1:CAS:528:DC%2BD3sXnsFyqsb4%3D 10.1021/ja0378759 (Pubitemid 37280431)
-
(2003)
Journal of the American Chemical Society
, vol.125
, Issue.42
, pp. 12708-12709
-
-
Tang, Y.1
Tsai, S.-C.2
Khosla, C.3
-
58
-
-
0035802125
-
A biosynthetic classification of fungal and streptomycete fused-ring aromatic polyketides
-
1:CAS:528:DC%2BD3MXmvVyjtb8%3D 10.1002/1439-7633(20010903)2:9<612:: AID-CBIC612>3.0.CO;2-Z
-
R Thomas 2001 A biosynthetic classification of fungal and streptomycete fused-ring aromatic polyketides ChemBioChem 2 9 612 627 1:CAS:528: DC%2BD3MXmvVyjtb8%3D 10.1002/1439-7633(20010903)2:9<612::AID-CBIC612>3.0. CO;2-Z
-
(2001)
ChemBioChem
, vol.2
, Issue.9
, pp. 612-627
-
-
Thomas, R.1
-
59
-
-
37349092706
-
6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli
-
DOI 10.1016/j.ymben.2007.09.002, PII S109671760700050X
-
Y Wang BA Pfeifer 2008 6-Deoxyerythronolide b production through chromosomal localization of the deoxyerythronolide b synthase genes in E. coli Metab Eng 10 1 33 38 10.1016/j.ymben.2007.09.002 (Pubitemid 350298911)
-
(2008)
Metabolic Engineering
, vol.10
, Issue.1
, pp. 33-38
-
-
Wang, Y.1
Pfeifer, B.A.2
-
60
-
-
35648976621
-
Improving heterologous polyketide production in Escherichia coli by overexpression of an s-adenosylmethionine synthetase gene
-
1:CAS:528:DC%2BD2sXhsVCnsbfP
-
Y Wang BA Boghigian BA Pfeifer 2007 Improving heterologous polyketide production in Escherichia coli by overexpression of an s-adenosylmethionine synthetase gene Appl Environ Microbiol 77 2 367 373 1:CAS:528:DC%2BD2sXhsVCnsbfP
-
(2007)
Appl Environ Microbiol
, vol.77
, Issue.2
, pp. 367-373
-
-
Wang, Y.1
Boghigian, B.A.2
Pfeifer, B.A.3
-
62
-
-
0032082930
-
Phenylpropanoid biosynthesis and its regulation
-
1:CAS:528:DyaK1cXktFaku7k%3D 10.1016/S1369-5266(98)80113-1
-
B Weisshaar GI Jenkins 1998 Phenylpropanoid biosynthesis and its regulation Curr Opin Plant Biol 1 3 251 257 1:CAS:528:DyaK1cXktFaku7k%3D 10.1016/S1369-5266(98)80113-1
-
(1998)
Curr Opin Plant Biol
, vol.1
, Issue.3
, pp. 251-257
-
-
Weisshaar, B.1
Jenkins, G.I.2
-
63
-
-
30544434619
-
Combinatorial biosynthesis of reduced polyketides
-
DOI 10.1038/nrmicro1287, PII N1287
-
KJ Weissman PF Leadlay 2005 Combinatorial biosynthesis of reduced polyketides Nat Rev Microbiol 3 12 925 936 1:CAS:528:DC%2BD2MXht1OnsLbE 10.1038/nrmicro1287 (Pubitemid 43078156)
-
(2005)
Nature Reviews Microbiology
, vol.3
, Issue.12
, pp. 925-936
-
-
Weissman, K.J.1
Leadlay, P.F.2
-
64
-
-
34247474300
-
Efficient synthesis of simvastatin by use of whole-cell biocatalysis
-
DOI 10.1128/AEM.02820-06
-
XK Xie Y Tang 2007 Efficient synthesis of simvastatin by use of whole-cell biocatalysis Appl Environ Microbiol 73 7 2054 2060 1:CAS:528:DC%2BD2sXkt1Kqtrg%3D 10.1128/AEM.02820-06 (Pubitemid 46649493)
-
(2007)
Applied and Environmental Microbiology
, vol.73
, Issue.7
, pp. 2054-2060
-
-
Xie, X.1
Tang, Y.2
-
65
-
-
33751092257
-
Biosynthesis of Lovastatin Analogs with a Broadly Specific Acyltransferase
-
DOI 10.1016/j.chembiol.2006.09.008, PII S1074552106003413
-
XK Xie K Watanabe WA Wojcicki CCC Wang Y Tang 2006 Biosynthesis of lovastatin analogs with a broadly specific acyltransferase Chem Biol 13 1161 1169 1:CAS:528:DC%2BD28Xht1Cis7bJ 10.1016/j.chembiol.2006.09.008 (Pubitemid 44762191)
-
(2006)
Chemistry and Biology
, vol.13
, Issue.11
, pp. 1161-1169
-
-
Xie, X.1
Watanabe, K.2
Wojcicki, W.A.3
Wang, C.C.C.4
Tang, Y.5
-
66
-
-
34547129077
-
Improving simvastatin bioconversion in Escherichia coli by deletion of bioH
-
DOI 10.1016/j.ymben.2007.05.006, PII S1096717607000328
-
XK Xie WW Wong Y Tang 2007 Improving simvastatin bioconversion in Escherichia coli by deletion of BioH Metab Eng 9 4 379 386 1:CAS:528: DC%2BD2sXotlSks7Y%3D 10.1016/j.ymben.2007.05.006 (Pubitemid 47102688)
-
(2007)
Metabolic Engineering
, vol.9
, Issue.4
, pp. 379-386
-
-
Xie, X.1
Wong, W.W.2
Tang, Y.3
-
67
-
-
67650537065
-
Acyltransferase mediated polyketide release from a fungal megasynthase
-
1:CAS:528:DC%2BD1MXmsFWmt7c%3D 10.1021/ja903203g
-
XK Xie MJ Meehan W Xu PC Dorrestein Y Tang 2009 Acyltransferase mediated polyketide release from a fungal megasynthase J Am Chem Soc 131 24 8388 8389 1:CAS:528:DC%2BD1MXmsFWmt7c%3D 10.1021/ja903203g
-
(2009)
J Am Chem Soc
, vol.131
, Issue.24
, pp. 8388-8389
-
-
Xie, X.K.1
Meehan, M.J.2
Xu, W.3
Dorrestein, P.C.4
Tang, Y.5
-
69
-
-
35748974224
-
Biosynthesis of 5-deoxyflavanones in microorganisms
-
DOI 10.1002/biot.200700119
-
Y Yan L Huang MAG Koffas 2007 Biosynthesis of 5-deoxyflavanones in microorganisms Biotechnol J 2 10 1250 1262 1:CAS:528:DC%2BD2sXhtlSlu7rL 10.1002/biot.200700119 (Pubitemid 350047842)
-
(2007)
Biotechnology Journal
, vol.2
, Issue.10
, pp. 1250-1262
-
-
Yan, Y.1
Huang, L.2
Koffas, M.A.G.3
-
70
-
-
58549085193
-
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli
-
1:CAS:528:DC%2BD1MXks1Gmuw%3D%3D 10.1073/pnas.0809084105
-
W Zhang Y Li Y Tang 2008 Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli Proc Natl Acad Sci USA 105 52 20683 20688 1:CAS:528:DC%2BD1MXks1Gmuw%3D%3D 10.1073/pnas.0809084105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.52
, pp. 20683-20688
-
-
Zhang, W.1
Li, Y.2
Tang, Y.3
-
71
-
-
74849084621
-
Investigating the role of native propionyl-coa and methylmalonyl-coa metabolism on heterologous polyketide production in Escherichia coli
-
1:CAS:528:DC%2BD1MXhs1WjsbbK 10.1002/bit.22560
-
H Zhang BA Boghigian BA Pfeifer 2010 Investigating the role of native propionyl-coa and methylmalonyl-coa metabolism on heterologous polyketide production in Escherichia coli Biotechnol Bioeng 105 3 567 573 1:CAS:528:DC%2BD1MXhs1WjsbbK 10.1002/bit.22560
-
(2010)
Biotechnol Bioeng
, vol.105
, Issue.3
, pp. 567-573
-
-
Zhang, H.1
Boghigian, B.A.2
Pfeifer, B.A.3
|