-
1
-
-
0018939225
-
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent
-
Alberts A.W., Chen J., Kuron G., Hunt V., Huff J., Hoffman C., Rothrock J., Lopez M., Joshua H., Harris E., et al. Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc. Natl. Acad. Sci. USA 77 (1980) 3957-3961
-
(1980)
Proc. Natl. Acad. Sci. USA
, vol.77
, pp. 3957-3961
-
-
Alberts, A.W.1
Chen, J.2
Kuron, G.3
Hunt, V.4
Huff, J.5
Hoffman, C.6
Rothrock, J.7
Lopez, M.8
Joshua, H.9
Harris, E.10
-
2
-
-
0021072401
-
Biosynthesis of mevinolin: spectral assignment by double-quantum coherence NMR after high carbon-13 incorporation
-
Chan J.K., Moore R.N., and Vederas J.C. Biosynthesis of mevinolin: spectral assignment by double-quantum coherence NMR after high carbon-13 incorporation. J. Am. Chem. Soc. 105 (1983) 3334-3336
-
(1983)
J. Am. Chem. Soc.
, vol.105
, pp. 3334-3336
-
-
Chan, J.K.1
Moore, R.N.2
Vederas, J.C.3
-
3
-
-
0019195217
-
Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase
-
Endo A. Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. J. Antibiot. (Tokyo) 33 (1980) 334-336
-
(1980)
J. Antibiot. (Tokyo)
, vol.33
, pp. 334-336
-
-
Endo, A.1
-
4
-
-
0028205740
-
Revision of the biosynthetic origin of oxygens in mevinolin (lovastatin), a hypocholesterolemic drug from Aspergillus terreus MF 4845
-
Yoshizawa Y., Witter D.J., Liu Y., and Vederas J.C. Revision of the biosynthetic origin of oxygens in mevinolin (lovastatin), a hypocholesterolemic drug from Aspergillus terreus MF 4845. J. Am. Chem. Soc. 116 (1994) 2693-2694
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 2693-2694
-
-
Yoshizawa, Y.1
Witter, D.J.2
Liu, Y.3
Vederas, J.C.4
-
5
-
-
0036222207
-
Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs
-
Manzoni M., and Rollini M. Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl. Microbiol. Biotechnol. 58 (2002) 555-564
-
(2002)
Appl. Microbiol. Biotechnol.
, vol.58
, pp. 555-564
-
-
Manzoni, M.1
Rollini, M.2
-
6
-
-
0035843962
-
Structural mechanism for statin inhibition of HMG-CoA reductase
-
Istvan E.S., and Deisenhofer J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292 (2001) 1160-1164
-
(2001)
Science
, vol.292
, pp. 1160-1164
-
-
Istvan, E.S.1
Deisenhofer, J.2
-
7
-
-
0344961885
-
Bioconversion of compactin into pravastatin by Streptomyces sp
-
Park J.W., Lee J.K., Kwon T.J., Yi D.H., Kim Y.J., Moon S.H., Suh H.H., Kang S.M., and Park Y.I. Bioconversion of compactin into pravastatin by Streptomyces sp. Biotechnol. Lett. 25 (2003) 1827-1831
-
(2003)
Biotechnol. Lett.
, vol.25
, pp. 1827-1831
-
-
Park, J.W.1
Lee, J.K.2
Kwon, T.J.3
Yi, D.H.4
Kim, Y.J.5
Moon, S.H.6
Suh, H.H.7
Kang, S.M.8
Park, Y.I.9
-
8
-
-
33751073073
-
-
Ye, H. June 2005. Huvastatin and Its Preparation and Formulation Comprising the Huvastatin. WO PCT 2005054173.
-
-
-
-
9
-
-
33751094231
-
-
Lee, J. Ha, T., Park, C., Lee, H., Lee, G., and Chang, Y. April 2005. Process for the preparation of simvastatin. U.S. patent PCT 20050080275.
-
-
-
-
10
-
-
33751081719
-
-
Hong, C.I., Kim, J.W., Shin, H.J., Kang, T.W., and Cho, D.O. December 2004. Process for Preparing Simvastatin. U.S. patent 6833461B2.
-
-
-
-
11
-
-
33751093222
-
-
Parthasaradhi Reddy, B. July 2005. A Novel Process for the Preparation of Simvastatin. PCT WO2005066150.
-
-
-
-
12
-
-
0022486908
-
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin
-
Hoffman W.F., Alberts A.W., Anderson P.S., Chen J.S., Smith R.L., and Willard A.K. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin. J. Med. Chem. 29 (1986) 849-852
-
(1986)
J. Med. Chem.
, vol.29
, pp. 849-852
-
-
Hoffman, W.F.1
Alberts, A.W.2
Anderson, P.S.3
Chen, J.S.4
Smith, R.L.5
Willard, A.K.6
-
13
-
-
33751117912
-
-
Morgan, B., Burk, M., Levin, M., Zhu, Z., Chaplin, J., Kustedjo, K., Huang, Z., and Greenberg, W. May 2005. Methods for Making Simvastatin and Intermediates. PCT WO 2005040107.
-
-
-
-
14
-
-
0030897549
-
Purification and characterization of a lovastatin esterase from Clonostachys compactiuscula
-
Schimmel T.G., Borneman W.S., and Conder M.J. Purification and characterization of a lovastatin esterase from Clonostachys compactiuscula. Appl. Environ. Microbiol. 63 (1997) 1307-1311
-
(1997)
Appl. Environ. Microbiol.
, vol.63
, pp. 1307-1311
-
-
Schimmel, T.G.1
Borneman, W.S.2
Conder, M.J.3
-
15
-
-
0033168682
-
Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene
-
Hendrickson L., Davis C.R., Roach C., Nguyen D.K., Aldrich T., McAda P.C., and Reeves C.D. Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene. Chem. Biol. 6 (1999) 429-439
-
(1999)
Chem. Biol.
, vol.6
, pp. 429-439
-
-
Hendrickson, L.1
Davis, C.R.2
Roach, C.3
Nguyen, D.K.4
Aldrich, T.5
McAda, P.C.6
Reeves, C.D.7
-
16
-
-
0033591447
-
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis
-
Kennedy J., Auclair K., Kendrew S.G., Park C., Vederas J.C., and Hutchinson C.R. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science 284 (1999) 1368-1372
-
(1999)
Science
, vol.284
, pp. 1368-1372
-
-
Kennedy, J.1
Auclair, K.2
Kendrew, S.G.3
Park, C.4
Vederas, J.C.5
Hutchinson, C.R.6
-
17
-
-
0036321084
-
Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum
-
Abe Y., Suzuki T., Ono C., Iwamoto K., Hosobuchi M., and Yoshikawa H. Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum. Mol. Genet. Genomics 267 (2002) 636-646
-
(2002)
Mol. Genet. Genomics
, vol.267
, pp. 636-646
-
-
Abe, Y.1
Suzuki, T.2
Ono, C.3
Iwamoto, K.4
Hosobuchi, M.5
Yoshikawa, H.6
-
18
-
-
9144262560
-
Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis
-
Cox R.J., Glod F., Hurley D., Lazarus C.M., Nicholson T.P., Rudd B.A., Simpson T.J., Wilkinson B., and Zhang Y. Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis. Chem. Commun. (Camb.) (2004) 2260-2261
-
(2004)
Chem. Commun. (Camb.)
, pp. 2260-2261
-
-
Cox, R.J.1
Glod, F.2
Hurley, D.3
Lazarus, C.M.4
Nicholson, T.P.5
Rudd, B.A.6
Simpson, T.J.7
Wilkinson, B.8
Zhang, Y.9
-
19
-
-
0027162890
-
A dramatic change in the rate-limiting step of beta-lactam hydrolysis results from the substitution of the active-site serine residue by a cysteine in the class-C beta-lactamase of Enterobacter cloacae 908R
-
Dubus A., Monnaie D., Jacobs C., Normark S., and Frere J.M. A dramatic change in the rate-limiting step of beta-lactam hydrolysis results from the substitution of the active-site serine residue by a cysteine in the class-C beta-lactamase of Enterobacter cloacae 908R. Biochem. J. 292 (1993) 537-543
-
(1993)
Biochem. J.
, vol.292
, pp. 537-543
-
-
Dubus, A.1
Monnaie, D.2
Jacobs, C.3
Normark, S.4
Frere, J.M.5
-
20
-
-
0028224698
-
Crystallographic structure of a phosphonate derivative of the Enterobacter cloacae P99 cephalosporinase: mechanistic interpretation of a beta-lactamase transition-state analog
-
Lobkovsky E., Billings E.M., Moews P.C., Rahil J., Pratt R.F., and Knox J.R. Crystallographic structure of a phosphonate derivative of the Enterobacter cloacae P99 cephalosporinase: mechanistic interpretation of a beta-lactamase transition-state analog. Biochemistry 33 (1994) 6762-6772
-
(1994)
Biochemistry
, vol.33
, pp. 6762-6772
-
-
Lobkovsky, E.1
Billings, E.M.2
Moews, P.C.3
Rahil, J.4
Pratt, R.F.5
Knox, J.R.6
-
21
-
-
0041842502
-
Identification of residues critical for catalysis in a class C beta-lactamase by combinatorial scanning mutagenesis
-
Goldberg S.D., Iannuccilli W., Nguyen T., Ju J., and Cornish V.W. Identification of residues critical for catalysis in a class C beta-lactamase by combinatorial scanning mutagenesis. Protein Sci. 12 (2003) 1633-1645
-
(2003)
Protein Sci.
, vol.12
, pp. 1633-1645
-
-
Goldberg, S.D.1
Iannuccilli, W.2
Nguyen, T.3
Ju, J.4
Cornish, V.W.5
-
22
-
-
0021999525
-
Dihydromonacolin L and monacolin X, new metabolites which inhibit cholesterol biosynthesis
-
Endo A., Hasumi K., Nakamura T., Kunishima M., and Masuda M. Dihydromonacolin L and monacolin X, new metabolites which inhibit cholesterol biosynthesis. J. Antibiot. (Tokyo) 38 (1985) 321-327
-
(1985)
J. Antibiot. (Tokyo)
, vol.38
, pp. 321-327
-
-
Endo, A.1
Hasumi, K.2
Nakamura, T.3
Kunishima, M.4
Masuda, M.5
-
23
-
-
0022968859
-
Monacolin M, a new inhibitor of cholesterol biosynthesis
-
Endo A., Komagata D., and Shimada H. Monacolin M, a new inhibitor of cholesterol biosynthesis. J. Antibiot. (Tokyo) 39 (1986) 1670-1673
-
(1986)
J. Antibiot. (Tokyo)
, vol.39
, pp. 1670-1673
-
-
Endo, A.1
Komagata, D.2
Shimada, H.3
-
24
-
-
0034703754
-
Lovastatin nonaketide synthase catalyzes an intramolecular diels-alder reaction of a substrate analogue
-
Auclair K., Sutherland A., Kennedy J., Witter D.J., Van den Heever J.P., Hutchinson C.R., and Vederas J.C. Lovastatin nonaketide synthase catalyzes an intramolecular diels-alder reaction of a substrate analogue. J. Am. Chem. Soc. 122 (2000) 11519-11520
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 11519-11520
-
-
Auclair, K.1
Sutherland, A.2
Kennedy, J.3
Witter, D.J.4
Van den Heever, J.P.5
Hutchinson, C.R.6
Vederas, J.C.7
-
25
-
-
0030875774
-
Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase
-
Jacobsen J.R., Hutchinson C.R., Cane D.E., and Khosla C. Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. Science 277 (1997) 367-369
-
(1997)
Science
, vol.277
, pp. 367-369
-
-
Jacobsen, J.R.1
Hutchinson, C.R.2
Cane, D.E.3
Khosla, C.4
-
26
-
-
23744444815
-
Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1
-
Murli S., MacMillan K.S., Hu Z., Ashley G.W., Dong S.D., Kealey J.T., Reeves C.D., and Kennedy J. Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1. Appl. Environ. Microbiol. 71 (2005) 4503-4509
-
(2005)
Appl. Environ. Microbiol.
, vol.71
, pp. 4503-4509
-
-
Murli, S.1
MacMillan, K.S.2
Hu, Z.3
Ashley, G.W.4
Dong, S.D.5
Kealey, J.T.6
Reeves, C.D.7
Kennedy, J.8
-
27
-
-
0038058643
-
Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes
-
Sorensen J.L., Auclair K., Kennedy J., Hutchinson C.R., and Vederas J.C. Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes. Org. Biomol. Chem. 1 (2003) 50-59
-
(2003)
Org. Biomol. Chem.
, vol.1
, pp. 50-59
-
-
Sorensen, J.L.1
Auclair, K.2
Kennedy, J.3
Hutchinson, C.R.4
Vederas, J.C.5
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