Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH

Biochemistry

Volumn 45, Issue 25, 2006, Pages 7904-7912

  Yeh, Ellen ^a   Cole, Lindsay J ^b   Barr, Eric W ^c   Bollinger Jr , J Martin ^c   Ballou, David P ^b   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; CHLORINATION; REACTION KINETICS; REDOX REACTIONS; SPECTROSCOPIC ANALYSIS;

CONFORMATIONAL DYNAMICS; FLAVIN; FLAVOPROTEIN MONOOXYGENASES; HALOGENASE REBH; TRYPTOPHAN;

ENZYME KINETICS;

7 CHLOROTRYPTOPHAN; CHLORIDE ION; FLAVINE ADENINE NUCLEOTIDE; FLAVINE NUCLEOTIDE; FLAVOPROTEIN; HALOGENASE REBH; HYPOCHLORITE; OXYGEN; REBECCAMYCIN; TRYPTOPHAN; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CHLORINATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; GEL PERMEATION CHROMATOGRAPHY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SPECTROSCOPY;

ACTINOMYCETALES; CARBAZOLES; FLAVIN-ADENINE DINUCLEOTIDE; FLAVINS; INDOLES; KINETICS; OXIDATION-REDUCTION; OXIDOREDUCTASES; TRYPTOPHAN;

EID: 33745963527     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060607d     Document Type: Article

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