The taxol pathway 10-O-acetyltransferase shows regioselective promiscuity with the oxetane hydroxyl of 4-deacetyltaxanes

Journal of the American Chemical Society

Volumn 130, Issue 50, 2008, Pages 17187-17194

  Ondari, Mark E ^a   Walker, Kevin D ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ANHYDRIDES; ACETYLTRANSFERASE ACTIVITIES; ACYL GROUPS; ACYL TRANSFERASES; ALUMINUM HYDRIDES; BIOSYNTHETIC PATHWAYS; DEACETYLBACCATIN; DIACETYL; DITERPENE; ENZYME FUNCTIONS; III SUBSTRATES; NATURAL PRODUCTS; NATURAL SUBSTRATES; OXETANE; PACLITAXEL; PROTECTING GROUPS; REGIOCHEMISTRY; REGIOSELECTIVE; REGIOSELECTIVE ACETYLATIONS; TAXUS CUSPIDATA;

ACETYLATION; ALUMINA; ENZYMES; ESTERS; HYDROGELS; OLEFINS; SILANES; SODIUM;

SUBSTRATES;

10 DEACETYLBACCATIN III; 13 ACETYLBACCATIN III; 4 DEACETYLBACCATIN III; 7 ACETYLBACCATIN III; 7,13 DIACETYL 4 DEACETYLBACCATIN III; ACYLTRANSFERASE; BACCATIN III; OXETANE DERIVATIVE; PACLITAXEL; TAXANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DEACETYLATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE; STEREOCHEMISTRY; TAXUS;

ACETYLATION; ACETYLTRANSFERASES; ANTINEOPLASTIC AGENTS; BRIDGED COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HETEROCYCLIC COMPOUNDS; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PACLITAXEL; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TAXOIDS; TAXUS;

EID: 58049202807     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja8067534     Document Type: Article

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