-
1
-
-
33645523606
-
Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy
-
Albertini, V., Jain, A., Vignati, S., Napoli, S., Rinaldi, A., Kwee, I., etal. (2006) Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy. Nucleic Acids Res 34: 1721-1734.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 1721-1734
-
-
Albertini, V.1
Jain, A.2
Vignati, S.3
Napoli, S.4
Rinaldi, A.5
Kwee, I.6
-
2
-
-
0028340901
-
Cloning of the macrolide antibiotic biosynthesis gene acyA, which encodes 3-O-acyltransferase, from Streptomyces thermotolerans and its use for direct fermentative production of a hybrid macrolide antibiotic
-
Arisawa, A., Kawamura, N., Takeda, K., Tsunekawa, H., Okamura, K., and Okamoto, R. (1994) Cloning of the macrolide antibiotic biosynthesis gene acyA, which encodes 3-O-acyltransferase, from Streptomyces thermotolerans and its use for direct fermentative production of a hybrid macrolide antibiotic. Appl Environ Microbiol 60: 2657-2660.
-
(1994)
Appl Environ Microbiol
, vol.60
, pp. 2657-2660
-
-
Arisawa, A.1
Kawamura, N.2
Takeda, K.3
Tsunekawa, H.4
Okamura, K.5
Okamoto, R.6
-
3
-
-
40549140724
-
Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity
-
Baig, I., Perez, M., Braña, A.F., Gomathinayagam, R., Damodaran, C., Salas, J.A., etal. (2008) Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity. J Nat Prod 71: 199-207.
-
(2008)
J Nat Prod
, vol.71
, pp. 199-207
-
-
Baig, I.1
Perez, M.2
Braña, A.F.3
Gomathinayagam, R.4
Damodaran, C.5
Salas, J.A.6
-
4
-
-
34249855554
-
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
-
Barcelo, F., Scotta, C., Ortiz-Lombardía, M., Méndez, C., Salas, J.A., and Portugal, J. (2007) Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences. Nucleic Acids Res 35: 2215-2226.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 2215-2226
-
-
Barcelo, F.1
Scotta, C.2
Ortiz-Lombardía, M.3
Méndez, C.4
Salas, J.A.5
Portugal, J.6
-
5
-
-
0025889742
-
Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo
-
Blume, S.W., Snyder, R.C., Ray, R., Thomas, S., Koller, C.A., and Miller, D.M. (1991) Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo. J Clin Invest 88: 1613-1621.
-
(1991)
J Clin Invest
, vol.88
, pp. 1613-1621
-
-
Blume, S.W.1
Snyder, R.C.2
Ray, R.3
Thomas, S.4
Koller, C.A.5
Miller, D.M.6
-
6
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
7
-
-
0019551730
-
'Western blotting': electrophoretic transfer of proteins from sodium dodecyl sulphate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A
-
Burnette, W.N. (1981) 'Western blotting': electrophoretic transfer of proteins from sodium dodecyl sulphate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem 112: 195-203.
-
(1981)
Anal Biochem
, vol.112
, pp. 195-203
-
-
Burnette, W.N.1
-
8
-
-
0034425217
-
Structural basis of DNA recognition by anticancer antibiotics, chromomycin A(3), and mithramycin: roles of minor groove width and ligand flexibility
-
Chakrabarti, S., Bhattacharyya, D., and Dasgupta, D. (2001) Structural basis of DNA recognition by anticancer antibiotics, chromomycin A(3), and mithramycin: roles of minor groove width and ligand flexibility. Biopolymers 56: 85-95.
-
(2001)
Biopolymers
, vol.56
, pp. 85-95
-
-
Chakrabarti, S.1
Bhattacharyya, D.2
Dasgupta, D.3
-
9
-
-
0035089787
-
Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons
-
Chatterjee, S., Zaman, K., Ryu, H., Conforto, A., and Ratan, R.R. (2001) Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons. Ann Neurol 49: 345-354.
-
(2001)
Ann Neurol
, vol.49
, pp. 345-354
-
-
Chatterjee, S.1
Zaman, K.2
Ryu, H.3
Conforto, A.4
Ratan, R.R.5
-
10
-
-
46249092188
-
Pancreatic cancer - is the wall crumbling?
-
Chua, Y.J., and Zalcberg, J.R. (2008) Pancreatic cancer - is the wall crumbling? Ann Oncol 19: 1224-1230.
-
(2008)
Ann Oncol
, vol.19
, pp. 1224-1230
-
-
Chua, Y.J.1
Zalcberg, J.R.2
-
11
-
-
33750996156
-
Pathway-specific differences between tumor cell lines and normal and tumor tissue cells
-
Ertel, A., Verghese, A., Byers, S.W., Ochs, M., and Tozeren, A. (2006) Pathway-specific differences between tumor cell lines and normal and tumor tissue cells. Mol Cancer 5: 55.
-
(2006)
Mol Cancer
, vol.5
, pp. 55
-
-
Ertel, A.1
Verghese, A.2
Byers, S.W.3
Ochs, M.4
Tozeren, A.5
-
12
-
-
0031690038
-
Identification of two genes from Streptomyces argillaceus encoding two glycosyltransferases involved in the transfer of a disaccharide during the biosynthesis of the antitumor drug mithramycin
-
Fernández, E., Weibbach, U., Sánchez Reillo, C., Braña, A.F., Méndez, C., Rohr, J., and Salas, J.A. (1998) Identification of two genes from Streptomyces argillaceus encoding two glycosyltransferases involved in the transfer of a disaccharide during the biosynthesis of the antitumor drug mithramycin. J Bacteriol 180: 4929-4937.
-
(1998)
J Bacteriol
, vol.180
, pp. 4929-4937
-
-
Fernández, E.1
Weibbach, U.2
Sánchez Reillo, C.3
Braña, A.F.4
Méndez, C.5
Rohr, J.6
Salas, J.A.7
-
13
-
-
0043240257
-
Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells
-
Fibach, E., Bianchi, N., Borgatti, M., Prus, E., and Gambari, R. (2003) Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells. Blood 102: 1276-1281.
-
(2003)
Blood
, vol.102
, pp. 1276-1281
-
-
Fibach, E.1
Bianchi, N.2
Borgatti, M.3
Prus, E.4
Gambari, R.5
-
14
-
-
0026741927
-
A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens
-
Hara, O., and Hutchinson, C.R. (1992) A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens. J Bacteriol 174: 5141-5144.
-
(1992)
J Bacteriol
, vol.174
, pp. 5141-5144
-
-
Hara, O.1
Hutchinson, C.R.2
-
15
-
-
34250304990
-
Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A
-
Jia, Z., Zhang, J., Wei, D., Wang, L., Yuan, P., Le, X., etal. (2007) Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A. Cancer Res 67: 4878-4885.
-
(2007)
Cancer Res
, vol.67
, pp. 4878-4885
-
-
Jia, Z.1
Zhang, J.2
Wei, D.3
Wang, L.4
Yuan, P.5
Le, X.6
-
16
-
-
0003869903
-
Practical Streptomyces Genetics
-
Norwich, UK: The John Innes Foundation.
-
Kieser, T., Bibb, M.J., Buttner, M.J., Chater, K.F., and Hopwood, D.A. (2000) Practical Streptomyces Genetics. Norwich, UK: The John Innes Foundation.
-
(2000)
-
-
Kieser, T.1
Bibb, M.J.2
Buttner, M.J.3
Chater, K.F.4
Hopwood, D.A.5
-
17
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
22
-
-
34948856450
-
Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis
-
Menéndez, N., Braña, A.F., Salas, J.A., and Méndez, C. (2007) Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis. Microbiology 153: 3061-3070.
-
(2007)
Microbiology
, vol.153
, pp. 3061-3070
-
-
Menéndez, N.1
Braña, A.F.2
Salas, J.A.3
Méndez, C.4
-
23
-
-
0023447838
-
Mithramycin selectively inhibits transcription of G-C containing DNA
-
Miller, D.M., Polansky, D.A., Thomas, S.D., Ray, R., Campbell, V.W., Sanchez, J., and Koller, C.A. (1987) Mithramycin selectively inhibits transcription of G-C containing DNA. Am J Med Sci 294: 388-394.
-
(1987)
Am J Med Sci
, vol.294
, pp. 388-394
-
-
Miller, D.M.1
Polansky, D.A.2
Thomas, S.D.3
Ray, R.4
Campbell, V.W.5
Sanchez, J.6
Koller, C.A.7
-
24
-
-
0038548145
-
Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3
-
Mir, M.A., Majee, S., Das, S., and Dasgupta, D. (2003) Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3. Bioorg Med Chem 11: 2791-2801.
-
(2003)
Bioorg Med Chem
, vol.11
, pp. 2791-2801
-
-
Mir, M.A.1
Majee, S.2
Das, S.3
Dasgupta, D.4
-
25
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assay
-
Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assay. J Immunol Methods 65: 55-63.
-
(1983)
J Immunol Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
26
-
-
0037067081
-
Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate
-
Moss, S.J., Bai, L., Toelzer, S., Carroll, B.J., Mahmud, T., Yu, T.W., and Floss, H.G. (2002) Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4, 5-desepoxymaytansinol, not maytansinol, as its substrate. J Am Chem Soc 124: 6544-6545.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 6544-6545
-
-
Moss, S.J.1
Bai, L.2
Toelzer, S.3
Carroll, B.J.4
Mahmud, T.5
Yu, T.W.6
Floss, H.G.7
-
27
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
Newman, J., and Cragg, G.M. (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70: 461-477.
-
(2007)
J Nat Prod
, vol.70
, pp. 461-477
-
-
Newman, J.1
Cragg, G.M.2
-
28
-
-
71149121326
-
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives
-
Olano, C., Gómez, C., Pérez, M., Palomino, M., Pineda-Lucena, A., Carbajo, R.J., etal. (2009) Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives. Chem Biol 16: 1031-1044.
-
(2009)
Chem Biol
, vol.16
, pp. 1031-1044
-
-
Olano, C.1
Gómez, C.2
Pérez, M.3
Palomino, M.4
Pineda-Lucena, A.5
Carbajo, R.J.6
-
29
-
-
54349108393
-
Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis
-
Pérez, M., Baig, I., Braña, A.F., Salas, J.A., Rohr, J., and Méndez, C. (2008) Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis. Chembiochem 9: 2295-2304.
-
(2008)
Chembiochem
, vol.9
, pp. 2295-2304
-
-
Pérez, M.1
Baig, I.2
Braña, A.F.3
Salas, J.A.4
Rohr, J.5
Méndez, C.6
-
30
-
-
0024338673
-
Mithramycin blocks protein binding and function of the SV40 early promoter
-
Ray, R., Snyder, R.C., Thomas, S., Koller, C.A., and Miller, D.M. (1989) Mithramycin blocks protein binding and function of the SV40 early promoter. J Clin Invest 83: 2003-2007.
-
(1989)
J Clin Invest
, vol.83
, pp. 2003-2007
-
-
Ray, R.1
Snyder, R.C.2
Thomas, S.3
Koller, C.A.4
Miller, D.M.5
-
31
-
-
0004175398
-
The Chemistry of Antitumor Antibiotics
-
New York, USA: Wiley-Interscience.
-
Remers, W.A. (1979) The Chemistry of Antitumor Antibiotics, Vol. 1. New York, USA: Wiley-Interscience.
-
(1979)
, vol.1
-
-
Remers, W.A.1
-
32
-
-
0038701795
-
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis
-
Remsing, L.L., González, A.M., Nur-e-Alam, M., Fernández-Lozano, M.J., Braña, A.F., Rix, U., etal. (2003) Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis. J Am Chem Soc 125: 5745-5753.
-
(2003)
J Am Chem Soc
, vol.125
, pp. 5745-5753
-
-
Remsing, L.L.1
González, A.M.2
Nur-e-Alam, M.3
Fernández-Lozano, M.J.4
Braña, A.F.5
Rix, U.6
-
33
-
-
0344994565
-
The biosynthesis of aureolic acid group antibiotics
-
Rohr, J., Méndez, C., and Salas, J.A. (1999) The biosynthesis of aureolic acid group antibiotics. Bioorg Chem 27: 41-54.
-
(1999)
Bioorg Chem
, vol.27
, pp. 41-54
-
-
Rohr, J.1
Méndez, C.2
Salas, J.A.3
-
34
-
-
0004136246
-
Molecular Cloning: A Laboratory Manual
-
and , 3rd edn. Cold Spring Harbor, NY, USA: Cold Spring Harbor Laboratory.
-
Sambrook, J., and Russell, D.W. (2001) Molecular Cloning: A Laboratory Manual, 3rd edn. Cold Spring Harbor, NY, USA: Cold Spring Harbor Laboratory.
-
(2001)
-
-
Sambrook, J.1
Russell, D.W.2
-
35
-
-
0027168887
-
Solution structure of the mithramycin dimer-DNA complex
-
Sastry, M., and Patel, D.J. (1993) Solution structure of the mithramycin dimer-DNA complex. Biochemistry 32: 6588-6604.
-
(1993)
Biochemistry
, vol.32
, pp. 6588-6604
-
-
Sastry, M.1
Patel, D.J.2
-
36
-
-
0029142792
-
Solution structure of mithramycin dimers bound to partially overlapping sites on DNA
-
Sastry, M., Fiala, R., and Patel, D.J. (1995) Solution structure of mithramycin dimers bound to partially overlapping sites on DNA. J Mol Biol 251: 674-689.
-
(1995)
J Mol Biol
, vol.251
, pp. 674-689
-
-
Sastry, M.1
Fiala, R.2
Patel, D.J.3
-
37
-
-
0032900389
-
Treatment of patients with primary glioblastoma multiforme with standard postoperative radiotherapy and radiosurgical boost: prognostic factors and long-term outcome
-
Shrieve, D.C., Alexander, E., 3rd, Black, P.M., Wen, P.Y., Fine, H.A., Kooy, H.M., and Loeffler, J.S. (1999) Treatment of patients with primary glioblastoma multiforme with standard postoperative radiotherapy and radiosurgical boost: prognostic factors and long-term outcome. J Neurosurg 90: 72-77.
-
(1999)
J Neurosurg
, vol.90
, pp. 72-77
-
-
Shrieve, D.C.1
Alexander 3rd, E.2
Black, P.M.3
Wen, P.Y.4
Fine, H.A.5
Kooy, H.M.6
Loeffler, J.S.7
-
38
-
-
0027440273
-
Studies of the 2:1 chromomycin A3-Mg2+ complex in methanol: role of the carbohydrates in complex formation
-
Silva, D.J., and Kahne, D.E. (1993) Studies of the 2:1 chromomycin A3-Mg2+ complex in methanol: role of the carbohydrates in complex formation. J Am Chem Soc 115: 7962-7970.
-
(1993)
J Am Chem Soc
, vol.115
, pp. 7962-7970
-
-
Silva, D.J.1
Kahne, D.E.2
-
40
-
-
0000925453
-
Antitumor Compounds of Natural Origin
-
Aszalos, A. (ed.). Boca Raton, FL, USA: CRC Press
-
Skarbek, J.D., and Speedie, M.K. (1981) Antitumor antibiotics of the aureolic acid group: chromomycin A3, mithramycin A, and olivomycin A. In Antitumor Compounds of Natural Origin, Vol. 1. Aszalos, A. (ed.). Boca Raton, FL, USA: CRC Press, pp. 191-235.
-
(1981)
Antitumor antibiotics of the aureolic acid group: chromomycin A3, mithramycin A, and olivomycin A
, vol.1
, pp. 191-235
-
-
Skarbek, J.D.1
Speedie, M.K.2
-
41
-
-
0025754048
-
Mithramycin blocks transcriptional initiation of the c-myc P1 and P2 promoters
-
Snyder, R.C., Ray, R., Blume, S., and Miller, D.M. (1991) Mithramycin blocks transcriptional initiation of the c-myc P1 and P2 promoters. Biochemistry 30: 4290-4297.
-
(1991)
Biochemistry
, vol.30
, pp. 4290-4297
-
-
Snyder, R.C.1
Ray, R.2
Blume, S.3
Miller, D.M.4
-
42
-
-
0344359757
-
The structure of mithramycin reinvestigated
-
Wohlert, S.E., Künzel, E., Machinek, R., Méndez, C., Salas, J.A., and Rohr, J. (1999) The structure of mithramycin reinvestigated. J Nat Prod 62: 119-121.
-
(1999)
J Nat Prod
, vol.62
, pp. 119-121
-
-
Wohlert, S.E.1
Künzel, E.2
Machinek, R.3
Méndez, C.4
Salas, J.A.5
Rohr, J.6
|