-
1
-
-
0014040099
-
New amino acids from Streptomyces
-
Argoudelis A.D., Herr R.R., Mason D.J., Pyke T.R., and Zieserl J.F. New amino acids from Streptomyces. Biochemistry 6 (1967) 165-170
-
(1967)
Biochemistry
, vol.6
, pp. 165-170
-
-
Argoudelis, A.D.1
Herr, R.R.2
Mason, D.J.3
Pyke, T.R.4
Zieserl, J.F.5
-
2
-
-
33947162005
-
Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica
-
Beer L.L., and Moore B.S. Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. Org. Lett. 9 (2007) 845-848
-
(2007)
Org. Lett.
, vol.9
, pp. 845-848
-
-
Beer, L.L.1
Moore, B.S.2
-
3
-
-
33645017788
-
Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis
-
Blasiak L.C., Vaillancourt F.H., Walsh C.T., and Drennan C.L. Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature 440 (2006) 368-371
-
(2006)
Nature
, vol.440
, pp. 368-371
-
-
Blasiak, L.C.1
Vaillancourt, F.H.2
Walsh, C.T.3
Drennan, C.L.4
-
4
-
-
27744579584
-
Mechanism of oxygen activation by taurine: α-ketoglutarate dioxygenase (TauD) from Escherichia coli
-
Bollinger Jr. J.M., Price J.C., Hoffart L.M., Barr E.W., and Krebs C. Mechanism of oxygen activation by taurine: α-ketoglutarate dioxygenase (TauD) from Escherichia coli. Eur. J. Inorg. Chem. 2005 (2005) 4245-4254
-
(2005)
Eur. J. Inorg. Chem.
, vol.2005
, pp. 4245-4254
-
-
Bollinger Jr., J.M.1
Price, J.C.2
Hoffart, L.M.3
Barr, E.W.4
Krebs, C.5
-
5
-
-
32644436910
-
Kutznerides 1-4, depsipeptides from the actinomycete Kutzneria sp. 744 inhabiting mycorrhizal roots of Picea abies seedlings
-
Broberg A., Menkis A., and Vasiliauskas R. Kutznerides 1-4, depsipeptides from the actinomycete Kutzneria sp. 744 inhabiting mycorrhizal roots of Picea abies seedlings. J. Nat. Prod. 69 (2006) 97-102
-
(2006)
J. Nat. Prod.
, vol.69
, pp. 97-102
-
-
Broberg, A.1
Menkis, A.2
Vasiliauskas, R.3
-
6
-
-
29844440702
-
Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica
-
Buchanan G.O., Williams P.G., Feling R.H., Kauffman C.A., Jensen P.R., and Fenical W. Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica. Org. Lett. 7 (2005) 2731-2734
-
(2005)
Org. Lett.
, vol.7
, pp. 2731-2734
-
-
Buchanan, G.O.1
Williams, P.G.2
Feling, R.H.3
Kauffman, C.A.4
Jensen, P.R.5
Fenical, W.6
-
7
-
-
0041335630
-
The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000
-
Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T., Gwinn M.L., Dodson R.J., Deboy R.T., Durkin A.S., Kolonay J.F., et al. The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000. Proc. Natl. Acad. Sci. USA 100 (2003) 10181-10186
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 10181-10186
-
-
Buell, C.R.1
Joardar, V.2
Lindeberg, M.3
Selengut, J.4
Paulsen, I.T.5
Gwinn, M.L.6
Dodson, R.J.7
Deboy, R.T.8
Durkin, A.S.9
Kolonay, J.F.10
-
8
-
-
1342290169
-
The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products
-
Butler A., and Carter-Franklin J.N. The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products. Nat. Prod. Rep. 21 (2004) 180-188
-
(2004)
Nat. Prod. Rep.
, vol.21
, pp. 180-188
-
-
Butler, A.1
Carter-Franklin, J.N.2
-
9
-
-
34447535180
-
Incorporation of nonmethyl branches by isoprenoid-like logic: multiple β-alkylation events in the biosynthesis of myxovirescin A1
-
Calderone C.T., Iwig D.F., Dorrestein P.C., Kelleher N.L., and Walsh C.T. Incorporation of nonmethyl branches by isoprenoid-like logic: multiple β-alkylation events in the biosynthesis of myxovirescin A1. Chem. Biol. 14 (2007) 835-846
-
(2007)
Chem. Biol.
, vol.14
, pp. 835-846
-
-
Calderone, C.T.1
Iwig, D.F.2
Dorrestein, P.C.3
Kelleher, N.L.4
Walsh, C.T.5
-
10
-
-
1542378704
-
Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates
-
Costas M., Mehn M.P., Jensen M.P., and Que Jr. L. Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates. Chem. Rev. 104 (2004) 939-986
-
(2004)
Chem. Rev.
, vol.104
, pp. 939-986
-
-
Costas, M.1
Mehn, M.P.2
Jensen, M.P.3
Que Jr., L.4
-
11
-
-
33845281095
-
Cytochrome P-450 and chloroperoxidase: thiolate-ligated heme enzymes. Spectroscopic determination of their active-site structures and mechanistic implications of thiolate ligation
-
Dawson J.H., and Sono M. Cytochrome P-450 and chloroperoxidase: thiolate-ligated heme enzymes. Spectroscopic determination of their active-site structures and mechanistic implications of thiolate ligation. Chem. Rev. 87 (1987) 1255-1276
-
(1987)
Chem. Rev.
, vol.87
, pp. 1255-1276
-
-
Dawson, J.H.1
Sono, M.2
-
12
-
-
1142310932
-
Crystal structure and mechanism of a bacterial fluorinating enzyme
-
Dong C., Huang F., Deng H., Schaffrath C., Spencer J.B., O'Hagan D., and Naismith J.H. Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature 427 (2004) 561-565
-
(2004)
Nature
, vol.427
, pp. 561-565
-
-
Dong, C.1
Huang, F.2
Deng, H.3
Schaffrath, C.4
Spencer, J.B.5
O'Hagan, D.6
Naismith, J.H.7
-
13
-
-
25844517049
-
Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination
-
Dong C., Flecks S., Unversucht S., Haupt C., van Pee K.-H., and Naismith J.H. Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination. Science 309 (2005) 2216-2219
-
(2005)
Science
, vol.309
, pp. 2216-2219
-
-
Dong, C.1
Flecks, S.2
Unversucht, S.3
Haupt, C.4
van Pee, K.-H.5
Naismith, J.H.6
-
14
-
-
25444465451
-
Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis
-
Dorrestein P.C., Yeh E., Garneau-Tsodikova S., Kelleher N.L., and Walsh C.T. Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proc. Natl. Acad. Sci. USA 102 (2005) 13843-13848
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13843-13848
-
-
Dorrestein, P.C.1
Yeh, E.2
Garneau-Tsodikova, S.3
Kelleher, N.L.4
Walsh, C.T.5
-
15
-
-
3042551455
-
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula
-
Edwards D.J., Marquez B.L., Nogle L.M., McPhail K., Goeger D.E., Roberts M.A., and Gerwick W.H. Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem. Biol. 11 (2004) 817-833
-
(2004)
Chem. Biol.
, vol.11
, pp. 817-833
-
-
Edwards, D.J.1
Marquez, B.L.2
Nogle, L.M.3
McPhail, K.4
Goeger, D.E.5
Roberts, M.A.6
Gerwick, W.H.7
-
16
-
-
0029001789
-
Structure and mechanism of para-hydroxybenzoate hydroxylase
-
Entsch B., and van Berkel W.J. Structure and mechanism of para-hydroxybenzoate hydroxylase. FASEB J. 9 (1995) 476-483
-
(1995)
FASEB J.
, vol.9
, pp. 476-483
-
-
Entsch, B.1
van Berkel, W.J.2
-
17
-
-
37249024344
-
Discovery and characterization of a marine bacterial SAM-dependent chlorinase
-
Eustaquio A.S., Pojer F., Noel J.P., and Moore B.S. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat. Chem. Biol. 4 (2008) 69-74
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 69-74
-
-
Eustaquio, A.S.1
Pojer, F.2
Noel, J.P.3
Moore, B.S.4
-
18
-
-
33751100882
-
Developing a new resource for drug discovery: marine actinomycete bacteria
-
Fenical W., and Jensen P.R. Developing a new resource for drug discovery: marine actinomycete bacteria. Nat. Chem. Biol. 2 (2006) 666-673
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 666-673
-
-
Fenical, W.1
Jensen, P.R.2
-
19
-
-
35948990530
-
Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the α-ketoglutarate-dependent halogenase CytC3 from Streptomyces
-
Fujimori D.G., Barr E.W., Matthews M.L., Koch G.M., Yonce J.R., Walsh C.T., Bollinger J.M., Krebs C., and Riggs-Gelasco P.J. Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the α-ketoglutarate-dependent halogenase CytC3 from Streptomyces. J. Am. Chem. Soc. 129 (2007) 13408-13409
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 13408-13409
-
-
Fujimori, D.G.1
Barr, E.W.2
Matthews, M.L.3
Koch, G.M.4
Yonce, J.R.5
Walsh, C.T.6
Bollinger, J.M.7
Krebs, C.8
Riggs-Gelasco, P.J.9
-
20
-
-
36749099421
-
Cloning and characterization of the biosynthetic gene cluster for kutznerides
-
Fujimori D.G., Hrvatin S., Neumann C.S., Strieker M., Marahiel M.A., and Walsh C.T. Cloning and characterization of the biosynthetic gene cluster for kutznerides. Proc. Natl. Acad. Sci. USA 104 (2007) 16498-16503
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 16498-16503
-
-
Fujimori, D.G.1
Hrvatin, S.2
Neumann, C.S.3
Strieker, M.4
Marahiel, M.A.5
Walsh, C.T.6
-
21
-
-
33645461070
-
Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis
-
Galonic D.P., Vaillancourt F.H., and Walsh C.T. Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis. J. Am. Chem. Soc. 128 (2006) 3900-3901
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 3900-3901
-
-
Galonic, D.P.1
Vaillancourt, F.H.2
Walsh, C.T.3
-
22
-
-
33846379972
-
Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3
-
Galonic D.P., Barr E.W., Walsh C.T., Bollinger J.M., and Krebs C. Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3. Nat. Chem. Biol. 3 (2007) 113-116
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 113-116
-
-
Galonic, D.P.1
Barr, E.W.2
Walsh, C.T.3
Bollinger, J.M.4
Krebs, C.5
-
23
-
-
0001655184
-
Naturally occurring organohalogen compounds
-
Gribble G.W. Naturally occurring organohalogen compounds. Acc. Chem. Res. 31 (1998) 141-152
-
(1998)
Acc. Chem. Res.
, vol.31
, pp. 141-152
-
-
Gribble, G.W.1
-
24
-
-
4944226169
-
Natural organohalogens: a new frontier for medicinal agents?
-
Gribble G.W. Natural organohalogens: a new frontier for medicinal agents?. J. Chem. Educ. 81 (2004) 1441-1449
-
(2004)
J. Chem. Educ.
, vol.81
, pp. 1441-1449
-
-
Gribble, G.W.1
-
25
-
-
33646137808
-
Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of β-lactone ring opening and a mechanism for irreversible binding
-
Groll M., Huber R., and Potts B.C.M. Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of β-lactone ring opening and a mechanism for irreversible binding. J. Am. Chem. Soc. 128 (2006) 5136-5141
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 5136-5141
-
-
Groll, M.1
Huber, R.2
Potts, B.C.M.3
-
27
-
-
0022346887
-
The role of the chlorine substituents in the antibiotic vancomycin: preparation and characterization of mono- and didechlorovancomycin
-
Harris C.M., Kannan R., Kopecka H., and Harris T.M. The role of the chlorine substituents in the antibiotic vancomycin: preparation and characterization of mono- and didechlorovancomycin. J. Am. Chem. Soc. 107 (1985) 6652-6658
-
(1985)
J. Am. Chem. Soc.
, vol.107
, pp. 6652-6658
-
-
Harris, C.M.1
Kannan, R.2
Kopecka, H.3
Harris, T.M.4
-
28
-
-
0033519204
-
The biosynthesis of barbamide - a radical pathway for "biohalogenation"?
-
Hartung J. The biosynthesis of barbamide - a radical pathway for "biohalogenation"?. Angew. Chem. Int. Ed. 38 (1999) 1209-1211
-
(1999)
Angew. Chem. Int. Ed.
, vol.38
, pp. 1209-1211
-
-
Hartung, J.1
-
29
-
-
2442628211
-
Fe(II)/α-ketoglutarate-dependent hydroxylases and related enzymes
-
Hausinger R.P. Fe(II)/α-ketoglutarate-dependent hydroxylases and related enzymes. Crit. Rev. Biochem. Mol. Biol. 39 (2004) 21-68
-
(2004)
Crit. Rev. Biochem. Mol. Biol.
, vol.39
, pp. 21-68
-
-
Hausinger, R.P.1
-
30
-
-
33749542309
-
Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase
-
Hoffart L.M., Barr E.W., Guyer R.B., Bollinger Jr. J.M., and Krebs C. Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase. Proc. Natl. Acad. Sci. USA 103 (2006) 14738-14743
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 14738-14743
-
-
Hoffart, L.M.1
Barr, E.W.2
Guyer, R.B.3
Bollinger Jr., J.M.4
Krebs, C.5
-
31
-
-
34250818263
-
A genomic screening approach to the structure-guided identification of drug candidates from natural sources
-
Hornung A., Bertazzo M., Dziarnowski A., Schneider K., Welzel K., Wohlert S.-E., Holzenkämpfer M., Nicholson G.J., Bechthold A., Süssmuth R.D., et al. A genomic screening approach to the structure-guided identification of drug candidates from natural sources. ChemBioChem 8 (2007) 757-766
-
(2007)
ChemBioChem
, vol.8
, pp. 757-766
-
-
Hornung, A.1
Bertazzo, M.2
Dziarnowski, A.3
Schneider, K.4
Welzel, K.5
Wohlert, S.-E.6
Holzenkämpfer, M.7
Nicholson, G.J.8
Bechthold, A.9
Süssmuth, R.D.10
-
32
-
-
0034674155
-
Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis
-
Isupov M.N., Dalby A.R., Brindley A.A., Izumi Y., Tanabe T., Murshudov G.N., and Littlechild J.A. Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis. J. Mol. Biol. 299 (2000) 1035-1049
-
(2000)
J. Mol. Biol.
, vol.299
, pp. 1035-1049
-
-
Isupov, M.N.1
Dalby, A.R.2
Brindley, A.A.3
Izumi, Y.4
Tanabe, T.5
Murshudov, G.N.6
Littlechild, J.A.7
-
33
-
-
0034600905
-
Purification and partial characterization of tryptophan 7-halogenase (PrnA) from Pseudomonas fluorescens
-
Keller S., Wage T., Hohaus K., Holzer M., Eichhorn E., and van Pee K.H. Purification and partial characterization of tryptophan 7-halogenase (PrnA) from Pseudomonas fluorescens. Angew. Chem. Int. Ed. 39 (2000) 2300-2302
-
(2000)
Angew. Chem. Int. Ed.
, vol.39
, pp. 2300-2302
-
-
Keller, S.1
Wage, T.2
Hohaus, K.3
Holzer, M.4
Eichhorn, E.5
van Pee, K.H.6
-
34
-
-
33846219119
-
Characterization of the aminocarboxycyclopropane-forming enzyme CmaC
-
Kelly W.L., Boyne M.T., Yeh E., Vosburg D.A., Galonic D.P., Kelleher N.L., and Walsh C.T. Characterization of the aminocarboxycyclopropane-forming enzyme CmaC. Biochemistry 46 (2007) 359-368
-
(2007)
Biochemistry
, vol.46
, pp. 359-368
-
-
Kelly, W.L.1
Boyne, M.T.2
Yeh, E.3
Vosburg, D.A.4
Galonic, D.P.5
Kelleher, N.L.6
Walsh, C.T.7
-
35
-
-
0001061073
-
Alkane functionalization at nonheme iron centers. Stoichiometric transfer of metal-bound ligands to alkane
-
Kojima T., Leising R.A., Yan S., and Que Jr. L. Alkane functionalization at nonheme iron centers. Stoichiometric transfer of metal-bound ligands to alkane. J. Am. Chem. Soc. 115 (1993) 11328-11335
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 11328-11335
-
-
Kojima, T.1
Leising, R.A.2
Yan, S.3
Que Jr., L.4
-
36
-
-
35348982831
-
Regiospecific chlorination of (S)-β-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027
-
Lin S., VanLanen S.G., and Shen B. Regiospecific chlorination of (S)-β-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027. J. Am. Chem. Soc. 129 (2007) 12432-12438
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 12432-12438
-
-
Lin, S.1
VanLanen, S.G.2
Shen, B.3
-
37
-
-
0030061093
-
X-ray structure of a vanadium-containing enzyme: Chloroperoxidase from the fungus Curvularia inaequalis
-
Messerschmidt A., and Wever R. X-ray structure of a vanadium-containing enzyme: Chloroperoxidase from the fungus Curvularia inaequalis. Proc. Natl. Acad. Sci. USA 93 (1996) 392-396
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 392-396
-
-
Messerschmidt, A.1
Wever, R.2
-
38
-
-
0037267037
-
New frontiers in biological halogenation
-
Murphy C.D. New frontiers in biological halogenation. J. Appl. Microbiol. 94 (2003) 539-548
-
(2003)
J. Appl. Microbiol.
, vol.94
, pp. 539-548
-
-
Murphy, C.D.1
-
40
-
-
0034282210
-
Relative reactivity of lysine and other peptide-bound amino acids to oxidation by hypochlorite
-
Nightingale Z.D., Lancha A.H., Handelman S.K., Dolnikowski G.G., Busse S.C., Dratz E.A., Blumberg J.B., and Handelman G.J. Relative reactivity of lysine and other peptide-bound amino acids to oxidation by hypochlorite. Free Radic. Biol. Med. 29 (2000) 425-433
-
(2000)
Free Radic. Biol. Med.
, vol.29
, pp. 425-433
-
-
Nightingale, Z.D.1
Lancha, A.H.2
Handelman, S.K.3
Dolnikowski, G.G.4
Busse, S.C.5
Dratz, E.A.6
Blumberg, J.B.7
Handelman, G.J.8
-
41
-
-
0037149459
-
Biochemistry: biosynthesis of an organofluorine molecule
-
O'Hagan D., Schaffrath C., Cobb S.L., Hamilton J.T., and Murphy C.D. Biochemistry: biosynthesis of an organofluorine molecule. Nature 416 (2002) 279
-
(2002)
Nature
, vol.416
, pp. 279
-
-
O'Hagan, D.1
Schaffrath, C.2
Cobb, S.L.3
Hamilton, J.T.4
Murphy, C.D.5
-
42
-
-
33646463757
-
Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica"
-
Oh D.C., Williams P.G., Kauffman C.A., Jensen P.R., and Fenical W. Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica". Org. Lett. 8 (2006) 1021-1024
-
(2006)
Org. Lett.
, vol.8
, pp. 1021-1024
-
-
Oh, D.C.1
Williams, P.G.2
Kauffman, C.A.3
Jensen, P.R.4
Fenical, W.5
-
43
-
-
0029969534
-
Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula
-
Orjala J., and Gerwick W.H. Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula. J. Nat. Prod. 59 (1996) 427-430
-
(1996)
J. Nat. Prod.
, vol.59
, pp. 427-430
-
-
Orjala, J.1
Gerwick, W.H.2
-
44
-
-
34247513435
-
Nucleophilic addition to a p-benzyne derived from an enediyne: a new mechanism for halide incorporation into biomolecules
-
Perrin C.L., Rodgers B.L., and O'Connor J.M. Nucleophilic addition to a p-benzyne derived from an enediyne: a new mechanism for halide incorporation into biomolecules. J. Am. Chem. Soc. 129 (2007) 4795-4799
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 4795-4799
-
-
Perrin, C.L.1
Rodgers, B.L.2
O'Connor, J.M.3
-
46
-
-
0343986411
-
One motif - many different reactions
-
Que Jr. L. One motif - many different reactions. Nat. Struct. Biol. 7 (2000) 182-184
-
(2000)
Nat. Struct. Biol.
, vol.7
, pp. 182-184
-
-
Que Jr., L.1
-
47
-
-
38349022535
-
Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula
-
Ramaswamy A.V., Sorrels C.M., and Gerwick W.H. Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula. J. Nat. Prod. 70 (2007) 1977-1986
-
(2007)
J. Nat. Prod.
, vol.70
, pp. 1977-1986
-
-
Ramaswamy, A.V.1
Sorrels, C.M.2
Gerwick, W.H.3
-
48
-
-
0032514839
-
Neomangicols: structures and absolute stereochemistries of unprecedented halogenated sesterterpenes from a marine fungus of the genus Fusarium
-
Renner M.K., Jensen P.R., and Fenical W. Neomangicols: structures and absolute stereochemistries of unprecedented halogenated sesterterpenes from a marine fungus of the genus Fusarium. J. Org. Chem. 63 (1998) 8346-8354
-
(1998)
J. Org. Chem.
, vol.63
, pp. 8346-8354
-
-
Renner, M.K.1
Jensen, P.R.2
Fenical, W.3
-
49
-
-
0000714445
-
Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties
-
Rodrigues Pereira E., Belin L., Sancelme M., Prudhomme M., Ollier M., Rapp M., Severe D., Riou J.F., Fabbro D., and Meyer T. Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties. J. Med. Chem. 39 (1996) 4471-4477
-
(1996)
J. Med. Chem.
, vol.39
, pp. 4471-4477
-
-
Rodrigues Pereira, E.1
Belin, L.2
Sancelme, M.3
Prudhomme, M.4
Ollier, M.5
Rapp, M.6
Severe, D.7
Riou, J.F.8
Fabbro, D.9
Meyer, T.10
-
50
-
-
12244279574
-
Combinatorial biosynthesis of antitumor indolocarbazole compounds
-
Sanchez C., Zhu L., Brana A.F., Salas A.P., Rohr J., Mendez C., and Salas J.A. Combinatorial biosynthesis of antitumor indolocarbazole compounds. Proc. Natl. Acad. Sci. USA 102 (2005) 461-466
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 461-466
-
-
Sanchez, C.1
Zhu, L.2
Brana, A.F.3
Salas, A.P.4
Rohr, J.5
Mendez, C.6
Salas, J.A.7
-
51
-
-
33745047747
-
Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives
-
Sanchez C., Mendez C., and Salas J.A. Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives. J. Ind. Microbiol. Biotechnol. 33 (2006) 560-568
-
(2006)
J. Ind. Microbiol. Biotechnol.
, vol.33
, pp. 560-568
-
-
Sanchez, C.1
Mendez, C.2
Salas, J.A.3
-
52
-
-
0032558148
-
Biosynthesis of the marine cyanobacterial metabolite barbamide. 1. Origin of the trichloromethyl group
-
Sitachitta N., Rossi J., Roberts M.A., Gerwick W.H., Fletcher M.D., and Willis C.L. Biosynthesis of the marine cyanobacterial metabolite barbamide. 1. Origin of the trichloromethyl group. J. Am. Chem. Soc. 120 (1998) 7131-7132
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 7131-7132
-
-
Sitachitta, N.1
Rossi, J.2
Roberts, M.A.3
Gerwick, W.H.4
Fletcher, M.D.5
Willis, C.L.6
-
53
-
-
0029646104
-
The crystal structure of chloroperoxidase: a heme peroxidase-cytochrome P450 functional hybrid
-
Sundaramoorthy M., Terner J., and Poulos T.L. The crystal structure of chloroperoxidase: a heme peroxidase-cytochrome P450 functional hybrid. Structure 3 (1995) 1367-1378
-
(1995)
Structure
, vol.3
, pp. 1367-1378
-
-
Sundaramoorthy, M.1
Terner, J.2
Poulos, T.L.3
-
54
-
-
0036008844
-
Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis
-
Thomas M.G., Burkart M.D., and Walsh C.T. Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis. Chem. Biol. 9 (2002) 171-184
-
(2002)
Chem. Biol.
, vol.9
, pp. 171-184
-
-
Thomas, M.G.1
Burkart, M.D.2
Walsh, C.T.3
-
55
-
-
34447302758
-
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
-
Udwary D.W., Zeigler L., Asolkar R.N., Singan V., Lapidus A., Fenical W., Jensen P.R., and Moore B.S. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc. Natl. Acad. Sci. USA 104 (2007) 10376-10381
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 10376-10381
-
-
Udwary, D.W.1
Zeigler, L.2
Asolkar, R.N.3
Singan, V.4
Lapidus, A.5
Fenical, W.6
Jensen, P.R.7
Moore, B.S.8
-
56
-
-
33750970295
-
Enzymatic generation of the antimetabolite γ,γ-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete
-
Ueki M., Galonic D.P., Vaillancourt F.H., Garneau-Tsodikova S., Yeh E., Vosburg D.A., Schroeder F.C., Osada H., and Walsh C.T. Enzymatic generation of the antimetabolite γ,γ-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete. Chem. Biol. 13 (2006) 1183-1191
-
(2006)
Chem. Biol.
, vol.13
, pp. 1183-1191
-
-
Ueki, M.1
Galonic, D.P.2
Vaillancourt, F.H.3
Garneau-Tsodikova, S.4
Yeh, E.5
Vosburg, D.A.6
Schroeder, F.C.7
Osada, H.8
Walsh, C.T.9
-
57
-
-
24144485937
-
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis
-
Vaillancourt F.H., Yeh E., Vosburg D.A., O'Connor S.E., and Walsh C.T. Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis. Nature 436 (2005) 1191-1194
-
(2005)
Nature
, vol.436
, pp. 1191-1194
-
-
Vaillancourt, F.H.1
Yeh, E.2
Vosburg, D.A.3
O'Connor, S.E.4
Walsh, C.T.5
-
59
-
-
33748588122
-
Nature's inventory of halogenation catalysts: oxidative strategies predominate
-
Vaillancourt F.H., Yeh E., Vosburg D.A., Garneau-Tsodikova S., and Walsh C.T. Nature's inventory of halogenation catalysts: oxidative strategies predominate. Chem. Rev. 106 (2006) 3364-3378
-
(2006)
Chem. Rev.
, vol.106
, pp. 3364-3378
-
-
Vaillancourt, F.H.1
Yeh, E.2
Vosburg, D.A.3
Garneau-Tsodikova, S.4
Walsh, C.T.5
-
60
-
-
0029843080
-
Biosynthesis of halogenated metabolites by bacteria
-
van Pee K.H. Biosynthesis of halogenated metabolites by bacteria. Annu. Rev. Microbiol. 50 (1996) 375-399
-
(1996)
Annu. Rev. Microbiol.
, vol.50
, pp. 375-399
-
-
van Pee, K.H.1
-
61
-
-
84983210879
-
Enzymology and molecular genetics of biological halogenation
-
Gribble G. (Ed), Springer, New York
-
van Pee K.-H., and Zehner S. Enzymology and molecular genetics of biological halogenation. In: Gribble G. (Ed). Handbook of Environmental Chemistry Vol. 3 (2003), Springer, New York 171-199
-
(2003)
Handbook of Environmental Chemistry
, vol.3
, pp. 171-199
-
-
van Pee, K.-H.1
Zehner, S.2
-
62
-
-
0033637505
-
Selective oxygen transfer catalysed by heme peroxidases: synthetic and mechanistic aspects
-
van Rantwijk F., and Sheldon R.A. Selective oxygen transfer catalysed by heme peroxidases: synthetic and mechanistic aspects. Curr. Opin. Biotechnol. 11 (2000) 554-564
-
(2000)
Curr. Opin. Biotechnol.
, vol.11
, pp. 554-564
-
-
van Rantwijk, F.1
Sheldon, R.A.2
-
63
-
-
0032759084
-
X-ray structure determination of a vanadium-dependent haloperoxidase from Ascophyllum nodosum at 2.0 A resolution
-
Weyand M., Hecht H.J., Kie M., Liaud M.F., Vilter H., and Schomburg D. X-ray structure determination of a vanadium-dependent haloperoxidase from Ascophyllum nodosum at 2.0 A resolution. J. Mol. Biol. 293 (1999) 595-611
-
(1999)
J. Mol. Biol.
, vol.293
, pp. 595-611
-
-
Weyand, M.1
Hecht, H.J.2
Kie, M.3
Liaud, M.F.4
Vilter, H.5
Schomburg, D.6
-
64
-
-
34447558011
-
Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster
-
Winter J.M., Moffitt M.C., Zazopoulos E., McAlpine J.B., Dorrestein P.C., and Moore B.S. Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. J. Biol. Chem. 282 (2007) 16362-16368
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 16362-16368
-
-
Winter, J.M.1
Moffitt, M.C.2
Zazopoulos, E.3
McAlpine, J.B.4
Dorrestein, P.C.5
Moore, B.S.6
-
65
-
-
15244349569
-
Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis
-
Yeh E., Garneau S., and Walsh C.T. Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis. Proc. Natl. Acad. Sci. USA 102 (2005) 3960-3965
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 3960-3965
-
-
Yeh, E.1
Garneau, S.2
Walsh, C.T.3
-
66
-
-
33745963527
-
Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH
-
Yeh E., Cole L.J., Barr E.W., Bollinger Jr. J.M., Ballou D.P., and Walsh C.T. Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH. Biochemistry 45 (2006) 7904-7912
-
(2006)
Biochemistry
, vol.45
, pp. 7904-7912
-
-
Yeh, E.1
Cole, L.J.2
Barr, E.W.3
Bollinger Jr., J.M.4
Ballou, D.P.5
Walsh, C.T.6
-
67
-
-
33846842522
-
Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases
-
Yeh E., Blasiak L.C., Koglin A., Drennan C.L., and Walsh C.T. Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases. Biochemistry 46 (2007) 1284-1292
-
(2007)
Biochemistry
, vol.46
, pp. 1284-1292
-
-
Yeh, E.1
Blasiak, L.C.2
Koglin, A.3
Drennan, C.L.4
Walsh, C.T.5
-
68
-
-
17844408703
-
A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005
-
Zehner S., Kotzsch A., Bister B., Sussmuth R.D., Mendez C., Salas J.A., and van Pee K.-H. A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005. Chem. Biol. 12 (2005) 445-452
-
(2005)
Chem. Biol.
, vol.12
, pp. 445-452
-
-
Zehner, S.1
Kotzsch, A.2
Bister, B.3
Sussmuth, R.D.4
Mendez, C.5
Salas, J.A.6
van Pee, K.-H.7
-
69
-
-
36749093357
-
Mechanism of enzymatic fluorination in Streptomyces cattleya
-
Zhu X., Robinson D.A., McEwan A.R., O'Hagan D., and Naismith J.H. Mechanism of enzymatic fluorination in Streptomyces cattleya. J. Am. Chem. Soc. 129 (2007) 14597-14604
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 14597-14604
-
-
Zhu, X.1
Robinson, D.A.2
McEwan, A.R.3
O'Hagan, D.4
Naismith, J.H.5
|