Increased penicillin production in penicillium chrysogenum production strains via balanced overexpression of isopenicillin n acyltransferase

Applied and Environmental Microbiology

Volumn 78, Issue 19, 2012, Pages 7107-7113

  Weber, Stefan S ^a   Polli, Fabiola ^a   Boer, Rémon ^b   Bovenberg, Roel A L ^a,b   Driessen, Arnold J M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b DSM BIOTECHNOLOGY CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CLUSTER ENCODING; COENZYME A; COPY NUMBER; ISOPENICILLIN N SYNTHASE; KEY ENZYMES; LIMITING STEP; OVER-EXPRESSION; PENICILLIN PRODUCTION; PENICILLIUM CHRYSOGENUM; PHENYLACETIC ACID; PRODUCTION STRAIN; PROTEIN LEVEL; SIDE-CHAINS; STRAIN IMPROVEMENT; SYNTHETASES;

AMINO ACIDS; BIOCHEMISTRY; ENZYMES; GENE ENCODING; PLANTS (BOTANY);

STRAIN;

ACYL COA 6 AMINOPENICILLANIC ACID ACYLTRANSFERASE; ACYL-COA-6-AMINOPENICILLANIC ACID ACYLTRANSFERASE; ACYLTRANSFERASE; PENICILLIN BINDING PROTEIN; PENICILLIN DERIVATIVE;

ACETIC ACID; ANTIBIOTICS; CATALYSIS; CLUSTER ANALYSIS; ENZYME ACTIVITY; FUNGUS; GENE EXPRESSION;

ARTICLE; BIOSYNTHESIS; GENE DOSAGE; GENE EXPRESSION; GENETICS; METABOLIC ENGINEERING; METABOLISM; MULTIGENE FAMILY; PENICILLIUM CHRYSOGENUM;

ACYLTRANSFERASES; GENE DOSAGE; GENE EXPRESSION; METABOLIC ENGINEERING; MULTIGENE FAMILY; PENICILLIN-BINDING PROTEINS; PENICILLINS; PENICILLIUM CHRYSOGENUM;

PENICILLIUM CHRYSOGENUM;

EID: 84868332788     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.01529-12     Document Type: Article

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