Synthesis and biochemical analysis of complex chain-elongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases

Journal of the American Chemical Society

Volumn 131, Issue 43, 2009, Pages 15784-15793

  Mortison, Jonathan D ^a   Kittendorf, Jeffrey D ^a   Sherman, David H ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6-DEOXYERYTHRONOLIDE B SYNTHASE; AGLYCONES; BIOCHEMICAL ANALYSIS; CATALYTIC ELEMENT; CHEMO-ENZYMATIC SYNTHESIS; COMPARATIVE ANALYSIS; ENZYME SYSTEMS; IN-VITRO; MACRO-CYCLIZATION; MACROLACTONES; MOLECULAR SELECTIVITY; MOLECULAR SPECIFICITY; NATURAL PRODUCTS; PIKROMYCIN; POLYKETIDE ASSEMBLY; POLYKETIDE SYNTHASES; SIMILARITIES AND DIFFERENCES; SUBSTRATE RECOGNITION;

BIOCHEMISTRY; BIOSYNTHESIS; PLANTS (BOTANY);

ENZYMES;

6 DEOXYERYTHRONOLIDE B SYNTHASE; ERYTHROMYCIN; PIKROMYCIN; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL ENGINEERING; CYCLIZATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ENZYME SYNTHESIS; MOLECULAR RECOGNITION; PROTEIN PROCESSING;

ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, THIN LAYER; ERYTHROMYCIN; MACROLIDES; POLYKETIDE SYNTHASES; SUBSTRATE SPECIFICITY;

EID: 70350639418     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9060596     Document Type: Article

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