메뉴 건너뛰기




Volumn 39, Issue 2, 2012, Pages 227-241

Protein engineering towards natural product synthesis and diversification

Author keywords

[No Author keywords available]

Indexed keywords

16 DECARBOXY 16 METHYL 28,29 DIDEHYDRONYSTATIN; ACTINORHODINE; ALKALOID; AMPHOTERICIN B; AMPHOTERICIN B DERIVATIVE; ARTEMISININ; BACTERIAL ENZYME; BSG 020; CHALCONE SYNTHASE; CYCLOSPORIN DERIVATIVE; DAPTOMYCIN; ERYTHROMYCIN; FUNGAL ENZYME; GELDANAMYCIN; LIMONENE; MEVINOLIN; NATURAL PRODUCTS AND THEIR SYNTHETIC DERIVATIVES; NONRIBOSOMAL PEPTIDE SYNTHETASE; NYSTATIN; PENICILLIN G; PEPTIDE SYNTHASE; PINENE; POLYKETIDE SYNTHASE; RAPAMYCIN; SURFACTIN; TERPENE; TERPENOID; TETRACYCLINE; TRIOSTIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN;

EID: 84857633496     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-011-1044-2     Document Type: Review
Times cited : (20)

References (103)
  • 1
    • 77749265076 scopus 로고    scopus 로고
    • Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates
    • 20131801 1:CAS:528:DC%2BC3cXhsVyjtLc%3D 10.1021/bi902088z
    • J Aaron X Lin DE Cane DW Christianson 2010 Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates Biochemistry 49 8 1787 1797 20131801 1:CAS:528: DC%2BC3cXhsVyjtLc%3D 10.1021/bi902088z
    • (2010) Biochemistry , vol.49 , Issue.8 , pp. 1787-1797
    • Aaron, J.1    Lin, X.2    Cane, D.E.3    Christianson, D.W.4
  • 2
    • 36349025257 scopus 로고    scopus 로고
    • Enzymatic synthesis of cyclic triterpenes
    • 18033581 1:CAS:528:DC%2BD2sXhtlemsbjL 10.1039/b616857b
    • I Abe 2007 Enzymatic synthesis of cyclic triterpenes Nat Prod Rep 24 6 1311 1331 18033581 1:CAS:528:DC%2BD2sXhtlemsbjL 10.1039/b616857b
    • (2007) Nat Prod Rep , vol.24 , Issue.6 , pp. 1311-1331
    • Abe, I.1
  • 3
    • 34248526212 scopus 로고    scopus 로고
    • Structure-based engineering of a plant type III polyketide synthase: Formation of an unnatural nonaketide naphthopyrone
    • 17439126 1:CAS:528:DC%2BD2sXkt1ShsLc%3D 10.1021/ja070375l
    • I Abe H Morita S Oguro H Noma K Wanibuchi N Kawahara Y Goda H Noguchi T Kohno 2007 Structure-based engineering of a plant type III polyketide synthase: formation of an unnatural nonaketide naphthopyrone J Am Chem Soc 129 18 5976 5980 17439126 1:CAS:528:DC%2BD2sXkt1ShsLc%3D 10.1021/ja070375l
    • (2007) J Am Chem Soc , vol.129 , Issue.18 , pp. 5976-5980
    • Abe, I.1    Morita, H.2    Oguro, S.3    Noma, H.4    Wanibuchi, K.5    Kawahara, N.6    Goda, Y.7    Noguchi, H.8    Kohno, T.9
  • 4
    • 13444282087 scopus 로고    scopus 로고
    • A plant type III polyketide synthase that produces pentaketide chromone
    • 15686354 1:CAS:528:DC%2BD2MXjtFKguw%3D%3D 10.1021/ja0431206
    • I Abe Y Utsumi S Oguro H Morita Y Sano H Noguchi 2005 A plant type III polyketide synthase that produces pentaketide chromone J Am Chem Soc 127 5 1362 1363 15686354 1:CAS:528:DC%2BD2MXjtFKguw%3D%3D 10.1021/ja0431206
    • (2005) J Am Chem Soc , vol.127 , Issue.5 , pp. 1362-1363
    • Abe, I.1    Utsumi, Y.2    Oguro, S.3    Morita, H.4    Sano, Y.5    Noguchi, H.6
  • 5
    • 32644440102 scopus 로고    scopus 로고
    • Active site residues governing substrate selectivity and polyketide chain length in aloesone synthase
    • 16367761 1:CAS:528:DC%2BD28XktlCnsA%3D%3D 10.1111/j.1742-4658.2005.05059. x
    • I Abe T Watanabe W Lou H Noguchi 2006 Active site residues governing substrate selectivity and polyketide chain length in aloesone synthase FEBS J 273 1 208 218 16367761 1:CAS:528:DC%2BD28XktlCnsA%3D%3D 10.1111/j.1742-4658. 2005.05059.x
    • (2006) FEBS J , vol.273 , Issue.1 , pp. 208-218
    • Abe, I.1    Watanabe, T.2    Lou, W.3    Noguchi, H.4
  • 6
    • 0037319699 scopus 로고    scopus 로고
    • The chalcone synthase superfamily of type III polyketide synthases
    • 12636085 1:CAS:528:DC%2BD3sXisVKls7s%3D 10.1039/b100917f
    • MB Austin JP Noel 2003 The chalcone synthase superfamily of type III polyketide synthases Nat Prod Rep 20 1 79 110 12636085 1:CAS:528: DC%2BD3sXisVKls7s%3D 10.1039/b100917f
    • (2003) Nat Prod Rep , vol.20 , Issue.1 , pp. 79-110
    • Austin, M.B.1    Noel, J.P.2
  • 7
    • 33646118964 scopus 로고    scopus 로고
    • Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase
    • 16638533 1:CAS:528:DC%2BD28XivVGku7k%3D 10.1016/j.chembiol.2006.01.004
    • A Baerga-Ortiz B Popovic AP Siskos HM O'Hare D Spiteller MG Williams N Campillo JB Spencer PF Leadlay 2006 Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase Chem Biol 13 3 277 285 16638533 1:CAS:528:DC%2BD28XivVGku7k%3D 10.1016/j.chembiol.2006.01.004
    • (2006) Chem Biol , vol.13 , Issue.3 , pp. 277-285
    • Baerga-Ortiz, A.1    Popovic, B.2    Siskos, A.P.3    O'Hare, H.M.4    Spiteller, D.5    Williams, M.G.6    Campillo, N.7    Spencer, J.B.8    Leadlay, P.F.9
  • 8
    • 34547927914 scopus 로고    scopus 로고
    • Rapid identification of enzyme variants for re-engineered alkaloid biosynthesis in periwinkle
    • 17719488 1:CAS:528:DC%2BD2sXpsFehsrs%3D 10.1016/j.chembiol.2007.07.008
    • P Bernhardt E McCoy SE O'Connor 2007 Rapid identification of enzyme variants for re-engineered alkaloid biosynthesis in periwinkle Chem Biol 14 8 888 897 17719488 1:CAS:528:DC%2BD2sXpsFehsrs%3D 10.1016/j.chembiol.2007.07.008
    • (2007) Chem Biol , vol.14 , Issue.8 , pp. 888-897
    • Bernhardt, P.1    McCoy, E.2    O'Connor, S.E.3
  • 11
    • 0034013269 scopus 로고    scopus 로고
    • Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
    • 10712928 1:CAS:528:DC%2BD3cXitVOkt7k%3D 10.1016/S1074-5521(00)00091-0
    • G Challis J Ravel CA Townsend 2000 Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains Chem Biol 7 3 211 224 10712928 1:CAS:528:DC%2BD3cXitVOkt7k%3D 10.1016/S1074-5521(00)00091-0
    • (2000) Chem Biol , vol.7 , Issue.3 , pp. 211-224
    • Challis, G.1    Ravel, J.2    Townsend, C.A.3
  • 12
    • 58149095417 scopus 로고    scopus 로고
    • Biosynthesis of polyketide synthase extender units
    • 19374124 1:CAS:528:DC%2BD1cXhsFWju7vJ 10.1039/b801658p
    • YA Chan AM Podevels BM Kevany MG Thomas 2009 Biosynthesis of polyketide synthase extender units Nat Prod Rep 26 1 90 114 19374124 1:CAS:528: DC%2BD1cXhsFWju7vJ 10.1039/b801658p
    • (2009) Nat Prod Rep , vol.26 , Issue.1 , pp. 90-114
    • Chan, Y.A.1    Podevels, A.M.2    Kevany, B.M.3    Thomas, M.G.4
  • 13
    • 62649153772 scopus 로고    scopus 로고
    • Computational structure-based redesign of enzyme activity
    • 19228942 1:CAS:528:DC%2BD1MXjt1Gks7k%3D 10.1073/pnas.0900266106
    • C-Y Chen I Georgiev AC Anderson BR Donald 2009 Computational structure-based redesign of enzyme activity Proc Natl Acad Sci USA 106 10 3764 3769 19228942 1:CAS:528:DC%2BD1MXjt1Gks7k%3D 10.1073/pnas.0900266106
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.10 , pp. 3764-3769
    • Chen, C.-Y.1    Georgiev, I.2    Anderson, A.C.3    Donald, B.R.4
  • 14
    • 33751009100 scopus 로고    scopus 로고
    • Redesign of central enzyme in alkaloid biosynthesis
    • 17113995 1:CAS:528:DC%2BD28Xht1Cis7bO 10.1016/j.chembiol.2006.10.009
    • S Chen MC Galan C Coltharp SE O'Connor 2006 Redesign of central enzyme in alkaloid biosynthesis Chem Biol 13 11 1137 1141 17113995 1:CAS:528: DC%2BD28Xht1Cis7bO 10.1016/j.chembiol.2006.10.009
    • (2006) Chem Biol , vol.13 , Issue.11 , pp. 1137-1141
    • Chen, S.1    Galan, M.C.2    Coltharp, C.3    O'Connor, S.E.4
  • 15
    • 0030756031 scopus 로고    scopus 로고
    • Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin
    • 9250661 1:CAS:528:DyaK2sXkvFeqt7s%3D 10.1093/emboj/16.14.4174
    • E Conti T Stachelhaus MA Marahiel 1997 Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin EMBO J 16 14 4174 4183 9250661 1:CAS:528:DyaK2sXkvFeqt7s%3D 10.1093/emboj/16.14.4174
    • (1997) EMBO J , vol.16 , Issue.14 , pp. 4174-4183
    • Conti, E.1    Stachelhaus, T.2    Marahiel, M.A.3
  • 16
    • 34250790717 scopus 로고    scopus 로고
    • Polyketides, proteins and genes in fungi: Programmed nano-machines begin to reveal their secrets
    • 17581644 1:CAS:528:DC%2BD2sXms1egu7c%3D 10.1039/b704420h
    • RJ Cox 2007 Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets Org Biomol Chem 5 13 2010 2026 17581644 1:CAS:528:DC%2BD2sXms1egu7c%3D 10.1039/b704420h
    • (2007) Org Biomol Chem , vol.5 , Issue.13 , pp. 2010-2026
    • Cox, R.J.1
  • 17
    • 0035956988 scopus 로고    scopus 로고
    • One ring or two? Determination of ring number in carotenoids by lycopene ε-cyclases
    • 10.1073/pnas.051618398
    • F Cunningham E Gantt 2000 One ring or two? Determination of ring number in carotenoids by lycopene ε-cyclases Proc Natl Acad Sci USA 98 5 2905 2910 10.1073/pnas.051618398
    • (2000) Proc Natl Acad Sci USA , vol.98 , Issue.5 , pp. 2905-2910
    • Cunningham, F.1    Gantt, E.2
  • 18
    • 0033835264 scopus 로고    scopus 로고
    • Site-directed mutagenesis of squalene-hopene cyclase: Altered substrate specificity and product distribution
    • 1:CAS:528:DC%2BD3cXnt1Wntro%3D 10.1016/S1074-5521(00)00003-X
    • T Dang GD Prestwich 2000 Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution Chem and Biol 7 8 643 649 1:CAS:528:DC%2BD3cXnt1Wntro%3D 10.1016/S1074-5521(00)00003-X
    • (2000) Chem and Biol , vol.7 , Issue.8 , pp. 643-649
    • Dang, T.1    Prestwich, G.D.2
  • 19
    • 66149105072 scopus 로고    scopus 로고
    • Biosynthesis of aromatic polyketides in bacteria
    • 19292437 1:CAS:528:DC%2BD1MXjt1Kjsrk%3D 10.1021/ar8002249
    • A Das C Khosla 2009 Biosynthesis of aromatic polyketides in bacteria Acc Chem Res 42 5 631 639 19292437 1:CAS:528:DC%2BD1MXjt1Kjsrk%3D 10.1021/ar8002249
    • (2009) Acc Chem Res , vol.42 , Issue.5 , pp. 631-639
    • Das, A.1    Khosla, C.2
  • 20
    • 0036005606 scopus 로고    scopus 로고
    • The biosynthesis of C5-C25 terpenoid compounds
    • 12013278 1:CAS:528:DC%2BD38XktFShsrc%3D 10.1039/b002685i
    • PM Dewick 2002 The biosynthesis of C5-C25 terpenoid compounds Nat Prod Rep 19 2 181 222 12013278 1:CAS:528:DC%2BD38XktFShsrc%3D 10.1039/b002685i
    • (2002) Nat Prod Rep , vol.19 , Issue.2 , pp. 181-222
    • Dewick, P.M.1
  • 21
    • 77954203515 scopus 로고    scopus 로고
    • Insights into bacterial 6-methylsalicylic acid synthase and its engineering to orsellinic acid synthase for spirotetronate generation
    • 20534347 1:CAS:528:DC%2BC3cXmslCjtr4%3D 10.1016/j.chembiol.2010.04.009
    • W Ding C Lei Q He Q Zhang Y Bi W Liu 2010 Insights into bacterial 6-methylsalicylic acid synthase and its engineering to orsellinic acid synthase for spirotetronate generation Chem Biol 17 5 495 503 20534347 1:CAS:528:DC%2BC3cXmslCjtr4%3D 10.1016/j.chembiol.2010.04.009
    • (2010) Chem Biol , vol.17 , Issue.5 , pp. 495-503
    • Ding, W.1    Lei, C.2    He, Q.3    Zhang, Q.4    Bi, Y.5    Liu, W.6
  • 22
    • 0037199494 scopus 로고    scopus 로고
    • Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics
    • 12135394 1:CAS:528:DC%2BD38XkvFCltr8%3D 10.1021/bi0259406
    • K Eppelmann T Stachelhaus MA Marahiel 2002 Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics Biochemistry 41 30 9718 9726 12135394 1:CAS:528:DC%2BD38XkvFCltr8%3D 10.1021/bi0259406
    • (2002) Biochemistry , vol.41 , Issue.30 , pp. 9718-9726
    • Eppelmann, K.1    Stachelhaus, T.2    Marahiel, M.A.3
  • 23
    • 79957450871 scopus 로고    scopus 로고
    • Directed evolution of nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo
    • 21609841 1:CAS:528:DC%2BC3MXmslOksL0%3D 10.1016/j.chembiol.2011.03.008
    • B Evans Y Chen WW Metcalf H Zhao NL Kelleher 2011 Directed evolution of nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo Chem Biol 18 5 601 607 21609841 1:CAS:528:DC%2BC3MXmslOksL0%3D 10.1016/j.chembiol.2011.03.008
    • (2011) Chem Biol , vol.18 , Issue.5 , pp. 601-607
    • Evans, B.1    Chen, Y.2    Metcalf, W.W.3    Zhao, H.4    Kelleher, N.L.5
  • 24
    • 0032805888 scopus 로고    scopus 로고
    • Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis
    • 10426957 1:CAS:528:DyaK1MXltVShsLg%3D 10.1038/11553
    • JL Ferrer JM Jez ME Bowman RA Dixon JP Noel 1999 Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis Nat Struct Biol 6 8 775 784 10426957 1:CAS:528:DyaK1MXltVShsLg%3D 10.1038/11553
    • (1999) Nat Struct Biol , vol.6 , Issue.8 , pp. 775-784
    • Ferrer, J.L.1    Jez, J.M.2    Bowman, M.E.3    Dixon, R.A.4    Noel, J.P.5
  • 25
    • 34547547069 scopus 로고    scopus 로고
    • Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes
    • 17620609 1:CAS:528:DC%2BD2sXosVClsLc%3D 10.1073/pnas.0705348104
    • M Fischbach JR Lai ED Roche CT Walsh DR Liu 2007 Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes Proc Natl Acad Sci USA 104 29 11951 11956 17620609 1:CAS:528:DC%2BD2sXosVClsLc%3D 10.1073/pnas.0705348104
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.29 , pp. 11951-11956
    • Fischbach, M.1    Lai, J.R.2    Roche, E.D.3    Walsh, C.T.4    Liu, D.R.5
  • 26
    • 69549111337 scopus 로고    scopus 로고
    • Antibiotics for emerging pathogens
    • 19713519 1:CAS:528:DC%2BD1MXhtVersrzK 10.1126/science.1176667
    • MA Fischbach CT Walsh 2009 Antibiotics for emerging pathogens Science 325 5944 1089 1093 19713519 1:CAS:528:DC%2BD1MXhtVersrzK 10.1126/science.1176667
    • (2009) Science , vol.325 , Issue.5944 , pp. 1089-1093
    • Fischbach, M.A.1    Walsh, C.T.2
  • 27
    • 0035861905 scopus 로고    scopus 로고
    • Bicyclic triterpenes as new main products of squalene-hopene cyclase by mutation at conserved tyrosine residues
    • 11749956 10.1016/S0014-5793(01)03153-2
    • C Füll 2001 Bicyclic triterpenes as new main products of squalene-hopene cyclase by mutation at conserved tyrosine residues FEBS Lett 509 3 361 364 11749956 10.1016/S0014-5793(01)03153-2
    • (2001) FEBS Lett , vol.509 , Issue.3 , pp. 361-364
    • Füll, C.1
  • 28
    • 57349132506 scopus 로고    scopus 로고
    • Probing the aglycon promiscuity of an engineered glycosyltransferase
    • 18924204 1:CAS:528:DC%2BD1cXhsVCgtLfL 10.1002/anie.200803508
    • RW Gantt RD Goff GJ Williams JS Thorson 2008 Probing the aglycon promiscuity of an engineered glycosyltransferase Angew Chem Int Ed Engl 47 46 8889 8892 18924204 1:CAS:528:DC%2BD1cXhsVCgtLfL 10.1002/anie.200803508
    • (2008) Angew Chem Int Ed Engl , vol.47 , Issue.46 , pp. 8889-8892
    • Gantt, R.W.1    Goff, R.D.2    Williams, G.J.3    Thorson, J.S.4
  • 29
    • 71149114259 scopus 로고    scopus 로고
    • Directed evolution and structural characterization of a simvastatin synthase
    • 19875080 1:CAS:528:DC%2BD1MXhtlCnt7fM 10.1016/j.chembiol.2009.09.017
    • X Gao X Xie I Pashkov MR Sawaya J Laidman W Zhang R Cacho TO Yeates Y Tang 2009 Directed evolution and structural characterization of a simvastatin synthase Chem Biol 16 10 1064 1074 19875080 1:CAS:528:DC%2BD1MXhtlCnt7fM 10.1016/j.chembiol.2009.09.017
    • (2009) Chem Biol , vol.16 , Issue.10 , pp. 1064-1074
    • Gao, X.1    Xie, X.2    Pashkov, I.3    Sawaya, M.R.4    Laidman, J.5    Zhang, W.6    Cacho, R.7    Yeates, T.O.8    Tang, Y.9
  • 30
    • 0035923511 scopus 로고    scopus 로고
    • Molecular scaffolds for chemical wizardry: Learning nature's rules for terpene cyclases
    • 11717417 1:CAS:528:DC%2BD3MXovVygu7c%3D 10.1073/pnas.261562898
    • B Greenhagen J Chappell 2001 Molecular scaffolds for chemical wizardry: learning nature's rules for terpene cyclases Proc Natl Acad Sci USA 98 24 13479 13481 11717417 1:CAS:528:DC%2BD3MXovVygu7c%3D 10.1073/pnas.261562898
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.24 , pp. 13479-13481
    • Greenhagen, B.1    Chappell, J.2
  • 31
    • 33745631233 scopus 로고    scopus 로고
    • Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases
    • 16785438 1:CAS:528:DC%2BD28XmvVajt70%3D 10.1073/pnas.0601605103
    • B Greenhagen PE O'Maille JP Noel J Chappell 2006 Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases Proc Natl Acad Sci USA 103 26 9826 9831 16785438 1:CAS:528: DC%2BD28XmvVajt70%3D 10.1073/pnas.0601605103
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.26 , pp. 9826-9831
    • Greenhagen, B.1    O'Maille, P.E.2    Noel, J.P.3    Chappell, J.4
  • 32
    • 8144230760 scopus 로고    scopus 로고
    • Selective interaction between nonribosomal peptide synthetases is facilitated by short communication-mediating domains
    • 15498872 1:CAS:528:DC%2BD2cXhtVWisL3F 10.1073/pnas.0404932101
    • M Hahn T Stachelhaus 2004 Selective interaction between nonribosomal peptide synthetases is facilitated by short communication-mediating domains Proc Natl Acad Sci USA 101 44 15585 15590 15498872 1:CAS:528:DC%2BD2cXhtVWisL3F 10.1073/pnas.0404932101
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.44 , pp. 15585-15590
    • Hahn, M.1    Stachelhaus, T.2
  • 33
    • 31044442400 scopus 로고    scopus 로고
    • Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides
    • 16407157 1:CAS:528:DC%2BD28XpsVSnsg%3D%3D 10.1073/pnas.0508409103
    • M Hahn T Stachelhaus 2006 Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides Proc Natl Acad Sci USA 103 2 275 280 16407157 1:CAS:528:DC%2BD28XpsVSnsg%3D%3D 10.1073/pnas.0508409103
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.2 , pp. 275-280
    • Hahn, M.1    Stachelhaus, T.2
  • 34
    • 69249202590 scopus 로고    scopus 로고
    • The biosynthetic logic of polyketide diversity
    • 19514004 1:CAS:528:DC%2BD1MXntlOitbs%3D 10.1002/anie.200806121
    • C Hertweck 2009 The biosynthetic logic of polyketide diversity Angew Chem Int Ed Engl 48 26 4688 4716 19514004 1:CAS:528:DC%2BD1MXntlOitbs%3D 10.1002/anie.200806121
    • (2009) Angew Chem Int Ed Engl , vol.48 , Issue.26 , pp. 4688-4716
    • Hertweck, C.1
  • 35
    • 33846923183 scopus 로고    scopus 로고
    • Type II polyketide synthases: Gaining a deeper insight into enzymatic teamwork
    • 17268612 1:CAS:528:DC%2BD2sXislygtLc%3D 10.1039/b507395m
    • C Hertweck A Luzhetskyy Y Rebets A Bechthold 2007 Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork Nat Prod Rep 24 1 162 190 17268612 1:CAS:528:DC%2BD2sXislygtLc%3D 10.1039/b507395m
    • (2007) Nat Prod Rep , vol.24 , Issue.1 , pp. 162-190
    • Hertweck, C.1    Luzhetskyy, A.2    Rebets, Y.3    Bechthold, A.4
  • 36
    • 21544447561 scopus 로고    scopus 로고
    • Mutational analysis of a monoterpene synthase reaction: Altered catalysis through directed mutagenesis of (-)-pinene synthase from Abies grandis
    • 15978541 1:CAS:528:DC%2BD2MXlslyntbo%3D 10.1016/j.abb.2005.05.017
    • D Hyatt R Croteau 2005 Mutational analysis of a monoterpene synthase reaction: Altered catalysis through directed mutagenesis of (-)-pinene synthase from Abies grandis Arch Biochem Biophys 439 2 222 233 15978541 1:CAS:528:DC%2BD2MXlslyntbo%3D 10.1016/j.abb.2005.05.017
    • (2005) Arch Biochem Biophys , vol.439 , Issue.2 , pp. 222-233
    • Hyatt, D.1    Croteau, R.2
  • 37
    • 34547696794 scopus 로고    scopus 로고
    • Rational conversion of substrate and product specificity in a Salvia monoterpene synthase: Structural insights into the evolution of terpene synthase function
    • 17557809 1:CAS:528:DC%2BD2sXptFKns7o%3D 10.1105/tpc.106.047779
    • S Kampranis D Ioannidis A Purvis W Mahrez E Ninga NA Katerelos S Anssour JM Dunwell J Degenhardt A Makris PW Goodenough CB Johnson 2007 Rational conversion of substrate and product specificity in a Salvia monoterpene synthase: Structural insights into the evolution of terpene synthase function Plant Cell 19 6 1994 2005 17557809 1:CAS:528:DC%2BD2sXptFKns7o%3D 10.1105/tpc.106.047779
    • (2007) Plant Cell , vol.19 , Issue.6 , pp. 1994-2005
    • Kampranis, S.1    Ioannidis, D.2    Purvis, A.3    Mahrez, W.4    Ninga, E.5    Katerelos, N.A.6    Anssour, S.7    Dunwell, J.M.8    Degenhardt, J.9    Makris, A.10    Goodenough, P.W.11    Johnson, C.B.12
  • 39
    • 65349098181 scopus 로고    scopus 로고
    • Revisiting the modularity of modular polyketide synthases
    • 19217343 1:CAS:528:DC%2BD1MXlsVektr0%3D 10.1016/j.cbpa.2008.12.018
    • C Khosla S Kapur DE Cane 2009 Revisiting the modularity of modular polyketide synthases Curr Opin Chem Biol 13 2 135 143 19217343 1:CAS:528:DC%2BD1MXlsVektr0%3D 10.1016/j.cbpa.2008.12.018
    • (2009) Curr Opin Chem Biol , vol.13 , Issue.2 , pp. 135-143
    • Khosla, C.1    Kapur, S.2    Cane, D.E.3
  • 41
    • 72949113214 scopus 로고    scopus 로고
    • Protostadienol synthase from Aspergillus fumigatus: Functional conversion into lanosterol synthase
    • 19951700 1:CAS:528:DC%2BC3cXpsFWi 10.1016/j.bbrc.2009.11.160
    • M Kimura T Kushiro M Shibuya Y Ebizuka I Abe 2010 Protostadienol synthase from Aspergillus fumigatus: Functional conversion into lanosterol synthase Biochem Biophys Res Commun 391 1 899 902 19951700 1:CAS:528:DC%2BC3cXpsFWi 10.1016/j.bbrc.2009.11.160
    • (2010) Biochem Biophys Res Commun , vol.391 , Issue.1 , pp. 899-902
    • Kimura, M.1    Kushiro, T.2    Shibuya, M.3    Ebizuka, Y.4    Abe, I.5
  • 42
    • 71449089781 scopus 로고    scopus 로고
    • A single amino acid substitution converts benzophenone synthase into phenylpyrone synthase
    • 19710020 1:CAS:528:DC%2BD1MXhtlequ7nP 10.1074/jbc.M109.038927
    • T Klundt M Bocola M Lutge T Beuerle B Liu L Beerhues 2009 A single amino acid substitution converts benzophenone synthase into phenylpyrone synthase J Biol Chem 284 45 30957 30964 19710020 1:CAS:528:DC%2BD1MXhtlequ7nP 10.1074/jbc.M109.038927
    • (2009) J Biol Chem , vol.284 , Issue.45 , pp. 30957-30964
    • Klundt, T.1    Bocola, M.2    Lutge, M.3    Beuerle, T.4    Liu, B.5    Beerhues, L.6
  • 43
    • 69949172389 scopus 로고    scopus 로고
    • Characterization of a sabinene synthase gene from rough lemon (Citrus jambhiri)
    • 19433341 1:CAS:528:DC%2BD1MXhtlShtbfF 10.1016/j.jplph.2009.04.003
    • K Kohzaki K Gomi Y Yamasaki-Kokudo R Ozawa J Takabayashi K Akimitsu 2009 Characterization of a sabinene synthase gene from rough lemon (Citrus jambhiri) J Plant Physiol 166 15 1700 1704 19433341 1:CAS:528:DC%2BD1MXhtlShtbfF 10.1016/j.jplph.2009.04.003
    • (2009) J Plant Physiol , vol.166 , Issue.15 , pp. 1700-1704
    • Kohzaki, K.1    Gomi, K.2    Yamasaki-Kokudo, Y.3    Ozawa, R.4    Takabayashi, J.5    Akimitsu, K.6
  • 44
    • 0027546460 scopus 로고
    • Strictosidine: From alkaloid to enzyme to gene
    • 7763429 1:CAS:528:DyaK3sXitV2gtLs%3D 10.1016/S0031-9422(00)95128-8
    • TM Kutchan 1993 Strictosidine: from alkaloid to enzyme to gene Phytochemistry 32 3 493 506 7763429 1:CAS:528:DyaK3sXitV2gtLs%3D 10.1016/S0031-9422(00)95128-8
    • (1993) Phytochemistry , vol.32 , Issue.3 , pp. 493-506
    • Kutchan, T.M.1
  • 45
    • 77956942908 scopus 로고    scopus 로고
    • Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity
    • 20666435 1:CAS:528:DC%2BC3cXptlClsbs%3D 10.1021/cb100175a
    • DH Kwan PF Leadlay 2010 Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity ACS Chem Biol 5 9 829 838 20666435 1:CAS:528:DC%2BC3cXptlClsbs%3D 10.1021/cb100175a
    • (2010) ACS Chem Biol , vol.5 , Issue.9 , pp. 829-838
    • Kwan, D.H.1    Leadlay, P.F.2
  • 46
    • 56049119642 scopus 로고    scopus 로고
    • Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases
    • 19022183 1:CAS:528:DC%2BD1cXhsVWmsrjL 10.1016/j.chembiol.2008.09.012
    • DH Kwan Y Sun F Schulz H Hong B Popovic JC Sim-Stark SF Haydock PF Leadlay 2008 Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases Chem Biol 15 11 1231 1240 19022183 1:CAS:528:DC%2BD1cXhsVWmsrjL 10.1016/j.chembiol.2008.09.012
    • (2008) Chem Biol , vol.15 , Issue.11 , pp. 1231-1240
    • Kwan, D.H.1    Sun, Y.2    Schulz, F.3    Hong, H.4    Popovic, B.5    Sim-Stark, J.C.6    Haydock, S.F.7    Leadlay, P.F.8
  • 47
    • 33748065356 scopus 로고    scopus 로고
    • Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection
    • 16925399 1:CAS:528:DC%2BD28Xns1Wqt7Y%3D 10.1021/ja063238h
    • JR Lai MA Fischbach DR Liu CT Walsh 2006 Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection J Am Chem Soc 128 34 11002 11003 16925399 1:CAS:528: DC%2BD28Xns1Wqt7Y%3D 10.1021/ja063238h
    • (2006) J Am Chem Soc , vol.128 , Issue.34 , pp. 11002-11003
    • Lai, J.R.1    Fischbach, M.A.2    Liu, D.R.3    Walsh, C.T.4
  • 48
    • 77956371200 scopus 로고    scopus 로고
    • Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
    • 20643967 1:CAS:528:DC%2BC3cXhtVWmtrnM 10.1073/pnas.1006138107
    • E Leonard PK Ajikumar K Thayer W-H Xiao JD Mo B Tidor G Stephanopoulos KLJ Prather 2010 Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control Proc Natl Acad Sci USA 107 31 13654 13659 20643967 1:CAS:528:DC%2BC3cXhtVWmtrnM 10.1073/pnas.1006138107
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.31 , pp. 13654-13659
    • Leonard, E.1    Ajikumar, P.K.2    Thayer, K.3    Xiao, W.-H.4    Mo, J.D.5    Tidor, B.6    Stephanopoulos, G.7    Prather, K.L.J.8
  • 49
    • 23844557146 scopus 로고    scopus 로고
    • A novel ensemble-based scoring and search algorithm for protein redesign and its application to modify the substrate specificity of the gramicidin synthetase A phenylalanine adenylation enzyme
    • 16108714 1:CAS:528:DC%2BD2MXotFemsbw%3D 10.1089/cmb.2005.12.740
    • R Lilien BW Stevens AC Anderson BR Donald 2005 A novel ensemble-based scoring and search algorithm for protein redesign and its application to modify the substrate specificity of the gramicidin synthetase A phenylalanine adenylation enzyme J Comput Biol 12 6 740 761 16108714 1:CAS:528: DC%2BD2MXotFemsbw%3D 10.1089/cmb.2005.12.740
    • (2005) J Comput Biol , vol.12 , Issue.6 , pp. 740-761
    • Lilien, R.1    Stevens, B.W.2    Anderson, A.C.3    Donald, B.R.4
  • 50
    • 26844446540 scopus 로고    scopus 로고
    • Enzyme redesign: Two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase
    • 16218577 1:CAS:528:DC%2BD2MXhtVarurvN 10.1021/ja053791j
    • S Lodeiro T Schulz-Gasch SP Matsuda 2005 Enzyme redesign: two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase J Am Chem Soc 127 41 14132 14133 16218577 1:CAS:528:DC%2BD2MXhtVarurvN 10.1021/ja053791j
    • (2005) J Am Chem Soc , vol.127 , Issue.41 , pp. 14132-14133
    • Lodeiro, S.1    Schulz-Gasch, T.2    Matsuda, S.P.3
  • 51
    • 34548694786 scopus 로고    scopus 로고
    • Structure-based engineering of strictosidine synthase: Auxiliary for alkaloid libraries
    • 17884630 1:CAS:528:DC%2BD2sXhtVOnsr%2FJ 10.1016/j.chembiol.2007.08.009
    • E Loris S Panjikar M Ruppert L Barleben M Unger H Schübel 2007 Structure-based engineering of strictosidine synthase: auxiliary for alkaloid libraries Chem Biol 14 9 979 985 17884630 1:CAS:528:DC%2BD2sXhtVOnsr%2FJ 10.1016/j.chembiol.2007.08.009
    • (2007) Chem Biol , vol.14 , Issue.9 , pp. 979-985
    • Loris, E.1    Panjikar, S.2    Ruppert, M.3    Barleben, L.4    Unger, M.5    Schübel, H.6
  • 52
    • 33745473834 scopus 로고    scopus 로고
    • The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed β-propeller fold in plant proteins
    • 16531499 1:CAS:528:DC%2BD28Xjslaksb8%3D 10.1105/tpc.105.038018
    • X Ma S Panjikar J Koepke E Loris J Stöckigt 2006 The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed β-propeller fold in plant proteins Plant Cell 18 4 907 920 16531499 1:CAS:528:DC%2BD28Xjslaksb8%3D 10.1105/tpc.105.038018
    • (2006) Plant Cell , vol.18 , Issue.4 , pp. 907-920
    • Ma, X.1    Panjikar, S.2    Koepke, J.3    Loris, E.4    Stöckigt, J.5
  • 53
    • 0033515090 scopus 로고    scopus 로고
    • Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
    • 10051557 1:CAS:528:DyaK1MXhvVSrtbg%3D 10.1073/pnas.96.5.1846
    • R McDaniel A Thamchaipenet C Gustafsson H Fu M Betlach G Ashley 1999 Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products Proc Natl Acad Sci USA 96 5 1846 1851 10051557 1:CAS:528:DyaK1MXhvVSrtbg%3D 10.1073/pnas.96.5.1846
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.5 , pp. 1846-1851
    • McDaniel, R.1    Thamchaipenet, A.2    Gustafsson, C.3    Fu, H.4    Betlach, M.5    Ashley, G.6
  • 54
    • 0037129406 scopus 로고    scopus 로고
    • Directed evolution to generate cycloartenol synthase mutants that produce lanosterol
    • 11950371 1:CAS:528:DC%2BD38XhvFymur0%3D 10.1021/ol0257225
    • M Meyer R Xu SPT Matsuda 2002 Directed evolution to generate cycloartenol synthase mutants that produce lanosterol Org Lett 4 8 1395 1398 11950371 1:CAS:528:DC%2BD38XhvFymur0%3D 10.1021/ol0257225
    • (2002) Org Lett , vol.4 , Issue.8 , pp. 1395-1398
    • Meyer, M.1    Xu, R.2    Matsuda, S.P.T.3
  • 55
    • 17844400062 scopus 로고    scopus 로고
    • Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: Combinatorial biosynthesis and directed evolution
    • 10.1016/j.chembiol.2005.02.010 1:CAS:528:DC%2BD2MXjsFKitb8%3D
    • B Mijts PC Lee C Schmidt-Danner 2006 Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution Chem Biol 12 4 453 460 10.1016/j.chembiol.2005.02.010 1:CAS:528:DC%2BD2MXjsFKitb8%3D
    • (2006) Chem Biol , vol.12 , Issue.4 , pp. 453-460
    • Mijts, B.1    Lee, P.C.2    Schmidt-Danner, C.3
  • 56
    • 0036007875 scopus 로고    scopus 로고
    • Biosynthesis and attachment of novel bacterial polyketide synthase starter units
    • 11902441 1:CAS:528:DC%2BD38XitF2gtL8%3D 10.1039/b003939j
    • BS Moore C Hertweck 2002 Biosynthesis and attachment of novel bacterial polyketide synthase starter units Nat Prod Rep 19 1 70 99 11902441 1:CAS:528:DC%2BD38XitF2gtL8%3D 10.1039/b003939j
    • (2002) Nat Prod Rep , vol.19 , Issue.1 , pp. 70-99
    • Moore, B.S.1    Hertweck, C.2
  • 57
    • 34247239393 scopus 로고    scopus 로고
    • Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens
    • 17462571 1:CAS:528:DC%2BD2sXkslaitbw%3D 10.1016/j.chembiol.2007.02.003
    • H Morita S Kondo S Oguro H Noguchi S Sugio I Abe T Kohno 2007 Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens Chem Biol 14 4 359 369 17462571 1:CAS:528:DC%2BD2sXkslaitbw%3D 10.1016/j.chembiol.2007.02.003
    • (2007) Chem Biol , vol.14 , Issue.4 , pp. 359-369
    • Morita, H.1    Kondo, S.2    Oguro, S.3    Noguchi, H.4    Sugio, S.5    Abe, I.6    Kohno, T.7
  • 58
    • 42949168883 scopus 로고    scopus 로고
    • Increasing complexity of a diterpene synthase reaction with a single residue switch
    • 18366162 1:CAS:528:DC%2BD1cXjslSgt7s%3D 10.1021/ja710524w
    • D Morrone M Xu DB Fulton MK Determan RJ Peters 2008 Increasing complexity of a diterpene synthase reaction with a single residue switch J Am Chem Soc 130 16 5400 5401 18366162 1:CAS:528:DC%2BD1cXjslSgt7s%3D 10.1021/ja710524w
    • (2008) J Am Chem Soc , vol.130 , Issue.16 , pp. 5400-5401
    • Morrone, D.1    Xu, M.2    Fulton, D.B.3    Determan, M.K.4    Peters, R.J.5
  • 59
    • 77749271279 scopus 로고    scopus 로고
    • Point mutations (Q19P and N23K) increase the operational solubility of a 2alpha-O-benzoyltransferase that conveys various acyl groups from CoA to a taxane acceptor
    • 20108947 1:CAS:528:DC%2BC3cXht1Sgtrw%3D 10.1021/np900524d
    • IN Nawarathne KD Walker 2010 Point mutations (Q19P and N23K) increase the operational solubility of a 2alpha-O-benzoyltransferase that conveys various acyl groups from CoA to a taxane acceptor J Nat Prod 73 2 151 159 20108947 1:CAS:528:DC%2BC3cXht1Sgtrw%3D 10.1021/np900524d
    • (2010) J Nat Prod , vol.73 , Issue.2 , pp. 151-159
    • Nawarathne, I.N.1    Walker, K.D.2
  • 60
    • 33751218042 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of novel antibiotics related to daptomycin
    • 17090667 1:CAS:528:DC%2BD28Xht1Kqu7bE 10.1073/pnas.0608589103
    • KT Nguyen D Ritz JQ Gu D Alexander M Chu V Miao P Brian RH Baltz 2006 Combinatorial biosynthesis of novel antibiotics related to daptomycin Proc Natl Acad Sci USA 103 46 17462 17467 17090667 1:CAS:528:DC%2BD28Xht1Kqu7bE 10.1073/pnas.0608589103
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.46 , pp. 17462-17467
    • Nguyen, K.T.1    Ritz, D.2    Gu, J.Q.3    Alexander, D.4    Chu, M.5    Miao, V.6    Brian, P.7    Baltz, R.H.8
  • 61
    • 33646115667 scopus 로고    scopus 로고
    • High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase
    • 16638534 10.1016/j.chembiol.2006.01.003 1:CAS:528:DC%2BD28XivVGku7Y%3D
    • HM O'Hare A Baerga-Ortiz B Popovic JB Spencer PF Leadlay 2006 High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase Chem Biol 13 3 287 296 16638534 10.1016/j.chembiol.2006.01.003 1:CAS:528:DC%2BD28XivVGku7Y%3D
    • (2006) Chem Biol , vol.13 , Issue.3 , pp. 287-296
    • O'Hare, H.M.1    Baerga-Ortiz, A.2    Popovic, B.3    Spencer, J.B.4    Leadlay, P.F.5
  • 62
    • 0035979338 scopus 로고    scopus 로고
    • In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of Pyochelin: Characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities
    • 11467965 1:CAS:528:DC%2BD3MXkvVWntr0%3D 10.1021/bi010519n
    • H Patel CT Walsh 2001 In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of Pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities Biochemistry 40 30 9023 9031 11467965 1:CAS:528:DC%2BD3MXkvVWntr0%3D 10.1021/bi010519n
    • (2001) Biochemistry , vol.40 , Issue.30 , pp. 9023-9031
    • Patel, H.1    Walsh, C.T.2
  • 63
    • 0042664008 scopus 로고    scopus 로고
    • Alternative termination chemistries utilized by monoterpene cyclases: Chimeric analysis of bornyl diphosphate, 1, 8-cineole, and sabinene synthases
    • 12941302 1:CAS:528:DC%2BD3sXmslehtLc%3D 10.1016/S0003-9861(03)00347-3
    • RJ Peters RB Croteau 2003 Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1, 8-cineole, and sabinene synthases Arch Biochem Biophys 417 2 203 211 12941302 1:CAS:528:DC%2BD3sXmslehtLc%3D 10.1016/S0003-9861(03)00347-3
    • (2003) Arch Biochem Biophys , vol.417 , Issue.2 , pp. 203-211
    • Peters, R.J.1    Croteau, R.B.2
  • 64
    • 38349068782 scopus 로고    scopus 로고
    • Engineered synthesis of 7-oxo- and 15-deoxy-15-oxo-amphotericins: Insights into structure-activity relationships in polyene antibiotics
    • 18215775 1:CAS:528:DC%2BD1cXpt12quw%3D%3D 10.1016/j.chembiol.2007.11.008
    • P Power T Dunne B Murphy L Nic Lochlainn D Rai C Borissow B Rawlings P Caffrey 2008 Engineered synthesis of 7-oxo- and 15-deoxy-15-oxo-amphotericins: insights into structure-activity relationships in polyene antibiotics Chem Biol 15 1 78 86 18215775 1:CAS:528:DC%2BD1cXpt12quw%3D%3D 10.1016/j.chembiol.2007.11. 008
    • (2008) Chem Biol , vol.15 , Issue.1 , pp. 78-86
    • Power, P.1    Dunne, T.2    Murphy, B.3    Nic Lochlainn, L.4    Rai, D.5    Borissow, C.6    Rawlings, B.7    Caffrey, P.8
  • 65
    • 65249143793 scopus 로고    scopus 로고
    • Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis
    • 19233921 1:CAS:528:DC%2BD1MXltFarsLw%3D 10.1128/JB.01747-08
    • A Ramos C Olano AF Brana C Mendez JA Salas 2009 Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis J Bacteriol 191 8 2871 2875 19233921 1:CAS:528:DC%2BD1MXltFarsLw%3D 10.1128/JB.01747-08
    • (2009) J Bacteriol , vol.191 , Issue.8 , pp. 2871-2875
    • Ramos, A.1    Olano, C.2    Brana, A.F.3    Mendez, C.4    Salas, J.A.5
  • 66
    • 0035951074 scopus 로고    scopus 로고
    • Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations
    • 11747421 1:CAS:528:DC%2BD3MXos12itbw%3D 10.1021/bi015864r
    • CD Reeves S Murli GW Ashley M Piagentini CR Hutchinson R McDaniel 2001 Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations Biochemistry 40 51 15464 15470 11747421 1:CAS:528:DC%2BD3MXos12itbw%3D 10.1021/bi015864r
    • (2001) Biochemistry , vol.40 , Issue.51 , pp. 15464-15470
    • Reeves, C.D.1    Murli, S.2    Ashley, G.W.3    Piagentini, M.4    Hutchinson, C.R.5    McDaniel, R.6
  • 67
    • 0037435603 scopus 로고    scopus 로고
    • A model of structure and catalysis for ketoreductase domains in modular polyketide synthases
    • 12515540 1:CAS:528:DC%2BD38XptlOksLo%3D 10.1021/bi0268706
    • R Reid M Piagentini E Rodriguez G Ashley N Viswanathan J Carney DV Santi CR Hutchinson R McDaniel 2003 A model of structure and catalysis for ketoreductase domains in modular polyketide synthases Biochemistry 42 1 72 79 12515540 1:CAS:528:DC%2BD38XptlOksLo%3D 10.1021/bi0268706
    • (2003) Biochemistry , vol.42 , Issue.1 , pp. 72-79
    • Reid, R.1    Piagentini, M.2    Rodriguez, E.3    Ashley, G.4    Viswanathan, N.5    Carney, J.6    Santi, D.V.7    Hutchinson, C.R.8    McDaniel, R.9
  • 68
    • 0036774667 scopus 로고    scopus 로고
    • Modification of post-PKS tailoring steps through combinatorial biosynthesis
    • 12430723 1:CAS:528:DC%2BD38XptVehs74%3D 10.1039/b103920m
    • U Rix C Fischer LL Remsing J Rohr 2002 Modification of post-PKS tailoring steps through combinatorial biosynthesis Nat Prod Rep 19 5 542 580 12430723 1:CAS:528:DC%2BD38XptVehs74%3D 10.1039/b103920m
    • (2002) Nat Prod Rep , vol.19 , Issue.5 , pp. 542-580
    • Rix, U.1    Fischer, C.2    Remsing, L.L.3    Rohr, J.4
  • 69
    • 0033941389 scopus 로고    scopus 로고
    • Molecular breeding of carotenoid biosynthetic pathways
    • 10888843 1:CAS:528:DC%2BD3cXltFCnsL8%3D 10.1038/77319
    • C Schmidt-Dannert D Umeno FH Arnold 2000 Molecular breeding of carotenoid biosynthetic pathways Nat Biotechnol 18 7 750 753 10888843 1:CAS:528: DC%2BD3cXltFCnsL8%3D 10.1038/77319
    • (2000) Nat Biotechnol , vol.18 , Issue.7 , pp. 750-753
    • Schmidt-Dannert, C.1    Umeno, D.2    Arnold, F.H.3
  • 70
    • 0037524493 scopus 로고    scopus 로고
    • Nonribosomal peptides: From genes to products
    • 12828367 1:CAS:528:DC%2BD3sXls1Klur8%3D 10.1039/b111145k
    • D Schwarzer R Finking MA Marahiel 2003 Nonribosomal peptides: from genes to products Nat Prod Rep 20 3 275 287 12828367 1:CAS:528:DC%2BD3sXls1Klur8%3D 10.1039/b111145k
    • (2003) Nat Prod Rep , vol.20 , Issue.3 , pp. 275-287
    • Schwarzer, D.1    Finking, R.2    Marahiel, M.A.3
  • 71
    • 0037069721 scopus 로고    scopus 로고
    • Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis
    • 12465912 1:CAS:528:DC%2BD38Xos1Kisrw%3D 10.1021/ol0269897
    • M Segura S Lodiero MM Meyer AJ Patel SPT Matsuda 2002 Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis Org Lett 4 25 4459 4462 12465912 1:CAS:528:DC%2BD38Xos1Kisrw%3D 10.1021/ol0269897
    • (2002) Org Lett , vol.4 , Issue.25 , pp. 4459-4462
    • Segura, M.1    Lodiero, S.2    Meyer, M.M.3    Patel, A.J.4    Matsuda, S.P.T.5
  • 72
    • 33847049467 scopus 로고    scopus 로고
    • X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate
    • 17261032 1:CAS:528:DC%2BD2sXhtVens70%3D 10.1021/bi0622524
    • E Shishova L Di Constanzo DE Cane DW Christianson 2007 X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate Biochemistry 46 7 1941 1951 17261032 1:CAS:528:DC%2BD2sXhtVens70%3D 10.1021/bi0622524
    • (2007) Biochemistry , vol.46 , Issue.7 , pp. 1941-1951
    • Shishova, E.1    Di Constanzo, L.2    Cane, D.E.3    Christianson, D.W.4
  • 73
    • 14844362054 scopus 로고    scopus 로고
    • Molecular mechanisms underlying nonribosomal peptide synthesis: Approaches to new antibiotics
    • 15700962 1:CAS:528:DC%2BD2MXkvFSktw%3D%3D 10.1021/cr0301191
    • SA Sieber MA Marahiel 2005 Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics Chem Rev 105 2 715 738 15700962 1:CAS:528:DC%2BD2MXkvFSktw%3D%3D 10.1021/cr0301191
    • (2005) Chem Rev , vol.105 , Issue.2 , pp. 715-738
    • Sieber, S.A.1    Marahiel, M.A.2
  • 74
    • 0028908601 scopus 로고
    • Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA
    • 7534306 1:CAS:528:DyaK2MXksVCnuro%3D 10.1074/jbc.270.11.6163
    • T Stachelhaus MA Marahiel 1995 Modular structure of peptide synthetases revealed by dissection of the multifunctional enzyme GrsA J Biol Chem 270 11 6163 6169 7534306 1:CAS:528:DyaK2MXksVCnuro%3D 10.1074/jbc.270.11.6163
    • (1995) J Biol Chem , vol.270 , Issue.11 , pp. 6163-6169
    • Stachelhaus, T.1    Marahiel, M.A.2
  • 75
    • 0033179468 scopus 로고    scopus 로고
    • The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
    • 10421756 1:CAS:528:DyaK1MXlsVynsLY%3D 10.1016/S1074-5521(99)80082-9
    • T Stachelhaus HD Mootz MA Marahiel 1999 The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases Chem Biol 6 8 493 505 10421756 1:CAS:528:DyaK1MXlsVynsLY%3D 10.1016/S1074-5521(99)80082-9
    • (1999) Chem Biol , vol.6 , Issue.8 , pp. 493-505
    • Stachelhaus, T.1    Mootz, H.D.2    Marahiel, M.A.3
  • 76
    • 0029034197 scopus 로고
    • Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains
    • 7604280 1:CAS:528:DyaK2MXmsl2jurc%3D 10.1126/science.7604280
    • T Stachelhaus A Schneider MA Marahiel 1995 Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains Science 269 5220 69 72 7604280 1:CAS:528:DyaK2MXmsl2jurc%3D 10.1126/science.7604280
    • (1995) Science , vol.269 , Issue.5220 , pp. 69-72
    • Stachelhaus, T.1    Schneider, A.2    Marahiel, M.A.3
  • 77
    • 0030796451 scopus 로고    scopus 로고
    • Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-Aristolochene synthase
    • 1:CAS:528:DyaK2sXmtFGntrs%3D
    • C Starks K Back J Chappell JP Noel 1997 Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-Aristolochene synthase Nature 277 5333 1815 1820 1:CAS:528:DyaK2sXmtFGntrs%3D
    • (1997) Nature , vol.277 , Issue.5333 , pp. 1815-1820
    • Starks, C.1    Back, K.2    Chappell, J.3    Noel, J.P.4
  • 78
    • 0034887171 scopus 로고    scopus 로고
    • Polyketide biosynthesis: A millennium review
    • 11548049 1:CAS:528:DC%2BD3MXltlyqsbo%3D 10.1039/a909079g
    • J Staunton KJ Weissman 2001 Polyketide biosynthesis: a millennium review Nat Prod Rep 18 4 380 416 11548049 1:CAS:528:DC%2BD3MXltlyqsbo%3D 10.1039/a909079g
    • (2001) Nat Prod Rep , vol.18 , Issue.4 , pp. 380-416
    • Staunton, J.1    Weissman, K.J.2
  • 79
    • 0031891866 scopus 로고    scopus 로고
    • Sesquiterpene synthases from grand fir (Abies grandis) - Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization and bacterial expression of delta-selinene synthase and gamma-humulene synthase
    • 9442047 1:CAS:528:DyaK1cXnsVGlsg%3D%3D 10.1074/jbc.273.4.2078
    • CL Steele J Crock J Bohlmann R Croteau 1998 Sesquiterpene synthases from grand fir (Abies grandis) - Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization and bacterial expression of delta-selinene synthase and gamma-humulene synthase J Biol Chem 273 4 2078 2089 9442047 1:CAS:528:DyaK1cXnsVGlsg%3D%3D 10.1074/jbc.273.4.2078
    • (1998) J Biol Chem , vol.273 , Issue.4 , pp. 2078-2089
    • Steele, C.L.1    Crock, J.2    Bohlmann, J.3    Croteau, R.4
  • 80
    • 0142135988 scopus 로고    scopus 로고
    • Polyketide chain length control by chain length factor
    • 14558809 1:CAS:528:DC%2BD3sXnsFyqsb4%3D 10.1021/ja0378759
    • Y Tang SC Tsai C Khosla 2003 Polyketide chain length control by chain length factor J Am Chem Soc 125 42 12708 12709 14558809 1:CAS:528: DC%2BD3sXnsFyqsb4%3D 10.1021/ja0378759
    • (2003) J Am Chem Soc , vol.125 , Issue.42 , pp. 12708-12709
    • Tang, Y.1    Tsai, S.C.2    Khosla, C.3
  • 81
    • 1942489379 scopus 로고    scopus 로고
    • Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates
    • 15099062 1:CAS:528:DC%2BD2cXisl2itrw%3D 10.1021/ja048778y
    • G Uguru C Milne M Borg F Flett CP Smith J Micklefield 2004 Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates J Am Chem Soc 126 16 5032 5033 15099062 1:CAS:528:DC%2BD2cXisl2itrw%3D 10.1021/ja048778y
    • (2004) J Am Chem Soc , vol.126 , Issue.16 , pp. 5032-5033
    • Uguru, G.1    Milne, C.2    Borg, M.3    Flett, F.4    Smith, C.P.5    Micklefield, J.6
  • 82
    • 1342304132 scopus 로고    scopus 로고
    • Evolution of a pathway to novel long-chain carotenoids
    • 14973014 1:CAS:528:DC%2BD2cXhslOitL4%3D 10.1128/JB.186.5.1531-1536.2004
    • D Umeno FH Arnold 2004 Evolution of a pathway to novel long-chain carotenoids J Bacteriol 186 5 1531 1536 14973014 1:CAS:528:DC%2BD2cXhslOitL4%3D 10.1128/JB.186.5.1531-1536.2004
    • (2004) J Bacteriol , vol.186 , Issue.5 , pp. 1531-1536
    • Umeno, D.1    Arnold, F.H.2
  • 83
    • 14844342448 scopus 로고    scopus 로고
    • Diversifying carotenoid biosynthetic pathways by directed evolution
    • 1:CAS:528:DC%2BD2MXjtVOhtL0%3D 10.1128/MMBR.69.1.51-78.2005
    • D Umeno AV Tobias FH Arnold 2005 Diversifying carotenoid biosynthetic pathways by directed evolution Microbiol Mol Biol R 69 1 51 78 1:CAS:528:DC%2BD2MXjtVOhtL0%3D 10.1128/MMBR.69.1.51-78.2005
    • (2005) Microbiol Mol Biol R , vol.69 , Issue.1 , pp. 51-78
    • Umeno, D.1    Tobias, A.V.2    Arnold, F.H.3
  • 84
    • 79953065470 scopus 로고    scopus 로고
    • Carotenoids and their cleavage products: Biosynthesis and functions
    • 21321752 1:CAS:528:DC%2BC3MXjvVehu7c%3D 10.1039/c0np00036a
    • MH Walter D Strack 2011 Carotenoids and their cleavage products: biosynthesis and functions Nat Prod Rep 28 4 663 692 21321752 1:CAS:528:DC%2BC3MXjvVehu7c%3D 10.1039/c0np00036a
    • (2011) Nat Prod Rep , vol.28 , Issue.4 , pp. 663-692
    • Walter, M.H.1    Strack, D.2
  • 85
    • 0035798705 scopus 로고    scopus 로고
    • Alteration of product specificity of Rhodobacter sphaeroides phytoene desaturase by directed evolution
    • 11526111 1:CAS:528:DC%2BD3MXosVKgsbs%3D 10.1074/jbc.M105786200
    • C-W Wang JC Liao 2001 Alteration of product specificity of Rhodobacter sphaeroides phytoene desaturase by directed evolution J Biol Chem 276 44 41161 41164 11526111 1:CAS:528:DC%2BD3MXosVKgsbs%3D 10.1074/jbc.M105786200
    • (2001) J Biol Chem , vol.276 , Issue.44 , pp. 41161-41164
    • Wang, C.-W.1    Liao, J.C.2
  • 86
    • 0034518317 scopus 로고    scopus 로고
    • Directed evolution of metabolically engineered Escherichia coli for carotenoid production
    • 11101317 1:CAS:528:DC%2BD3cXnsFansrc%3D 10.1021/bp000124f
    • C-W Wang M-K Oh JC Liao 2000 Directed evolution of metabolically engineered Escherichia coli for carotenoid production Biotechnol Prog 16 6 922 926 11101317 1:CAS:528:DC%2BD3cXnsFansrc%3D 10.1021/bp000124f
    • (2000) Biotechnol Prog , vol.16 , Issue.6 , pp. 922-926
    • Wang, C.-W.1    Oh, M.-K.2    Liao, J.C.3
  • 87
    • 33746354671 scopus 로고    scopus 로고
    • Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli
    • 16799553 1:CAS:528:DC%2BD28XmvFyqsr8%3D 10.1038/nchembio803
    • K Watanabe K Hotta AP Praseuth K Koketsu A Migita CN Boddy CC Wang H Oguri H Oikawa 2006 Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli Nat Chem Biol 2 8 423 428 16799553 1:CAS:528: DC%2BD28XmvFyqsr8%3D 10.1038/nchembio803
    • (2006) Nat Chem Biol , vol.2 , Issue.8 , pp. 423-428
    • Watanabe, K.1    Hotta, K.2    Praseuth, A.P.3    Koketsu, K.4    Migita, A.5    Boddy, C.N.6    Wang, C.C.7    Oguri, H.8    Oikawa, H.9
  • 88
    • 70349554130 scopus 로고    scopus 로고
    • Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli
    • 19588480 1:CAS:528:DC%2BD1MXhtVSnsr7F 10.1002/cbic.200900260
    • K Watanabe K Hotta AP Praseuth M Searcey CCC Wang H Oguri H Oikawa 2009 Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli ChemBioChem 10 12 1965 1968 19588480 1:CAS:528:DC%2BD1MXhtVSnsr7F 10.1002/cbic.200900260
    • (2009) ChemBioChem , vol.10 , Issue.12 , pp. 1965-1968
    • Watanabe, K.1    Hotta, K.2    Praseuth, A.P.3    Searcey, M.4    Wang, C.C.C.5    Oguri, H.6    Oikawa, H.7
  • 89
    • 30544434619 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of reduced polyketides
    • 16322741 1:CAS:528:DC%2BD2MXht1OnsLbE 10.1038/nrmicro1287
    • KJ Weissman PF Leadlay 2005 Combinatorial biosynthesis of reduced polyketides Nat Rev Microbiol 3 12 925 936 16322741 1:CAS:528:DC%2BD2MXht1OnsLbE 10.1038/nrmicro1287
    • (2005) Nat Rev Microbiol , vol.3 , Issue.12 , pp. 925-936
    • Weissman, K.J.1    Leadlay, P.F.2
  • 90
    • 0037180538 scopus 로고    scopus 로고
    • Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase
    • 12432096 1:CAS:528:DC%2BD3sXjvVGj 10.1073/pnas.232591099
    • DA Whittington ML Wise M Urbansky RM Coates RB Croteau DW Christianson 2002 Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase Proc Natl Acad Sci USA 99 24 15375 15380 12432096 1:CAS:528:DC%2BD3sXjvVGj 10.1073/pnas.232591099
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.24 , pp. 15375-15380
    • Whittington, D.A.1    Wise, M.L.2    Urbansky, M.3    Coates, R.M.4    Croteau, R.B.5    Christianson, D.W.6
  • 91
    • 37549036742 scopus 로고    scopus 로고
    • A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase
    • 18052062 1:CAS:528:DC%2BD2sXhtlOgsrrF 10.1021/ja074977g
    • PR Wilderman RJ Peters 2007 A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase J Am Chem Soc 129 51 15736 15737 18052062 1:CAS:528:DC%2BD2sXhtlOgsrrF 10.1021/ja074977g
    • (2007) J Am Chem Soc , vol.129 , Issue.51 , pp. 15736-15737
    • Wilderman, P.R.1    Peters, R.J.2
  • 92
    • 41949101106 scopus 로고    scopus 로고
    • Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization
    • 18420146 1:CAS:528:DC%2BD1cXkvFWqtL4%3D 10.1016/j.chembiol.2008.02.017
    • GJ Williams RD Goff C Zhang JS Thorson 2008 Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization Chem Biol 15 4 393 401 18420146 1:CAS:528:DC%2BD1cXkvFWqtL4%3D 10.1016/j.chembiol.2008.02.017
    • (2008) Chem Biol , vol.15 , Issue.4 , pp. 393-401
    • Williams, G.J.1    Goff, R.D.2    Zhang, C.3    Thorson, J.S.4
  • 93
    • 34548685673 scopus 로고    scopus 로고
    • Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution
    • 17828251 1:CAS:528:DC%2BD2sXhtVCrtrjF 10.1038/nchembio.2007.28
    • GJ Williams C Zhang JS Thorson 2007 Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution Nat Chem Biol 3 10 657 662 17828251 1:CAS:528:DC%2BD2sXhtVCrtrjF 10.1038/nchembio.2007.28
    • (2007) Nat Chem Biol , vol.3 , Issue.10 , pp. 657-662
    • Williams, G.J.1    Zhang, C.2    Thorson, J.S.3
  • 94
    • 48849097496 scopus 로고    scopus 로고
    • Protein plasticity: A single amino acid substitution in the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase generates Protosta-13(17), 24-dien-3b-ol, a rearrangement product
    • 18494476 1:CAS:528:DC%2BD1cXmtF2rsr4%3D 10.1021/ol800799n
    • T-K Wu HY Wen C-H Chang Y-T Liu 2008 Protein plasticity: a single amino acid substitution in the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase generates Protosta-13(17), 24-dien-3b-ol, a rearrangement product Org Lett 10 12 2529 2532 18494476 1:CAS:528:DC%2BD1cXmtF2rsr4%3D 10.1021/ol800799n
    • (2008) Org Lett , vol.10 , Issue.12 , pp. 2529-2532
    • Wu, T.-K.1    Wen, H.Y.2    Chang, C.-H.3    Liu, Y.-T.4
  • 95
    • 0034680764 scopus 로고    scopus 로고
    • An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates
    • 10956654 1:CAS:528:DC%2BD3cXosVSktb0%3D 10.1074/jbc.M005811200
    • H Xiang RA Tschirret-Guth PR Ortiz De Montellano 2000 An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates J Biol Chem 275 46 35999 36006 10956654 1:CAS:528:DC%2BD3cXosVSktb0%3D 10.1074/jbc.M005811200
    • (2000) J Biol Chem , vol.275 , Issue.46 , pp. 35999-36006
    • Xiang, H.1    Tschirret-Guth, R.A.2    Ortiz De Montellano, P.R.3
  • 96
    • 33751092257 scopus 로고    scopus 로고
    • Biosynthesis of lovastatin analogs with a broadly specific acyltransferase
    • 17113998 1:CAS:528:DC%2BD28Xht1Cis7bJ 10.1016/j.chembiol.2006.09.008
    • XK Xie K Watanabe WA Wojcicki CCC Wang Y Tang 2006 Biosynthesis of lovastatin analogs with a broadly specific acyltransferase Chem Biol 13 1161 1169 17113998 1:CAS:528:DC%2BD28Xht1Cis7bJ 10.1016/j.chembiol.2006.09.008
    • (2006) Chem Biol , vol.13 , pp. 1161-1169
    • Xie, X.K.1    Watanabe, K.2    Wojcicki, W.A.3    Wang, C.C.C.4    Tang, Y.5
  • 97
    • 34250688380 scopus 로고    scopus 로고
    • Following evolution's lead to a single residue switch for diterpene synthase product outcome
    • 17456599 1:CAS:528:DC%2BD2sXlslGhsbY%3D 10.1073/pnas.0611454104
    • M Xu PR Wilderman RJ Peters 2007 Following evolution's lead to a single residue switch for diterpene synthase product outcome Proc Natl Acad Sci USA 104 18 7397 7401 17456599 1:CAS:528:DC%2BD2sXlslGhsbY%3D 10.1073/pnas.0611454104
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.18 , pp. 7397-7401
    • Xu, M.1    Wilderman, P.R.2    Peters, R.J.3
  • 98
    • 77957155737 scopus 로고    scopus 로고
    • Trends for diverse production strategies of plant medicinal alkaloids
    • 20730220 1:CAS:528:DC%2BC3cXhtFyisLnI 10.1039/c005378c
    • L Yang J Stöckigt 2010 Trends for diverse production strategies of plant medicinal alkaloids Nat Prod Rep 27 10 1469 1479 20730220 1:CAS:528:DC%2BC3cXhtFyisLnI 10.1039/c005378c
    • (2010) Nat Prod Rep , vol.27 , Issue.10 , pp. 1469-1479
    • Yang, L.1    Stöckigt, J.2
  • 99
    • 44949201614 scopus 로고    scopus 로고
    • Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways
    • 18559271 1:CAS:528:DC%2BD1cXnt1alu78%3D 10.1016/j.chembiol.2008.05.006
    • Y Yoshikuni FA Dietrich FF Nowroozi PC Babbitt JD Keasling 2008 Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways Chem Biol 15 6 607 618 18559271 1:CAS:528:DC%2BD1cXnt1alu78%3D 10.1016/j.chembiol.2008.05.006
    • (2008) Chem Biol , vol.15 , Issue.6 , pp. 607-618
    • Yoshikuni, Y.1    Dietrich, F.A.2    Nowroozi, F.F.3    Babbitt, P.C.4    Keasling, J.D.5
  • 100
    • 33646178621 scopus 로고    scopus 로고
    • Designed divergent evolution of enzyme function
    • 16495946 1:CAS:528:DC%2BD28Xjs1agtrc%3D 10.1038/nature04607
    • Y Yoshikuni TE Ferrin JD Keasling 2006 Designed divergent evolution of enzyme function Nature 440 7087 1078 1082 16495946 1:CAS:528: DC%2BD28Xjs1agtrc%3D 10.1038/nature04607
    • (2006) Nature , vol.440 , Issue.7087 , pp. 1078-1082
    • Yoshikuni, Y.1    Ferrin, T.E.2    Keasling, J.D.3
  • 101
    • 30744464570 scopus 로고    scopus 로고
    • Engineering cotton (+)-d-cadinene synthase to an altered function: Germacrene d-4-ol synthase
    • 16426975 1:CAS:528:DC%2BD28XmsV2qtw%3D%3D 10.1016/j.chembiol.2005.10.016
    • Y Yoshikuni VJJ Martin TE Ferrin JD Keasling 2006 Engineering cotton (+)-d-cadinene synthase to an altered function: germacrene d-4-ol synthase Chem Biol 13 1 91 98 16426975 1:CAS:528:DC%2BD28XmsV2qtw%3D%3D 10.1016/j.chembiol. 2005.10.016
    • (2006) Chem Biol , vol.13 , Issue.1 , pp. 91-98
    • Yoshikuni, Y.1    Martin, V.J.J.2    Ferrin, T.E.3    Keasling, J.D.4
  • 102
    • 57049185719 scopus 로고    scopus 로고
    • Engineering natural products using combinatorial biosynthesis and biocatalysis
    • 18992814 1:CAS:528:DC%2BD1cXhsVKrtLjK 10.1016/j.copbio.2008.10.012
    • H Zhou X Xie Y Tang 2008 Engineering natural products using combinatorial biosynthesis and biocatalysis Curr Opin Biotechnol 19 6 590 596 18992814 1:CAS:528:DC%2BD1cXhsVKrtLjK 10.1016/j.copbio.2008.10.012
    • (2008) Curr Opin Biotechnol , vol.19 , Issue.6 , pp. 590-596
    • Zhou, H.1    Xie, X.2    Tang, Y.3
  • 103
    • 79951823575 scopus 로고    scopus 로고
    • Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase
    • 21280577 1:CAS:528:DC%2BC3MXhsVSitLg%3D 10.1021/ja110146z
    • G Zocher ME Richter U Mueller C Hertweck 2011 Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase J Am Chem Soc 133 7 2292 2302 21280577 1:CAS:528:DC%2BC3MXhsVSitLg%3D 10.1021/ja110146z
    • (2011) J Am Chem Soc , vol.133 , Issue.7 , pp. 2292-2302
    • Zocher, G.1    Richter, M.E.2    Mueller, U.3    Hertweck, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.