Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues

Journal of the American Chemical Society

Volumn 133, Issue 4, 2011, Pages 976-985

  Mo, Sangjoon ^a   Kim, Dong Hwan ^b,c   Lee, Jong Hyun ^a   Park, Je Won ^a   Basnet, Devi B ^a   Ban, Yeon Hee ^a   Yoo, Young Ji ^a   Chen, Shu Wei ^a   Park, Sung Ryeol ^a   Choi, Eun Ae ^a   Kim, Eunji ^a   Jin, Ying Yu ^d   Lee, Sung Kwon ^d   Park, Ju Yeol ^e   Liu, Yuan ^f   Lee, Mi Ok ^b   Lee, Keum Soon ^b   Kim, Sang Jun ^b   Kim, Dooil ^g   Park, Byoung Chul ^g   Lee, Sang Gi ^a   Kwon, Ho Jeong ^e   Suh, Joo Won ^d   Moore, Bradley S ^f   Lim, Si Kyu ^b   Yoon, Yeo Joon ^a   more..

^a Ewha Womans University   (South Korea)

^b GenoTech Corporation   (South Korea)

^c Chungnam National University   (South Korea)

^d Myong Ji University   (South Korea)

^e Yonsei University   (South Korea)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^g Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL GROUPS; BIOLOGICAL ACTIVITIES; BIOSYNTHETIC PATHWAY; CARRIER PROTEINS; COENZYME A; COMBINATORIAL BIOSYNTHESIS; ENGINEERED BIOSYNTHESIS; ENZYMATIC REACTION; FATTY ACID SYNTHASE; GENE CLUSTERS; IMMUNOSUPPRESSIVE AGENT; MACROLIDES; MULTI-STEP; MUTASYNTHESIS; NEURITE OUTGROWTH; NEW STRATEGY; NONCANONICAL DOMAINS; POLYKETIDE SYNTHASES; POLYKETIDES; UNIQUE FEATURES;

BIOCHEMISTRY; COORDINATION REACTIONS; FATTY ACIDS;

BIOSYNTHESIS;

36 FLUORO FK506; 36 METHYL FK506; ALLYL COMPOUND; CARRIER PROTEIN; FATTY ACID SYNTHASE; MACROLIDE; MALONYL COENZYME A; POLYKETIDE; POLYKETIDE SYNTHASE; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CHEMICAL REACTION; DRUG STRUCTURE; ENZYME MECHANISM; GENE CLUSTER; REACTION ANALYSIS;

MALONYL COENZYME A; MULTIGENE FAMILY; POLYKETIDE SYNTHASES; SEQUENCE DELETION; STREPTOMYCES; TACROLIMUS;

EID: 79851505835     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja108399b     Document Type: Article

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