Directed Evolution and Structural Characterization of a Simvastatin Synthase

Chemistry and Biology

Volumn 16, Issue 10, 2009, Pages 1064-1074

  Gao, Xue ^a   Xie, Xinkai ^a   Pashkov, Inna ^a   Sawaya, Michael R ^a   Laidman, Janel ^a   Zhang, Wenjun ^a   Cacho, Ralph ^a   Yeates, Todd O ^a   Tang, Yi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CHEMBIO; MICROBIO

Indexed keywords

ACYLTRANSFERASE; RECOMBINANT PROTEIN; SIMVASTATIN;

AMINO ACID SEQUENCE; ARTICLE; BIOCATALYSIS; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; ENZYME ACTIVE SITE; GENETICS; KINETICS; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ACYLTRANSFERASES; AMINO ACID SEQUENCE; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIRECTED MOLECULAR EVOLUTION; EVOLUTION, MOLECULAR; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SIMVASTATIN;

ESCHERICHIA COLI;

EID: 71149114259     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2009.09.017     Document Type: Article

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