Broad substrate specificity of ketoreductases derived from modular polyketide synthases

ChemBioChem

Volumn 7, Issue 3, 2006, Pages 478-484

  Bali, Shilpa ^a   O'Hare, Helen M ^b   Weissman, Kira J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b EPFL   (Switzerland)

Author keywords

Biosynthesis; Biotransformations; Broad specificity; Oxidoreductases; Polyketide synthase

Indexed keywords

1,2 CYCLOHEXANEDIONE; 4 METHYLCYCLOHEXANONE; ALCOHOL DERIVATIVE; ALLYLCYCLOHEXANONE; ANTIBIOTIC AGENT; CYCLOHEXANONE DERIVATIVE; CYCLOOCTANONE; CYCLOPENTANONE DERIVATIVE; DIHYDRORESORCINOL; ERYTHROMYCIN; GLUTATHIONE TRANSFERASE; KETOREDUCTASE; METHYLCYCLOHEXANONE; NATURAL PRODUCT; OXIDOREDUCTASE; POLYKETIDE; POLYKETIDE SYNTHASE; TYLOSIN; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; BIOTRANSFORMATION; CATALYST; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; REDUCTION; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS;

AMINO ACID MOTIFS; DIRECTED MOLECULAR EVOLUTION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES; POLYKETIDE SYNTHASES; RECOMBINANT PROTEINS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

EID: 33644905256     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200500430     Document Type: Article

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