Crystal structure of the priming β-ketosynthase from the R1128 polyketide biosynthetic pathway

Structure

Volumn 10, Issue 11, 2002, Pages 1559-1568

  Pan, Hu ^a   Tsai, Shiou Chuan ^a,b   Meadows, Eric S ^b   Miercke, Larry J W ^a   Keatinge Clay, Adrian T ^a   O'Connell, Joe ^a   Khosla, Chaitan ^b,c   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Stanford University   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

ketosynthase; Acyl chain; Aromatic polyketide; Biosynthetic engineering; Catalytic triad; Primer unit

Indexed keywords

ACETYL COENZYME A; BETA KETOSYNTHASE; DIMER; FUNCTIONAL GROUP; ISOENZYME; POLYKETIDE; PROTEIN ZHUH; UNCLASSIFIED DRUG; MULTIENZYME COMPLEX;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; ENZYME SPECIFICITY; ESCHERICHIA COLI; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ACETYL COENZYME A; AMINO ACID SEQUENCE; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ESCHERICHIA COLI; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 0036848668     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00889-4     Document Type: Article

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