Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics

British Journal of Pharmacology

Volumn 171, Issue 10, 2014, Pages 2508-2527

  Sousa Valente, J ^a   Andreou, A P ^a   Urban, L ^b   Nagy, I ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Inflammation; Nerve injury; Pain; TRPA1; TRPM2; TRPM3; TRPM8; TRPV1; TRPV4

Indexed keywords

ANALGESIC AGENT; POLYCYSTIN 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; TRANSIENT RECEPTOR POTENTIAL CHANNEL M3; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5; TRANSIENT RECEPTOR POTENTIAL CHANNEL M6; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; TRPML1 CHANNEL; TRPML2 CHANNEL; TRPML3 CHANNEL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT;

ALLODYNIA; ANALGESIA; BINDING SITE; COLD; DESENSITIZATION; DISEASE ASSOCIATION; DRUG EFFECT; DRUG TARGETING; HEAT; HYPERALGESIA; INFLAMMATORY PAIN; NEUROMODULATION; NOCICEPTION; NONHUMAN; PAIN; PERIPHERAL NERVE INJURY; PRIMARY SENSORY NEURON; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SENSITIZATION; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; VISCERAL PAIN; ANIMAL; DRUG DESIGN; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULARLY TARGETED THERAPY; NOCICEPTIVE PAIN; PAIN THRESHOLD; PATHOPHYSIOLOGY; PSYCHOLOGY;

ANALGESICS; ANIMALS; DRUG DESIGN; HUMANS; MEMBRANE TRANSPORT MODULATORS; MOLECULAR TARGETED THERAPY; NOCICEPTION; NOCICEPTIVE PAIN; PAIN THRESHOLD; SENSORY RECEPTOR CELLS; SIGNAL TRANSDUCTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84900823544     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12532     Document Type: Review

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