Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling

Journal of Neuroscience

Volumn 25, Issue 21, 2005, Pages 5109-5116

  Ahern, Gerard P ^a   Brooks, Ian M ^a   Miyares, Rosa Linda ^a   Wang, Xiang Bin ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Cations; Ionic strength; Nociception; Pain; TRPV1; VR1

Indexed keywords

CALCIUM; MAGNESIUM; PHOSPHOLIPASE C; RESINIFERATOXIN; SODIUM; TRANSIENT RECEPTOR POTENTIAL CHANNEL; VANILLOID RECEPTOR;

ANIMAL CELL; ARTICLE; BURNING SENSATION; CALCIUM SIGNALING; CATION TRANSPORT; ELECTROPHYSIOLOGY; EXTRACELLULAR CALCIUM; GENE; HUMAN; HUMAN CELL; IONIC STRENGTH; MOLECULAR MECHANICS; MOUSE; NOCICEPTION; NONHUMAN; OSMOLARITY; PAIN; PRIORITY JOURNAL; SENSITIZATION; SENSORY NERVE; SENSORY STIMULATION; TRPV1 GENE;

ADENOSINE TRIPHOSPHATE; AMINOBUTYRIC ACIDS; ANIMALS; ARACHIDONIC ACIDS; BEHAVIOR, ANIMAL; BRADYKININ; CALCIUM; CALCIUM CHANNEL BLOCKERS; CAPSAICIN; CATIONS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG INTERACTIONS; ELECTRIC STIMULATION; EXTRACELLULAR SPACE; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNESIUM SULFATE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROINJECTIONS; MODELS, BIOLOGICAL; MUTAGENESIS; NEURONS; NODOSE GANGLION; OOCYTES; PAIN; PATCH-CLAMP TECHNIQUES; PHORBOL 12,13-DIBUTYRATE; POLYUNSATURATED ALKAMIDES; PROTEIN KINASE C; SIGNAL TRANSDUCTION; TEMPERATURE; TIME FACTORS; TRANSFECTION; TRPV CATION CHANNELS;

EID: 19444363418     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0237-05.2005     Document Type: Article

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