Functional Transient Receptor Potential Vanilloid 1 is Expressed in Human Urothelial Cells

Journal of Urology

Volumn 182, Issue 6, 2009, Pages 2944-2950

  Charrua, Ana ^a,b   Reguenga, Carlos ^a,b   Cordeiro, João Miguel ^a   Correiade Sá, Paulo ^a   Paule, Cleope ^d   Nagy, Istvan ^d   Cruz, Francisco ^b,c   Avelino, António ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c HOSPITAL DE SÃO JOÃO   (Portugal)

^d CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

capsaicin; human; inflammation; TRPV1 protein; urinary bladder; urothelium

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CAPSAICIN; COBALT; MESSENGER RNA; NERVE GROWTH FACTOR; VANILLOID RECEPTOR 1;

ACIDITY; ARTICLE; BIOLUMINESCENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; GENE EXPRESSION; HEAT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOCYTOCHEMISTRY; INFLAMMATION; MALE; PATCH CLAMP; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPERATURE; UROTHELIUM; VOLTAGE CLAMP; WHOLE CELL;

CELLS, CULTURED; HUMANS; TRPV CATION CHANNELS; URINARY BLADDER; UROTHELIUM;

EID: 71849109253     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2009.08.022     Document Type: Article

References (25)

1. Szallasi A., Cruz F., and Geppetti P. TRPV1: a therapeutic target for novel analgesic drugs?. TIMM 12 (2006) 545
2. Szallasi A., Cortright D.N., Blum C.A., et al. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 6 (2007) 357
3. Davis J.B., Gray J., Gunthorpe M.J., et al. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405 (2000) 183
4. Charrua A., Cruz C.D., Cruz F., et al. TRPV1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis. J Urol 177 (2007) 1537
5. Yiangou Y., Facer P., Ford A., et al. Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder. BJU Int 87 (2001) 774
6. Avelino A., Cruz C., Nagy I., et al. Vanilloid receptor 1 expression in the rat urinary tract. Neuroscience 109 (2002) 787
7. Tominaga M., Caterina M.J., Malmberg A.B., et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21 (1998) 531
8. Birder L.A., Kanai A.J., de Groat W.C., et al. Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. PNAS 98 (2001) 13396
9. Caterina M.J., Schumacher M.A., Tominaga M., et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389 (1997) 816
10. Kullman F.A., Shah M.A., Birder L.A., et al. Functional TRP and ASIC-like channels in cultured urothelial cells from the rat. Am J Physiol Renal Physiol 296 (2009) F892
11. Xu X., Gordon B., Lin Z., et al. Functional TRPV4 channels and absence of capsaicin-evoked currents in freshly-isolated, guinea-pig urothelial cells. Channels (Austin) 3 (2009) 156
12. Lazzeri M., Vannucchi M.G., Zardo C., et al. Immunohistochemical evidence of vanilloid receptor 1 in normal human urinary bladder. Eur Urol 46 (2004) 792
13. Charrua A, Avelino A, Nagy I et al: Functional properties of TRPV1 expressed in human urothelial cells. Presented at annual meeting of International Continence Society, Christchurch, New Zealand, November 27, 2006.
14. Southgate J., Masters J.R.W., and Trejdosiewicz L.K. Culture of human urothelium. In: Freshney I., and Freshney M.G. (Eds). Culture of Epithelial Cells. 2nd ed. (2002), Wiley-Liss, New York 381-399 chapt 12
15. Smith G.D., Gunthorpe M.J., Kelsell R.E., et al. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418 (2002) 186
16. Apostolidis A., Popat R., Yiangou Y., et al. Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity. J Urol 174 (2005) 977
17. Rebelo S., Reguenga C., Osório L., et al. DRG11 immunohistochemical expression during embryonic development in the mouse. Dev Dyn 236 (2007) 2653
18. Singh Tahim A., Sántha P., and Nagy I. Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons. Neuroscience 136 (2005) 539
19. Everaerts W., Sepúlveda M.R., Gevaert T., et al. Where is TRPV1 expressed in the bladder, do we see the real channel?. Naunyn Schmiedebergs Arch Pharmacol 379 (2009) 421
20. Gavva N.R., Tamir R., Klionsky L., et al. Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol Pharmacol 68 (2005) 1524
21. Avelino A., and Cruz F. TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications. Naunyn Schmiedebergs Arch Pharmacol 373 (2006) 287
22. Xue Q., Jong B., Chen T., et al. Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor. J Neurochem 101 (2007) 212
23. Ji R.R., Samad T.A., Jin S.X., et al. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36 (2002) 57
24. Cockayne D.A., Hamilton S.G., Zhu Q.M., et al. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407 (2000) 1011
25. Sun Y., Keay S., De Deyne P.G., et al. Augmented stretch activated adenosine triphosphate release from bladder uroepithelial cells in patients with interstitial cystitis. J Urol 166 (2001) 1951