TRPV3 is a temperature-sensitive vanilloid receptor-like protein

Nature

Volumn 418, Issue 6894, 2002, Pages 186-190

  Smith, G D ^a   Gunthorpe, M J ^a   Kelsell, R E ^a   Hayes, P D ^a   Reilly, P ^a   Facer, P ^b   Wright, J E ^a   Jerman, J C ^a   Walhin, J P ^a   Ooi, L ^a   Egerton, J ^a   Charles, K J ^a   Smart, D ^a   Randall, A D ^a   Anand, P ^b   Davis, J B ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDITY; GENES; NEUROLOGY; SENSORY PERCEPTION;

THERMOSENSITIVE ION CHANNEL;

PROTEINS;

CAPSAICIN; CATION CHANNEL; GENE PRODUCT; PROTEIN TRPV3; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR LIKE PROTEIN; VANILLOID RECEPTOR LIKE PROTEIN 3;

BIOCHEMISTRY; CATION; PROTEIN; TEMPERATURE;

ACIDITY; ARTICLE; BASE PAIRING; CONTROLLED STUDY; GENE DISRUPTION; GENETIC TRANSCRIPTION; HEAT; HEAT SENSATION; HEAT SENSITIVITY; HUMAN; HUMAN CELL; MULTIGENE FAMILY; NERVE CELL; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSOR; SENSORY NERVE; SENSORY NERVE CELL; SPINAL GANGLION; TEMPERATURE DEPENDENCE;

AMINO ACID SEQUENCE; CALCIUM; CAPSAICIN; CATION TRANSPORT PROTEINS; CELL LINE; CLONING, MOLECULAR; ELECTROPHYSIOLOGY; GANGLIA, SPINAL; GENE EXPRESSION PROFILING; HEAT; HUMANS; ION CHANNEL GATING; ION CHANNELS; MOLECULAR SEQUENCE DATA; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN SUBUNITS; PROTONS; RECEPTORS, DRUG; RNA, MESSENGER; SEQUENCE HOMOLOGY; TRPV CATION CHANNELS;

EID: 18444408683     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00894     Document Type: Article

References (28)

1. The capsaicin receptor: A heat-activated ion channel in the pain pathway
2. Impaired nociception and pain sensation in mice lacking the capsaicin receptor
3. Vanilloin receptor-1 is essential for inflammatory thermal hyperalgesia
4. Similarities and differences between the responses of rat sensory neurons to noxious heat and capsaicin
5. Human calcium transport protein CAT 1
6. 2+ channel (ECACI)
7. Gene structure and chromosomal mapping of human epithelial calcium channel
8. Cloning and functional expression of a human orthologue of ratvanilloid receptor-1
9. Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2
10. A unified nomenclature for the superfamily of TRP cation channels
11. Structural conservation of the genes encoding CAT 1, CaT2 and related cation channels
12. The genomic region encompassing the nephropathic cystinosis gene (CTNS): Complete sequencing of a 200 kb segment and discovery of a novel gene within the common cystinosis-causing deletion
13. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
14. A capsaicin-receptor homologue with a high threshold for noxious heat
15. The diversity in the vanilloid (TRPV) receptor family of ion channels
16. Coexpression of P2X(3) and P2X(2) receptor subunits in varying amounts generates heterologous populations of P2X receptors that evoke a spectrum of agonist response comparable to that seen in sensory neurons
17. Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3 +
18. Basic local alignment search tool
19. Using GeneWise in the Drosophila annotation experiment
20. Prediction of complete gene structures in human genomic DNA
21. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
22. A novel method for real time quantitative RT-PCR
23. Expression pattern of human P2Y receptor subtypes: A quantitative reverse transcription-polymerase chain reaction study
24. Immunolocalization of SNS/PN3 and NaN/SNS 2 sodium channels in human pain states
25. Characterisation of human HtrA2, a novel serine protease involved in the mammalian cellular stress response
26. Ponting a simple modular architecture research tool: Identification of signalling domains
27. TMbase - A database of membrane spanning proteins segments