The roles of sodium channels in nociception: Implications for mechanisms of neuropathic pain

Pain Medicine

Volumn 12, Issue SUPPL. 3, 2011, Pages

  Liu, Min ^a   Wood, John N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Animal models; Nav1.7; Nav1.8; Nav1.9; Neuropathic pain; Null mutants; Voltage gated sodium channels

Indexed keywords

ANTIARRHYTHMIC AGENT; ANTICONVULSIVE AGENT; CARBAMAZEPINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MEXILETINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL NAV1.7; SODIUM CHANNEL NAV1.8; SODIUM CHANNEL NAV1.9; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; CHRONIC PAIN; DRUG MECHANISM; DRUG TARGETING; HUMAN; INFLAMMATION; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PATHOPHYSIOLOGY; VISCERAL PAIN;

EID: 79960367215     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/j.1526-4637.2011.01158.x     Document Type: Article

References (32)

1. Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment. Eur J Pain 2006;10(4):287-333.
2. Indo Y, Tsuruta M, Hayashida Y, etal. Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat Genet 1996;13(4):485-8.
3. Carroll WA, Donnelly-Roberts D, Jarvis MF. Selective P2X(7) receptor antagonists for chronic inflammation and pain. Purinergic Signal 2009;5(1):63-73.
4. Benarroch EE. Sodium channels and pain. Neurology 2007;68(3):233-6.
5. Wood JN, Boorman JP, Okuse K, Baker MD. Voltage-gated sodium channels and pain pathways. J Neurobiol 2004;61(1):55-71.
6. Zimmermann K, Leffler A, Babes A, etal. Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature 2007;447(7146):855-8.
7. Akopian AN, Souslova V, England S, etal. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci 1999;2(6):541-8.
8. Laird JM, Souslova V, Wood JN, Cervero F. Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice. J Neurosci 2002;22(19):8352-6.
9. Ostman JA, Nassar MA, Wood JN, Baker MD. GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9. J Physiol 2008;586(4):1077-87.
10. Maingret F, Coste B, Padilla F, etal. Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism. J Gen Physiol 2008;131(3):211-25.
11. Ritter AM, Martin WJ, Thorneloe KS. The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction. Neurosci Lett 2009;452(1):28-32.
12. Leo S, D'Hooge R, Meert T. Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice. Behav Brain Res 2010;208(1):149-57.
13. Lakso M, Pichel JG, Gorman JR, etal. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 1996;93(12):5860-5.
14. Lai J, Gold MS, Kim CS, etal. Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain 2002;95(1-2):143-52.
15. Stirling LC, Forlani G, Baker MD, etal. Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain 2005;113(1-2):27-36.
16. Boucher TJ, Okuse K, Bennett DL, etal. Potent analgesic effects of GDNF in neuropathic pain states. Science 2000;290(5489):124-7.
17. Hains BC, Klein JP, Saab CY, etal. Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neurosci 2003;23(26):8881-92.
18. Black JA, Cummins TR, Yoshimura N, de Groat WC, Waxman SG. Tetrodotoxin-resistant sodium channels Na(v)1.8/SNS and Na(v)1.9/NaN in afferent neurons innervating urinary bladder in control and spinal cord injured rats. Brain Res 2003;963(1-2):132-8.
19. Craner MJ, Klein JP, Renganathan M, Black JA, Waxman SG. Changes of sodium channel expression in experimental painful diabetic neuropathy. Ann Neurol 2002;52(6):786-92.
20. Nassar MA, Baker MD, Levato A, etal. Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain 2006;2:33.
21. Roza C, Laird JM, Souslova V, Wood JN, Cervero F. The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J Physiol 2003;550(Pt 3):921-6.
22. Jarvis MF, Honore P, Shieh CC, etal. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A 2007;104(20):8520-5.
23. Abrahamsen B, Zhao J, Asante CO, etal. The cell and molecular basis of mechanical, cold, and inflammatory pain. Science 2008;321(5889):702-5.
24. Huang HL, Cendan CM, Roza C, etal. Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves. Mol Pain 2008;4:33.
25. Xiao HS, Huang QH, Zhang FX, etal. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci U S A 2002;99(12):8360-5.
26. Nassar MA, Stirling LC, Forlani G, etal. Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A 2004;101(34):12706-11.
27. Cox JJ, Reimann F, Nicholas AK, etal. An SCN9A channelopathy causes congenital inability to experience pain. Nature 2006;444(7121):894-8.
28. Han C, Rush AM, Dib-Hajj SD, etal. Sporadic onset of erythermalgia: A gain-of-function mutation in Nav1.7. Ann Neurol 2006;59(3):553-8.
29. Rush AM, Dib-Hajj SD, Liu S, etal. A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Proc Natl Acad Sci U S A 2006;103(21):8245-50.
30. Fertleman CR, Baker MD, Parker KA, etal. SCN9A mutations in paroxysmal extreme pain disorder: Allelic variants underlie distinct channel defects and phenotypes. Neuron 2006;52(5):767-74.
31. Ghelardini C, Desaphy JF, Muraglia M, etal. Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models. Neuroscience 2010;169(2):863-73.
32. Bosmans F, Rash L, Zhu S, etal. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol 2006;69(2):419-29.