Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism

Journal of Neuroscience

Volumn 25, Issue 39, 2005, Pages 8924-8937

  Xu, Haoxing ^a   Blair, Nathaniel T ^a   Clapham, David E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Camphor; Capsaicin; Dorsal root ganglion; DRG; Nociceptor; Topical analgesic; Transient receptor potential; TRPV1

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; 4ALPHA PHORBOL DIDECANOATE; ALLYL ISOTHIOCYANATE; ANKYRIN; CAMPHOR; CAPSAICIN; CAPSAZEPINE; CARBACHOL; DIPHENYLBORONIC ANHYDRIDE; IONOMYCIN; MENTHOL; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PHOSPHOLIPASE C COUPLED RECEPTOR; PROTEIN KINASE C; PROTEIN TRPA1; PROTEIN TRPV3; RECEPTOR PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANIMAL CELL; ARTICLE; COLD SENSITIVITY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; LINIMENT; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; SENSORY NERVE; TEMPERATURE SENSITIVITY;

ANIMALS; CALCIUM CHANNELS; CAMPHOR; CAPSAICIN; CELL LINE; DRUG SYNERGISM; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; GANGLIA, SPINAL; HEAT; HUMANS; ION CHANNELS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TACHYPHYLAXIS; TETRADECANOYLPHORBOL ACETATE; TRPV CATION CHANNELS;

EID: 25644433563     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2574-05.2005     Document Type: Article

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