Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons

Neuroscience

Volumn 100, Issue 4, 2000, Pages 685-688

  Ahluwalia, J ^a,b   Urban, L ^b   Capogna, M ^b   Bevan, S ^b   Nagy, I ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b Novatis Inst for Medical Sciences   (United Kingdom)

Author keywords

CB1 receptor; DRG cell culture; Nociception; VR1 receptor

Indexed keywords

CANNABINOID; CANNABINOID RECEPTOR; RECEPTOR PROTEIN; VANILLOID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EXCITATION AND STIMULATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NEUROTRANSMITTER RELEASE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL GANGLION;

ANIMAL; CANNABINOIDS; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE; GANGLIA, SPINAL; MICROSCOPY, CONFOCAL; NEURONS, AFFERENT; NOCICEPTORS; RATS; RECEPTORS, DRUG;

EID: 0034638450     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00389-4     Document Type: Article

References (34)

1. Control of pain by endogenous cannabinoids
2. The capsaicin receptor:a heat-activated ion channel in the pain pathway
3. The cannabinoid CB1 receptor antagonist SR14176A, selectively facilitates nociceptive responses of dorsal horn neurons in the rat
4. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal and adult human brain
5. Immunocytochemical localisation of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites
6. Conduction velocity is related to morphological cell type in dorsal root ganglion neurons
7. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
8. The analgesic effect of R(+)-WIN55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
9. Cannabinoid suppression of noxious heat-evoked activity of wide dynamic range neurons in the lumbar dorsal horn of the rat
10. Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord
11. Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study
12. Regulation of cannabinoid mu opioid receptors in rat lumbar spinal cord following neonatal capsaicin treatment
13. Cannabinoid receptors undergo axonal flow in sensory nerves
14. The anti-hyperalgesic action of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain
15. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons
16. The cannabinoid receptor agonist WIN 55,212-2 mesylate blocks the development of hyperalgesia produced by capsaicin in rats
17. Spinal and supraspinal components of cannabinoid-induced antinociception
18. Nerve growth factor enhances regeneration but is not required as a survival factor for adult sensory neurons
19. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
20. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor
21. Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry
22. Spinal cannabinoids are anti-allodynic in rats with persistent inflammation
23. Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla
24. Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult dorsal root and nodose ganglia and its downregulation by axotomy
25. The role of neurokinin and N-methyl-D-aspartate receptors in the synaptic transmission from capsaicin-sensitive primary afferents in the rat spinal cord in vitro
26. Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia
27. Antihyperalgesic effects of spinal cannabinoids
28. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
29. CB1 receptor localization in rat spinal cord and roots, dorsal root ganglion and peripheral nerve
30. Mechanisms of cannabinoid-receptor-mediated inhibition of synaptic transmission in cultured hippocampal pyramidal neurons
31. The cloned capsaicin receptor integrates multiple pain-producing stimuli
32. Suppression of noxious stimulus-evoked expression of Fos protein-like immunoreactivity in rat spinal cord by a selective cannabinoid agonist
33. The neurobiology of cannabinoid analgesia
34. Differential blockade of the anti-nociceptive effects of centrally administered cannabinoids by SR141716A