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Progress in Medicinal Chemistry

Volumn 51, Issue , 2012, Pages 57-70

TRPV1 antagonists: Clinical setbacks and prospects for future development

(2) Kort, Michael E a Kym, Philip R a

a ABBOTT LABORATORIES (United States)

Author keywords

Acidic pH; Capsaicin; Core body temperature; Pain; TRPV1 antagonist; Vanilloid; VR1

Indexed keywords

(5 TERT BUTYL 2,3 DIHYDRO 1H INDEN 1 YL) 3 (1H INDAZOL 4 YL)UREA; 1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; A 889425; AMG 8562; AMG 8563; AS 1928370; AZD 1386; CAPSAICIN; GRC 6211; JTS 653; JYL 1421; KJM 429; MK 2295; N [4 [6 [4 (TRIFLUOROMETHYL)PHENYL] 4 PYRIMIDINYLOXY]BENZOTHIAZOL 2 YL]ACETAMIDE; PHE 377; PHE 575; RESINIFERATOXIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1 ANTAGONIST;

ALLODYNIA; ARTICLE; BINDING SITE; CORE TEMPERATURE; DRUG EFFICACY; DRUG HALF LIFE; DRUG MEGADOSE; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; HEAT SENSATION; HUMAN; HYPERTHERMIA; MAXIMUM PLASMA CONCENTRATION; NEUROPATHIC PAIN; NONHUMAN; OSTEOARTHRITIS; PAIN THRESHOLD; PERCEPTION DISORDER; PRIORITY JOURNAL; SENSORY DYSFUNCTION; SIDE EFFECT; SINGLE DRUG DOSE; TEMPERATURE SENSE; THERMOREGULATION; TOOTH PAIN;

EID: 84859885582 PISSN: 00796468 EISSN: 18757863 Source Type: Book Series
DOI: 10.1016/B978-0-12-396493-9.00002-9 Document Type: Chapter

Times cited : (61)

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