The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain

Journal of Pharmacology and Experimental Therapeutics

Volumn 304, Issue 1, 2003, Pages 56-62

  Walker, Katharine M ^a,b   Urban, Laszlo ^a   Medhurst, Stephen J ^a,c   Patel, Sadhana ^a   Panesar, Mohanjit ^a   Fox, Alyson J ^a   McIntyre, Peter ^a  

^a Novatis Inst for Medical Sciences   (United Kingdom)

^b PURDUE PHARMA L P   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; CAPSAICIN; CAPSAZEPINE; CARRAGEENAN; FREUND ADJUVANT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR ANTAGONIST; VANILLOID RECEPTOR TYPE 1;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; GUINEA PIG; HYPERALGESIA; INFLAMMATION; MALE; MECHANICAL STIMULATION; MOUSE; NERVE LIGATION; NEUROPATHIC PAIN; NOCICEPTIVE STIMULATION; NONHUMAN; PLANTARIS MUSCLE; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SPECIES DIFFERENCE; THERMAL STIMULATION; WITHDRAWAL REFLEX;

ALGORITHMS; ANIMALS; ANTICONVULSANTS; CAPSAICIN; CARBAMAZEPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HYPERALGESIA; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, WISTAR; RECEPTORS, DRUG; SCIATIC NERVE;

EID: 0037215646     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.042010     Document Type: Article

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