Neurovascular aspects of skin neurogenic inflammation

Journal of Investigative Dermatology Symposium Proceedings

Volumn 15, Issue 1, 2011, Pages 33-39

  Aubdool, Aisah A ^a   Brain, Susan D ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL ISOTHIOCYANATE; APOCYNIN; AZITHROMYCIN; CALCITONIN GENE RELATED PEPTIDE; CATALASE; CINNAMALDEHYDE; INTERLEUKIN 8; NEUROKININ 1 RECEPTOR; NEUROPEPTIDE; PROTEINASE; REACTIVE OXYGEN METABOLITE; SUBSTANCE P; SUPEROXIDE DISMUTASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1;

COLD; CONFERENCE PAPER; ERYTHEMA; FACE EDEMA; FIBROSIS; FLUSHING; HEAT; HUMAN; IMMUNOREACTIVITY; INFLAMMATION; NEUROLOGIC DISEASE; NOCICEPTION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PRURITUS; PUSTULE; ROSACEA; SKIN DISEASE; SPICE; THERMORECEPTOR; VEGETABLE;

ANIMALS; ANKYRINS; CALCITONIN GENE-RELATED PEPTIDE; DERMATITIS; DOGS; FEMALE; HAPLORHINI; HUMANS; MALE; MICE; NEUROGENIC INFLAMMATION; PAIN; PEPTIDE HYDROLASES; RATS; ROSACEA; SEX FACTORS; SKIN; SUBSTANCE P; TRPV CATION CHANNELS;

EID: 80955134436     PISSN: 10870024     EISSN: 15291774     Source Type: Journal    
DOI: 10.1038/jidsymp.2011.8     Document Type: Conference Paper

References (72)

1. Abram K, Silm H, Oona M (2010) Prevalence of rosacea in an Estonian working population using a standard classification. Acta Derm Venereol 90:269-73
2. Acharya MR, Venitz J, Figg WD et al. (2004) Chemically modified tetracyclines as inhibitors of matrix metalloproteinases. Drug Resist Updat 7:195-208 (Pubitemid 39024520)
3. Amadesi S, Nie J, Vergnolle N et al. (2004) Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci 24:4300-12 (Pubitemid 38608141)
4. Andersson DA, Gentry C, Moss S et al. (2008) Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci 28:2485-94 (Pubitemid 351348185)
5. Atoyan R, Shander D, Botchkareva NV (2009) Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J Invest Dermatol 129:2312-5
6. Aubdool AA, Graepel R, Brain SD (2011) A potential link between the TRPA1 and TRPV1 receptors in vivo. Inflamm Res 60:S203
7. Axelsson HE, Minde JK, Sonesson A et al. (2009) Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without norrbottnian congenital insensitivity to pain. Neuroscience 162:1322-32
8. Bae YI, Yun SJ, Lee JB et al. (2009) Clinical evaluation of 168 Korean patients with rosacea: the sun exposure correlates with the erythematotelangiec- tatic subtype. Ann Dermatol 21:243-9
9. Bakar O, Demircay Z, Yuksel M et al. (2007) The effect of azithromycin on reactive oxygen species in rosacea. Clin Exp Dermatol 32:197-200 (Pubitemid 46233028)
10. Baldwin HE (2007) Systemic therapy for rosacea. Skin Therapy Lett 12:1-5, 9
11. Bamford JT (2001) Rosacea: current thoughts on origin. Semin Cutan Med Surg 20:199-206 (Pubitemid 32927782)
12. Bautista DM, Jordt SE, Nikai T et al. (2006) TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124:1269-82
13. Berg M, Liden S (1989) An epidemiological study of rosacea. Acta Derm Venereol 69:419-23 (Pubitemid 19226109)
14. Berman B, Perez OA, Zell D (2007) Update on rosacea and anti-inflammatory-dose doxycycline. Drugs Today (Barc) 43:27-34 (Pubitemid 46448835)
15. Blount BW, Pelletier AL (2002) Rosacea: a common, yet commonly overlooked, condition. Am Fam Physician 66:435-40
16. Brain SD, Cox HM (2006) Neuropeptides and their receptors: innovative science providing novel therapeutic targets. Br J Pharmacol 147: S202-11 (Pubitemid 43077278)
17. Brain SD, Petty RG, Lewis JD et al. (1990) Cutaneous blood flow responses in the forearms of Raynaud's patients induced by local cooling and intradermal injections of CGRP and histamine. Br J Clin Pharmacol 30:853-9
18. Brain SD, Tippins JR, Morris HR et al. (1986) Potent vasodilator activity of calcitonin gene-related peptide in human skin. J Invest Dermatol 87:533-6 (Pubitemid 16027131)
19. Brain SD, Williams TJ, Tippins JR et al. (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313:54-6 (Pubitemid 15192304)
20. Brain SD, Williams TJ (1985) Inflammatory edema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. Br J Pharmacol 86:855-60 (Pubitemid 16211362)
21. Buechner SA (2005) Rosacea: an update. Dermatology 210:100-8 (Pubitemid 40463198)
22. Cao T, Gerard NP, Brain SD (1999) Analysis of neurokinin-1 (NK1) receptor-mediated oedema formation: use of NK1 knockout mice. Br J Pharmacol 126:U79
23. Caterina MJ, Leffler A, Malmberg AB et al. (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306-13 (Pubitemid 30226186)
24. Caterina MJ, Schumacher MA, Tominaga M et al. (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816-24 (Pubitemid 27462969)
25. Chizh BA, O'Donnell MB, Napolitano A et al. (2007) The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans. Pain 132:132-41 (Pubitemid 47494566)
26. Colburn RW, Lubin ML, Stone Jr DJ et al. (2007) Attenuated cold sensitivity in TRPM8 null mice. Neuron 54:379-86 (Pubitemid 46671410)
27. Costa SKP, Yshii LM, Poston RN et al. (2006) Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNF alpha in the cutaneous microvasculature. J Neuroimmunol 171:99-109 (Pubitemid 41832281)
28. Crawford GH, Pelle MT, James WD (2004) Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol 51:327-41 (Pubitemid 39178655)
29. Dahl MV, Ross AJ, Schlievert PM (2004) Temperature regulates bacterial protein production: possible role in rosacea. J Am Acad Dermatol 50:266-72 (Pubitemid 38174287)
30. Dai Y, Moriyama T, Higashi T et al. (2004) Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J Neurosci 24:4293-9 (Pubitemid 38612819)
31. Dai Y, Wang S, Tominaga M et al. (2007) Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest 117:1979-87 (Pubitemid 47036332)
32. Denda M, Tsutsumi M, Goto M et al. (2010) Topical application of TRPA1 agonists and brief cold exposure accelerate skin permeability barrier recovery. J Invest Derm 130:1942-5
33. del Camino D, Murphy S, Heiry M et al. (2010) TRPA1 contributes to cold hypersensitivity. J Neurosci 30:15165-74
34. Dianzani C, Lombardi G, Collino M et al. (2001) Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils. J Leukoc Biol 69:1013-8 (Pubitemid 32577905)
35. Foreman JC, Jordan CC, Oehme P et al. (1983) Structure activity relationships for some substance-P-related peptides that cause wheal and flare reactions in human-skin. J Physiol 335:449-65 (Pubitemid 13148380)
36. Gavva NR, Bannon AW, Hovland Jr DN et al. (2007) Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther 323:128-37 (Pubitemid 47443270)
37. Gavva NR, Treanor JJ, Garami A et al. (2008) Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain 136:202-10
38. Graepel R, Fernandes ES, Aubdool AA et al. (2011) 4-Oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and-independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther 337:117-24
39. Grant A, Amadesi S, Bunnett NW (2007) Protease-activated receptors: mechanisms by which proteases sensitize TRPV channels to induce neurogenic inflammation and pain. In: TRP Ion Channel Function in Sensory Transduction and Cellular Signalling Cascades (Liedkte WB, Heller S, eds). CRC Press: Boca Raton, Chapter 31
40. Grant AD, Gerard NP, Brain SD (2002) Evidence of a role for NK1 and CGRP receptors in mediating neurogenic vasodilatation in the mouse ear. Br J Pharmacol 135:356-62 (Pubitemid 34151167)
41. Grant AD, Pinter E, Salmon AM et al. (2005) An examination of neurogenic mechanisms involved in mustard oil-induced inflammation in the mouse. Eur J Pharmacol 507:273-80 (Pubitemid 40126864)
42. Gunthorpe MJ, Chizh BA (2009) Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway. Drug Discov Today 14:56-67
43. Guzman-Sanchez DA, Ishiuji Y, Patel T et al. (2007) Enhanced skin blood flow and sensitivity to noxious heat stimuli in papulopustular rosacea. J Am Acad Dermatol 57:800-5 (Pubitemid 47553073)
44. Jordt SE, Bautista DM, Chuang HH et al. (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260-5 (Pubitemid 38112043)
45. Karashima Y, Talavera K, Everaerts W et al. (2009) TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci USA 106:1273-8
46. Keeble JE, Bodkin JV, Liang L et al. (2009) Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms. Pain 141:135-42
47. Knowlton WM, Bifolck-Fisher A, Bautista DM et al. (2010) TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain 150:340-50
48. Kurkcuoglu N, Alaybeyi F (1991) Substance P immunoreactivity in rosacea. J Am Acad Dermatol 25:725-6
49. Lonne-Rahm S, Nordlind K, Edstrom DW et al. (2004) Laser treatment of rosacea-a pathoetiological study. Arch Dermatol 140:1345-9 (Pubitemid 39473634)
50. Marks R (2007) The enigma of rosacea. J Dermatolog Treat 18:326-8 (Pubitemid 350223201)
51. Marks R, Harcourt-Webster JN (1969) Histopathology of rosacea. Arch Dermatol 100:683-91
52. Miyachi Y (2000) Pharmacologic modulation of neutrophil functions. Clin Dermatol 18:369-73 (Pubitemid 30336516)
53. Nabeebaccus A, Zhang M, Shah AM (2011) NADPH oxidases and cardiac remodelling. Heart Fail Rev 16:5-12
54. Nagata K, Duggan A, Kumar G et al. (2005) Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci 25:4052-61 (Pubitemid 40563380)
55. Nilius B, Owsianik G, Voets T et al. (2007) Transient receptor potential cation channels in disease. Physiol Rev 87:165-217 (Pubitemid 46207713)
56. Obata K, Katsura H, Mizushima T et al. (2005) TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest 115:2393-401 (Pubitemid 41266201)
57. Powell FC, Corbally N, Powell D (1993) Substance P and rosacea. J Am Acad Dermatol 28:132-3
58. Pozsgai G, Bodkin JV, Graepel R et al. (2010) Evidence for the pathophy-siological relevance of TRPA1 receptors in the cardiovascular system in vivo. Cardiovasc Res 87:760-8
59. Salas MM, Hargreaves KM, Akopian AN (2009) TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci 29:1568-78
60. Seeliger S, Derian CK, Vergnolle N et al. (2003) Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo. FASEB J 17:1871-85 (Pubitemid 37214780)
61. Sinclair SR, Kane SA, Van der Schueren BJ et al. (2010) Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974). Br J Clin Pharmacol 69:15-22
62. Starr A, Graepel R, Keeble J et al. (2008) A reactive oxygen species-mediated component in neurogenic vasodilatation. Cardiovasc Res 78:139-47 (Pubitemid 351430963)
63. Steiner AA, Turek VF, Almeida MC et al. (2007) Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defence effectors. J Neurosci 27:7459-68 (Pubitemid 47066573)
64. Steinhoff M, Buddenkotte J, Shpacovitch V et al. (2005) Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 26:1-43 (Pubitemid 40209385)
65. Steinhoff M, Vergnolle N, Young SH et al. (2000) Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 6:151-8 (Pubitemid 30082358)
66. Sterner-Kock A, Braun RK, van der Vliet A et al. (1999) Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils. J Leukoc Biol 65:834-40 (Pubitemid 29279534)
67. Story GM, Peier AM, Reeve AJ et al. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819-29 (Pubitemid 36378884)
68. Wilkin J, Dahl M, Detmar M et al. (2002) Standard classification of rosacea: report of the national rosacea society expert committee on the classification and staging of rosacea. J Am Acad Dermatol 46:584-7
69. Wilkin JK (1980) Vasodilator rosacea. Arch Dermatol 116:598 (Pubitemid 10101723)
70. Wilkin JK (1988) Why is flushing limited to a mostly facial cutaneous distribution? J Am Acad Dermatol 19:309-13
71. Yamasaki K, Di Nardo A, Bardan A et al. (2007) Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med 13:975-80 (Pubitemid 47222043)
72. Zheng Y, Niyonsaba F, Ushio H et al. (2007) Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils. Br J Dermatol 157:1124-31 (Pubitemid 350115677)