The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor

British Journal of Pharmacology

Volumn 155, Issue 8, 2008, Pages 1145-1162

  Holzer, P ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Central nervous system; Hyperalgesia; Hyperthermia; Interference with TRPV1 trafficking; Molecular nocisensors; Nociception; Primary afferent neurones; Thermoregulation; Transient receptor potential vanilloid 1 (TRPV1) cation channels; TRPV1 blockers

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; 1 ISOQUINOLIN 5 YL 3 (4 TRIFLUOROMETHYL BENZYL)UREA; 3 (6 TERTBUTYL 2 METHYLPYRIDIN 3 YL) N (1H INDOL 6 YL)ACRYLAMIDE; 3 [2 PIPERIDIN 1 YL 6 (TRIFLUOROMETHYL)PYRIDIN 3 YL] N QUINOLIN 7 YLACRYLAMIDE; 4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; 5 CHLORO 6 [(3) 3 METHYL 4 [6 (TRIFLUOROMETHYL) 4 (3,4,5 TRIFLUOROPHENYL) 1H BENZIMIDAZOL 2 YL]PIPERAZIN 1 YL]PYRIDIN 3 YL)METHANOL; A 425619; AMG 0347; AMG 0610; AMG 517; AMG 6880; AMG 7472; AMG 7905; AMG 8163; AMG 8562; AMG 8563; AMG 9810; ANALGESIC AGENT; ANANDAMIDE; ANTINOCICEPTIVE AGENT; BOTULINUM TOXIN A; CAMPHOR; CAPSAICIN; CAPSAZEPINE; CIS CAPSAICIN; GINGEROL; LIDOCAINE ETHOBROMIDE; N [4 [6 (4 TRIFLUOROMETHYLPHENYL)PYRIMIDIN 4 YL OXY]BENZOTHIAZOL 2 YL]ACETAMIDE; N [6 [2 (CYCLOHEXYLMETHYLAMINO) 4 (TRIFLUOROMETHYL)PHENYL]PYRIMIDIN 4 YL]BENZO[D]THIAZOL 6 AMINE; PIPERINE; PLACEBO; RESINIFERATOXIN; SOMATOSTATIN; TERTBUTYL 2 [6[[2 (ACETYLAMINO) 1,3 BENZOTHIAZOL 4 YL]OXY] PYRIMIDIN 4 YL] 5 (TRIFLUOROMETHYL)PHENYLCARBAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4; ZINGERONE;

ANALGESIA; ANTINOCICEPTION; CELL MIGRATION; CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; CLINICAL TRIAL; CLUSTER HEADACHE; DESENSITIZATION; DRUG COMPETITION; DRUG MECHANISM; DRUG TARGETING; HUMAN; HYPERALGESIA; HYPERTHERMIA; INFLAMMATION; MIGRAINE; NEUROGENIC BLADDER; NEUROPATHY; NOCICEPTION; NONHUMAN; OSTEOARTHRITIS; OVERACTIVE BLADDER; PAIN; PATHOPHYSIOLOGY; POSTHERPETIC NEURALGIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; REVIEW; RISK ASSESSMENT; SENSITIZATION; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; THERMOGENESIS; THERMOREGULATION;

ANIMALS; BODY TEMPERATURE REGULATION; HUMANS; HYPERALGESIA; INFLAMMATION; PAIN; PAIN MEASUREMENT; TRPV CATION CHANNELS;

EID: 57549118558     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.351     Document Type: Review

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