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Volumn 11, Issue 12, 2010, Pages 823-836

Neuronal circuitry for pain processing in the dorsal horn

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; AMPA RECEPTOR; ANALGESIC AGENT; CALBINDIN; CALCIUM BINDING PROTEIN; CALRETININ; DYNORPHIN; ENKEPHALIN; G PROTEIN COUPLED RECEPTOR; GALANIN; GLUTAMATE DECARBOXYLASE; GLUTAMATE RECEPTOR; GLYCINE; GLYCINE TRANSPORTER 2; NEUROKININ 1 RECEPTOR; NEUROKININ B; NEURONAL NITRIC OXIDE SYNTHASE; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROTENSIN; PARVALBUMIN; PROTEIN KINASE C GAMMA; SEROTONIN 1A RECEPTOR; SEROTONIN 3 RECEPTOR; SOMATOSTATIN; SUBSTANCE P; VANILLOID RECEPTOR 1; VESICULAR INHIBITORY AMINO ACID TRANSPORTER;

EID: 78650517458     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn2947     Document Type: Article
Times cited : (1047)

References (159)
  • 1
    • 0028168576 scopus 로고
    • The contribution of GABAA and glycine receptors to central sensitization: Disinhibition and touch-evoked allodynia in the spinal cord
    • Sivilotti, L. & Woolf, C. J. The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J. Neurophysiol. 72, 169-179 (1994).
    • (1994) J. Neurophysiol. , vol.72 , pp. 169-179
    • Sivilotti, L.1    Woolf, C.J.2
  • 2
    • 0024602581 scopus 로고
    • Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: Effects of modulatory receptor systems and excitatory amino acid antagonists
    • Yaksh, T. L. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 37, 111-123 (1989).
    • (1989) Pain , vol.37 , pp. 111-123
    • Yaksh, T.L.1
  • 3
    • 76949120541 scopus 로고
    • The cytoarchitectonic organization of the spinal cord in the cat
    • Rexed, B. The cytoarchitectonic organization of the spinal cord in the cat. J. Comp. Neurol. 96, 414-495 (1952).
    • (1952) J. Comp. Neurol. , vol.96 , pp. 414-495
    • Rexed, B.1
  • 4
    • 0034737002 scopus 로고    scopus 로고
    • On the problem of lamination in the superficial dorsal horn of mammals: A reappraisal of the substantia gelatinosa in postnatal life
    • Woodbury, C. J., Ritter, A. M. & Koerber, H. R. On the problem of lamination in the superficial dorsal horn of mammals: a reappraisal of the substantia gelatinosa in postnatal life. J. Comp. Neurol. 417, 88-102 (2000).
    • (2000) J. Comp. Neurol. , vol.417 , pp. 88-102
    • Woodbury, C.J.1    Ritter, A.M.2    Koerber, H.R.3
  • 5
    • 38549180951 scopus 로고    scopus 로고
    • Visualizing cold spots: TRPM8-expressing sensory neurons and their projections
    • Dhaka, A., Earley, T. J., Watson, J. & Patapoutian, A. Visualizing cold spots: TRPM8-expressing sensory neurons and their projections. J. Neurosci. 28, 566-575 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 566-575
    • Dhaka, A.1    Earley, T.J.2    Watson, J.3    Patapoutian, A.4
  • 6
    • 34547515711 scopus 로고    scopus 로고
    • Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch
    • Liu, Q. et al. Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch. Nature Neurosci. 10, 946-948 (2007).
    • (2007) Nature Neurosci. , vol.10 , pp. 946-948
    • Liu, Q.1
  • 7
    • 71449102022 scopus 로고    scopus 로고
    • Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors
    • Seal, R. P . et al. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature 462, 651-655 (2009).
    • (2009) Nature , vol.462 , pp. 651-655
    • Seal, R.P.1
  • 8
    • 0030833052 scopus 로고    scopus 로고
    • Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig
    • Lawson, S. N., Crepps, B. A. & Perl, E. R. Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig. J. Physiol. 505, 177-191 (1997).
    • (1997) J. Physiol. , vol.505 , pp. 177-191
    • Lawson, S.N.1    Crepps, B.A.2    Perl, E.R.3
  • 9
    • 0032055877 scopus 로고    scopus 로고
    • Tackling pain at the source: New ideas about nociceptors
    • Snider, W. D. & McMahon, S. B. Tackling pain at the source: new ideas about nociceptors. Neuron 20, 629-632 (1998).
    • (1998) Neuron , vol.20 , pp. 629-632
    • Snider, W.D.1    McMahon, S.B.2
  • 10
    • 67449143397 scopus 로고    scopus 로고
    • Distribution of P2X(3)-immunoreactive fibers in hairy and glabrous skin of the rat
    • Taylor, A. M., Peleshok, J. C. & Ribeiro-da-Silva, A. Distribution of P2X(3)-immunoreactive fibers in hairy and glabrous skin of the rat. J. Comp. Neurol. 514, 555-566 (2009).
    • (2009) J. Comp. Neurol. , vol.514 , pp. 555-566
    • Taylor, A.M.1    Peleshok, J.C.2    Ribeiro-Da-Silva, A.3
  • 11
    • 0029926082 scopus 로고    scopus 로고
    • TrkA CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat
    • Bennett, D. L., Dmietrieva, N., Priestley, J. V., Clary, D. & McMahon, S. B. trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat. Neurosci. Lett. 206, 33-36 (1996).
    • (1996) Neurosci. Lett. , vol.206 , pp. 33-36
    • Bennett, D.L.1    Dmietrieva, N.2    Priestley, J.V.3    Clary, D.4    McMahon, S.B.5
  • 12
    • 0031971830 scopus 로고    scopus 로고
    • Differences in expression of oligosaccharides, neuropeptides, carbonic anhydrase and neurofilament in rat primary afferent neurons retrogradely labelled via skin, muscle or visceral nerves
    • Perry, M. J. & Lawson, S. N. Differences in expression of oligosaccharides, neuropeptides, carbonic anhydrase and neurofilament in rat primary afferent neurons retrogradely labelled via skin, muscle or visceral nerves. Neuroscience 85, 293-310 (1998).
    • (1998) Neuroscience , vol.85 , pp. 293-310
    • Perry, M.J.1    Lawson, S.N.2
  • 13
    • 0027329117 scopus 로고
    • The plant lectin Bandeiraea simplicifolia I-B4 identifies a subpopulation of small diameter primary sensory neurones which innervate the skin in the rat
    • Plenderleith, M. B. & Snow, P. J. The plant lectin Bandeiraea simplicifolia I-B4 identifies a subpopulation of small diameter primary sensory neurones which innervate the skin in the rat. Neurosci. Lett. 159, 17-20 (1993).
    • (1993) Neurosci. Lett. , vol.159 , pp. 17-20
    • Plenderleith, M.B.1    Snow, P.J.2
  • 14
    • 11344251617 scopus 로고    scopus 로고
    • Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd
    • Zylka, M. J., Rice, F. L. & Anderson, D. J. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 45, 17-25 (2005).
    • (2005) Neuron , vol.45 , pp. 17-25
    • Zylka, M.J.1    Rice, F.L.2    Anderson, D.J.3
  • 15
    • 66749156637 scopus 로고    scopus 로고
    • Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
    • Cavanaugh, D. J. et al. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc. Natl Acad. Sci. USA 106, 9075-9080 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 9075-9080
    • Cavanaugh, D.J.1
  • 16
    • 0021742806 scopus 로고
    • Effect of neonatal treatment with capsaicin on the numbers and properties of cutaneous afferent units from the hairy skin of the rat
    • Lynn, B. Effect of neonatal treatment with capsaicin on the numbers and properties of cutaneous afferent units from the hairy skin of the rat. Brain Res. 322, 255-260 (1984).
    • (1984) Brain Res. , vol.322 , pp. 255-260
    • Lynn, B.1
  • 17
    • 0030776204 scopus 로고    scopus 로고
    • Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord
    • Michael, G. J. et al. Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord. J. Neurosci. 17, 8476-8490 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 8476-8490
    • Michael, G.J.1
  • 18
    • 0019997754 scopus 로고
    • Synaptic complexes formed by functionally defined primary afferent units with fine myelinated fibers
    • Rethelyi, M., Light, A. R. & Perl, E. R. Synaptic complexes formed by functionally defined primary afferent units with fine myelinated fibers. J. Comp. Neurol. 207, 381-393 (1982).
    • (1982) J. Comp. Neurol. , vol.207 , pp. 381-393
    • Rethelyi, M.1    Light, A.R.2    Perl, E.R.3
  • 19
    • 0019960661 scopus 로고
    • Two types of synaptic glomeruli and their distribution in laminae I-III of the rat spinal cord
    • Ribeiro-da-Silva, A. & Coimbra, A. Two types of synaptic glomeruli and their distribution in laminae I-III of the rat spinal cord. J. Comp. Neurol. 209, 176-186 (1982).
    • (1982) J. Comp. Neurol. , vol.209 , pp. 176-186
    • Ribeiro-Da-Silva, A.1    Coimbra, A.2
  • 20
    • 0024502932 scopus 로고
    • Morphological characterization of substance P-like immunoreactive glomeruli in the superficial dorsal horn of the rat spinal cord and trigeminal subnucleus caudalis: A quantitative study
    • Ribeiro-da-Silva, A., Tagari, P. & Cuello, A. C. Morphological characterization of substance P-like immunoreactive glomeruli in the superficial dorsal horn of the rat spinal cord and trigeminal subnucleus caudalis: a quantitative study. J. Comp. Neurol. 281, 497-415 (1989).
    • (1989) J. Comp. Neurol. , vol.281 , pp. 497-415
    • Ribeiro-Da-Silva, A.1    Tagari, P.2    Cuello, A.C.3
  • 21
    • 0032995196 scopus 로고    scopus 로고
    • Volume transmission in the CNS and its relevance for neuropsychopharmacology
    • Zoli, M., Jansson, A., Sykova, E., Agnati, L. F. & Fuxe, K. Volume transmission in the CNS and its relevance for neuropsychopharmacology. Trends Pharmacol. Sci. 20, 142-150 (1999).
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 142-150
    • Zoli, M.1    Jansson, A.2    Sykova, E.3    Agnati, L.F.4    Fuxe, K.5
  • 22
    • 0030014621 scopus 로고    scopus 로고
    • Direct evidence of an extensive GABAergic innervation of the spinal dorsal horn by fibres descending from the rostral ventromedial medulla
    • Antal, M., Petko, M., Polgar, E., Heizmann, C. W. & Storm-Mathisen, J. Direct evidence of an extensive GABAergic innervation of the spinal dorsal horn by fibres descending from the rostral ventromedial medulla. Neuroscience 73, 509-518 (1996).
    • (1996) Neuroscience , vol.73 , pp. 509-518
    • Antal, M.1    Petko, M.2    Polgar, E.3    Heizmann, C.W.4    Storm-Mathisen, J.5
  • 23
    • 32544451583 scopus 로고    scopus 로고
    • Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats
    • Kato, G. et al. Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J. Neurosci. 26, 1787-1794 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 1787-1794
    • Kato, G.1
  • 24
    • 0037485919 scopus 로고    scopus 로고
    • Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain
    • Polgár, E. et al. Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain. Pain 104, 229-239 (2003).
    • (2003) Pain , vol.104 , pp. 229-239
    • Polgár, E.1
  • 25
    • 0025368953 scopus 로고
    • Light microscope study of the coexistence of GABA-like and glycine-like immunoreactivities in the spinal cord of the rat
    • Todd, A. J. & Sullivan, A. C. Light microscope study of the coexistence of GABA-like and glycine-like immunoreactivities in the spinal cord of the rat. J. Comp. Neurol. 296, 496-505 (1990).
    • (1990) J. Comp. Neurol. , vol.296 , pp. 496-505
    • Todd, A.J.1    Sullivan, A.C.2
  • 26
    • 0035887592 scopus 로고    scopus 로고
    • Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn
    • Keller, A. F., Coull, J. A., Chery, N., Poisbeau, P. & De Koninck, Y. Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn. J. Neurosci. 21, 7871-7880 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 7871-7880
    • Keller, A.F.1    Coull, J.A.2    Chery, N.3    Poisbeau, P.4    De Koninck, Y.5
  • 27
    • 34249655521 scopus 로고    scopus 로고
    • Cell-type-specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro
    • Yasaka, T. et al. Cell-type-specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro. J. Physiol. 581, 603-618 (2007).
    • (2007) J. Physiol. , vol.581 , pp. 603-618
    • Yasaka, T.1
  • 28
    • 0037243740 scopus 로고    scopus 로고
    • The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn
    • Todd, A. J. et al. The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn. Eur. J. Neurosci. 17, 13-27 (2003).
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 13-27
    • Todd, A.J.1
  • 29
    • 35348917225 scopus 로고    scopus 로고
    • Morphology of inhibitory and excitatory interneurons in superficial laminae of the rat dorsal horn
    • Maxwell, D. J., Belle, M. D., Cheunsuang, O., Stewart, A. & Morris, R. Morphology of inhibitory and excitatory interneurons in superficial laminae of the rat dorsal horn. J. Physiol. 584, 521-533 (2007).
    • (2007) J. Physiol. , vol.584 , pp. 521-533
    • Maxwell, D.J.1    Belle, M.D.2    Cheunsuang, O.3    Stewart, A.4    Morris, R.5
  • 30
    • 77957914572 scopus 로고    scopus 로고
    • Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach
    • Yasaka, T., Tiong, S. Y. X., Hughes, D. I., Riddell, J. S. & Todd, A. J. Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach. Pain 151, 475-488 (2010).
    • (2010) Pain , vol.151 , pp. 475-488
    • Yasaka, T.1    Tiong, S.Y.X.2    Hughes, D.I.3    Riddell, J.S.4    Todd, A.J.5
  • 31
    • 34548742876 scopus 로고    scopus 로고
    • Moving from an averaged to specific view of spinal cord pain processing circuits
    • Graham, B. A., Brichta, A. M. & Callister, R. J. Moving from an averaged to specific view of spinal cord pain processing circuits. J. Neurophysiol. 98, 1057-1063 (2007).
    • (2007) J. Neurophysiol. , vol.98 , pp. 1057-1063
    • Graham, B.A.1    Brichta, A.M.2    Callister, R.J.3
  • 32
    • 0037095823 scopus 로고    scopus 로고
    • Lamina-specific membrane and discharge properties of rat spinal dorsal horn neurones in vitro
    • Ruscheweyh, R. & Sandkuhler, J. Lamina-specific membrane and discharge properties of rat spinal dorsal horn neurones in vitro. J. Physiol. 541, 231-244 (2002).
    • (2002) J. Physiol. , vol.541 , pp. 231-244
    • Ruscheweyh, R.1    Sandkuhler, J.2
  • 33
    • 33646014745 scopus 로고    scopus 로고
    • The kv4.2 potassium channel subunit is required for pain plasticity
    • Hu, H. J. et al. The kv4.2 potassium channel subunit is required for pain plasticity. Neuron 50, 89-100 (2006).
    • (2006) Neuron , vol.50 , pp. 89-100
    • Hu, H.J.1
  • 34
    • 25844502592 scopus 로고    scopus 로고
    • Expression of A-type K channel α subunits Kv 4.2 and Kv 4.3 in rat spinal lamina II excitatory interneurons and colocalization with pain-modulating molecules
    • Huang, H. Y. et al. Expression of A-type K channel α subunits Kv 4.2 and Kv 4.3 in rat spinal lamina II excitatory interneurons and colocalization with pain-modulating molecules. Eur. J. Neurosci. 22, 1149-1157 (2005).
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 1149-1157
    • Huang, H.Y.1
  • 35
    • 0036554701 scopus 로고    scopus 로고
    • Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn
    • Grudt, T. J. & Perl, E. R. Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn. J. Physiol. 540, 189-207 (2002).
    • (2002) J. Physiol. , vol.540 , pp. 189-207
    • Grudt, T.J.1    Perl, E.R.2
  • 36
    • 0742322859 scopus 로고    scopus 로고
    • Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression
    • Hantman, A. W., van den Pol., A. N. & Perl, E. R. Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression. J. Neurosci. 24, 836-842 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 836-842
    • Hantman, A.W.1    Van Den Pol., A.N.2    Perl, E.R.3
  • 37
    • 0141646406 scopus 로고    scopus 로고
    • A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input
    • Lu, Y. & Perl, E. R. A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input. J. Neurosci. 23, 8752-8758 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 8752-8758
    • Lu, Y.1    Perl, E.R.2
  • 38
    • 17644396711 scopus 로고    scopus 로고
    • Modular organization of excitatory circuits between neurons of the spinal superficial dorsal horn (laminae i and II)
    • Lu, Y. & Perl, E. R. Modular organization of excitatory circuits between neurons of the spinal superficial dorsal horn (laminae I and II). J. Neurosci. 25, 3900-3907 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 3900-3907
    • Lu, Y.1    Perl, E.R.2
  • 39
    • 0024835205 scopus 로고
    • GABA-immunoreactive neurons in the dorsal horn of the rat spinal cord
    • Todd, A. J. & McKenzie, J. GABA-immunoreactive neurons in the dorsal horn of the rat spinal cord. Neuroscience 31, 799-806 (1989).
    • (1989) Neuroscience , vol.31 , pp. 799-806
    • Todd, A.J.1    McKenzie, J.2
  • 41
    • 77954511622 scopus 로고    scopus 로고
    • Inhibitory neurones of the spinal substantia gelatinosa mediate interaction of signals from primary afferents
    • Zheng, J., Lu, Y. & Perl, E. R. Inhibitory neurones of the spinal substantia gelatinosa mediate interaction of signals from primary afferents. J. Physiol. 588, 2065-2075 (2010).
    • (2010) J. Physiol. , vol.588 , pp. 2065-2075
    • Zheng, J.1    Lu, Y.2    Perl, E.R.3
  • 42
    • 25444519947 scopus 로고    scopus 로고
    • Molecular and genetic features of a labeled class of spinal substantia gelatinosa neurons in a transgenic mouse
    • Hantman, A. W. & Perl, E. R. Molecular and genetic features of a labeled class of spinal substantia gelatinosa neurons in a transgenic mouse. J. Comp. Neurol. 492, 90-100 (2005).
    • (2005) J. Comp. Neurol. , vol.492 , pp. 90-100
    • Hantman, A.W.1    Perl, E.R.2
  • 43
    • 0032106761 scopus 로고    scopus 로고
    • Nociceptive and thermoreceptive lamina i neurons are anatomically distinct
    • Han, Z. S., Zhang, E. T. & Craig, A. D. Nociceptive and thermoreceptive lamina I neurons are anatomically distinct. Nature Neurosci. 1, 218-225 (1998).
    • (1998) Nature Neurosci. , vol.1 , pp. 218-225
    • Han, Z.S.1    Zhang, E.T.2    Craig, A.D.3
  • 44
    • 0022591355 scopus 로고
    • A Golgi study of the neuronal population of the marginal zone (lamina I) of the rat spinal cord
    • Lima, D. & Coimbra, A. A Golgi study of the neuronal population of the marginal zone (lamina I) of the rat spinal cord. J. Comp. Neurol. 244, 53-71 (1986).
    • (1986) J. Comp. Neurol. , vol.244 , pp. 53-71
    • Lima, D.1    Coimbra, A.2
  • 45
    • 0037088833 scopus 로고    scopus 로고
    • Four cell types with distinctive membrane properties and morphologies in lamina i of the spinal dorsal horn of the adult rat
    • Prescott, S. A. & De Koninck, Y. Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat. J. Physiol. 539, 817-836 (2002).
    • (2002) J. Physiol. , vol.539 , pp. 817-836
    • Prescott, S.A.1    De Koninck, Y.2
  • 46
    • 70449529722 scopus 로고    scopus 로고
    • Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina i of the rat lumbar spinal dorsal horn
    • Al Ghamdi, K. S., Polgar, E. & Todd, A. J. Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal horn. Neuroscience 164, 1794-1804 (2009).
    • (2009) Neuroscience , vol.164 , pp. 1794-1804
    • Al Ghamdi, K.S.1    Polgar, E.2    Todd, A.J.3
  • 47
    • 0026354584 scopus 로고
    • Different populations of parvalbumin-and calbindin-D28k-immunoreactive neurons contain GABA and accumulate 3H-D-aspartate in the dorsal horn of the rat spinal cord
    • Antal, M. et al. Different populations of parvalbumin-and calbindin-D28k-immunoreactive neurons contain GABA and accumulate 3H-D-aspartate in the dorsal horn of the rat spinal cord. J. Comp. Neurol. 314, 114-124 (1991).
    • (1991) J. Comp. Neurol. , vol.314 , pp. 114-124
    • Antal, M.1
  • 48
    • 0027376797 scopus 로고
    • The localization of classical transmitters and neuropeptides within neurons in laminae I-III of the mammalian spinal dorsal horn
    • Todd, A. J. & Spike, R. C. The localization of classical transmitters and neuropeptides within neurons in laminae I-III of the mammalian spinal dorsal horn. Prog. Neurobiol. 41, 609-645 (1993).
    • (1993) Prog. Neurobiol. , vol.41 , pp. 609-645
    • Todd, A.J.1    Spike, R.C.2
  • 49
    • 33645860515 scopus 로고    scopus 로고
    • Characterization of neurons that express preprotachykinin B in the dorsal horn of the rat spinal cord
    • Polgár, E., Furuta, T., Kaneko, T. & Todd, A. Characterization of neurons that express preprotachykinin B in the dorsal horn of the rat spinal cord. Neuroscience 139, 687-697 (2006).
    • (2006) Neuroscience , vol.139 , pp. 687-697
    • Polgár, E.1    Furuta, T.2    Kaneko, T.3    Todd, A.4
  • 50
    • 0028177271 scopus 로고
    • Subpopulations of GABAergic neurons in laminae I-III of rat spinal dorsal horn defined by coexistence with classical transmitters, peptides, nitric oxide synthase or parvalbumin
    • Laing, I., Todd, A. J., Heizmann, C. W. & Schmidt, H. H. Subpopulations of GABAergic neurons in laminae I-III of rat spinal dorsal horn defined by coexistence with classical transmitters, peptides, nitric oxide synthase or parvalbumin. Neuroscience 61, 123-132 (1994).
    • (1994) Neuroscience , vol.61 , pp. 123-132
    • Laing, I.1    Todd, A.J.2    Heizmann, C.W.3    Schmidt, H.H.4
  • 51
    • 0025131635 scopus 로고
    • Immunocytochemical localization of protein kinase C subspecies in the rat spinal cord: Light and electron microscopic study
    • Mori, M., Kose, A., Tsujino, T. & Tanaka, C. Immunocytochemical localization of protein kinase C subspecies in the rat spinal cord: light and electron microscopic study. J. Comp. Neurol. 299, 167-177 (1990).
    • (1990) J. Comp. Neurol. , vol.299 , pp. 167-177
    • Mori, M.1    Kose, A.2    Tsujino, T.3    Tanaka, C.4
  • 52
    • 0033606406 scopus 로고    scopus 로고
    • The types of neuron which contain protein kinase C gamma in rat spinal cord
    • Polgár, E., Fowler, J. H., McGill, M. M. & Todd, A. J. The types of neuron which contain protein kinase C gamma in rat spinal cord. Brain Res. 833, 71-80 (1999).
    • (1999) Brain Res. , vol.833 , pp. 71-80
    • Polgár, E.1    Fowler, J.H.2    McGill, M.M.3    Todd, A.J.4
  • 53
    • 0027219352 scopus 로고
    • Coexistence of NADPH diaphorase with GABA, glycine, and acetylcholine in rat spinal cord
    • Spike, R. C., Todd, A. J. & Johnston, H. M. Coexistence of NADPH diaphorase with GABA, glycine, and acetylcholine in rat spinal cord. J. Comp. Neurol. 335, 320-333 (1993).
    • (1993) J. Comp. Neurol. , vol.335 , pp. 320-333
    • Spike, R.C.1    Todd, A.J.2    Johnston, H.M.3
  • 54
    • 0025267398 scopus 로고
    • The cells of origin of the spinothalamic tract of the rat: A quantitative reexamination
    • Burstein, R., Dado, R. J. & Giesler, G. J., Jr The cells of origin of the spinothalamic tract of the rat: a quantitative reexamination. Brain Res. 5 11, 329-337 (1990).
    • (1990) Brain Res. , vol.5 , Issue.11 , pp. 329-337
    • Burstein, R.1    Dado, R.J.2    Giesler Jr., G.J.3
  • 55
    • 0024541226 scopus 로고
    • Spinal lamina i projection neurons in the rat: Collateral innervation of parabrachial area and thalamus
    • Hylden, J. L., Anton, F. & Nahin, R. L. Spinal lamina I projection neurons in the rat: collateral innervation of parabrachial area and thalamus. Neuroscience 28, 27-37 (1989).
    • (1989) Neuroscience , vol.28 , pp. 27-37
    • Hylden, J.L.1    Anton, F.2    Nahin, R.L.3
  • 56
    • 0023790652 scopus 로고
    • The spinothalamic system of the rat: Structural types of retrogradely labelled neurons in the marginal zone (lamina I)
    • Lima, D. & Coimbra, A. The spinothalamic system of the rat: structural types of retrogradely labelled neurons in the marginal zone (lamina I). Neuroscience 27, 215-230 (1988).
    • (1988) Neuroscience , vol.27 , pp. 215-230
    • Lima, D.1    Coimbra, A.2
  • 57
    • 0026058666 scopus 로고
    • The spino-latero-reticular system of the rat: Projections from the superficial dorsal horn and structural characterization of marginal neurons involved
    • Lima, D., Mendes-Ribeiro, J. A. & Coimbra, A. The spino-latero-reticular system of the rat: projections from the superficial dorsal horn and structural characterization of marginal neurons involved. Neuroscience 45, 137-152 (1991).
    • (1991) Neuroscience , vol.45 , pp. 137-152
    • Lima, D.1    Mendes-Ribeiro, J.A.2    Coimbra, A.3
  • 58
    • 0344442742 scopus 로고    scopus 로고
    • A quantitative and morphological study of projection neurons in lamina i of the rat lumbar spinal cord
    • Spike, R. C., Puskar, Z., Andrew, D. & Todd, A. J. A quantitative and morphological study of projection neurons in lamina I of the rat lumbar spinal cord. Eur. J. Neurosci. 18, 2433-2448 (2003).
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 2433-2448
    • Spike, R.C.1    Puskar, Z.2    Andrew, D.3    Todd, A.J.4
  • 59
    • 0034052838 scopus 로고    scopus 로고
    • A Neurokinin 1 receptor expression by neurons in laminae I., III and IV of the rat spinal dorsal horn that project to the brainstem
    • Todd, A. J., McGill, M. M. & Shehab, S. A. Neurokinin 1 receptor expression by neurons in laminae, I., III and IV of the rat spinal dorsal horn that project to the brainstem. Eur. J. Neurosci. 12, 689-700 (2000).
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 689-700
    • Todd, A.J.1    McGill, M.M.2    Shehab, S.3
  • 60
    • 35548993566 scopus 로고    scopus 로고
    • Morphological characterization of spinal cord dorsal horn lamina i neurons projecting to the parabrachial nucleus in the rat
    • Almarestani, L., Waters, S. M., Krause, J. E., Bennett, G. J. & Ribeiro-da-Silva, A. Morphological characterization of spinal cord dorsal horn lamina I neurons projecting to the parabrachial nucleus in the rat. J. Comp. Neurol. 504, 287-297 (2007).
    • (2007) J. Comp. Neurol. , vol.504 , pp. 287-297
    • Almarestani, L.1    Waters, S.M.2    Krause, J.E.3    Bennett, G.J.4    Ribeiro-Da-Silva, A.5
  • 61
    • 0028928395 scopus 로고
    • Organization of the efferent projections from the spinal cervical enlargement to the parabrachial area and periaqueductal gray: A PHA-L study in the rat
    • Bernard, J. F., Dallel, R., Raboisson, P., Villanueva, L. & Le Bars, D. Organization of the efferent projections from the spinal cervical enlargement to the parabrachial area and periaqueductal gray: a PHA-L study in the rat. J. Comp. Neurol. 353, 480-505 (1995).
    • (1995) J. Comp. Neurol. , vol.353 , pp. 480-505
    • Bernard, J.F.1    Dallel, R.2    Raboisson, P.3    Villanueva, L.4    Le Bars, D.5
  • 62
    • 0028935232 scopus 로고
    • Topographic organization of spinal and trigeminal somatosensory pathways to the rat parabrachial and Kolliker-Fuse nuclei
    • Feil, K. & Herbert, H. Topographic organization of spinal and trigeminal somatosensory pathways to the rat parabrachial and Kolliker-Fuse nuclei. J. Comp. Neurol. 353, 506-528 (1995).
    • (1995) J. Comp. Neurol. , vol.353 , pp. 506-528
    • Feil, K.1    Herbert, H.2
  • 63
    • 0346780704 scopus 로고    scopus 로고
    • A comparative reappraisal of projections from the superficial laminae of the dorsal horn in the rat: The forebrain
    • Gauriau, C. & Bernard, J. F. A comparative reappraisal of projections from the superficial laminae of the dorsal horn in the rat: the forebrain. J. Comp. Neurol. 468, 24-56 (2004).
    • (2004) J. Comp. Neurol. , vol.468 , pp. 24-56
    • Gauriau, C.1    Bernard, J.F.2
  • 64
    • 0028366259 scopus 로고
    • Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with Phaseolus vulgaris leucoagglutinin
    • Slugg, R. M. & Light, A. R. Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with Phaseolus vulgaris leucoagglutinin. J. Comp. Neurol. 339, 49-61 (1994).
    • (1994) J. Comp. Neurol. , vol.339 , pp. 49-61
    • Slugg, R.M.1    Light, A.R.2
  • 65
    • 67650677093 scopus 로고    scopus 로고
    • Collateral projections of neurons in laminae I., III, and IV of rat spinal cord to thalamus, periaqueductal gray matter, and lateral parabrachial area
    • Al-Khater, K. M. & Todd, A. J. Collateral projections of neurons in laminae, I., III, and IV of rat spinal cord to thalamus, periaqueductal gray matter, and lateral parabrachial area. J. Comp. Neurol. 515, 629-646 (2009).
    • (2009) J. Comp. Neurol. , vol.515 , pp. 629-646
    • Al-Khater, K.M.1    Todd, A.J.2
  • 66
    • 56149119302 scopus 로고    scopus 로고
    • A quantitative study of spinothalamic neurons in laminae I, III, and IV in lumbar and cervical segments of the rat spinal cord
    • Al-Khater, K. M., Kerr, R. & Todd, A. J. A quantitative study of spinothalamic neurons in laminae, I, III, and IV in lumbar and cervical segments of the rat spinal cord. J. Comp. Neurol. 5 11, 1-18 (2008).
    • (2008) J. Comp. Neurol. , vol.511 , pp. 1-18
    • Al-Khater, K.M.1    Kerr, R.2    Todd, A.J.3
  • 67
    • 70849090918 scopus 로고    scopus 로고
    • A quantitative study of brainstem projections from lamina i neurons in the cervical and lumbar enlargement of the rat
    • Polgár, E., Wright, L. L. & Todd, A. J. A quantitative study of brainstem projections from lamina I neurons in the cervical and lumbar enlargement of the rat. Brain Res. 1308, 58-67 (2010).
    • (2010) Brain Res. , vol.1308 , pp. 58-67
    • Polgár, E.1    Wright, L.L.2    Todd, A.J.3
  • 68
    • 0030903732 scopus 로고    scopus 로고
    • Morphology and distribution of spinothalamic lamina i neurons in the monkey
    • Zhang, E. T. & Craig, A. D. Morphology and distribution of spinothalamic lamina I neurons in the monkey. J. Neurosci. 17, 3274-3284 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 3274-3284
    • Zhang, E.T.1    Craig, A.D.2
  • 69
    • 0029939970 scopus 로고    scopus 로고
    • Morphological classes of spinothalamic lamina i neurons in the cat
    • Zhang, E. T., Han, Z. S. & Craig, A. D. Morphological classes of spinothalamic lamina I neurons in the cat. J. Comp. Neurol. 367, 537-549 (1996).
    • (1996) J. Comp. Neurol. , vol.367 , pp. 537-549
    • Zhang, E.T.1    Han, Z.S.2    Craig, A.D.3
  • 70
    • 65549132753 scopus 로고    scopus 로고
    • Sensitization of lamina i spinoparabrachial neurons parallels heat hyperalgesia in the chronic constriction injury model of neuropathic pain
    • Andrew, D. Sensitization of lamina I spinoparabrachial neurons parallels heat hyperalgesia in the chronic constriction injury model of neuropathic pain. J. Physiol. 587, 2005-2017 (2009).
    • (2009) J. Physiol. , vol.587 , pp. 2005-2017
    • Andrew, D.1
  • 71
    • 0034076537 scopus 로고    scopus 로고
    • Physiological properties of the lamina i spinoparabrachial neurons in the rat
    • Bester, H., Chapman, V., Besson, J. M. & Bernard, J. F. Physiological properties of the lamina I spinoparabrachial neurons in the rat. J. Neurophysiol. 83, 2239-2259 (2000).
    • (2000) J. Neurophysiol. , vol.83 , pp. 2239-2259
    • Bester, H.1    Chapman, V.2    Besson, J.M.3    Bernard, J.F.4
  • 72
    • 1642267588 scopus 로고    scopus 로고
    • Distinctive membrane and discharge properties of rat spinal lamina i projection neurones in vitro
    • Ruscheweyh, R., Ikeda, H., Heinke, B. & Sandkuhler, J. Distinctive membrane and discharge properties of rat spinal lamina I projection neurones in vitro. J. Physiol. 555, 527-543 (2004).
    • (2004) J. Physiol. , vol.555 , pp. 527-543
    • Ruscheweyh, R.1    Ikeda, H.2    Heinke, B.3    Sandkuhler, J.4
  • 73
    • 17644371988 scopus 로고    scopus 로고
    • Response characterstics of spinothalamic tract neurons that project to the posterior thalamus in rats
    • Zhang, X. & Giesler, G. J. Jr. Response characterstics of spinothalamic tract neurons that project to the posterior thalamus in rats. J. Neurophysiol. 93, 2552-2564 (2005).
    • (2005) J. Neurophysiol. , vol.93 , pp. 2552-2564
    • Zhang, X.1    Giesler Jr., G.J.2
  • 74
    • 0015973811 scopus 로고
    • Responses of primate spinothalamic tract neurons to natural stimulation of hindlimb
    • Willis, W. D., Trevino, D. L., Coulter, J. D. & Maunz, R. A. Responses of primate spinothalamic tract neurons to natural stimulation of hindlimb. J. Neurophysiol. 37, 358-372 (1974).
    • (1974) J. Neurophysiol. , vol.37 , pp. 358-372
    • Willis, W.D.1    Trevino, D.L.2    Coulter, J.D.3    Maunz, R.A.4
  • 75
    • 0025813385 scopus 로고
    • Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin
    • Salter, M. W. & Henry, J. L. Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin. Neuroscience 43, 601-610 (1991).
    • (1991) Neuroscience , vol.43 , pp. 601-610
    • Salter, M.W.1    Henry, J.L.2
  • 76
    • 0030764290 scopus 로고    scopus 로고
    • Inhibition of hyperalgesia by ablation of lamina i spinal neurons expressing the substance P receptor
    • Mantyh, P. W. et al. Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science 278, 275-279 (1997).
    • (1997) Science , vol.278 , pp. 275-279
    • Mantyh, P.W.1
  • 77
    • 13044305848 scopus 로고    scopus 로고
    • Transmission of chronic nociception by spinal neurons expressing the substance P receptor
    • Nichols, M. L. et al. Transmission of chronic nociception by spinal neurons expressing the substance P receptor. Science 286, 1558-1561 (1999).
    • (1999) Science , vol.286 , pp. 1558-1561
    • Nichols, M.L.1
  • 78
    • 0029012284 scopus 로고
    • The types of neuron in spinal dorsal horn which possess neurokinin-1 receptors
    • Littlewood, N. K., Todd, A. J., Spike, R. C., Watt, C. & Shehab, S. A. The types of neuron in spinal dorsal horn which possess neurokinin-1 receptors. Neuroscience 66, 597-608 (1995).
    • (1995) Neuroscience , vol.66 , pp. 597-608
    • Littlewood, N.K.1    Todd, A.J.2    Spike, R.C.3    Watt, C.4    Shehab, S.A.5
  • 79
    • 0033134875 scopus 로고    scopus 로고
    • NK-1 receptor immunoreactivity in distinct morphological types of lamina i neurons of the primate spinal cord
    • Yu, X. H. et al. NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord. J. Neurosci. 19, 3545-3555 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 3545-3555
    • Yu, X.H.1
  • 80
    • 0037095729 scopus 로고    scopus 로고
    • Projection neurons in lamina i of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance P-containing afferents and respond to noxious stimulation
    • Todd, A. J. et al. Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance P-containing afferents and respond to noxious stimulation. J. Neurosci. 22, 4103-4113 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 4103-4113
    • Todd, A.J.1
  • 81
    • 77952547627 scopus 로고    scopus 로고
    • Tw o populations of neurokinin 1 receptor-expressing projection neurons in lamina i of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input
    • Polgár, E., Al Ghamdi, K. S. & Todd, A. J. Tw o populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input. Neuroscience 167, 1192-1204 (2010).
    • (2010) Neuroscience , vol.167 , pp. 1192-1204
    • Polgár, E.1    Al Ghamdi, K.S.2    Todd, A.J.3
  • 82
    • 58149374615 scopus 로고    scopus 로고
    • Large projection neurons in lamina i of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors
    • Polgár, E., Al-Khater, K. M., Shehab, S., Watanabe, M. & Todd, A. J. Large projection neurons in lamina I of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors. J. Neurosci. 28, 13150-13160 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 13150-13160
    • Polgár, E.1    Al-Khater, K.M.2    Shehab, S.3    Watanabe, M.4    Todd, A.J.5
  • 83
    • 0035793004 scopus 로고    scopus 로고
    • A population of large lamina i projection neurons with selective inhibitory input in rat spinal cord
    • Puskár, Z., Polgár, E. & Todd, A. J. A population of large lamina I projection neurons with selective inhibitory input in rat spinal cord. Neuroscience 102, 167-176 (2001).
    • (2001) Neuroscience , vol.102 , pp. 167-176
    • Puskár, Z.1    Polgár, E.2    Todd, A.J.3
  • 84
    • 0030839073 scopus 로고    scopus 로고
    • Cells in laminae III and IV of the rat spinal cord that possess the neurokinin-1 receptor and have dorsally directed dendrites receive a major synaptic input from tachykinin-containing primary afferents
    • Naim, M., Spike, R. C., Watt, C., Shehab, S. A. & Todd, A.J. Cells in laminae III and IV of the rat spinal cord that possess the neurokinin-1 receptor and have dorsally directed dendrites receive a major synaptic input from tachykinin-containing primary afferents. J. Neurosci. 17, 5536-5548 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 5536-5548
    • Naim, M.1    Spike, R.C.2    Watt, C.3    Shehab, S.A.4    Todd, A.J.5
  • 85
    • 33847670075 scopus 로고    scopus 로고
    • Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation
    • Polgár, E., Campbell, A. D., MacIntyre, L. M., Watanabe, M. & Todd, A. J. Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation. Mol. Pain 3, 4 (2007).
    • (2007) Mol. Pain , vol.3 , pp. 4
    • Polgár, E.1    Campbell, A.D.2    MacIntyre, L.M.3    Watanabe, M.4    Todd, A.J.5
  • 86
    • 0032466218 scopus 로고    scopus 로고
    • Cells in laminae III and IV of the rat spinal cord which possess the neurokinin-1 receptor receive monosynaptic input from myelinated primary afferents
    • Naim, M. M., Shehab, S. A. & Todd, A. J. Cells in laminae III and IV of the rat spinal cord which possess the neurokinin-1 receptor receive monosynaptic input from myelinated primary afferents. Eur. J. Neurosci. 10, 3012-3019 (1998).
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 3012-3019
    • Naim, M.M.1    Shehab, S.A.2    Todd, A.J.3
  • 87
    • 0032876841 scopus 로고    scopus 로고
    • Neurons in laminae III and IV of the rat spinal cord with the neurokinin-1 receptor receive few contacts from unmyelinated primary afferents which do not contain substance P
    • Sakamoto, H., Spike, R. C. & Todd, A. J. Neurons in laminae III and IV of the rat spinal cord with the neurokinin-1 receptor receive few contacts from unmyelinated primary afferents which do not contain substance P. Neuroscience 94, 903-908 (1999).
    • (1999) Neuroscience , vol.94 , pp. 903-908
    • Sakamoto, H.1    Spike, R.C.2    Todd, A.J.3
  • 88
    • 0033119709 scopus 로고    scopus 로고
    • GABAergic neurons that contain neuropeptide y selectively target cells with the neurokinin 1 receptor in laminae III and IV of the rat spinal cord
    • Polgár, E., Shehab, S. A., Watt, C. & Todd, A. J. GABAergic neurons that contain neuropeptide Y selectively target cells with the neurokinin 1 receptor in laminae III and IV of the rat spinal cord. J. Neurosci. 19, 2637-2646 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 2637-2646
    • Polgár, E.1    Shehab, S.A.2    Watt, C.3    Todd, A.J.4
  • 89
    • 77953188578 scopus 로고    scopus 로고
    • TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord
    • Uta, D. et al. TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord. Eur. J. Neurosci. 31, 1960-1973 (2010).
    • (2010) Eur. J. Neurosci. , vol.31 , pp. 1960-1973
    • Uta, D.1
  • 90
    • 51149102303 scopus 로고    scopus 로고
    • Innocuous not noxious, input activates PKCγ interneurons of the spinal dorsal horn via myelinated afferent fibers
    • Neumann, S., Braz, J. M., Skinner, K., Llewellyn-Smith, I. J. & Basbaum, A. I. Innocuous, not noxious, input activates PKCγ interneurons of the spinal dorsal horn via myelinated afferent fibers. J. Neurosci. 28, 7936-7944 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 7936-7944
    • Neumann, S.1    Braz, J.M.2    Skinner, K.3    Llewellyn-Smith, I.J.4    Basbaum, A.I.5
  • 91
    • 0142151031 scopus 로고    scopus 로고
    • Lack of evidence for sprouting of Abeta afferents into the superficial laminas of the spinal cord dorsal horn after nerve section
    • Hughes, D. I., Scott, D. T., Todd, A. J. & Riddell, J. S. Lack of evidence for sprouting of Abeta afferents into the superficial laminas of the spinal cord dorsal horn after nerve section. J. Neurosci. 23, 9491-9499 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 9491-9499
    • Hughes, D.I.1    Scott, D.T.2    Todd, A.J.3    Riddell, J.S.4
  • 92
    • 34248211748 scopus 로고    scopus 로고
    • Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat
    • Santos, S. F., Rebelo, S., Derkach, V. A. & Safronov, B.V. Excitatory interneurons dominate sensory processing in the spinal substantia gelatinosa of rat. J. Physiol. 581, 241-254 (2007).
    • (2007) J. Physiol. , vol.581 , pp. 241-254
    • Santos, S.F.1    Rebelo, S.2    Derkach, V.A.3    Safronov, B.V.4
  • 93
    • 21144437771 scopus 로고    scopus 로고
    • P boutons in lamina IX of the rodent spinal cord express high levels of glutamic acid decarboxylase-65 and originate from cells in deep medial dorsal horn
    • Hughes, D. I. et al. P boutons in lamina IX of the rodent spinal cord express high levels of glutamic acid decarboxylase-65 and originate from cells in deep medial dorsal horn. Proc. Natl Acad. Sci. USA 102, 9038-9043 (2005)
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 9038-9043
    • Hughes, D.I.1
  • 94
    • 0030466645 scopus 로고    scopus 로고
    • GABA and glycine in synaptic glomeruli of the rat spinal dorsal horn
    • Todd, A. J. GABA and glycine in synaptic glomeruli of the rat spinal dorsal horn. Eur. J. Neurosci. 8, 2492-2498 (1996).
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 2492-2498
    • Todd, A.J.1
  • 95
    • 0037190908 scopus 로고    scopus 로고
    • Synaptic relationships between hair follicle afferents and neurones expressing GABA and glycine-like immunoreactivity in the spinal cord of the rat
    • Watson, A. H., Hughes, D. I. & Bazzaz, A. A. Synaptic relationships between hair follicle afferents and neurones expressing GABA and glycine-like immunoreactivity in the spinal cord of the rat. J. Comp. Neurol. 452, 367-380 (2002).
    • (2002) J. Comp. Neurol. , vol.452 , pp. 367-380
    • Watson, A.H.1    Hughes, D.I.2    Bazzaz, A.A.3
  • 96
    • 0028999848 scopus 로고
    • Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation
    • Mantyh, P. W. et al. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science 268, 1629-1632 (1995).
    • (1995) Science , vol.268 , pp. 1629-1632
    • Mantyh, P.W.1
  • 97
    • 0036460778 scopus 로고    scopus 로고
    • Two major distinct subpopulations of neurokinin-3 receptor-expressing neurons in the superficial dorsal horn of the rat spinal cord
    • Ding, Y. Q. et al. Two major distinct subpopulations of neurokinin-3 receptor-expressing neurons in the superficial dorsal horn of the rat spinal cord. Eur. J. Neurosci. 16, 551-556 (2002).
    • (2002) Eur. J. Neurosci. , vol.16 , pp. 551-556
    • Ding, Y.Q.1
  • 98
    • 0030611545 scopus 로고    scopus 로고
    • Relationship of NK3 receptor-immunoreactivity to subpopulations of neurons in rat spinal cord
    • Seybold, V. S. et al. Relationship of NK3 receptor-immunoreactivity to subpopulations of neurons in rat spinal cord. J. Comp. Neurol. 381, 439-448 (1997).
    • (1997) J. Comp. Neurol. , vol.381 , pp. 439-448
    • Seybold, V.S.1
  • 99
    • 0032495861 scopus 로고    scopus 로고
    • A quantitative study of neurons which express neurokinin-1 or somatostatin sst2a receptor in rat spinal dorsal horn
    • Todd, A. J., Spike, R. C. & Polgar, E. A quantitative study of neurons which express neurokinin-1 or somatostatin sst2a receptor in rat spinal dorsal horn. Neuroscience 85, 459-473 (1998).
    • (1998) Neuroscience , vol.85 , pp. 459-473
    • Todd, A.J.1    Spike, R.C.2    Polgar, E.3
  • 100
    • 0030298514 scopus 로고    scopus 로고
    • The mu-opioid receptor (MOR1) is mainly restricted to neurons that do not contain GABA or glycine in the superficial dorsal horn of the rat spinal cord
    • Kemp, T., Spike, R. C., Watt, C. & Todd, A. J. The mu-opioid receptor (MOR1) is mainly restricted to neurons that do not contain GABA or glycine in the superficial dorsal horn of the rat spinal cord. Neuroscience 75, 1231-1238 (1996).
    • (1996) Neuroscience , vol.75 , pp. 1231-1238
    • Kemp, T.1    Spike, R.C.2    Watt, C.3    Todd, A.J.4
  • 101
    • 33644835431 scopus 로고    scopus 로고
    • The neuropeptide tyrosine Y1R is expressed in interneurons and projection neurons in the dorsal horn and area X of the rat spinal cord
    • Brumovsky, P. et al. The neuropeptide tyrosine Y1R is expressed in interneurons and projection neurons in the dorsal horn and area X of the rat spinal cord. Neuroscience 138, 1361-1376 (2006).
    • (2006) Neuroscience , vol.138 , pp. 1361-1376
    • Brumovsky, P.1
  • 102
    • 0032969282 scopus 로고    scopus 로고
    • The neuropeptide y Y1 receptor is a somatic receptor on dorsal root ganglion neurons and a postsynaptic receptor on somatostatin dorsal horn neurons
    • Zhang, X., Tong, Y. G., Bao, L. & Hokfelt, T. The neuropeptide Y Y1 receptor is a somatic receptor on dorsal root ganglion neurons and a postsynaptic receptor on somatostatin dorsal horn neurons. Eur. J. Neurosci. 11, 2211-2225 (1999).
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 2211-2225
    • Zhang, X.1    Tong, Y.G.2    Bao, L.3    Hokfelt, T.4
  • 103
    • 60349127812 scopus 로고    scopus 로고
    • Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro
    • Abe, K. et al. Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro. Neuroscience 159, 316-324 (2009).
    • (2009) Neuroscience , vol.159 , pp. 316-324
    • Abe, K.1
  • 104
    • 34347250846 scopus 로고    scopus 로고
    • Selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat
    • Lu, Y. & Perl, E. R. Selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat. J. Physiol. 582, 127-136 (2007).
    • (2007) J. Physiol. , vol.582 , pp. 127-136
    • Lu, Y.1    Perl, E.R.2
  • 105
    • 69049090729 scopus 로고    scopus 로고
    • Direct excitation of spinal GABAergic interneurons by noradrenaline
    • Gassner, M., Ruscheweyh, R. & Sandkuhler, J. Direct excitation of spinal GABAergic interneurons by noradrenaline. Pain 145, 204-210 (2009).
    • (2009) Pain , vol.145 , pp. 204-210
    • Gassner, M.1    Ruscheweyh, R.2    Sandkuhler, J.3
  • 106
    • 67349202612 scopus 로고    scopus 로고
    • Models and mechanisms of hyperalgesia and allodynia
    • Sandkuhler, J. Models and mechanisms of hyperalgesia and allodynia. Physiol. Rev. 89, 707-758 (2009).
    • (2009) Physiol. Rev. , vol.89 , pp. 707-758
    • Sandkuhler, J.1
  • 107
    • 32544460671 scopus 로고    scopus 로고
    • Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord
    • Torsney, C. & MacDermott, A. B. Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord. J. Neurosci. 26, 1833-1843 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 1833-1843
    • Torsney, C.1    MacDermott, A.B.2
  • 108
    • 0036703985 scopus 로고    scopus 로고
    • Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord
    • Moore, K. A. et al. Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J. Neurosci. 22, 6724-6731 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 6724-6731
    • Moore, K.A.1
  • 109
    • 0042860080 scopus 로고    scopus 로고
    • Trans-synaptic shift in anion gradient in spinal lamina i neurons as a mechanism of neuropathic pain
    • Coull, J. A. et al. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424, 938-942 (2003).
    • (2003) Nature , vol.424 , pp. 938-942
    • Coull, J.A.1
  • 110
    • 0032448274 scopus 로고    scopus 로고
    • Changes in GAD- and GABA-immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic precursors
    • Eaton, M. J., Plunkett, J. A., Karmally, S., Martinez, M. A. & Montanez, K. Changes in GAD- and GABA-immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic precursors. J. Chem. Neuroanat. 16, 57-72 (1998).
    • (1998) J. Chem. Neuroanat. , vol.16 , pp. 57-72
    • Eaton, M.J.1    Plunkett, J.A.2    Karmally, S.3    Martinez, M.A.4    Montanez, K.5
  • 111
    • 0030580562 scopus 로고    scopus 로고
    • Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts
    • Ibuki, T., Hama, A. T., Wang, X. T., Pappas, G. D. & Sagen, J. Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts. Neuroscience 76, 845-858 (1997).
    • (1997) Neuroscience , vol.76 , pp. 845-858
    • Ibuki, T.1    Hama, A.T.2    Wang, X.T.3    Pappas, G.D.4    Sagen, J.5
  • 112
    • 0031844349 scopus 로고    scopus 로고
    • Peripheral nerve insult induces NMDA receptor-mediated, delayed degeneration in spinal neurons
    • Azkue, J. J., Zimmermann, M., Hsieh, T. F. & Herdegen, T. Peripheral nerve insult induces NMDA receptor-mediated, delayed degeneration in spinal neurons. Eur. J. Neurosci. 10, 2204-2206 (1998).
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 2204-2206
    • Azkue, J.J.1    Zimmermann, M.2    Hsieh, T.F.3    Herdegen, T.4
  • 113
    • 23744437312 scopus 로고    scopus 로고
    • Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury
    • Scholz, J. et al. Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury. J. Neurosci. 25, 7317-7323 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 7317-7323
    • Scholz, J.1
  • 114
    • 0035871969 scopus 로고    scopus 로고
    • Cell death in the superficial dorsal horn in a model of neuropathic pain
    • Whiteside, G. T. & Munglani, R. Cell death in the superficial dorsal horn in a model of neuropathic pain. J. Neurosci. Res. 64, 168-173 (2001).
    • (2001) J. Neurosci. Res. , vol.64 , pp. 168-173
    • Whiteside, G.T.1    Munglani, R.2
  • 115
    • 22244446763 scopus 로고    scopus 로고
    • Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain
    • Polgár, E., Hughes, D. I., Arham, A. Z. & Todd, A. J. Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain. J. Neurosci. 25, 6658-6666 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 6658-6666
    • Polgár, E.1    Hughes, D.I.2    Arham, A.Z.3    Todd, A.J.4
  • 116
    • 4344618736 scopus 로고    scopus 로고
    • Lack of evidence for significant neuronal loss in laminae I-III of the spinal dorsal horn of the rat in the chronic constriction injury model
    • Polgár, E., Gray, S., Riddell, J. S. & Todd, A. J. Lack of evidence for significant neuronal loss in laminae I-III of the spinal dorsal horn of the rat in the chronic constriction injury model. Pain 111, 144-150 (2004).
    • (2004) Pain , vol.111 , pp. 144-150
    • Polgár, E.1    Gray, S.2    Riddell, J.S.3    Todd, A.J.4
  • 117
    • 51249118483 scopus 로고    scopus 로고
    • Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn
    • Polgár, E. & Todd, A. J. Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn. Neuroscience 156, 193-202 (2008).
    • (2008) Neuroscience , vol.156 , pp. 193-202
    • Polgár, E.1    Todd, A.J.2
  • 118
    • 0030966704 scopus 로고    scopus 로고
    • The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat
    • Hwang, J. H. & Yaksh, T. L. The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat. Pain 70, 15-22 (1997).
    • (1997) Pain , vol.70 , pp. 15-22
    • Hwang, J.H.1    Yaksh, T.L.2
  • 119
    • 0036237512 scopus 로고    scopus 로고
    • Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain
    • Malan, T. P., Mata, H. P. & Porreca, F. Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. Anesthesiology 96, 1161-1167 (2002).
    • (2002) Anesthesiology , vol.96 , pp. 1161-1167
    • Malan, T.P.1    Mata, H.P.2    Porreca, F.3
  • 120
    • 33845345216 scopus 로고    scopus 로고
    • Physiological properties of spinal lamina II GABAergic neurons in mice following peripheral nerve injury
    • Schoffnegger, D., Heinke, B., Sommer, C. & Sandkuhler, J. Physiological properties of spinal lamina II GABAergic neurons in mice following peripheral nerve injury. J. Physiol. 577, 869-878 (2006).
    • (2006) J. Physiol. , vol.577 , pp. 869-878
    • Schoffnegger, D.1    Heinke, B.2    Sommer, C.3    Sandkuhler, J.4
  • 121
    • 32844464001 scopus 로고    scopus 로고
    • Transient loss of terminals from non-peptidergic nociceptive fibers in the substantia gelatinosa of spinal cord following chronic constriction injury of the sciatic nerve
    • Bailey, A. L. & Ribeiro-da-Silva, A. Transient loss of terminals from non-peptidergic nociceptive fibers in the substantia gelatinosa of spinal cord following chronic constriction injury of the sciatic nerve. Neuroscience 138, 675-690 (2006).
    • (2006) Neuroscience , vol.138 , pp. 675-690
    • Bailey, A.L.1    Ribeiro-Da-Silva, A.2
  • 122
    • 0025316783 scopus 로고
    • Ultrastructural changes of the central scalloped (C1) primary afferent endings of synaptic glomeruli in the substantia gelatinosa Rolandi of the rat after peripheral neurotomy
    • Castro-Lopes, J. M., Coimbra, A., Grant, G. & Arvidsson, J. Ultrastructural changes of the central scalloped (C1) primary afferent endings of synaptic glomeruli in the substantia gelatinosa Rolandi of the rat after peripheral neurotomy. J. Neurocytol 19, 329-337 (1990).
    • (1990) J. Neurocytol , vol.19 , pp. 329-337
    • Castro-Lopes, J.M.1    Coimbra, A.2    Grant, G.3    Arvidsson, J.4
  • 123
    • 0037458899 scopus 로고    scopus 로고
    • Synaptic plasticity in spinal lamina i projection neurons that mediate hyperalgesia
    • Ikeda, H., Heinke, B., Ruscheweyh, R. & Sandkuhler, J. Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia. Science 299, 1237-1240 (2003).
    • (2003) Science , vol.299 , pp. 1237-1240
    • Ikeda, H.1    Heinke, B.2    Ruscheweyh, R.3    Sandkuhler, J.4
  • 124
    • 33745143553 scopus 로고    scopus 로고
    • Synaptic amplifier of inflammatory pain in the spinal dorsal horn
    • Ikeda, H. et al. Synaptic amplifier of inflammatory pain in the spinal dorsal horn. Science 312, 1659-1662 (2006).
    • (2006) Science , vol.312 , pp. 1659-1662
    • Ikeda, H.1
  • 125
    • 0141918783 scopus 로고    scopus 로고
    • AMPA receptor trafficking at excitatory synapses
    • Bredt, D. S. & Nicoll, R. A. AMPA receptor trafficking at excitatory synapses. Neuron 40, 361-379 (2003).
    • (2003) Neuron , vol.40 , pp. 361-379
    • Bredt, D.S.1    Nicoll, R.A.2
  • 126
    • 0037312605 scopus 로고    scopus 로고
    • PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
    • Esteban, J. A. et al. PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nature Neurosci. 6, 136-143 (2003).
    • (2003) Nature Neurosci. , vol.6 , pp. 136-143
    • Esteban, J.A.1
  • 127
    • 3042818669 scopus 로고    scopus 로고
    • Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen-unmasking method
    • Nagy, G. G. et al. Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen-unmasking method. J. Neurosci. 24, 5766-5777 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 5766-5777
    • Nagy, G.G.1
  • 128
    • 49049102134 scopus 로고    scopus 로고
    • Translocation of GluR1-containing AMPA receptors to a spinal nociceptive synapse during acute noxious stimulation
    • Larsson, M. & Broman, J. Translocation of GluR1-containing AMPA receptors to a spinal nociceptive synapse during acute noxious stimulation. J. Neurosci. 28, 7084-7090 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 7084-7090
    • Larsson, M.1    Broman, J.2
  • 129
    • 0027136681 scopus 로고
    • Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord
    • Randic, M., Jiang, M. C. & Cerne, R. Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord. J. Neurosci. 13, 5228-5241 (1993).
    • (1993) J. Neurosci. , vol.13 , pp. 5228-5241
    • Randic, M.1    Jiang, M.C.2    Cerne, R.3
  • 130
    • 0033490464 scopus 로고    scopus 로고
    • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    • Ji, R. R., Baba, H., Brenner, G. J. & Woolf, C. J. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nature Neurosci. 2, 1114-1119 (1999).
    • (1999) Nature Neurosci. , vol.2 , pp. 1114-1119
    • Ji, R.R.1    Baba, H.2    Brenner, G.J.3    Woolf, C.J.4
  • 131
    • 0026555273 scopus 로고
    • Peripheral nerve injury triggers central sprouting of myelinated afferents
    • Woolf, C. J., Shortland, P. & Coggeshall, R. E. Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature 355, 75-78 (1992).
    • (1992) Nature , vol.355 , pp. 75-78
    • Woolf, C.J.1    Shortland, P.2    Coggeshall, R.E.3
  • 132
    • 0033535120 scopus 로고    scopus 로고
    • Increased uptake and transport of cholera toxin B-subunit in dorsal root ganglion neurons after peripheral axotomy: Possible implications for sensory sprouting
    • Tong, Y. G. et al. Increased uptake and transport of cholera toxin B-subunit in dorsal root ganglion neurons after peripheral axotomy: possible implications for sensory sprouting. J. Comp. Neurol. 404, 143-158 (1999).
    • (1999) J. Comp. Neurol. , vol.404 , pp. 143-158
    • Tong, Y.G.1
  • 133
    • 0037469931 scopus 로고    scopus 로고
    • Evidence against cholera toxin B subunit as a reliable tracer for sprouting of primary afferents following peripheral nerve injury
    • Shehab, S. A., Spike, R. C. & Todd, A. J. Evidence against cholera toxin B subunit as a reliable tracer for sprouting of primary afferents following peripheral nerve injury. Brain Res. 964, 218-227 (2003).
    • (2003) Brain Res. , vol.964 , pp. 218-227
    • Shehab, S.A.1    Spike, R.C.2    Todd, A.J.3
  • 134
    • 42449159261 scopus 로고    scopus 로고
    • Identity of myelinated cutaneous sensory neurons projecting to nocireceptive laminae following nerve injury in adult mice
    • Woodbury, C. J., Kullmann, F. A., McIlwrath, S. L. & Koerber, H. R. Identity of myelinated cutaneous sensory neurons projecting to nocireceptive laminae following nerve injury in adult mice. J. Comp. Neurol. 508, 500-509 (2008).
    • (2008) J. Comp. Neurol. , vol.508 , pp. 500-509
    • Woodbury, C.J.1    Kullmann, F.A.2    McIlwrath, S.L.3    Koerber, H.R.4
  • 135
    • 0029954092 scopus 로고    scopus 로고
    • Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons
    • Neumann, S., Doubell, T. P., Leslie, T. & Woolf, C. J. Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons. Nature 384, 360-364 (1996).
    • (1996) Nature , vol.384 , pp. 360-364
    • Neumann, S.1    Doubell, T.P.2    Leslie, T.3    Woolf, C.J.4
  • 136
    • 0028334902 scopus 로고
    • Axotomy induces preprotachykinin gene expression in a subpopulation of dorsal root ganglion neurons
    • Noguchi, K., Dubner, R., De Leon, M., Senba, E. & Ruda, M. A. Axotomy induces preprotachykinin gene expression in a subpopulation of dorsal root ganglion neurons. J. Neurosci. Res. 37, 596-603 (1994).
    • (1994) J. Neurosci. Res. , vol.37 , pp. 596-603
    • Noguchi, K.1    Dubner, R.2    De Leon, M.3    Senba, E.4    Ruda, M.A.5
  • 137
    • 0033983432 scopus 로고    scopus 로고
    • Abnormal substance P release from the spinal cord following injury to primary sensory neurons
    • Malcangio, M., Ramer, M. S., Jones, M. G. & McMahon, S. B. Abnormal substance P release from the spinal cord following injury to primary sensory neurons. Eur. J. Neurosci. 12, 397-399 (2000).
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 397-399
    • Malcangio, M.1    Ramer, M.S.2    Jones, M.G.3    McMahon, S.B.4
  • 138
    • 33847236545 scopus 로고    scopus 로고
    • Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models
    • Hughes, D. I., Scott, D. T., Riddell, J. S. & Todd, A. J. Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models. J. Neurosci. 27, 2035-2044 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 2035-2044
    • Hughes, D.I.1    Scott, D.T.2    Riddell, J.S.3    Todd, A.J.4
  • 139
    • 0033555793 scopus 로고    scopus 로고
    • Peripheral inflammation facilitates Abeta fiber-mediated synaptic input to the substantia gelatinosa of the adult rat spinal cord
    • Baba, H., Doubell, T. P. & Woolf, C. J. Peripheral inflammation facilitates Abeta fiber-mediated synaptic input to the substantia gelatinosa of the adult rat spinal cord. J. Neurosci. 19, 859-867 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 859-867
    • Baba, H.1    Doubell, T.P.2    Woolf, C.J.3
  • 140
    • 40049085287 scopus 로고    scopus 로고
    • Spread of excitation across modality borders in spinal dorsal horn of neuropathic rats
    • Schoffnegger, D., Ruscheweyh, R. & Sandkuhler, J. Spread of excitation across modality borders in spinal dorsal horn of neuropathic rats. Pain 135, 300-310 (2008).
    • (2008) Pain , vol.135 , pp. 300-310
    • Schoffnegger, D.1    Ruscheweyh, R.2    Sandkuhler, J.3
  • 141
    • 0035310419 scopus 로고    scopus 로고
    • Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury
    • Okamoto, M. et al. Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury. J. Physiol. 532, 241-250 (2001).
    • (2001) J. Physiol. , vol.532 , pp. 241-250
    • Okamoto, M.1
  • 142
    • 0037386202 scopus 로고    scopus 로고
    • Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn
    • Kohno, T., Moore, K. A., Baba, H. & Woolf, C. J. Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn. J. Physiol. 548, 131-138 (2003).
    • (2003) J. Physiol. , vol.548 , pp. 131-138
    • Kohno, T.1    Moore, K.A.2    Baba, H.3    Woolf, C.J.4
  • 143
    • 0026489248 scopus 로고
    • Functional properties and axon terminations of interneurons in laminae III-V of the mammalian spinal dorsal horn in vitro
    • Schneider, S. P. Functional properties and axon terminations of interneurons in laminae III-V of the mammalian spinal dorsal horn in vitro. J. Neurophysiol. 68, 1746-1759 (1992).
    • (1992) J. Neurophysiol. , vol.68 , pp. 1746-1759
    • Schneider, S.P.1
  • 144
    • 0036196635 scopus 로고    scopus 로고
    • The caudal medullary ventrolateral reticular formation in nociceptive-cardiovascular integration. An experimental study in the rat
    • Lima, D., Albino-Teixeira, A. & Tavares, I. The caudal medullary ventrolateral reticular formation in nociceptive-cardiovascular integration. An experimental study in the rat. Exp. Physiol. 87, 267-274 (2002).
    • (2002) Exp. Physiol. , vol.87 , pp. 267-274
    • Lima, D.1    Albino-Teixeira, A.2    Tavares, I.3
  • 145
    • 0036199063 scopus 로고    scopus 로고
    • The nucleus of the solitary tract: An integrating station for nociceptive and cardiorespiratory afferents
    • Boscan, P., Pickering, A. E. & Paton, J. F. The nucleus of the solitary tract: an integrating station for nociceptive and cardiorespiratory afferents. Exp. Physiol. 87, 259-266 (2002).
    • (2002) Exp. Physiol. , vol.87 , pp. 259-266
    • Boscan, P.1    Pickering, A.E.2    Paton, J.F.3
  • 146
    • 0036199626 scopus 로고    scopus 로고
    • Pain pathways and parabrachial circuits in the rat
    • Gauriau, C. & Bernard, J. F. Pain pathways and parabrachial circuits in the rat. Exp. Physiol. 87, 251-258 (2002).
    • (2002) Exp. Physiol. , vol.87 , pp. 251-258
    • Gauriau, C.1    Bernard, J.F.2
  • 147
    • 63449092750 scopus 로고    scopus 로고
    • Descending control of nociception: Specificity, recruitment and plasticity
    • Heinricher, M. M., Tavares, I., Leith, J. L. & Lumb, B. M. Descending control of nociception: Specificity, recruitment and plasticity. Brain Res. Rev. 60, 214-225 (2009).
    • (2009) Brain Res. Rev. , vol.60 , pp. 214-225
    • Heinricher, M.M.1    Tavares, I.2    Leith, J.L.3    Lumb, B.M.4
  • 148
    • 0842305754 scopus 로고    scopus 로고
    • Posterior triangular thalamic neurons convey nociceptive messages to the secondary somatosensory and insular cortices in the rat
    • Gauriau, C. & Bernard, J. F. Posterior triangular thalamic neurons convey nociceptive messages to the secondary somatosensory and insular cortices in the rat. J. Neurosci. 24, 752-761 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 752-761
    • Gauriau, C.1    Bernard, J.F.2
  • 149
    • 0018568191 scopus 로고
    • Autotomy following peripheral nerve lesions: Experimental anaesthesia dolorosa
    • Wall, P. D. et al. Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa. Pain 7, 103-111 (1979).
    • (1979) Pain , vol.7 , pp. 103-111
    • Wall, P.D.1
  • 150
    • 0034255439 scopus 로고    scopus 로고
    • Spared nerve injury: An animal model of persistent peripheral neuropathic pain
    • Decosterd, I. & Woolf, C. J. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87, 149-158 (2000).
    • (2000) Pain , vol.87 , pp. 149-158
    • Decosterd, I.1    Woolf, C.J.2
  • 151
    • 0023895875 scopus 로고
    • A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
    • Bennett, G. J. & Xie, Y. K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33, 87-107 (1988).
    • (1988) Pain , vol.33 , pp. 87-107
    • Bennett, G.J.1    Xie, Y.K.2
  • 152
    • 0026727999 scopus 로고
    • An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
    • Kim, S. H. & Chung, J. M. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50, 355-363 (1992).
    • (1992) Pain , vol.50 , pp. 355-363
    • Kim, S.H.1    Chung, J.M.2
  • 153
    • 0019732156 scopus 로고
    • Spinal cord collaterals from axons of type II slowly adapting units in the cat
    • Brown, A. G., Fyffe, R. E., Rose, P. K. & Snow, P. J. Spinal cord collaterals from axons of type II slowly adapting units in the cat. J. Physiol. 316, 469-480 (1981).
    • (1981) J. Physiol. , vol.316 , pp. 469-480
    • Brown, A.G.1    Fyffe, R.E.2    Rose, P.K.3    Snow, P.J.4
  • 154
    • 0018770078 scopus 로고
    • Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers
    • Light, A. R. & Perl, E. R. Spinal termination of functionally identified primary afferent neurons with slowly conducting myelinated fibers. J. Comp. Neurol. 186, 133-150 (1979).
    • (1979) J. Comp. Neurol. , vol.186 , pp. 133-150
    • Light, A.R.1    Perl, E.R.2
  • 155
    • 0024439424 scopus 로고
    • Morphology and somatotopic organization of the central terminals of hindlimb hair follicle afferents in the rat lumbar spinal cord
    • Shortland, P., Woolf, C. J. & Fitzgerald, M. Morphology and somatotopic organization of the central terminals of hindlimb hair follicle afferents in the rat lumbar spinal cord. J. Comp. Neurol. 289, 416-433 (1989).
    • (1989) J. Comp. Neurol. , vol.289 , pp. 416-433
    • Shortland, P.1    Woolf, C.J.2    Fitzgerald, M.3
  • 156
    • 43249093054 scopus 로고    scopus 로고
    • Postnatal changes in the Rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat
    • Lorenzo, L. E., Ramien, M., St. Louis, M., De Koninck, Y. & Ribeiro-da-Silva, A. Postnatal changes in the Rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat. J. Comp. Neurol. 508, 592-604 (2008).
    • (2008) J. Comp. Neurol. , vol.508 , pp. 592-604
    • Lorenzo, L.E.1    Ramien, M.2    St. Louis, M.3    De Koninck, Y.4    Ribeiro-Da-Silva, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.