Noxious heat activates all capsaicin-sensitive and also a sub-population of capsaicin-insensitive dorsal root ganglion neurons

Neuroscience

Volumn 88, Issue 4, 1999, Pages 995-997

  Nagy, I ^a   Rang, H ^a  

^a Novartis Inst for Medical Research   (United Kingdom)

Author keywords

Capsaicin; Noxious heat threshold; Sensory neurons; Thermosensitivity; Whole cell voltage clamp

Indexed keywords

CAPSAICIN; VANILLOID RECEPTOR;

ANIMAL TISSUE; ARTICLE; CELL TYPE; CONTROLLED STUDY; HEAT SENSITIVITY; MALE; NERVE CELL STIMULATION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION; THERMAL STIMULATION;

ANIMALS; CAPSAICIN; CELLS, CULTURED; GANGLIA, SPINAL; HEAT; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SENSORY THRESHOLDS; THERMORECEPTORS;

EID: 0032889729     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00535-1     Document Type: Article

References (13)

1. Campbell J. N. and Meyer R. A. (1996) Cutaneous nociceptors. In Neurobiology of Nociceptors (eds Belmonte C. and Cervero F.), pp. 117-145. Oxford University Press, Oxford.
2. Caterina M. J., Schumacher M. A., Tominaga M., Rosen T. A., Levine J. D., Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 389:1997;816-824.
3. Cesare P., McNaughton P. A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc. natn. Acad. Sci. U.S.A. 93:1996;15435-15439.
4. Chen X., Belmonte C., Rang H. P. Capsaicin and carbon dioxide act by distinct mechanisms on sensory nerve terminals in the cat cornea. Pain. 70:1997;23-29.
5. Kirschstein T., Busselberg D., Treede R.-D. Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons. Neurosci. Lett. 231:1997;33-36.
6. Leem J. W., Willis W. D., Chung J. M. Cutaneous sensory receptors in the rat foot. J. Neurophysiol. 69:1993;1684-1699.
7. Nagy I., Rang H. Noxious heat activated currents in rat dorsal root ganglion neurons. J. Physiol. 506:1998;153P.
8. Nagy I., Rang H. Noxious heat-activated microscopic currents in rat dorsal root ganglion neurones. J. Physiol. 507:1998;29P.
9. Reichling D. B., Levine J. D. Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel. Proc. natn. Acad. Sci. U.S.A. 94:1997;7006-7011.
10. Seno N., Dray A. Capsaicin-induced activation of fine afferent fibres from rat skin in vitro. Neuroscience. 55:1993;563-569.
11. Simone D. E., Kajander K. C. Responses of cutaneous A-fiber nociceptors to noxious cold. J. Neurophysiol. 77:1997;2049-2060.
12. Szolcsanyi J. Effect of pain-producing chemical agents on the activity of slowly conducting afferent fibres. Acta Physiol. Acad. Sci. Hung. 56:1980;86.
13. Treede R. D., Meyer R. A., Raja S. N., Campbell J. N. Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. J. Physiol. 483:1995;747-758.