Discovery of XEN907, a spirooxindole blocker of Na V1.7 for the treatment of pain

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 12, 2011, Pages 3676-3681

  Chowdhury, Sultan ^a   Chafeev, Mikhail ^a   Liu, Shifeng ^a   Sun, Jianyu ^a   Raina, Vandna ^a   Chui, Ray ^a   Young, Wendy ^a   Kwan, Rainbow ^a   Fu, Jianmin ^a   Cadieux, Jay A ^a  

^a Xenon Pharmaceuticals Inc   (Canada)

Author keywords

Oxindole; Pain; SCN9A; Sodium channel; Spirooxindole

Indexed keywords

ANALGESIC AGENT; OXINDOLE; SODIUM CHANNEL NAV1.7; TETRACAINE; TETRODOTOXIN; UNCLASSIFIED DRUG; XEN 907;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOG; DRUG ABSORPTION; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; NONHUMAN; PAIN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANALGESICS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PAIN; SODIUM CHANNELS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79957814341     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.088     Document Type: Article

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