UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 34, 2013, Pages

  Moore, Carlene ^a   Cevikbas, Ferda ^b   Pasolli, H Amalia ^c   Chen, Yong ^a   Kong, Wei ^d   Kempkes, Cordula ^b   Parekh, Puja ^a   Lee, Suk Hee ^a   Kontchou, Nelly Ange ^a   Ye, Iwei ^b   Jokerst, Nan Marie ^d   Fuchs, Elaine ^c   Steinhoff, Martin ^b   Liedtke, Wolfgang B ^a,e  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d Duke University   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Calcium permeable channels; Epithelial neuronal cross talk; Photodermatitis; Phototransduction

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; CYTOKERATIN 1; ENDOTHELIN 1; GSK 205; INTERLEUKIN 6; MESSENGER RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR ANTAGONIST; TRPV4 PROTEIN, MOUSE; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SURFACE; CONTROLLED STUDY; EPIDERMIS; GENE SILENCING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; INNERVATION; KERATINOCYTE; MACROPHAGE; MECHANICAL STIMULATION; MELANOCYTE; MERKEL CELL; MOUSE; NEUTROPHIL; NOCICEPTION; NONHUMAN; PHOTODERMATOSIS; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RADIATION ABSORPTION; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SKIN CELL; SKIN DEFECT; SKIN EPITHELIUM; SKIN PAIN; SUNBURN; TACTILE DISCRIMINATION; TOPICAL TREATMENT; ULTRAVIOLET B RADIATION; ULTRAVIOLET RADIATION; ANALYSIS OF VARIANCE; ANIMAL; CELL CULTURE; CYTOLOGY; ELECTRON MICROSCOPY; EPITHELIUM CELL; METABOLISM; PAIN; PATHOLOGY; RADIATION RESPONSE; SKIN; TRANSGENIC MOUSE;

ANALYSIS OF VARIANCE; ANIMALS; CELLS, CULTURED; ENDOTHELIN-1; EPITHELIAL CELLS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; PAIN; SIGNAL TRANSDUCTION; SKIN; SUNBURN; TRPV CATION CHANNELS; ULTRAVIOLET RAYS;

EID: 84882743050     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1312933110     Document Type: Article

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