Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins

Cancer Research

Volumn 61, Issue 9, 2001, Pages 3760-3769

  Tsavaler, Larisa ^a   Shapero, Michael H ^a   Morkowski, Stan ^a   Laus, Reiner ^a  

^a Dendreon   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; COMPLEMENTARY DNA; GENE PRODUCT; MESSENGER RNA; PROTEIN TRP P8; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BREAST TUMOR; COLON TUMOR; CONTROLLED STUDY; DNA LIBRARY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LUNG TUMOR; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PREDICTION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DOMAIN; RECEPTOR POTENTIAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SKIN TUMOR;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CALCIUM CHANNELS; CLONING, MOLECULAR; COS CELLS; CRICETINAE; DNA, COMPLEMENTARY; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION; ION CHANNELS; MALE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; ORGAN SPECIFICITY; PROSTATE; PROSTATIC NEOPLASMS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TRPM CATION CHANNELS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 0035328671     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Cancer statistics, 1996
2. Purification of a human prostate specific antigen
3. The second stanford conference on international standardization of prostate specific antigen assays
4. Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening
5. Serum concentrations of prostate specific antigen and its complex with α1-antichymotrypsin before diagnosis of prostate cancer
6. Correlation of serum concentrations of PSA-ACT complex with total PSA in random and serial specimens from patients with BPH and prostate cancer
7. Measurement of the proportion of free to total prostate-specific antigen improves diagnostic performance of prostate-specific antigen in the diagnostic gray zone of total prostate-specific antigen
8. The value of screening tests in the detection of prostate cancer. Part II: Retrospective analysis of free/total prostate-specific analysis ratio, age-specific reference ranges, and PSA density
9. Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
10. Monoclonal antibody 7E11. C5 staining of viable LNCaP cells
11. Comparison of serum PSMA, PSA levels with results of Cytogen-356 ProstaScint scanning in prostatic cancer patients
12. Comparison of prostate specific antigen, prostate specific membrane antigen, and LNCaP-based enzyme-linked immunosorbent assays in prostatic cancer patients and patients with benign prostatic enlargement
13. Western blot assay for prostate-specific membrane antigen in serum of prostate cancer patients
14. Generation of human cytolytic T lymphocyte lines directed against prostate-specific antigen (PSA) employing a PSA oligoepitope peptide
15. Infusion of dendritic cells pulsed with HLA-A2-specific prostate- specific membrane antigen peptides: A Phase II prostate cancer vaccine trial involving patients with hormone-refractory metastatic disease
16. 2+ mobilization
17. 2+ channel protein (TRPC7) highly expressed in brain
18. Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis
19. Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)
20. Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries
21. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
22. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
23. Molecular characterization of the Drosophila trp locus: A putative integral membrane protein required for phototransduction
24. Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene
25. 2+ entry
26. 2+-permeable cation channel activated by calcium store depletion
27. TRPC1, a human homolog of a Drosophila store-operated channel
28. New light on TRP and TRPL
29. Coassembly of TRP and TRPL produces a distinct store-operated conductance
30. Capacitative calcium entry revisited
31. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
32. LNCaP model of human prostatic carcinoma
33. Establishment and characterization of a human prostatic carcinoma cell line (PC-3)
34. Isolation of a human prostate carcinoma cell line (DU 145)
35. Isolation of cDNAs that are differentially expressed between androgen-dependent and androgen-independent prostate carcinoma cells using differential display PCR
36. A new era for cancer immunotherapy based on the genes that encode cancer antigens
37. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening
38. 2+ mobilization on expression of androgen-regulated genes: Interference with androgen receptor-mediated transactivation by AP-1 proteins