Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased α2C-adrenoceptor co-expression and functional inhibition by clonidine

Pain

Volumn 113, Issue 3, 2005, Pages 386-394

  Ma, Weiya ^a   Zhang, Yong ^a   Bantel, Carsten ^a   Eisenach, James C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenergic; Capsaicin; Dorsal root ganglion; Immunocytochemistry; Intracellular calcium; Peripheral nerve

Indexed keywords

ALPHA 2C ADRENERGIC RECEPTOR; CALCIUM; CAPSAICIN; CLONIDINE; ION CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CALCIUM CELL LEVEL; CELL COUNT; CELL DAMAGE; CONTROLLED STUDY; DRUG RESPONSE; ELECTRIC FIELD; ELECTROSTIMULATION; EXPERIMENTAL TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INHIBITION KINETICS; LUMBAR SPINE; MALE; MICROSCOPY; NERVE CELL; NERVE INJURY; NERVE LIGATION; NONHUMAN; PERFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL GANGLION; SPINAL NERVE; STIMULATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CALCIUM; CELL COUNT; CELL SIZE; CLONIDINE; FUNCTIONAL LATERALITY; FURA-2; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; ION CHANNELS; LIGATION; MALE; NEURAL INHIBITION; NEURONS; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; SPINAL CORD INJURIES; TIME FACTORS; TRPV CATION CHANNELS;

EID: 12344278982     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2004.11.018     Document Type: Article

References (33)

1. M.J. Caterina, M.A. Schumacher, M. Tominaga, T.A. Rosen, J.D. Levine, and D. Julius The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature 389 1997 816 824
2. M. Chacur, E.D. Milligan, L.S. Gazda, C. Armstrong, H. Wang, K.J. Tracey, S.F. Maier, and L.R. Watkins A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats Pain 94 2001 231 244
3. S.R. Chaplan, F.W. Bach, J.W. Pogrel, J.M. Chung, and T.L. Yaksh Quantitative assessment of tactile allodynia in the rat paw J Neurosci Methods 53 1994 55 63
4. 2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain Neuroreport 8 1997 3119 3122
5. K.D. Davis, R.D. Treede, S.N. Raja, R.A. Meyer, and J.N. Campbell Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain Pain 47 1991 309 317
6. F. Duflo, X. Li, C. Bantel, C. Pancaro, M. Vincler, and J.C. Eisenach Peripheral nerve injury alters the α-adrenoceptor subtype activated by clonidine for analgesia Anesthesiology 97 2002 636 641
7. F. Duflo, Y. Zhang, and J.C. Eisenach Electrical field stimulation to study inhibitory mechanisms in individual sensory neurons in culture Anesthesiology 100 2004 740 743
8. J.C. Eisenach, S. DuPen, M. Dubois, R. Miguel, and D. Allin Epidural Clonidine Study Group. Epidural clonidine analgesia for intractable cancer pain Pain 61 1995 391 399
9. 2-adrenergic agonists for regional anesthesia - a clinical review of clonidine (1984-1995) Anesthesiology 85 1996 655 674
10. C.A. Fairbanks, L.S. Stone, K.F. Kitto, H.O. Nguyen, I.J. Posthumus, and G.L. Wilcox alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic- opioid synergy J Pharmacol Exp Ther 300 2002 282 290
11. + and K+ channels of dorsal root ganglion neurons in a neuropathic pain model Brain Res 832 1999 195 206
12. L.J. Hudson, S. Bevan, G. Wotherspoon, C. Gentry, A. Fox, and J. Winter VR1 protein expression increases in undamaged DRG neurons after partial nerve injury Eur J Neurosci 13 2001 2105 2114
13. S.H. Kim, and J.M. Chung An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat Pain 50 1992 355 363
14. W. Ma, W.H. Zheng, S. Kar, and R. Quirion Morphine treatment induced calcitonin gene-related peptide and substance P increases in cultured dorsal root ganglion neurons Neuroscience 99 2000 529 539
15. M.H. Ossipov, D. Bian, T.P. Malan Jr, J. Lai, and F. Porreca Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats Pain 79 1999 127 133
16. Y.Z. Pan, and H.L. Pan Primary afferent stimulation differentially potentiates excitatory and inhibitory inputs to spinal lamina II outer and inner neurons J Neurophysiol 91 2004 2413 2421
17. 2-adrenergic receptors J Neurophysiol 87 2002 1938 1947
18. M. Petersen, J. Zhang, J.M. Zhang, and R.H. LaMotte Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction Pain 67 1996 391 397
19. J.D. Pomonis, J.E. Harrison, L. Mark, D.R. Bristol, K.J. Valenzano, and K.N. Walker N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl) tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflammatory and neuropathic pain J Pharmacol Exp Ther 306 2003 387 393
20. 2-adrenoceptors Anesth Analg 87 1998 941 948
21. L.S. Premkumar, and G.P. Ahern Induction of vanilloid receptor channel activity by protein kinase C Nature 408 2000 985 990
22. 2-adrenoceptor agonists clonidine and dexmedetomidine on the prevention and treatment of experimental neuropathic pain Anesth Analg 77 1993 104 109
23. R. Radhakrishnan, S.A. Moore, and K.A. Sluka Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats Pain 104 2003 567 577
24. M.H. Rashid, M. Inoue, S. Kondo, T. Kawashima, S. Bakoshi, and H. Ueda Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain J Pharmacol Exp Ther 304 2003 940 948
25. J. Sato, and E.R. Perl Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury Science 251 1991 1608 1610
26. 2-adrenoceptors in rat dorsal root ganglia Pain 84 2000 319 330
27. L.S. Stone, L. Vulchanova, M.S. Riedl, J. Wang, F.G. Williams, G.L. Wilcox, and R. Elde Effects of peripheral nerve injury on alpha-2A and alpha-2C adrenergic receptor immunoreactivity in the rat spinal cord Neuroscience 93 1999 1399 1407
28. Y.M. Ulrich-Lai, C.M. Flores, C.A. Harding-Rose, H.E. Goodis, and K.M. Hargreaves Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from rat trigeminal ganglion: evidence for intraganglionic neurotransmission Pain 91 2001 219 226
29. K.M. Walker, L. Urban, S.J. Medhurst, S. Patel, M. Panesar, A.J. Fox, and P. McIntyre The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain J Pharmacol Exp Ther 304 2003 56 62
30. R. Wang, W. Guo, M.H. Ossipov, T.W. Vanderah, F. Porreca, and J. Lai Glial cell line-derived neurotrophic factor normalized neurochemical chances in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain Neuroscience 121 2003 815 824
31. J.L. Xing, S.J. Hu, Z. Jian, and J.H. Duan Subthreshold membrane potential oscillation mediates the excitatory effect of norepinephrine in chronically compressed dorsal root ganglion neurons in the rat Pain 105 2003 177 183
32. J. Yagi, and R. Sumino Inhibition of a hyperpolarization-activated current by clonidine in rat dorsal root ganglion neurons J Neurophysiol 80 1998 1094 1104
33. J.M. Zhang, X.J. Song, and R.H. LaMotte An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion Pain 72 1997 51 57