Advances of Research on Glycinin and β-Conglycinin: A Review of Two Major Soybean Allergenic Proteins

Critical Reviews in Food Science and Nutrition

Volumn 54, Issue 7, 2014, Pages 850-862

  Wang, Tao ^a   Qin, Gui Xin ^a   Sun, Ze Wei ^a   Zhao, Yuan ^a  

^a JILIN AGRICULTURAL UNIVERSITY   (China)

Author keywords

Allergenicity; detection or exploration methods; glycinin; in vivo research models; ingredient processing; conglycinin

Indexed keywords

ALLERGENS; ANIMALS; RESEARCH;

ALLERGENICITY; CONGLYCININ; EXPLORATION METHODS; GLYCININ; RESEARCH MODELS;

PROTEINS;

ALLERGEN; BETA CONGLYCININ PROTEIN, GLYCINE MAX; BETA-CONGLYCININ PROTEIN, GLYCINE MAX; GLOBULIN; GLYCININ; PLANT ANTIGEN; SEED STORAGE PROTEIN; SOYBEAN PROTEIN;

ANIMAL; ANIMAL MODEL; CHEMISTRY; DISEASE MODEL; FERMENTATION; FOOD ALLERGY; FOOD HANDLING; HUMAN; IMMUNOLOGY; METHODOLOGY; MOUSE; RAT; REVIEW; SOYBEAN; SWINE;

ALLERGENS; ANIMALS; ANTIGENS, PLANT; DISEASE MODELS, ANIMAL; FERMENTATION; FOOD HANDLING; FOOD HYPERSENSITIVITY; GLOBULINS; HUMANS; MICE; MODELS, ANIMAL; RATS; SEED STORAGE PROTEINS; SOYBEAN PROTEINS; SOYBEANS; SWINE;

EID: 84893619723     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408398.2011.613534     Document Type: Article

References (200)

1. Achouri, A., Joyce, I. B., Yaylayan, V. A. and Yeboah, F. K. 2005. Functional properties of glycated soy 11S glycinin. J. Food. Sci., 70 (4): 269-274.
2. Adachi, A., Horikawa, T., Shimizu, H., Sarayama, Y., Ogawa, T. and Sjolander, S. 2008. Soybean β-conglycinin as the main allergen in a patient with food-dependent exercise-induced anaphylaxis by tofu: Food processing alters pepsin resistance. Clin. Exp. Allergy, 39: 167-173.
3. Adachi, M., Kanamori, J., masuda, T., Yagasaki, K., Kitamura, K., Mikami, B. and Utsumi, S. 2003. Crystal structure of soybean 11S glycinin A3B4 homohexamer. Proc. Natl. Acad. Sci. USA., 100 (12): 7395-7400.
4. Adachi, M., Takenaka, Y., Gidamis, A. B., Mikami, B. and Utsumi, S. 2001. Crystal structure of soybean proglycinin A1aB1b homotrimer. J. Mol. Biol., 305 (2): 291-305.
5. Aguirre, L., Garro, M. S. and de Giori, G. S. 2008. Enzymatic hydrolysis of soybean protein using lactic acid bacteria. Food Chem., 111: 976-982.
6. Aldrich, C. G., Merchen, N. R. and Drackley, J. K. 1995. The effect of roasting temperature applied to whole soybeans on site of digestion by steers. I: Organic matter, energy, fiber, and fatty acid digestion. J. Anim. Sci., 93 (7): 2120-2130.
7. 1999. Allergen Data Collection: Soybean (Glycine max). Internet Symp. Food Allergens., 1 (2): 51-79. Available from http://www.food-allergens.de
8. Amigo-Benavent, M., Athanasopoulos, V. I., Ferranti, P., Villamiel, M. and del Castillo, M. D. 2009. Carbohydrate moieties on the in vitro immunoreactivity of soy β-conglycinin. Food Res. Int., 42: 819-825.
9. Amnuaycheewa, P. and deMejia, E. G. 2010. Purification, characterisation, and quantification of the soy allergen profilin (Gly m 3) in soy products. Food Chem., 119: 1671-1680.
10. Astwood, J. D., Leach, J. N. and Fuchs, R. L. 1996. Stability of food allergens to digestion in vitro. Nat. Biotechnol., 14: 1269-1273.
11. Badley, R. A., Atkinson, D., Hauser, H., Oldani, D., Green, J. P. and Stubbs, J. M. 1975. The structure, physical and chemical properties of the soy bean protein glycinin. Biochim. Biophys. Acta-Protein Structure, 412 (2): 214-228.
12. Ballmer-Weber, B. K., Holzhauser, T., Scibilia, J., Mittag, D., Zisa, G., Ortolani, C., Oesterballe, M., Poulsen, L. K., Vieths, S. and Bindslev-Jensen, C. 2007. Clinical characteristics of soybean allergy in Europe: A double-blind, placebo-controlled food challenge study. J. Allergy Clin. Immunol., 119: 1489-1496.
13. Bals, R. and Welsch, U. 1997. Lectins and antibodies to blood group antigens as markers for the basal cells of the human respiratory epithelium. Microsc. Res. Techniq, 38 (5): 505-511.
14. Barać, M. and Stanojević, S. 2005. The effect of microwave roasting on soybean protein composition and components with trypsin inhibitor activity. Acta Alimentaria, 34 (1): 23-31.
15. Beardslee, T. A. 2000. IgE epitope mapping of soybean glycinin G1 acidic chain. Paper AAI9976975, ETD collection for University of Nebraska, Lincoln, NE
16. Beardslee, T. A., Zeece, M. G., Sarath, G. and Markwell, J. P. 2000. Soybean glycinin G1 acidic chain shares IgE epitopes with peanut allergen Arah3. Int. Arch. Allergy Immunol., 123: 299-307.
17. Bennis, A. 1998. Asthma and food allergy. Revue Française d'Allergologie et 'Immunologie Clinique, 38 (7S): 186-195.
18. Berk, Z. 1992. Technology of Production of edible flours and protein products from soybeans. Food and Agriculture Organization of the United Nations Rome 1992.
19. Birk, Y. 1985. The Bowman-Birk inhibitor. Trypsin- and chymotrypsin-inhibitor from soybeans. Int. J. Peptide Protein Res., 25 (2): 113-131.
20. Bittencourt, A. L., Soares, M. F. M., Piresm, R. R., Honmoto, C. S., Tanaka, M. K. and Jacob, C. M. 2007. Immunogenicity and allergenicity of 2S, 7S and 11S soy protein fractions. Braz. J. Pharm. Sci., 43 (4): 597-605.
21. Boge, E. L., Boylston, T. D. and Wilson, L. A. 2009. Effect of cultivar and roasting method on composition of roasted soybeans. J. Sci. Food Agric., 89 (5): 821-826.
22. Brandão, A. R., Barbosa, H. S. and Arruda, M. A. Z. 2010. Image analysis of two-dimensional gel electrophoresis for comparative proteomics of transgenic and non-transgenic soybean seeds. J. Proteomics, 73 (8): 1433-1440.
23. Breiteneder, H. and Radauer, C. 2004. " A classification of plant food allergens ". In J. Allergy Clin. Immunol Vol. 113(5), 821-830.
24. Burks, A. W. Jr., Brooks, J. R. and Sampson, H. A. 1988. Allergenicity of major component proteins of soybean assay (ELISA) and immunoblotting in children with atopic dermatitis and positive soy challenges. J. Allergy Clin. Immunol., 81: 1135-1142.
25. Burks, A. W., Cockrell, G., Connaughton, C., Guin, J., Allen, W. and Helmet, R. M. 1994. Identification of peanut agglutinin and soybean trypsin inhibitor as minor legume allergens. Int Arch Allergy Immunol., 105 (2): 143-149.
26. Canadian Food Inspection Agency. (2007). Soy: One of the nine most common food allergens. Available from http://dsp-psd.pwgsc.gc.ca/Collection/A104-27-2-2005E.pdf.
27. Cantani, A. 2008. Pediatric Allergy, Asthma and Immunology, 1st ed., 652 Germany: Springer-Verlag, Berlin-Heidelberg.
28. Catsimpoolas, N., Campbell, T. G. and Meyer, E. W. 1968. Immunochemical study of changes in reserve proteins of germinating soybean seeds. Plant Physiol., 43 (5): 799-805.
29. Catsimpoolas, N. and Ekenstam, C. 1969. Isolation of alpha, beta, and gamma conglycinins. Biochim. Biophys. Acta-Protein Struct., 129 (2): 490-497.
30. Chen, F., Hao, Y., Piao, X. S., Ma, X., Wu, G. Y., Qiao, S. Y., Li, D. F. and Wang, J. J. 2011. Soybean-derived β-conglycinin affects proteome expression in pig intestinal cells in vivo and in vitro. J. Anim. Sci., 89: 743-753.
31. Coates, J. B., Medeiros, J. S., Thanh, V. H. and Nielsen, N. C. 1985. Characterization of the subunits of β-conglycinin. Arch. Biochem. Biophys., 243 (1): 184-194.
32. Cordle, C. T. 2004. Soy protein allergy: Incidence and relative severity. J. Nutr., 134 (5): 1213S-1219S.
33. De La Barca, A. M., Wall, A. and López-Díaz, J. A. 2005. Allergenicity, trypsin inhibitor activity and nutritive quality of enzymatically modified soy proteins. Int. J. Food Sci. Nutr., 56 (3): 203-211.
34. Dreau, D., Lalles, J. P., Toullec, R. and Salmon, H. 1995. B and T lymphocytes are enhanced in the gut of piglets fed heat-treated soybean proteins. Vet. Immun. lmmunopathol, 47 (1-2): 69-79.
35. Eastham, E. J., Lichauco, T., Pang, K. and Walker, W. A. 1982. Antigenicity of infant formulas and the induction of systemic immunological tolerance by oral feeding: Cow's milk versus soy milk. J. Pediatr. Gastroenterol. Nutr., 1: 23-28.
36. El-Shemy, H. A., Khalafalla, M. M., Fujita, K. and Ishimoto, M. 2007. Improvement of protein quality in transgenic soybean plants. Biologia Plantarum, 51 (2): 277-284.
37. Faldet, M. A. and Satter, L. D. 1991. Feeding heat-treated full fat soybeans to cows in early lactation. J. Dairy Sci., 74 (9): 3047-3054.
38. Feng, J., Liu, X., Xu, Z. R., Wang, Y. Z. and Liu, J. X. 2007. Effects of fermented soybean meal on digestive enzyme activities and intestinal morphology in broilers. Poultry Sci., 86: 1149-1154.
39. Frias, J., Song, Y. S., Martínez-Villaluenga, C., De Mejia, E. G. and Vidal-Valverde, C. 2008a. Fermented soyabean products as hypoallergenic food. Proc. Nutr. Soc., 67 (OCE): E39
40. Frias, J., Song, Y. S., Martínez-Villaluenga, C., De Mejia, E. G. and Vidal-Valverde, C. 2008b. Immunoreactivity and amino acid content of fermented soybean products. J. Agric. Food Chem., 56 (1): 99-105.
41. Friesen, K. G., Nelssen, J. L., Goodband, R. D., Behnke, K. C. and Kats, L. J. 1993. The effect of moist extrusion of soy products on growth performance and nutrient utilization in the early-weaned pig. J. Anim Sci., 71: 2099-2109.
42. García, M. C., Marina, M. L. and Torre, M. 2000. Determination by perfusion reversed-phase high-performance liquid chromatography of the soybean protein content of commercial soybean products prepared directly from whole soybeans. J. Chromatogr. A., 881 (1-2): 37-46.
43. García-Ruiz, C., García, M. A., García, M. C. and Marina, M. L. 2006. Development of a capillary electrophoresis method for the determination of soybean proteins in soybean-rice gluten-free dietary products. Electrophoresis, 27: 452-460.
44. García-Ruiz, C., García, M. C., Torre, M. and Marina, M. L. 1999. Characterization and quantitation of soybean proteins in commercial soybean products by capillary electrophoresis. Electrophoresis, 20 (10): 2003-2012.
45. Gisele, K., Denise, A. M. V. and Jenny, F. 2001. Population study of food allergy in France. J. Allergy Clin. Immunol., 108: 133-140.
46. Gonzalez, R., Polo, F., Zapatero, L., Caravaca, F. and Carreira, J. 1992. Purification and characterization of major inhalant allergens from soybean hulls. Clin. Expe. Allergy., 22(8): 748-755.
47. Govindaraju, K. and Srinivas, H. 2007. Controlled enzymatic hydrolysis of glycinin: Susceptibility of acidic and basic subunits to proteolytic enzymes. LWT-Food Sci. Technol., 40: 1056-1065.
48. Graham, R., Neeta, P. and Francesca, L. S. 2003. Food allergy as a risk factor for life-threatening asthma in childhood: A case-controlled study. J. Allergy Clin. Immunol., 112: 168-174.
49. Guo, P. F., Piao, X. S., Ou, D. Y., Li, D. F. and Hao, Y. 2007. Characterization of the antigenic specificity of soybean protein β-conglycinin and its effects on growth and immune function in rats. Arch. Anim. Nutr., 61 (3): 189-200.
50. Hamilton, R. M. G. and McNiven, M. A. 2000. Replacement of soybean meal with roasted full-fat soybeans from high-protein or conventional cultivars in diets for broiler chickens. Can. J. Anim. Sci., 80: 483-488.
51. Han, B. Z. 2003. Characterization and Product Innovation of Sufu, a Chinese Fermented Soybean Food. Doctoral Dissertation., Wageningen, The Netherlands: Wageningen University.
52. Han, P. F., Ma, X. and Yin, J. D. 2010. The effects of lipoic acid on soybean β-conglycinin-induced anaphylactic reactions in a rat model. Arch. Anim. Nut., 64 (3): 254-264.
53. Hancock, J. D., Lewis, A. J., Jones, D. B., Giesemann, M. A. and Healy, B. J. 1990. Processing methods affects the nutritional values of low-inhibitor soybeans for nursery pigs.: 52-55. Conference Paper, Kansas State University Swine Day 1990. Report of Progress 610
54. Hancock, J. D., Lewis, A. J., Reddy, P. G., Jones, D. B. and Giesemann, M. A. 1991. Extrusion processing of low-inhibitor soybeans improves growth performance of nursery pigs fed protein-adequate diets.: 48-52. Conference Paper, Kansas State University Swine Day 1991. Report of Progress 641
55. Hao, Y., Li, D. F., Piao, X. L. and Piao, X. S. 2010. Forsythia suspensa extract alleviates hypersensitivity induced by soybean β-conglycinin in weaned piglets. J. Ethnopharmacol., 128: 412-418.
56. Hari, B. K., Jiang, G. Q., Krishnan, A. H. and Wiebo, W. J. 2000. Seed storage protein composition of non-nodulating soybean (Glycine max (L.) Merr.) and its influence on protein quality. Plant Sci., 157: 191-199.
57. Hefle, S. L., Lambrecht, D. and Nordlee, J. A. 2005. Session 54I, Toxicology & Safety Evaluation: General, 54I-4. IFT Annual Meeting, July 15-20, New Orleans, LA
58. Heimo, B. and Mills, E. N. C. 2005. Plant food allergens-structural and functional aspects of allergenicity. Biotechnol. Adv., 23: 395-399.
59. Helm, R. M., Cockrell, G., Connaughton, C., Sampson, H. A., Bannon, G. A., Beilinson, V., Livingstone, D., Nielsen, N. C. and Burks, A. W. 2000a. A soybean G2 glycinin allergen. 1. Identification and characterization. Int. Arch. Allergy Immunol., 123: 205-212.
60. Helm, R. M., Cockrell, G., Connaughton, C., Sampson, H. A., Bannon, G. A., Beilinson, V., Nielsen, N. C. and Burks, A. W. 2000b. A soybean G2 glycinin allergen. 2. Epitope mapping and three-dimensional modeling. Int. Arch. Allergy Immunol., 123: 213-219.
61. Helm, R. M., Richard, W. E. and Oscar, L. F. 2003. Nonmurine animal models of food allergy. Environ. Health Perspect., 111: 239-244.
62. Herian, A. M., Taylor, S. T. and Bush, R. K. 1993. Allergenic reactivity of various soybean products as determined by RAST inhibition. J. Food. Sci., 58 (2): 385-388.
63. Hirano, H., Chikafusa, F. and Kyuya, H. 1984. The complete amino acid sequence of the A3 subunit of the glycinin seed storage protein of the soybean (Glycine max (L.) Merrill. J. Biol. Chem., 259 (23): 14371-14377.
64. Hirano, H., Kagawa, H., Kamata, Y. and Yamauchi, F. 1986. Structural homology among the major 7s globulin subunits of soybean seed storage proteins. Phytochemistry, 26 (1): 41-45.
65. Holzhauser, T., Wackermann, O., Ballmer-Weber, B. K., Bindslev-Jensen, C., Scibilia, J., Perono-Garoffo, L., Utsumi, S., Poulsen, L. K. and Vieths, S. 2009. Soybean (Glycine max) allergy in Europe: Gly m 5 (β-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy. J. Allergy Clin. Immunol., 123: 452-458.
66. Houston, N. L., Lee, D. G., Stevenson, S. E., Ladics, G. S., Bannon, G. A., McClain, S., Privalle, L., Stagg, N., Herouet-Guicheney, C., MacIntosh, S. C. and Thelen, J. J. 2011. Quantitation of soybean allergens using tandem mass spectrometry. J. Proteome Res., 10 (2): 763-773.
67. Hu, X. Z., Xu, X. B., Fan, J. F., Cheng, Y. Q. and Li, L. T. 2011. Functional properties of microbial transglutaminase modified soybean glycinin and β-conglycinin. Int. J. Food Eng., 7 (2) Article 4, DOI: 10.2202/1556-3758.2158
68. Huang, Q., Xu, H. B., Yu, Z., Gao, P. and Liu, S. 2010. Inbred Chinese Wuzhishan (WZS) minipig model for soybean glycinin and β-conglycinin allergy. J. Agric. Food Chem., 58 (8): 5194-5198.
69. Inatsu, Y., Nakamura, N., Yuriko, Y., Fushimi, T., Watanasiritum, L. and Kawamoto, S. 2006. Characterization of Bacillus subtilis strains in Thua nao, a traditional fermented soybean food in northern Thailand. Lett. Appl. Microbiol., 43 (3): 237-242.
70. Jeffers, J. G., Shanley, K. J. and Meyer, E. K. 1991. Diagnostic testing of dogs for food hypersensitivity. J. Am. Vet. Med. Assoc., 198: 245-250.
71. John, W. E. and Elizabeth, J. F. 1989. Soy products and the human diet. Am. J. Clin. Nutr., 49: 725-737.
72. Kagawa, H. and Hirano, H. 1988 past. Identification and structural characterization of the glycinin seed storage protein A7 subunit of soybean. Plant Sci., 56 (3): 189-195.
73. Karen, T. and Chandra, R. K. 2002. The management and prevention of food anaphylaxis. Nutr. Res., 22: 89-110.
74. Kazuhiro, Y., Toshio, T., Miyo, S. and Keisuke, K. 1997. Biochemical characterization of soybean protein consisting of different subunits of glycinin. J. Allergy Clin. Immunol., 45 (3): 656-660.
75. Kimber, I., Dearman, R. J., Penninks, A. H., Knippels, L. M. J., Buchanan, R. B., Hammerberg, B., Jackson, H. A. and Helm, R. M. 2003. Assessment of protein allergenicity on the basis of immune reactivity: Animal models. Environ. Health Perspect., 11: 1125-1130.
76. Kleine-Tebbe, J., Vogel, L., Crowell, D. N., Haustein, U. F. and Vieths, S. 2002. Severe oral allergy syndrome and anaphylactic reactions caused by a Bet v 1- related PR-10 protein in soybean, SAM22. J. Allergy Clin. Immunol., 110 (5): 797-804.
77. Koppelman, S. J. 2004. Detection of soy proteins in processed foods: Literature overview and new experimental work. J. AOAC Int., 87 (6): 1398-1407.
78. Koshiyama, I. and Fukushima, D. 1976. Identification of the 7S globulin with β-conglycinin in soybean seeds. Phytochemistry, 15 (1): 157-159.
79. Krishnan, H., Natarajan, S. S., Mahmoud, A. A. and Nelson, R. L. 2007. Identification of glycinin and β-conglycinin subunits that contribute to the increased protein content of high-protein soybean lines. J. Agric. Food Chem., 55: 1839-1845.
80. Krishnan, H. B., Kim, W. S., Jang, S. C. and Kerley, M. S. 2009. All three subunits of soybean β-conglycinin are potential food allergens. J. Agric. and Food Chem., 57 (3): 938-943.
81. Kunitz, M. 1947. Crystalline soybean trypsin inhibitor, II. General properties. J. Exp. Med., 30: 291-310.
82. Kwon, D. Y., Daily, J. W. III, Kim, H. J. and Park, S. M. 2010. Antidiabetic effects of fermented soybean products on type 2 diabetes. Nutr. Res., 30: 1-13.
83. Lagemaat, J. V. D., Silvan, J. M., Moreno, F. J., Olano, A. and Castillo, M. D. D. 2007. In vitro glycation and antigenicity of soy proteins. Food Res. Int., 40: 153-160.
84. Lalles, J. P., Dreau, D., Femenia, F., Parodi, A. L. and Toullec, R. 1996. Feeding heated soybean flour increases the density of B and T lymphocytes in the small intestine of calves. Vet. Immunol. lmmunopathology, 52: 105-l15.
85. Lalles, J. P., Tukur, H. M., Salgado, P., Mills, E. N. C., Morgan, M. R. A. and Quilien, L. 1999. Immunochemical studies on gastric and intestinal digestion of soybean glycinin and β-Conglycinin in vivo. J. Agric. Food Chem., 47: 2797-2806.
86. Lee, D. G., Houston, N. L., Stevenson, S. E., Ladics, G. S., McClain, S., Privalle, L. and Thelen, J. J. 2010. Mass spectrometry analysis of soybean seed proteins: Optimization of gel-free quantitative workflow. Anal. Methods, 2: 1577-1583.
87. Lee, H. W., Keum, E. H., Lee, S. J., Sung, D. E., Chung, D. H. and Lee, S. I. 2007. Allergenicity of proteolytic hydrolysates of the soybean 11S globulin. J. Food. Sci., 72 (3): 168-172.
88. Lee, J. O., Lee, S. I., Cho, S. H., Oh, C. K. and Ryu, C. H. 2004. A new technique to produce hypoallergenic soybean proteins using three different fermenting microorganisms. J. Allergy Clin. Immunol., 113: 239 (Abstract)
89. Lei, M. G. and Reeck, G. R. 1987. Two-dimensional electrophoretic analysis of the proteins of isolated soybean protein bodies and of the glycosylation of soybean proteins. J. Agric. Food Chem., 35 (3): 296-300.
90. Li, D. F., ed. 2003. Soybean Antinutritional Factors, 154 Beijing, China: China Science Press.
91. Li, D. F., Nelssen, J. L., Reddy, P. G., Blecha, F., Hancock, J. D., Alee, G. L., Goodband, R. D. and Klemm, R. D. 1990. Transient hypersensitivity to soybean meal in the early-weaned pig. J. Anim. Sci., 68: 1750-1759.
92. Li, D. F., Nelssen, J. L., Reddy, P. G., Blecha, F., Klemm, R. and Goodband, R. D. 1991. Interrelationship between hypersensitivity to soybean proteins and growth performance in early-weaned pigs. J. Anim. Sci., 69: 4062-4069.
93. Li, J. G., Zhao, H., Zhou, J. C., Gao, G. and Wang, K. N. 2009. Effect of roasting and extrusion on the bioavailability of Selenium in soybean for young pigs. J. Appl. Biosci., 27: 1697-1704.
94. Liu, X., Feng, J., Xu, Z. R., Lu, Y. P. and Liu, Y. Y. 2007. The effects of fermented soybean meal on growth performance and immune characteristics in weaned piglets. Turk. J. Vet. Anim. Sci., 31 (5): 341-345.
95. Liu, X., Feng, J., Xu, Z. R., Wang, Y. Z. and Liu, J. X. 2008. Oral allergy syndrome and anaphylactic reactions in BALB/c mice caused by soybean glycinin and β-conglycinin. Clin. Exp. Allergy, 38: 350-356.
96. Lotan, R., Siegelman, H. W., Lis, H. and Sharon, N. 1974. Subunit structure of soybean agglutinin. J. Biol. Chem., 249: 1219-1224.
97. Ma, X., He, P. L., Sun, P. and Han, P. F. 2010a. Lipoic acid: An immunomodulator that attenuates glycinin-induced anaphylactic reactions in a rat model. J. Agric. Food Chem., 58 (8): 5086-5092.
98. Ma, X., Sun, P., He, P. L., Han, P. F., Wang, J. J., Qiao, S. Y. and Li, D. F. 2010b. Development of monoclonal antibodies and a competitive ELISA detection method for glycinin, an allergen in soybean. Food Chem., 121: 546-551.
99. MacIsaac, J. L., Burgoyne, K. L., Anderson, D. M. and Rathgeber, B. R. 2005. Roasted full-fat soybeans in starter, grower, and finisher diets for female broiler turkeys. J. Appl. Poult. Res., 14: 116-121.
100. Makio, K. 2005. Immunological functions of soy sauce: Hypoallergenicity and antiallergic activity of soy sauce. J. Biosci. Bioeng., 100: 144-151.
101. Meisel, H. 1993. Enzyme-linked immunosorbent assay and immunobiotting using IgY antibodies against soybean glycinin A. Int. Dairy J., 3: 149-161.
102. Mervyn, J. M., Victor, J. M., David, J. W. and James, R. B. 1985. A study of the quaternary structure of glycinin. Biochim. Biophys. Acta-Protein Struct. Mol. Enzymol., 827: 119-126.
103. Metcalfe, D. D., Astwood, J. D., Townsend, R. Sampson and Taylor, H. A. S. L. and Fuchs, R. L. 1996. Assessment of the allergenic potential of foods derived from genetically engineered crop plants. Crit. Rev. Food Sci. Nutr., 36 Suppl: S165-S186.
104. Mills, E. N. C. and Breiteneder, H. 2005. Food allergy and its relevance to industrial food proteins. Biotechnol. Adv., 23: 409-414.
105. Mills, E. N. C., Huang, L., Noel, T. R., Gunning, A. P. and Morris, V. J. 2001. Formation of thermally-induced aggregates of the soya globulin β-conglycinin. Biochim. Biophys. Acta, 1547 (2): 339-350.
106. Mills, E. N. C., Marigheto, N. A., Wellner, N., Fairhurst, S. A., Jenkins, J. A., Mann, R. and Belton, P. S. 2003. Thermally induced structural changes in glycinin, the 11S globulin of soya bean (Glycine max)-An in situ spectroscopic study. Biochim. Biophys. Acta, 1648 (1-2): 105-114.
107. Moneret-Vautrin, D. A., Guérin, L., Kanny, G., Flabbee, J., Frémont, S. and Morisset, M. 1999. Cross-allergenicity of peanut and lupine: the risk of lupine allergy in patients allergic to peanuts. J. Allergy Clin. Immunol., 104: 883-888.
108. Moreira, M. A., Hermodson, M. A., Larkins, B. A. and Nielsen, N. C. 1979. Partial characterization of the acidic and basic polypeptides of glycinin. J. Biol. Chem., 254: 9921-9926.
109. Moreira, M. A., Hermodson, M. A., Larkins, B. A. and Nielsen, N. C. 1981a. Comparison of the primary structure of the acidic polypeptides of glycinin. Arch. Biochem. Biophys., 210: 633-642.
110. Moreira, M. A., Mahoney, W. C., Larkins, B. A. and Nielsen, N. C. 1981b. Comparison of the antigenic properties of the glycinin polypeptides. Arch. Biochem. Biophys., 210: 643-646.
111. Moreno, F. J. 2007. Gastrointestinal digestion of food allergens: Effect on their allergenicity. Biomed. Pharmacother., 61: 150-160.
112. Morishita, N., Kamiya, K., Matsumoto, T., Sakai, S., Teshima, R., Urisu, A., Moriyama, T., Ogawa, T., Akiyama, H. and Morimatsu, F. 2008. Reliable enzyme-linked immunosorbent assay for the determination of soybean proteins in processed foods. J. Agric. Food Chem., 56: 6818-6824.
113. Moroz, L. A. and Yang, W. H. 1980. Kunitz soybean trypsin inhibitor-A specific allergen in food anaphylaxis. N. Engl. J. Med., 302: 1126-1128.
114. Motoyasu, A., Yasuyuki, T., Andrew, B. G., Bunzo, M. and Shigeru, U. 2001. Crystal structure of soybean proglycinin A1aB1b homotrimer. J. Mol. Biol., 305: 291-305.
115. Mridula, D., Goyal, R. K., Bhargav, V. K. and Manikantan, M. R. 2007. Effect of roasting on texture, colour and acceptability of soybean for making sattu. Am. J. Food Technol., 2 (4): 265-272.
116. Müller, U., Weber, W., Hoffmann, A., Franke, S., Lange, R. and Vieths, S. 1998. Commercial soybean lecithins: A source of hidden allergens?. Zeitschrift für Lebensmitteluntersuchung und -Forschung A, 27 (5): 341-351.
117. Natarajan, S., Xu, C., Bae, H., Bailey, B. A., Cregan, P., Caperna, T. J., Garrett, W. M. and Luthria, D. 2007. Proteomic and genetic analysis of glycinin subunits of sixteen soybean genotypes. Plant Physiol. Biochem., 45 (6-7): 436-444.
118. Natarajan, S., Xu, C., Caperna, T. J. and Garrett, W. M. 2005. Comparison of protein solubilization methods suitable for proteomic analysis of soybean seed proteins. Anal. Biochem., 342: 214-220.
119. Natarajan, S. S., Xu, C., Bae, H., Caperna, T. J. and Garrett, W. M. 2006. Characterization of storage proteins in wild (Glycine soja) and cultivated (Glycine max) soybean seeds using proteomic analysis. J. Agric. Food Chem., 54: 3114-3120.
120. O'Farrell, P. H. 1975. High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem., 250 (10): 4007-4021.
121. Ogawa, T., Bando, N., Tsuji, H., Nishikawa, K. and Kitamura, K. 1995. Alpha-subunit of beta-conglycinin, an allergenic protein recognized by IgE antibodies of soybean-sensitive patients with atopic dermatitis. Biosci. Biotechnol. Biochem., 59 (5): 831-833.
122. Ogawa, T., Bandom, N. T., Tsuji, H., Okajima, H., Nishikawa, K. and Sasaoka, K. 1991. Investigation of the IgE-binding proteins in soybeans by immunoblotting with the sera of the soybean-sensitive patients with atopic dermatitis. J. Nutr. Sci. Vitaminol. (Tokyo), 37 (6): 555-565.
123. Ogawa, A., Samoto, M. and Takahashi, K. 2000. Soybean allergens and hypoallergenic soybean products. J. Nutr. Sci. Vitaminol. (Tokyo), 46 (6): 271-279.
124. Ogawa, T., Tsuji, H., Bando, N., Kitamura, K., Zhu, Y. L. and Hirano, H. 1993. Identification of the soybean allergenic protein, Gly m Bd 30K, with the soybean seed 34-kDa oil-body-associated protein. Biosci. Biotechnol. Biochem., 57: 1030-1033.
125. Ohishi, A., Watanab, K., Urushibata, M., Utsuno, K., Ikuta, K., Sugimoto, K. and Harada, H. 1994. Detection of soybean antigenicity and reduction by twin-screw extrusion. J. Am. Oil Chemists' Soc., 71 (12): 1391-1396.
126. Ouedraogo, C. L., Lalles, J. P., Toullec, R. and Grongnet, J. F. 1998. Roasted full fat soybean as an ingredient of milk replacers for goat kids. Small Ruminant Res., 28: 53-59.
127. Pastoret, P. P., Philip, G., Hervre, B. and Andre, G. 1998. " Immunology of the pig ". In Handbook of Vertebrate Immunology, 373-419. San Diego, CA: Pastoret, P. P., Philip, G., Hervre, B. and Andre, G., Eds. Academic Press.
128. Pedersen, M. H., Holzhauser, T., Bisson, C., Conti, A., Jensen, L. B., Skov, P. S., Bindslev-Jensen, C., Brinch, D. S. and Poulsen, L. K. 2008. Soybean allergen detection methods-A comparison study. Mol. Nutr Food Res., 52: 1486-1496.
129. Peisker, M. 2001. Manufacturing of soy protein concentrate for animal nutrition. Cah. Options Mediterr, 54: 103-107.
130. Peñas, E., Gomez, R., Frias, J., Baeza, M. L. and Vidal-Valverde, C. 2011. High hydrostatic pressure effects on immunoreactivity and nutritional quality of soybean products. Food Chem., 125: 423-429.
131. Perez, M. D., Mills, E. N. C., Lambert, N., Johnson, L. T. and Morgan, M. R. A. 2000. The use of anti-soya globulin antisera in investigating soya digestion in vivo. J. Sci. Food Agric., 80: 513-521.
132. Plumb, G. W., Lambert, N., Mills, E. N. C., Tatton, M. J., Ursel, C. C. M. and Bogracheva, T. 1995. Characterizations of monoclonal antibodies against β-conglycinin from soya bean (Glycine max) and their use as probes for thermal denaturation. J. Sci. Food Agric., 67: 511-520.
133. Plumb, G. W., Mills, E. N. C., Tatton, M. J., Ursel, C. C. M., Lambert, N. and Morgan, M. R. A. 1994. Effect of thermal and Proteolytic processing on glycinin, the 11S globulin of soy(Glycine max): A study utilizing monoclonal and polyclonal antibodies. J. Agric. Food Chem., 42: 834-840.
134. Pospiech, M., Tremlová, B., Renčová, E. and Randulová, Z. 2009. Immunohistochemical detection of soya protein-Optimisation and verification of the method. Czech J. Food. Sci., 27: 11-19.
135. Prasad, D. A. and Morrill, J. L. 1976. Effect of processing soybeans on their use by calves. J. Dairy Sci., 59 (2): 329-332.
136. Puppo, M. C., Beaumal, V., Speroni, F., de Lamballerie, M., Añón, M. C. and Anton, M. 2011. β-Conglycinin and glycinin soybean protein emulsions treated by combined temperature-high-pressure treatment. Food Hydrocolloid, 25 (3): 389-397.
137. Rajni, M., Dianne, T. T. and Perry, K. W. 2003. Characterization of storage proteins in different soybean varieties and their relationship to tofu yield and texture. Food Chem., 82: 265-273.
138. Refstiea, S., Sahlstrom, S., Brathenc, E., Baeverfjorda, G. and Krogedald, P. 2005. Lactic acid fermentation eliminates indigestible carbohydrates and antinutritional factors in soybean meal for Atlantic salmon (Salmo salar). Aquaculture, 246: 331-345.
139. Rihs, H. P., Chen, Z., Rueff, F., Rozynek, P., Heimann, H. and Baur, X. 1999. IgE binding of the recombinant allergen soybean profilin (rGly m 3) is mediated by conformational epitopes. J. Allergy Clin. Immunol, 104 (6): 1293-1301.
140. Robert, A. S. 2007. Selecting soy protein for animal feed.: 1-11. 15th Annual ASAIM Southeast Asian Feed Technology and Nutrition Workshop, Jalan Pratama, Indonesia.
141. Rodhouse, S. L., Herkelman, K. L. and Veum, T. L. 1992. Effect of extrusion on the ileal and fecald igestibilities of lysine, nitrogen, and energy in diets for young pigs. J. Anim. Sci., 70: 827-835.
142. Rodrigo, M. J., Morell, F. Helm, Swanson, R. M. M., Greife, A. Anto and Sunyer, J. M. J. and Reed, C. E. 1990. Identification and partial characterization of the soybean-dust allergen involved in the Barcelona asthma epidemic. J. Allergy Clin. Immunol., 85 (4): 778-784.
143. Rouquié, D., Capt, A., Eby, W. H., Sekar, V. and Hérouet-Guicheney, C. 2010. Investigation of endogenous soybean food allergens by using a 2-dimensional gel electrophoresis approach. Regul. Toxicol. Pharmacol., 58: S47-S53.
144. Russett, J. C. 1998. Soy protein concentrate for animal feeds. Chemurgy Report from Research.,: 1-12.
145. Saitoh, S., Urushibata, M., Ikuta, K., Fujimaki, A. and Harada, H. 2000. Antigenicity in soybean hypocotyls and its reduction by twin-screw extrusion. J. Am. Oil Chem. Soc., 77 (4): 419-424.
146. Sakai, S., Adachi, R., Akiyama, H., Teshima, R., Morishita, N., Matsumoto, T. and Urisu, A. 2010. Enzyme-linked immunosorbent assay kit for the determination of soybean protein in processed foods: interlaboratory evaluation. J. AOAC Int., 93 (1): 243-248.
147. Sampson, H. A. 2004. Update on food allergy. J. Allergy Clin. Immunol., 113: 805-819.
148. Sánchez-Martínez, M. L., Aguilar-Caballos, M. P. and Gómez-Hens, A. 2009. Homogeneous immunoassay for soy protein determination in food samples using gold nanoparticles as labels and light scattering detection. Analytica Chim. Acta, 636: 58-62.
149. Sato, K., Yamagishi, T. and Yamauchi, F. 1986. Quantitative analysis of soybean proteins by densitometry on gel electrophoresis. Cereal Chem., 63 (6): 493-496.
150. Savage, J. H., Kaeding, A. J., Matsui, E. C. and Wood, R. A. 2010). The natural history of soy allergy. J. Allergy Clin. Immunol., 125: 683-686.
151. Savithiry, N., Xu, C. P., Ba, H. H., Bryan, A. B., Perry, C. and Thomas, J. C. 2007). Proteomic and genetic analysis of glycinin subunits of sixteen soybean genotypes. Plant Physiol. Biochem., 45: 436-444.
152. Saz, J. M. and Marina, M. L. 2007. High performance liquid chromatography and capillary electrophoresis in the analysis of soybean proteins and peptides in foodstuffs. J. Separation Sci., 30 (4): 431-451.
153. Scott, H. S. and Donald, Y. M. L. 2007. Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. J. Allergy Clin. Immunol., 119: 1462-1469.
154. Scott, H. S. and Hugh, A. S. 2006. Food allergy. J. Allergy Clin. Immunol., 117: 470-475.
155. Shibasaki, M., Suzuki, S., Tajima, S., Nemoto, H. and Kuruome, T. 1980. Allergenicity of major component proteins of soybean. Int. Arch. Allergy Appl. Immunol., 61: 441-448.
156. Sissons, J. W., Nyrup, A., Kilshaw, P. J. and Smith, R. H. 1982. Ehanol denaturatiotn of soya bean protein antigens. J. Sci. Food Agric., 33 (8): 706-710.
157. Song, Y. S., Martinez-Villaluenga, J. F. C. and Meji, E. G. D. 2008. Quantification of human IgE immunoreactive soybean proteins in commercial soy ingredients and products. J. Food. Sci., 73 (6): T90-T99. (10)
158. Song, Y. S., Martinez-Villaluenga, J. F. C., Vidal-Valdeverde, C. and Meji, E. G. D. 2008. Immunoreactivity reduction of soybean meal by fermentation, effect on amino acid composition and antigenicity of commercial soy products. Food Chem., 108: 571-581.
159. Song, Y. S., Perezb, V. G., Pettigrewb, J. E., Martinez-Villaluengaa, C. and de Mejiaa, E. G. 2010. Fermentation of soybean meal and its inclusion in diets for newly weaned pigs reduced diarrhea and measures of immunoreactivity in the plasma. Anim. Feed Sci. Technol., 159: 41-49.
160. Soya-Information about Soy and Soya Products, Available from http://www.soya.be/soy-allergy.php
161. Speroni, F., Bolontrade, A. J., Añón, M. C. and de Lamballerie, M. 2010. Effects of NaCl addition and high pressure treatment on thermal properties of soybean proteins. International Conference on Food Innovation, 25-29 October, Universitat Politècnica de València, Valencia, Spain.
162. Stanley, J. S. and Bannon, G. A. 1999. Biochemical aspects of food allergens. Immunol. Allergy Clin. North Am., 19: 605-617.
163. Staswick, P. E., Hermodson, M. A. and Nielsen, N. C. 1981. Identification of the acidic and basic subunit complexes of glycinin. J. Biol. Chem., 256: 8752-8755.
164. Staswick, P. E., Hermodson, M. A. and Nielsen, N. C. 1984a. The amino acid sequence of the A2Bla subunit of glycinin. J. Biol. Chem., 259: 13424-13430.
165. Staswick, P. E., Hermodson, M. A. and Nielsen, N. C. 1984b. Identification of the cystines which link the acidic and basic components of the glycinin subunit. J. Biol. Chem., 259: 13431-13435.
166. Sun, P., Li, D. F., Li, Z. J., Dong, B. and Wang, F. L. 2008. Effects of glycinin on IgE-mediated increase of mast cell numbers and histamine release in the small intestine. J. Nutr. Biochem., 19 (9): 627-633.
167. Sun, P. and Qin, G. X. 2006. Effects of steam-processing on the content and immunogenicity of purified soybean antigens. China J. Vet. Sci., 26: 551-554.
168. Symptoms of Soy Allergies. Available from http://www.exitallergy.com/allergy-articles/symptoms-of-soy-allergy. php
169. Tan-Wilson, A. L., Chen, J. C., Duggan, M. C., Chapman, C., Obach, R. S. and Wilson, K. A. 1987. Soybean Bowman-Birk trypsin isoinhibitors: Classification and report of a glycine-rich trypsin inhibitor class. J. Agric. Food Chem., 35: 974-980.
170. Tezuka, M., Yagasaki, K. and Ono, T. 2004. Characters of soybean glycinin groups I, IIa, and IIb caused by heating. J. Agric. Food Chem., 52: 1693-1699.
171. Thanh, V. H. and Shibasaki, K. 1976. Heterogeneity of beta-conglycinin. Biochim. Biophys. Acta-Protein Struct., 439 (2): 326-338.
172. Thanh, V. H. and Shibasaki, K. 1978. Major proteins of soybean seeds. Subunit structure of beta.-conglycinin. J. Agr. Food Chem., 26 (3): 692-695.
173. Tice, E. M., Eastridge, M. L. and Firkins, J. L. 1992. Raw soybeans and roasted soybeans of different particle sizes. 1. Digestibility and utilization by lactating cows. J. Dairy Sci., 76 (1): 224-235.
174. Tsuji, H. Bando, Hiemori, N. M., Yamanishi, R. Kimoto, Nishikawa, M. K. and Ogawa, T. 1997. Purification of characterization of soybean allergen Gly m Bd 28K. Biosci. Biotechnol. Biochem., 61 (6): 942-947.
175. WISHH. Traditional soy foods. Available from http://www.wishh.org/aboutsoy/traditional.html
176. Tulloch, P. A. and Blagrove, R. J. 1985. Electron microscopy of seed-storage globulins. Arch. Biochem. Biophys., 241: 521-532.
177. US Food and Drug Administration. (2004). Food Allergen Labeling and Consumer Protection Act of. 2004. US Food and Drug Administration, Silver Spring, MD
178. Utsumi, S., Inaba, H. and Mori, T. 1981. Heterogeneity of soybean glycinin. Phytochemistry, 20: 585-589.
179. Victor, P. R. H., Cecilio, C. S. and Maria, M. Y. E. 2007. Interfacial and foaming characteristics of soy globulins as a function of pH and ionic strength. Colloid. Surf. A: Physicochem. Eng. Aspect, 309: 202-215.
180. Wang, T., Qin, G. X., Sun, Z. W., Zhao, Y. and Zhang, B. 2010. Comparative study on the residual rate of immunoreactive soybean glycinin (11S) in digestive tracts of pigs in different ages. Food Agric. Immunol., 21 (03): 201-208.
181. Wang, T., Qin, G. X., Zhao, Y. and Sun, Z. W. 2009. Comparative study on the stability of soybean (Glycine max) β-conglycinin in vivo. Food Agric. Immunol., 20 (4): 295-304.
182. Wang, T., Qin, G. X., Zhao, Y., Sun, Z. W., Wang, L. M., Bao, N., Zhang, B., Zhu, D., Sun, L. and Wang, H. F. 2008. Determination of immunocompetence of glycinin, β-conglycinin and soybean agglutinin in soybean hulls. Soybean Sci., 27 (1): 158-161.
183. Wang, Y. C., Yu, R. C. and Chou, C. C. 2002. Growth and survival of bifidobacteria and lactic acid bacteria during the fermentation and storage of cultured soymilk drinks. Food Microbiol., 19 (5): 501-508.
184. Wilson, S., Blaschek, K. and deMejia, E. G. 2005. Allergenic proteins in soybean: Processing and reduction of P34 allergenicity. Nutr. Rev., 63 (2): 47-58.
185. Xiang, P., Beardslee, T. A., Zeece, M. G., Markwell, J. and Sarath, G. 2002. Identification and analysis of a conserved immunoglobulin E-binding epitope in soybean G1a and G2a and peanut Ara h 3 glycinins. Arch. Biochem. Biophys., 408 (1): 51-57.
186. Xu, C. H, Yang, X. Q., Yu, S. J., Qi, J. R., Guo, R., Sun, W. W., Yao, Y. J. and Zhao, M. M. 2010b. The effect of glycosylation with dextran chains of differing lengths on the thermal of aggregation of β-conglycinin and glycinin. Food Res. Int., 43: 2270-2276.
187. Xu, J., Zhou, A., Wang, Z. and Ai, D. 2010a. Effects of glycinin and β-conglycinin on integrity and immune responses of mouse intestinal epithelial cells. J. Anim. Plant Sci., 20 (3): 170-174.
188. Yamakawa, H., Akiyama, H., Endo, Y., Miyatake, K., Sakata, K., Sakai, S., Moriyama, T., Urisu, A. and Maitani, T. 2007. Specific detection of soybean residues in processed foods by the polymerase chain reaction. Biosci. Biotechnol. Biochem, 71 (1): 269-272.
189. Yang, W. H. W., Chung, S. Y., Ajayi, O., Krishnamurthy, K., Konan, K. and Goodrich-Schneider, R. 2010. Use of pulsed ultraviolet light to reduce the allergenic potency of soybean extracts. Int. J. Food Eng., 6 (3) article 11, DOI: 10.2202/1556-3758.1876.
190. Yasumoto, K., Sudo, M. and Suzuki, T. 1990. Quantitation of soya protein by enzyme linked immunosorbent assay of its characteristic peptide. J. Sci. Food Agric., 50 (3): 377-389.
191. You, J. M., Li, D. F., Qiao, S. Y., Wang, Z. R., He, P. L., Ou, D. Y. and Dong, B. 2008. Development of a monoclonal antibody-based competitive ELISA for detection of β-conglycinin, an allergen from soybean. Food Chem., 106: 352-360.
192. Zarkadas, C. G., Gagnon, C., Gleddie, S., Khanizadeh, S., Cober, E. R. and Guillemette, R. J. D. 2007. Assessment of the protein quality of fourteen soybean [Glycine max (L.) Merr.] cultivars using amino acid analysis and two-dimensional electrophoresis. Food Res. Int., 40 (1): 129-146.
193. Zhang, B. 2009. The Distribution of Soybean Antigens in Digestive Tract of Different Physiological Stage. Master's Thesis, Changchun, China: Jilin Agricultural University.
194. Zhang, G. Y., Yukako, H., Shinya, M., Yasuki, M. and Tomohiko, M. 2002. Molecular species of glycinin in some soybean cultivars. Phytochemistry, 60: 675-681.
195. Zhang, H. K., Li, L. T. and Mittal, G. S. 2010. Effects of high processing on soybean β-conglycinin. J. Food Process Eng., 33 (3): 568-583.
196. Zhang, H. K., Li, L. T., Tatsumi, E. and Kotwal, S. 2003. Influence of high pressure on conformational changes of soybean glycinin. Innovative Food Sci. Emerg. Technol., 4: 269-275.
197. Zhao, Y., Qin, G. X., Sun, Z. W., Zhang, B. and Wang, T. 2010a. Effects of glycinin and β-conglycinin on enterocyte apoptosis, proliferation and migration of piglets. Food Agric. Immunol., 21 (03): 209-218.
198. Zhao, Y., Qin, G. X., Sun, Z. W., Zhang, B. and Wang, T. 2010b. Stability and immunoreactivity of glycinin and β-conglycinin to hydrolysis in vitro. Food Agric. Immunol., 21 (3): 253-263.
199. Zhao, Y., Qin, G. X., Sun, Z. W., Zhang, X. D., Bao, N., Wang, T., Zhang, B., Zhang, B. L., Zhu, D. and Sun, L. 2008. Disappearance of immunoreactive glycinin and β-conglycinin in the digestive tract of piglets. Arch. Anim. Nut., 62 (4): 322-330.
200. Zhao, Y., Qin, G. X., Wang, T., Zhang, B. and Zhu, D. 2007. Comparisons of immunocompetence and inhibit competence of main antinutritional factors in different processed soybean products. Soybean Sci., 26 (6): 930-934.