-
1
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
58149296552
-
Tumor resistance to apoptosis
-
Fulda S. Tumor resistance to apoptosis. Int J Cancer 2009; 124: 511-5.
-
(2009)
Int J Cancer
, vol.124
, pp. 511-515
-
-
Fulda, S.1
-
5
-
-
0023664012
-
Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates
-
Waxman L, Fagan JM, Goldberg AL. Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates. J Biol Chem 1987; 262: 2451-7.
-
(1987)
J Biol Chem
, vol.262
, pp. 2451-2457
-
-
Waxman, L.1
Fagan, J.M.2
Goldberg, A.L.3
-
6
-
-
2342613652
-
The proteasome: A suitable antineoplastic target
-
Adams J. The proteasome: a suitable antineoplastic target. Nature Reviews 2004; 4: 349-60.
-
(2004)
Nature Reviews
, vol.4
, pp. 349-360
-
-
Adams, J.1
-
7
-
-
0028018268
-
The ubiquitin-proteasome proteolytic pathway
-
Ciechanover A. The ubiquitin-proteasome proteolytic pathway. Cell 1994; 79: 13-21.
-
(1994)
Cell
, vol.79
, pp. 13-21
-
-
Ciechanover, A.1
-
8
-
-
2442480795
-
Multiple cell death pathways as regulators of tumour initiation and progression
-
Jäättelä M. Multiple cell death pathways as regulators of tumour initiation and progression. Oncogene 2004; 23: 2746-56.
-
(2004)
Oncogene
, vol.23
, pp. 2746-2756
-
-
Jäättelä, M.1
-
9
-
-
80052198371
-
Mitochondrial drug targets in cell death and cancer
-
Ferrin F, Linares CI, Muntane J. Mitochondrial drug targets in cell death and cancer. Curr Pharm Des 2011; 17: 2002-16.
-
(2011)
Curr Pharm Des
, vol.17
, pp. 2002-2016
-
-
Ferrin, F.1
Linares, C.I.2
Muntane, J.3
-
10
-
-
80052190938
-
Principles and therapeutic relevance for targeting mitochondria in aging and neurodegenerative diseases
-
Serviddio G, Ronmano AD, Cassano T, Bellanti F, Altomare E, Vendemial G. Principles and therapeutic relevance for targeting mitochondria in aging and neurodegenerative diseases. Curr Pharm Des 2011; 17: 2036-55.
-
(2011)
Curr Pharm Des
, vol.17
, pp. 2036-2055
-
-
Serviddio, G.1
Ronmano, A.D.2
Cassano, T.3
Bellanti, F.4
Altomare, E.5
Vendemial, G.6
-
11
-
-
80052206063
-
Mitochondrial dysfunction and targeted drugs: A focus on diabetes
-
Victor VM, Rocha M, Banuls C, Bellod L, Hernandez-Mijares A. Mitochondrial dysfunction and targeted drugs: a focus on diabetes. Curr Pharm Des 2011; 17: 1986-2001.
-
(2011)
Curr Pharm Des
, vol.17
, pp. 1986-2001
-
-
Victor, V.M.1
Rocha, M.2
Banuls, C.3
Bellod, L.4
Hernandez-Mijares, A.5
-
12
-
-
80052241269
-
Mitochondrial therapeutics for cardioprotection
-
Carreira RS, Lee P, Gottlieb RA. Mitochondrial therapeutics for cardioprotection. Curr Pharm Des 2011; 17: 2017-35.
-
(2011)
Curr Pharm Des
, vol.17
, pp. 2017-2035
-
-
Carreira, R.S.1
Lee, P.2
Gottlieb, R.A.3
-
13
-
-
33845977959
-
Mitochondrial Membrane Permeabilization in Cell Death
-
Kroemer G, Galluzi L, Brenner C. Mitochondrial Membrane Permeabilization in Cell Death. Physiol Rev 2007; 87: 99-163.
-
(2007)
Physiol Rev
, vol.87
, pp. 99-163
-
-
Kroemer, G.1
Galluzi, L.2
Brenner, C.3
-
14
-
-
0013851005
-
Evidence discriminating between the chemical and the chemiosmotic mechanisms of electron transport phosphorylation
-
Mitchell P, Moyle J. Evidence discriminating between the chemical and the chemiosmotic mechanisms of electron transport phosphorylation. Nature 1965; 208: 1205-6.
-
(1965)
Nature
, vol.208
, pp. 1205-1206
-
-
Mitchell, P.1
Moyle, J.2
-
15
-
-
0013844789
-
Stoichiometry of proton translocation through the respiratory chain and adenosine triphosphatase systems of rat mitochondria
-
Mitchell P, Moyle J. Stoichiometry of proton translocation through the respiratory chain and adenosine triphosphatase systems of rat mitochondria. Nature 1965; 208: 147-51.
-
(1965)
Nature
, vol.208
, pp. 147-151
-
-
Mitchell, P.1
Moyle, J.2
-
16
-
-
33847059997
-
The mitochondrial energy transduction system and aging process
-
Navarro A, Boveris A. The mitochondrial energy transduction system and aging process. Am J Physiol Cell Physiol 2007; 292: C670-86.
-
(2007)
Am J Physiol Cell Physiol
, vol.292
, pp. 670-686
-
-
Navarro, A.1
Boveris, A.2
-
17
-
-
9544246860
-
Mitochondrial permeability transition is central coordinating event of apoptosis
-
Marchetti P, Castedo M, Susin SA et al. Mitochondrial permeability transition is central coordinating event of apoptosis. J Exp Med 1996; 184: 1155-60.
-
(1996)
J Exp Med
, vol.184
, pp. 1155-1160
-
-
Marchetti, P.1
Castedo, M.2
Susin, S.A.3
-
18
-
-
27644597606
-
Mitochondrial permeability transition in apoptosis and necrosis
-
Zamzami N, Larochette N, Kroemer G. Mitochondrial permeability transition in apoptosis and necrosis. Cell Death Differ 2005; 12: 1478-80.
-
(2005)
Cell Death Differ
, vol.12
, pp. 1478-1480
-
-
Zamzami, N.1
Larochette, N.2
Kroemer, G.3
-
19
-
-
0031918742
-
The mitochondrial death/life regulator in apoptosis and necrosis
-
Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 1998; 60: 619-42.
-
(1998)
Annu Rev Physiol
, vol.60
, pp. 619-642
-
-
Kroemer, G.1
Dallaporta, B.2
Resche-Rigon, M.3
-
20
-
-
0029116916
-
The mitochondrial permeability transition
-
Zoratti M, Szabo I. The mitochondrial permeability transition. Biochim Biophys Acta 1995; 1241: 139-76.
-
(1995)
Biochim Biophys Acta
, vol.1241
, pp. 139-176
-
-
Zoratti, M.1
Szabo, I.2
-
21
-
-
85039809699
-
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
-
Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973; 156: 435-44.
-
(1973)
Biochem J
, vol.156
, pp. 435-444
-
-
Boveris, A.1
Chance, B.2
-
22
-
-
0015363173
-
The cellular production of hydrogen peroxide
-
Boveris A, Oshino N, Chance B. The cellular production of hydrogen peroxide. Biochem J 1972; 128: 617-30.
-
(1972)
Biochem J
, vol.128
, pp. 617-630
-
-
Boveris, A.1
Oshino, N.2
Chance, B.3
-
23
-
-
51249109260
-
Mitochondrial drug-delivery systems for macromolecule and their therapeutic application to mitochondrial diseases
-
Yamada Y, Harashima H. Mitochondrial drug-delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. Adv Drug Deliv Rev 2008; 60: 1439-62.
-
(2008)
Adv Drug Deliv Rev
, vol.60
, pp. 1439-1462
-
-
Yamada, Y.1
Harashima, H.2
-
24
-
-
0030876148
-
Role of endogenous and exogenous antioxidants in the defense against functional damage and lipid peroxidation in rat liver mitochondria
-
Augustin W, Wiswedel I, Noack H, Reinheckel T, Reichelt O. Role of endogenous and exogenous antioxidants in the defense against functional damage and lipid peroxidation in rat liver mitochondria. Mol Cell Biochem1997; 174: 199-205.
-
(1997)
Mol Cell Biochem
, vol.174
, pp. 199-205
-
-
Augustin, W.1
Wiswedel, I.2
Noack, H.3
Reinheckel, T.4
Reichelt, O.5
-
26
-
-
33644847375
-
2+: Molecular determinants and functional consequences
-
2+: molecular determinants and functional consequences. Physiol Rev 2006; 86: 369-408.
-
(2006)
Physiol Rev
, vol.86
, pp. 369-408
-
-
Rizzuto, R.1
Pozzan, T.2
-
28
-
-
0034641918
-
The biochemistry of apoptosis
-
Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-76.
-
(2000)
Nature
, vol.407
, pp. 770-776
-
-
Hengartner, M.O.1
-
29
-
-
33847328289
-
The Bcl-2 apoptotic switch in cancer development and therapy
-
Adams JM, Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007; 26: 1324-37.
-
(2007)
Oncogene
, vol.26
, pp. 1324-1337
-
-
Adams, J.M.1
Cory, S.2
-
30
-
-
22044458016
-
Serum cytochrome c indicates in vivo-apoptosis and it can serve as a prognostic marker during cancer therapy
-
Barczyk K, Kreuter M, Pryjma J. Serum cytochrome c indicates in vivo-apoptosis and it can serve as a prognostic marker during cancer therapy. Int J Cancer 2005; 114: 167-73.
-
(2005)
Int J Cancer
, vol.114
, pp. 167-173
-
-
Barczyk, K.1
Kreuter, M.2
Pryjma, J.3
-
31
-
-
0035811496
-
Endonuclease G is an apoptotic DNase when released from mitochondria
-
Li LY, Luo X, Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 2001; 412: 95-99.
-
(2001)
Nature
, vol.412
, pp. 95-99
-
-
Li, L.Y.1
Luo, X.2
Wang, X.3
-
33
-
-
0035956426
-
A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast
-
Pavlov EV, Priault M, Pietkiewicz D. A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast. J Cell Biol 2001; 155: 725-32.
-
(2001)
J Cell Biol
, vol.155
, pp. 725-732
-
-
Pavlov, E.V.1
Priault, M.2
Pietkiewicz, D.3
-
34
-
-
0034630187
-
The mitochondrion in cell death control: Certainties and incognita
-
Loeffler M, Kroemer G. The mitochondrion in cell death control: certainties and incognita. Exp Cell Res 2000; 256: 19-26.
-
(2000)
Exp Cell Res
, vol.256
, pp. 19-26
-
-
Loeffler, M.1
Kroemer, G.2
-
35
-
-
0035931765
-
Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells
-
Shimizu S, Matsuoka Y, Shinohara Y, Yoneda Y, Tsujimoto Y. Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J Cell Biol 2001; 152: 237-50.
-
(2001)
J Cell Biol
, vol.152
, pp. 237-250
-
-
Shimizu, S.1
Matsuoka, Y.2
Shinohara, Y.3
Yoneda, Y.4
Tsujimoto, Y.5
-
36
-
-
7944225778
-
Dynamic evolution of adenine nucleotide translocase interactome during chemotherapy-induced apoptosis
-
Verrier F, Deniaud A, Lebras M. Dynamic evolution of adenine nucleotide translocase interactome during chemotherapy-induced apoptosis. Oncogene 2004; 23: 8049-64.
-
(2004)
Oncogene
, vol.23
, pp. 8049-8064
-
-
Verrier, F.1
Deniaud, A.2
Lebras, M.3
-
37
-
-
32544448056
-
Role of mitochondria as the gardens of cell death
-
Kim R, Emi M, Tanabe M. Role of mitochondria as the gardens of cell death. Cancer Chemother Pharmacol 2006; 57: 545-53.
-
(2006)
Cancer Chemother Pharmacol
, vol.57
, pp. 545-553
-
-
Kim, R.1
Emi, M.2
Tanabe, M.3
-
38
-
-
0037070178
-
Regulated and unregulated mitochondrial permeability transition pores: A new paradigm of pore structure and function?
-
He L, Lemaster JJ. Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett 2002; 512: 1-7.
-
(2002)
FEBS Lett
, vol.512
, pp. 1-7
-
-
He, L.1
Lemaster, J.J.2
-
39
-
-
0033782031
-
Cytochrome c release from mitochondria: All or nothing
-
Martinou JC, Desagher S, Antonsson B. Cytochrome c release from mitochondria: all or nothing. Nat Cell Biol 2000; 2: E41-3.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 41-43
-
-
Martinou, J.C.1
Desagher, S.2
Antonsson, B.3
-
40
-
-
0036775488
-
Role of mitochondrial inner membrane permeabilisation in necrotic cell death, apoptosis, and autophagy
-
Lemasters JJ, Qian T, He L. Role of mitochondrial inner membrane permeabilisation in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal 2002; 4: 769-81.
-
(2002)
Antioxid Redox Signal
, vol.4
, pp. 769-781
-
-
Lemasters, J.J.1
Qian, T.2
He, L.3
-
41
-
-
0035957969
-
The mitochondrian: Is it central to apoptosis?
-
Finkel E. The mitochondrian: is it central to apoptosis? Science 2001; 292: 624-6.
-
(2001)
Science
, vol.292
, pp. 624-626
-
-
Finkel, E.1
-
42
-
-
34247371033
-
Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy
-
Maddika S, Ande SR, Panigrahi S. Cell survival, cell death and cell cycle pathways are interconnected: Implications for cancer therapy. Drug Resistance Updates 2007; 10: 13-29.
-
(2007)
Drug Resistance Updates
, vol.10
, pp. 13-29
-
-
Maddika, S.1
Ande, S.R.2
Panigrahi, S.3
-
43
-
-
0033386851
-
Mitochondrial membrane permeabilisation during the apoptotic process
-
Jacotot E, Costantini P, Laboureau E, Zamzami N, Susin SA, Kroemer G. Mitochondrial membrane permeabilisation during the apoptotic process. Ann N Y Acad Sci 1999; 887: 18-30.
-
(1999)
Ann N Y Acad Sci
, vol.887
, pp. 18-30
-
-
Jacotot, E.1
Costantini, P.2
Laboureau, E.3
Zamzami, N.4
Susin, S.A.5
Kroemer, G.6
-
44
-
-
49349117553
-
Apoptosis signalling pathways in anticancer therapy
-
Fulda S, Debatin KM. Apoptosis signalling pathways in anticancer therapy. Curr Cancer Ther Rev 2008; 4: 14-20.
-
(2008)
Curr Cancer Ther Rev
, vol.4
, pp. 14-20
-
-
Fulda, S.1
Debatin, K.M.2
-
48
-
-
33746906633
-
Mitochondria in cancer
-
Kroemer G. Mitochondria in cancer. Oncogene 2006; 25: 4630-2.
-
(2006)
Oncogene
, vol.25
, pp. 4630-4632
-
-
Kroemer, G.1
-
49
-
-
70349606857
-
Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis
-
Singh KK, Ayyasamy V, Owens KM, Koul MS, Vujcic M. Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis. J Hum Genet 2009; 54: 516-24.
-
(2009)
J Hum Genet
, vol.54
, pp. 516-524
-
-
Singh, K.K.1
Ayyasamy, V.2
Owens, K.M.3
Koul, M.S.4
Vujcic, M.5
-
50
-
-
33746930794
-
Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer
-
King A, Selak MA, Gottlieb E. Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene 2006; 25: 4675-82.
-
(2006)
Oncogene
, vol.25
, pp. 4675-4682
-
-
King, A.1
Selak, M.A.2
Gottlieb, E.3
-
51
-
-
72049125350
-
Cancer associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, et al. Cancer associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009; 462: 739-44.
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
53
-
-
33746927077
-
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
-
Robey RB, Hay N. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 2006; 25: 4683-96.
-
(2006)
Oncogene
, vol.25
, pp. 4683-4696
-
-
Robey, R.B.1
Hay, N.2
-
55
-
-
3442886811
-
The pathophysiology of mitochondrial cell death
-
Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004; 305: 626-9.
-
(2004)
Science
, vol.305
, pp. 626-629
-
-
Green, D.R.1
Kroemer, G.2
-
56
-
-
33746880609
-
Mitochondrial factors with dual roles in death and survival
-
Cheng WC, Berman SB, Ivanovska I, et al. Mitochondrial factors with dual roles in death and survival. Oncogene 2006; 25: 4697-705.
-
(2006)
Oncogene
, vol.25
, pp. 4697-4705
-
-
Cheng, W.C.1
Berman, S.B.2
Ivanovska, I.3
-
57
-
-
33746912767
-
The permeability transition pore complex in cancer cell death
-
Brenner C, Grimm S. The permeability transition pore complex in cancer cell death. Oncogene 2006; 25: 4744-56.
-
(2006)
Oncogene
, vol.25
, pp. 4744-4756
-
-
Brenner, C.1
Grimm, S.2
-
58
-
-
33746933765
-
The many shapes of mitochondrial death
-
Cereghetti GM, Scorrano L. The many shapes of mitochondrial death. Oncogene 2006; 25: 4717-4724.
-
(2006)
Oncogene
, vol.25
, pp. 4717-4724
-
-
Cereghetti, G.M.1
Scorrano, L.2
-
59
-
-
33746883125
-
p53 and Nur77/TR3: Transcription factors that directly target mitochondria for cell death induction
-
Moll UM, Marchenko N, Zhang XK. p53 and Nur77/TR3: Transcription factors that directly target mitochondria for cell death induction. Oncogene 2006; 25: 4725-43.
-
(2006)
Oncogene
, vol.25
, pp. 4725-4743
-
-
Moll, U.M.1
Marchenko, N.2
Zhang, X.K.3
-
60
-
-
33746905052
-
Mitochondria in hematopoiesis and hematological diseases
-
Fontenay M, Cathelin S, Amiot M, Gyan E, Solary E. Mitochondria in hematopoiesis and hematological diseases. Oncogene 2006; 25: 4757-67.
-
(2006)
Oncogene
, vol.25
, pp. 4757-4767
-
-
Fontenay, M.1
Cathelin, S.2
Amiot, M.3
Gyan, E.4
Solary, E.5
-
61
-
-
74049160403
-
Targeting the Warburg effect in haematological malignancies: From PET to therapy
-
Shanmugam M, McBrayer SK, Rosen ST. Targeting the Warburg effect in haematological malignancies: from PET to therapy. Curr Opin Oncol 2009; 21: 531-6.
-
(2009)
Curr Opin Oncol
, vol.21
, pp. 531-536
-
-
Shanmugam, M.1
McBrayer, S.K.2
Rosen, S.T.3
-
62
-
-
33746924468
-
Hexokinase II: Cancer's Double-Edged Sword Acting as Both Facilitator and Gatekeeper of Malignancy when Bound to Mitochondria
-
Mathupala SP, Ko YH, Pedersen PL. Hexokinase II: Cancer's Double-Edged Sword Acting as Both Facilitator and Gatekeeper of Malignancy when Bound to Mitochondria. Oncogene 2006; 25: 4777-86.
-
(2006)
Oncogene
, vol.25
, pp. 4777-4786
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
64
-
-
77950083955
-
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells
-
He Y, Wu J, Dressman DC, et al. Heteroplasmic mitochondrial DNA mutations in normal and tumour cells. Nature 2010; 464: 610-4.
-
(2010)
Nature
, vol.464
, pp. 610-614
-
-
He, Y.1
Wu, J.2
Dressman, D.C.3
-
65
-
-
0031736203
-
Somatic mutations of the mitochondrial genome in human colorectal tumours
-
Polyak K, Li Y, Zhu H, et al. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 1998; 20: 291-3.
-
(1998)
Nat Genet
, vol.20
, pp. 291-293
-
-
Polyak, K.1
Li, Y.2
Zhu, H.3
-
66
-
-
76749101102
-
Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer
-
Hung WY, Wu CW, Yin PH, et al. Somatic mutations in mitochondrial genome and their potential roles in the progression of human gastric cancer. Biochim Biophys Acta 2010; 1800: 264-70.
-
(2010)
Biochim Biophys Acta
, vol.1800
, pp. 264-270
-
-
Hung, W.Y.1
Wu, C.W.2
Yin, P.H.3
-
67
-
-
76249097338
-
Cancer cell mitochondria confer apoptosis resistance and promote metastasis
-
Kulawiec M, Owens KM, Singh KK. Cancer cell mitochondria confer apoptosis resistance and promote metastasis. Cancer Biol Ther 2009; 8: 1378-85.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 1378-1385
-
-
Kulawiec, M.1
Owens, K.M.2
Singh, K.K.3
-
70
-
-
0034027867
-
Studies on biomarkers in cancer etiology and prevention: A summary and challenge of 20 years of interdisciplinary research
-
Bartsch H. Studies on biomarkers in cancer etiology and prevention: a summary and challenge of 20 years of interdisciplinary research. Mutat Res 2000; 462: 255-79.
-
(2000)
Mutat Res
, vol.462
, pp. 255-279
-
-
Bartsch, H.1
-
71
-
-
0034011261
-
Oxyradicals and DNA damage
-
Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis 2000; 21: 361-70.
-
(2000)
Carcinogenesis
, vol.21
, pp. 361-370
-
-
Marnett, L.J.1
-
72
-
-
41149105722
-
Mitochondria in cancer cells: What is so special about them?
-
Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria in cancer cells: what is so special about them? Trends Cell Biol 2008; 18: 165-73.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 165-173
-
-
Gogvadze, V.1
Orrenius, S.2
Zhivotovsky, B.3
-
74
-
-
63849158757
-
Mitochondria: From bioenergetics to the metabolic regulation of carcinogenesis
-
Bellance N, Lestienne P, Rossignol R. Mitochondria: from bioenergetics to the metabolic regulation of carcinogenesis. Front Biosci 2009; 14: 4015-34.
-
(2009)
Front Biosci
, vol.14
, pp. 4015-4034
-
-
Bellance, N.1
Lestienne, P.2
Rossignol, R.3
-
75
-
-
34247895697
-
Voltage-dependent anion channels are dispensable for mitochondrialdependent cell death
-
Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD. Voltage-dependent anion channels are dispensable for mitochondrialdependent cell death. Nat Cell Biol 2007; 9: 550-5.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 550-555
-
-
Baines, C.P.1
Kaiser, R.A.2
Sheiko, T.3
Craigen, W.J.4
Molkentin, J.D.5
-
76
-
-
34247895699
-
Mitochondrial apoptosis without VDAC
-
Galluzzi L, Kroemer G. Mitochondrial apoptosis without VDAC. Nat Cell Biol 2007; 9: 487-9.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 487-489
-
-
Galluzzi, L.1
Kroemer, G.2
-
77
-
-
0842307483
-
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
-
Kokoszka JE, Waymire KG, Levy SE, et al. The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature 2004; 427: 461-5.
-
(2004)
Nature
, vol.427
, pp. 461-465
-
-
Kokoszka, J.E.1
Waymire, K.G.2
Levy, S.E.3
-
78
-
-
15844375853
-
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
-
Baines CP, Kaiser RA, Purcell NH, et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 2005; 434: 658-62.
-
(2005)
Nature
, vol.434
, pp. 658-662
-
-
Baines, C.P.1
Kaiser, R.A.2
Purcell, N.H.3
-
79
-
-
33751505090
-
Electrophysiological characterisation of the Cyclophilin D-deleted mitochondrial permeability transition pore
-
De Marchi U, Basso E, Szabo I, Zoratti M. Electrophysiological characterisation of the Cyclophilin D-deleted mitochondrial permeability transition pore. Mol Membr Biol 2006; 23: 521-30.
-
(2006)
Mol Membr Biol
, vol.23
, pp. 521-530
-
-
De Marchi, U.1
Basso, E.2
Szabo, I.3
Zoratti, M.4
-
80
-
-
34247485841
-
Role of the mitochondrial membrane permeability transition in cell death
-
Tsujimoto Y, Shimizu S. Role of the mitochondrial membrane permeability transition in cell death. Apoptosis 2007; 12: 835-40.
-
(2007)
Apoptosis
, vol.12
, pp. 835-840
-
-
Tsujimoto, Y.1
Shimizu, S.2
-
81
-
-
58149487806
-
Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells
-
Hu Z, Guo X, Yu Q, et al. Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells. FBS Lett 2009; 583: 383-8.
-
(2009)
FBS Lett
, vol.583
, pp. 383-388
-
-
Hu, Z.1
Guo, X.2
Yu, Q.3
-
82
-
-
65549130400
-
Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults
-
Lee J, Schriner SE, Wallace DC. Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults. Biochim Biophys Acta 2009; 1787: 364-70.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 364-370
-
-
Lee, J.1
Schriner, S.E.2
Wallace, D.C.3
-
83
-
-
44849101183
-
Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo
-
Jang JY, Choi Y, Jeon YK, Kim CW. Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo. Breast Cancer Res 2008; 10: R11.
-
(2008)
Breast Cancer Res
, vol.10
-
-
Jang, J.Y.1
Choi, Y.2
Jeon, Y.K.3
Kim, C.W.4
-
84
-
-
77649190623
-
The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells
-
Gallerne C, Touat Z, Chen ZX, et al. The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells. Int J Biochem Cell Biol 2010; 42: 623-9.
-
(2010)
Int J Biochem Cell Biol
, vol.42
, pp. 623-629
-
-
Gallerne, C.1
Touat, Z.2
Chen, Z.X.3
-
85
-
-
58149340656
-
A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies
-
Schimmer AD, O'Brien S, Kantarjian H, et al. A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies. Clin Cancer Res 2008; 14: 8295-301.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 8295-8301
-
-
Schimmer, A.D.1
O'Brien, S.2
Kantarjian, H.3
-
86
-
-
0035891212
-
Adenine nucleotide translocator mediates the mitochondrial membrane permeabilisation induced by Ionidamine, arsenite and CD437
-
Belzacq AS, El Hamel C, Vieira HL, et al. Adenine nucleotide translocator mediates the mitochondrial membrane permeabilisation induced by Ionidamine, arsenite and CD437. Oncogene 2001; 20: 7579-87.
-
(2001)
Oncogene
, vol.20
, pp. 7579-7587
-
-
Belzacq, A.S.1
El Hamel, C.2
Vieira, H.L.3
-
87
-
-
74049160403
-
Targeting the Warburg effect in haematological malignancies: From PET to Therapy
-
Shanmugam M, McBrayer SK, Rosen ST. Targeting the Warburg effect in haematological malignancies: from PET to Therapy. Curr Opin Oncol 2009; 21: 531-6.
-
(2009)
Curr Opin Oncol
, vol.21
, pp. 531-536
-
-
Shanmugam, M.1
McBrayer, S.K.2
Rosen, S.T.3
-
88
-
-
0038206442
-
Phase II study of Ionidamine and diazepam in the treatment of recurrent glioblastoma multiform
-
Oudard S, Carpentier A, Banu, E, et al. Phase II study of Ionidamine and diazepam in the treatment of recurrent glioblastoma multiform. J Neurooncol 2003; 63: 81-6.
-
(2003)
J Neurooncol
, vol.63
, pp. 81-86
-
-
Oudard, S.1
Carpentier, A.2
Banu, E.3
-
89
-
-
9244240959
-
Lonidamine significantly increases the activity of epirubicin in patients with advanced breast cancer: Results from a multicenter prospective randomised trial
-
Dogliott L, Berruti A, Buniva T, et al. Lonidamine significantly increases the activity of epirubicin in patients with advanced breast cancer: results from a multicenter prospective randomised trial. J Clin Oncol 1996; 14: 1165-72.
-
(1996)
J Clin Oncol
, vol.14
, pp. 1165-1172
-
-
Dogliott, L.1
Berruti, A.2
Buniva, T.3
-
90
-
-
0037108676
-
Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: Final results of a phase III study with a factorial design
-
Berruti A, Bitossi R, Gorzegno G, et al. Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of a phase III study with a factorial design. J Clin Oncol 2002; 20: 4150-9.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4150-4159
-
-
Berruti, A.1
Bitossi, R.2
Gorzegno, G.3
-
91
-
-
0035123284
-
Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study
-
De Lena M, Lorusso V, Latorre A, et al. Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study. Eur J Cancer 2001; 37: 364-8.
-
(2001)
Eur J Cancer
, vol.37
, pp. 364-368
-
-
De Lena, M.1
Lorusso, V.2
Latorre, A.3
-
92
-
-
58849088375
-
Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion
-
Mullauer FB, Kessler JH, Medema JP. Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion. Apoptosis 2009; 14: 191-202.
-
(2009)
Apoptosis
, vol.14
, pp. 191-202
-
-
Mullauer, F.B.1
Kessler, J.H.2
Medema, J.P.3
-
93
-
-
3242810661
-
Betulinic acid: A promising anti-cancer candidate
-
Eiznhamer DA, Xu ZQ. Betulinic acid: a promising anti-cancer candidate. IDRugs 2004; 7: 359-73.
-
(2004)
IDRugs
, vol.7
, pp. 359-373
-
-
Eiznhamer, D.A.1
Xu, Z.Q.2
-
94
-
-
0033646961
-
Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors
-
Fulda S, Debatin KM. Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors. Med Pediatr Oncol 2000; 35: 616-8.
-
(2000)
Med Pediatr Oncol
, vol.35
, pp. 616-618
-
-
Fulda, S.1
Debatin, K.M.2
-
95
-
-
0032545386
-
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
-
Fulda S, Scaffidi C, Susin S A, et al. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem 1998; 273: 33942-8.
-
(1998)
J Biol Chem
, vol.273
, pp. 33942-33948
-
-
Fulda, S.1
Scaffidi, C.2
Susin, S.A.3
-
96
-
-
0032189535
-
Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells
-
Fulda S, Susin SA, Kroemer G, Debatin KM. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. Cancer Res 1998; 58: 4453-60.
-
(1998)
Cancer Res
, vol.58
, pp. 4453-4460
-
-
Fulda, S.1
Susin, S.A.2
Kroemer, G.3
Debatin, K.M.4
-
97
-
-
0030815250
-
Betulinic acid triggers CD95 (APO-1/Fas)-and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
-
Fulda S, Friesen C, Los M, et al. Betulinic acid triggers CD95 (APO-1/Fas)-and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res 1997; 57: 4956-64.
-
(1997)
Cancer Res
, vol.57
, pp. 4956-4964
-
-
Fulda, S.1
Friesen, C.2
Los, M.3
-
98
-
-
33747622523
-
Molecular profiling of signalling proteins for effects induced by the anti-cancer compound GSAO with 400 antibodies
-
Cadd VA, Hogg PJ, Harris AL, Feller SM. Molecular profiling of signalling proteins for effects induced by the anti-cancer compound GSAO with 400 antibodies. BMC Cancer 2006; 6: 155.
-
(2006)
BMC Cancer
, vol.6
, pp. 155
-
-
Cadd, V.A.1
Hogg, P.J.2
Harris, A.L.3
Feller, S.M.4
-
99
-
-
58149095551
-
Metabolism of the tumor angiogenesis inhibitor 4-(N-(S-Glutathionylacetyl) amino)phenylarsonous acid
-
Dilda PJ, Ramsay EE, Corti A, Pompella A, Hogg PJ. Metabolism of the tumor angiogenesis inhibitor 4-(N-(S-Glutathionylacetyl) amino)phenylarsonous acid. J Biol Chem 2008; 283: 35428-34.
-
(2008)
J Biol Chem
, vol.283
, pp. 35428-35434
-
-
Dilda, P.J.1
Ramsay, E.E.2
Corti, A.3
Pompella, A.4
Hogg, P.J.5
-
100
-
-
0142010897
-
A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells
-
Don AS, Kisker O, Dilda P, et al. A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells. Cancer Cell 2003; 3: 497-509.
-
(2003)
Cancer Cell
, vol.3
, pp. 497-509
-
-
Don, A.S.1
Kisker, O.2
Dilda, P.3
-
101
-
-
70350075458
-
Optimisation of the antitumour efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol
-
Dilda PJ, Decollogne S, Weerakoon L, et al. Optimisation of the antitumour efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol. J Med Chem 2009; 52: 6209-16.
-
(2009)
J Med Chem
, vol.52
, pp. 6209-6216
-
-
Dilda, P.J.1
Decollogne, S.2
Weerakoon, L.3
-
102
-
-
84858738899
-
The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase
-
Park D, Chiu J, Perrone GG, Dilda PJ, Hogg PJ. The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell Intl 2012; 12: 11.
-
(2012)
Cancer Cell Intl
, vol.12
, pp. 11
-
-
Park, D.1
Chiu, J.2
Perrone, G.G.3
Dilda, P.J.4
Hogg, P.J.5
-
103
-
-
0342368618
-
Current issues in the management of acute promyelocytic leukemia
-
Slack JL, Rusiniak ME. Current issues in the management of acute promyelocytic leukemia. Ann Hematol 2000; 79: 227-38.
-
(2000)
Ann Hematol
, vol.79
, pp. 227-238
-
-
Slack, J.L.1
Rusiniak, M.E.2
-
104
-
-
0037221034
-
All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition
-
Notario B, Zamora M, Vinas O, Mampel T. All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition. Mol Pharmacol 2003; 63: 224-31.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 224-231
-
-
Notario, B.1
Zamora, M.2
Vinas, O.3
Mampel, T.4
-
105
-
-
33751181914
-
Motexafin gadolinium: A novel redox active drug for cancer therapy
-
Magda D, Miller RA. Motexafin gadolinium: a novel redox active drug for cancer therapy. Semin Cancer Biol 2006; 16: 466-76.
-
(2006)
Semin Cancer Biol
, vol.16
, pp. 466-476
-
-
Magda, D.1
Miller, R.A.2
-
106
-
-
56149091530
-
Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: A Children's Oncology Group phase I study
-
Bradley KA, Pollack IF, Reid JM, et al. Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children's Oncology Group phase I study. Neuro Oncol 2008; 10: 752-8.
-
(2008)
Neuro Oncol
, vol.10
, pp. 752-758
-
-
Bradley, K.A.1
Pollack, I.F.2
Reid, J.M.3
-
107
-
-
0034642510
-
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis
-
Costantini P, Belzacq A, La Vieira H, et al. Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis. Oncogene 2000; 19: 307-14.
-
(2000)
Oncogene
, vol.19
, pp. 307-314
-
-
Costantini, P.1
Belzacq, A.2
La Vieira, H.3
-
108
-
-
34547481318
-
An NQO1-and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by lapachone
-
Bey EA, Bentle MS, Reinicke KE, et al. An NQO1-and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by lapachone. Proc Natl Acad Sci USA 2007; 104: 11832-7.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 11832-11837
-
-
Bey, E.A.1
Bentle, M.S.2
Reinicke, K.E.3
-
109
-
-
3543084996
-
Effective treatment of advanced solid tumours by the combination of arsenic trioxide and L-buthionine-sulfoximine
-
Maeda H, Ohizumi H, Segawa T, Kakehi Y, Ogawa O, Kakizuka A. Effective treatment of advanced solid tumours by the combination of arsenic trioxide and L-buthionine-sulfoximine. Cell Death Differ 2004; 11: 737-46.
-
(2004)
Cell Death Differ
, vol.11
, pp. 737-746
-
-
Maeda, H.1
Ohizumi, H.2
Segawa, T.3
Kakehi, Y.4
Ogawa, O.5
Kakizuka, A.6
-
110
-
-
33947309495
-
Phase I trial of imexon in patients with advanced malignancy
-
Dragovich T, Mendelson D, Wong L, et al. Phase I trial of imexon in patients with advanced malignancy. J Clin Oncol 2007; 25: 1779-84.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1779-1784
-
-
Dragovich, T.1
Mendelson, D.2
Wong, L.3
-
111
-
-
77956056306
-
Phase I trial of imexon, a prooxidant, in combination with docetaxel for the treatment of pateints with advanced breast, non-small cell lung and prostate cancer
-
Moulder S, Dhillon N, Ng C, et al. Phase I trial of imexon, a prooxidant, in combination with docetaxel for the treatment of pateints with advanced breast, non-small cell lung and prostate cancer. Invest New Drugs 2010; 28: 634-40.
-
(2010)
Invest New Drugs
, vol.28
, pp. 634-640
-
-
Moulder, S.1
Dhillon, N.2
Ng, C.3
-
112
-
-
38049096222
-
Reactive oxygen species may have antitumor activity in metastatic melanoma
-
Tuma RS. Reactive oxygen species may have antitumor activity in metastatic melanoma. J Natl Cancer Inst 2008; 100: 11-12.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 11-12
-
-
Tuma, R.S.1
-
113
-
-
53349153454
-
Elesclomol induces cancer cell apoptosis through oxidative stress
-
Kirshner JR, He S, Balasubramanyam V, et al. Elesclomol induces cancer cell apoptosis through oxidative stress. Mol Cancer Ther 2008; 7: 2319-27.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2319-2327
-
-
Kirshner, J.R.1
He, S.2
Balasubramanyam, V.3
-
114
-
-
33846856501
-
Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors
-
Berkenblit A, Eder JP Jr., Ryan DP, et al. Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors. Clin Cancer Res 2007; 13: 584-90.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 584-590
-
-
Berkenblit, A.1
Eder Jr., J.P.2
Ryan, D.P.3
-
115
-
-
73949153317
-
Phase II, randomised, controlled, double-blinded trial of weekly elesclomol plus paclitaxel versus paclitaxel alone for stage IV metastatic melanoma
-
O'Day S, Gonzalez R, Lawson D, et al. Phase II, randomised, controlled, double-blinded trial of weekly elesclomol plus paclitaxel versus paclitaxel alone for stage IV metastatic melanoma. J Clin Oncol 2009; 27: 5452-8.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5452-5458
-
-
O'Day, S.1
Gonzalez, R.2
Lawson, D.3
-
116
-
-
33144488485
-
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir
-
Alexandre J, Nicco C, Chéreau C, et al. Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir. J Natl Cancer Inst 2006; 98: 236-44.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 236-244
-
-
Alexandre, J.1
Nicco, C.2
Chéreau, C.3
-
117
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by phenylethyl isothiocyanate
-
Trachootham D, Zhou Y, Zhang H, et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by phenylethyl isothiocyanate. Cancer Cell 2006; 10: 241-52.
-
(2006)
Cancer Cell
, vol.10
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
-
118
-
-
33750448018
-
Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential
-
Xiao D, Lew KL, Zeng Y, et al. Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential. Carcinogenesis 2006; 27: 2223-34.
-
(2006)
Carcinogenesis
, vol.27
, pp. 2223-2234
-
-
Xiao, D.1
Lew, K.L.2
Zeng, Y.3
-
119
-
-
77956218104
-
Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells
-
Xiao D, Powolny AA, Moura MB, et al. Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells. J Biol Chem 2010; 285: 26558-69.
-
(2010)
J Biol Chem
, vol.285
, pp. 26558-26569
-
-
Xiao, D.1
Powolny, A.A.2
Moura, M.B.3
-
120
-
-
84863583356
-
Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotxic to ovarian cancer cultures
-
Chan DK, Miskimins WK. Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotxic to ovarian cancer cultures. J Ovarian Res 2012; 5: 19.
-
(2012)
J Ovarian Res
, vol.5
, pp. 19
-
-
Chan, D.K.1
Miskimins, W.K.2
-
121
-
-
18744413903
-
Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives: Structure-activity relationships
-
Wood L, Leese MR, Leblond B, et al. Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives: structure-activity relationships. Anticancer Drug Des 2001; 16: 209-15.
-
(2001)
Anticancer Drug Des
, vol.16
, pp. 209-215
-
-
Wood, L.1
Leese, M.R.2
Leblond, B.3
-
122
-
-
0034699294
-
Cancer: A radical approach to treatment
-
Cleveland JL, Kastan MB. Cancer: a radical approach to treatment. Nature 2000; 407: 309-11.
-
(2000)
Nature
, vol.407
, pp. 309-311
-
-
Cleveland, J.L.1
Kastan, M.B.2
-
123
-
-
69249212263
-
Activity of 2-methoxyoestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: A Hoosier Oncology Group trial
-
Matei D, Schilder J, Sutton G, et al. Activity of 2-methoxyoestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial. Gynecol Oncol 2009; 115: 90-6.
-
(2009)
Gynecol Oncol
, vol.115
, pp. 90-96
-
-
Matei, D.1
Schilder, J.2
Sutton, G.3
-
124
-
-
63149115931
-
Phase I trial of 2-methoxyestradiol NanoCrystal dispersion in advanced solid malignancies
-
Tevaarwerk AJ, Holen KD, Alberti DB, et al. Phase I trial of 2-methoxyestradiol NanoCrystal dispersion in advanced solid malignancies. Clin Cancer Res 2009; 15: 1460-5.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1460-1465
-
-
Tevaarwerk, A.J.1
Holen, K.D.2
Alberti, D.B.3
-
125
-
-
44449160071
-
2-mediated oxidation and inactivation of phosphatises in growth factor signalling
-
2-mediated oxidation and inactivation of phosphatises in growth factor signalling. Proc Natl Acad Sci USA 2008; 105: 7147-52.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 7147-7152
-
-
Juarez, J.C.1
Manuia, M.2
Burnett, M.E.3
-
126
-
-
0037827160
-
Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxidedependent apoptosis
-
Nonn L, Berggren M, Powis G. Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxidedependent apoptosis. Mol Cancer Res 2003; 1: 682-9.
-
(2003)
Mol Cancer Res
, vol.1
, pp. 682-689
-
-
Nonn, L.1
Berggren, M.2
Powis, G.3
-
127
-
-
33747371086
-
Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells
-
Kropotov A, Gogvadze V, Shupliakov O, et al. Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells. Exp Cell Res 2006; 312: 2806-15.
-
(2006)
Exp Cell Res
, vol.312
, pp. 2806-2815
-
-
Kropotov, A.1
Gogvadze, V.2
Shupliakov, O.3
-
128
-
-
80055049908
-
Mitochondrial peroxiredoxin III is apotential target for cancer therapy
-
Song IS, Kim HK, Jeong SH, et al. Mitochondrial peroxiredoxin III is apotential target for cancer therapy. Int J Mol Sci 2011; 12: 7163-85.
-
(2011)
Int J Mol Sci
, vol.12
, pp. 7163-7185
-
-
Song, I.S.1
Kim, H.K.2
Jeong, S.H.3
-
129
-
-
0035002230
-
Increased expression of peroxiredoxin II confers resistance to cisplatin
-
Chung YM, Yoo YD, Park JK, Kim YT, Kim HJ. Increased expression of peroxiredoxin II confers resistance to cisplatin. Anticancer Res 2001; 21: 1129-33.
-
(2001)
Anticancer Res
, vol.21
, pp. 1129-1133
-
-
Chung, Y.M.1
Yoo, Y.D.2
Park, J.K.3
Kim, Y.T.4
Kim, H.J.5
-
130
-
-
67649279837
-
Sulfiredoxin transloaction into mitochondria play a crucial role in reducing hyperoxidised peroxiredoxin III
-
Noh YH, Baek JY, Jeong W, Rhee SG, Chang TS. Sulfiredoxin transloaction into mitochondria play a crucial role in reducing hyperoxidised peroxiredoxin III. J Biol Chem 2009; 284: 8470-7.
-
(2009)
J Biol Chem
, vol.284
, pp. 8470-8477
-
-
Noh, Y.H.1
Baek, J.Y.2
Jeong, W.3
Rhee, S.G.4
Chang, T.S.5
-
131
-
-
33745950626
-
Mitochondrial outer membrane permeabilisation during apoptosis: The innocent bystander scenario
-
Chipuk JE, Bouchier-Hayes L, Green DR. Mitochondrial outer membrane permeabilisation during apoptosis: the innocent bystander scenario. Cell Death Differ 2006; 13: 1396-402.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1396-1402
-
-
Chipuk, J.E.1
Bouchier-Hayes, L.2
Green, D.R.3
-
132
-
-
54549114986
-
BAX activation is initiated at a novel interaction site
-
Gavathiotis E, Suzuki M, Davis ML, et al. BAX activation is initiated at a novel interaction site. Nature 2008; 455: 1076-81.
-
(2008)
Nature
, vol.455
, pp. 1076-1081
-
-
Gavathiotis, E.1
Suzuki, M.2
Davis, M.L.3
-
133
-
-
33947409221
-
TOM22, a core component of the mitochondrial outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax
-
Bellot G, Cartron PF, Er E, et al. TOM22, a core component of the mitochondrial outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. Cell Death Differ 2007; 14: 785-94.
-
(2007)
Cell Death Differ
, vol.14
, pp. 785-794
-
-
Bellot, G.1
Cartron, P.F.2
Er, E.3
-
134
-
-
65249133454
-
TOM-independent complex formation of Bax and Bak in mammalian mitochondria during TNFinduced apoptosis
-
Ross K, Rudel T, Kozjak-Pavlovic V. TOM-independent complex formation of Bax and Bak in mammalian mitochondria during TNFinduced apoptosis. Cell Death Differ 2009; 16: 697-707.
-
(2009)
Cell Death Differ
, vol.16
, pp. 697-707
-
-
Ross, K.1
Rudel, T.2
Kozjak-Pavlovic, V.3
-
135
-
-
71749097850
-
Bax activates endophilin B1 oligomerisation and lipid membrane vesiculation
-
Rostovtseva TK, Boukari H, Antignani A, et al. Bax activates endophilin B1 oligomerisation and lipid membrane vesiculation. J Biol Chem 2009; 284: 34390-9.
-
(2009)
J Biol Chem
, vol.284
, pp. 34390-34399
-
-
Rostovtseva, T.K.1
Boukari, H.2
Antignani, A.3
-
136
-
-
33745685054
-
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA 1-dependent cristae remodeling
-
Cipolat S, Rudka T, Hartmann D, et al. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA 1-dependent cristae remodeling. Cell 2006; 126: 163-75.
-
(2006)
Cell
, vol.126
, pp. 163-175
-
-
Cipolat, S.1
Rudka, T.2
Hartmann, D.3
-
137
-
-
33745699393
-
OPA 1 controls apoptotic cristae remodeling independently from mitochondrial fusion
-
Frezza C, Cipolat S, Martins de Brito O, et al. OPA 1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 2006; 126: 177-89.
-
(2006)
Cell
, vol.126
, pp. 177-189
-
-
Frezza, C.1
Cipolat, S.2
Martins de Brito, O.3
-
138
-
-
60849086456
-
Bcl-2 inhibitors: Small molecules with a big impact on cancer therapy
-
Vogler M, Dinsdale D, Dyer MJ, Cohen GM. Bcl-2 inhibitors: small molecules with a big impact on cancer therapy. Cell Death Differ 2009; 16: 360-7.
-
(2009)
Cell Death Differ
, vol.16
, pp. 360-367
-
-
Vogler, M.1
Dinsdale, D.2
Dyer, M.J.3
Cohen, G.M.4
-
139
-
-
67549141546
-
Different forms of cell death induced by putative BCL2 inhibitors
-
Vogler M, Weber K, Dinsdale D, et al. Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ 2009; 16: 1030-9.
-
(2009)
Cell Death Differ
, vol.16
, pp. 1030-1039
-
-
Vogler, M.1
Weber, K.2
Dinsdale, D.3
-
140
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumors
-
Oltersdorf T, Elmore, SW, Shoemaker AR, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumors. Nature 2005; 435: 677-81.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
-
141
-
-
34548814971
-
Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukaemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
-
Kang MH, Kang YH, Szymanska B, et al. Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukaemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. Blood 2007; 110: 2057-66.
-
(2007)
Blood
, vol.110
, pp. 2057-2066
-
-
Kang, M.H.1
Kang, Y.H.2
Szymanska, B.3
-
142
-
-
56149097601
-
Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins
-
Tagscherer KE, Fassl A, Campos B, et al. Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins. Oncogene 2008; 27: 6646-56.
-
(2008)
Oncogene
, vol.27
, pp. 6646-6656
-
-
Tagscherer, K.E.1
Fassl, A.2
Campos, B.3
-
143
-
-
54249093808
-
Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737
-
Kutuk O, Letai A. Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737. Cancer Res 2008; 68: 7985-94.
-
(2008)
Cancer Res
, vol.68
, pp. 7985-7994
-
-
Kutuk, O.1
Letai, A.2
-
144
-
-
42049104916
-
Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer
-
Hann CL, Daniel VC, Sugar EA, et al. Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer. Cancer Res 2008; 68: 2321-8.
-
(2008)
Cancer Res
, vol.68
, pp. 2321-2328
-
-
Hann, C.L.1
Daniel, V.C.2
Sugar, E.A.3
-
145
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
Tse C, Shoemaker AR, Adickes J, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res 2008; 68: 3421-8.
-
(2008)
Cancer Res
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
-
146
-
-
51249185922
-
Gossypol and some other terpenoids, flavonoids, and phenols that affect quality of cottonseed protein
-
Lynn A, Jones L. Gossypol and some other terpenoids, flavonoids, and phenols that affect quality of cottonseed protein. Am Oil Chemists Soc 1979; 56: 727-30.
-
(1979)
Am Oil Chemists Soc
, vol.56
, pp. 727-730
-
-
Lynn, A.1
Jones, L.2
-
147
-
-
58149168589
-
Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy
-
Azmi AS, Mohammad RM. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. J Cell Physiol 2009; 218: 13-21.
-
(2009)
J Cell Physiol
, vol.218
, pp. 13-21
-
-
Azmi, A.S.1
Mohammad, R.M.2
-
148
-
-
65649130832
-
An open-label, multicentre, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer
-
Liu G, Kelly WK, Wilding G, Leopold L, Brill K, Somer B. An open-label, multicentre, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. Clin Cancer Res 2009; 15: 3172-219.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3172-3219
-
-
Liu, G.1
Kelly, W.K.2
Wilding, G.3
Leopold, L.4
Brill, K.5
Somer, B.6
-
149
-
-
42449147919
-
Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)
-
Kitada S, Kress CL, Krajewska M, Jia L, Pellecchia M, Reed JC. Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Blood 2008; 111: 3211-9.
-
(2008)
Blood
, vol.111
, pp. 3211-3219
-
-
Kitada, S.1
Kress, C.L.2
Krajewska, M.3
Jia, L.4
Pellecchia, M.5
Reed, J.C.6
-
150
-
-
33749016520
-
A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo
-
Shoemaker AR, Oleksijew A, Bauch J, et al. A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo. Cancer Res 2006; 66: 8731-9.
-
(2006)
Cancer Res
, vol.66
, pp. 8731-8739
-
-
Shoemaker, A.R.1
Oleksijew, A.2
Bauch, J.3
-
151
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M, Marcellus RC, Roulston A, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci USA 2007; 104: 19512-7.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19512-19517
-
-
Nguyen, M.1
Marcellus, R.C.2
Roulston, A.3
-
152
-
-
34249982915
-
Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
-
Trudel S, Li ZH, Rauw J, Tiedemann RE, Wen XY, Stewart AK. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood 2007; 109: 5430-8.
-
(2007)
Blood
, vol.109
, pp. 5430-5438
-
-
Trudel, S.1
Li, Z.H.2
Rauw, J.3
Tiedemann, R.E.4
Wen, X.Y.5
Stewart, A.K.6
-
153
-
-
58849164097
-
Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
-
O'Brien SM, Claxton DF, Crump M, et al. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood 2009; 113: 299-305.
-
(2009)
Blood
, vol.113
, pp. 299-305
-
-
O'Brien, S.M.1
Claxton, D.F.2
Crump, M.3
-
154
-
-
58149340656
-
A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies
-
Schimmer A D, O'Brien S, Kantarjian H, et al. A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies. Clin Cancer Res 2008; 14: 8295-301.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 8295-8301
-
-
Schimmer, A.D.1
O'Brien, S.2
Kantarjian, H.3
-
155
-
-
77957029255
-
Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis
-
Parikh SA, Kantarjian H, Schimmer A, et al. Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clinical lymphoma, myeloma & leukemia 2010; 10: 285-9.
-
(2010)
Clinical lymphoma, myeloma & leukemia
, vol.10
, pp. 285-289
-
-
Parikh, S.A.1
Kantarjian, H.2
Schimmer, A.3
-
157
-
-
59449091820
-
Phase I/II study of G3139 (Bcl-2 antisense oligonucleotide) in combination with doxorubicin and docetaxel in breast cancer
-
Moulder SL, Symmans WF, Booser DJ, et al. Phase I/II study of G3139 (Bcl-2 antisense oligonucleotide) in combination with doxorubicin and docetaxel in breast cancer. Clin Cancer Res 2008; 14: 7909-16.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7909-7916
-
-
Moulder, S.L.1
Symmans, W.F.2
Booser, D.J.3
-
158
-
-
34047217206
-
Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia
-
O'Brien S, Moore JO, Boyd TE, et al. Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol 2007; 25: 1114-1120.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1114-1120
-
-
O'Brien, S.1
Moore, J.O.2
Boyd, T.E.3
-
159
-
-
54049145194
-
Phase II multicenter study of oblimersen sodium, a Bcl2 antisense oligonucleotide, in combination with rituximab in patients with recurrent Bcell nonHodgkin lymphoma
-
Pro B, Leber B, Smith M, et al. Phase II multicenter study of oblimersen sodium, a Bcl2 antisense oligonucleotide, in combination with rituximab in patients with recurrent Bcell nonHodgkin lymphoma. Br J Haematol 2008; 143: 355-60.
-
(2008)
Br J Haematol
, vol.143
, pp. 355-360
-
-
Pro, B.1
Leber, B.2
Smith, M.3
-
160
-
-
68449085118
-
Phase III randomised study of dexamethasone with or without oblimersen sodium for patients with advanced multiple myeloma
-
Chanan-Khan AA, Niesvizky R, Hohl RJ, et al. Phase III randomised study of dexamethasone with or without oblimersen sodium for patients with advanced multiple myeloma. Leuk Lymphoma 2009; 50: 559-65.
-
(2009)
Leuk Lymphoma
, vol.50
, pp. 559-565
-
-
Chanan-Khan, A.A.1
Niesvizky, R.2
Hohl, R.J.3
-
161
-
-
39749166555
-
Randomized phase II Study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103
-
Rudin CM, Salgia R, Wang X, et al. Randomized phase II Study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103. J Clin Oncol 2008; 26: 870-6.
-
(2008)
J Clin Oncol
, vol.26
, pp. 870-876
-
-
Rudin, C.M.1
Salgia, R.2
Wang, X.3
-
162
-
-
0034691130
-
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
-
Wang JL, Liu D, Zhang ZJ, et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci USA 2000; 97: 7124-9.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7124-7129
-
-
Wang, J.L.1
Liu, D.2
Zhang, Z.J.3
-
163
-
-
33645059697
-
The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death
-
Manero F, Gautier F, Gallenne T, et al. The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. Cancer Res 2006; 66: 2757-64.
-
(2006)
Cancer Res
, vol.66
, pp. 2757-2764
-
-
Manero, F.1
Gautier, F.2
Gallenne, T.3
-
164
-
-
34249825191
-
HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells
-
Oliver L, Mahé B, Gréé R, Vallette FM, Juin P. HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells. Leuk Res 2007; 31: 859-63.
-
(2007)
Leuk Res
, vol.31
, pp. 859-863
-
-
Oliver, L.1
Mahé, B.2
Gréé, R.3
Vallette, F.M.4
Juin, P.5
-
166
-
-
4944242891
-
Polyamines and cancer: Old molecules, new understanding
-
Gerner EW, Meyskens FL. Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer 2004; 4: 781-92.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 781-792
-
-
Gerner, E.W.1
Meyskens, F.L.2
-
167
-
-
0028956729
-
Polyamines as targets for therapeutic intervention
-
Marton LJ, Pegg AE. Polyamines as targets for therapeutic intervention. Annu Rev Pharmacol Toxicol 1995; 35: 55-91.
-
(1995)
Annu Rev Pharmacol Toxicol
, vol.35
, pp. 55-91
-
-
Marton, L.J.1
Pegg, A.E.2
-
168
-
-
0023923949
-
Synthetic polyamine analogs as antineoplastics
-
Bergeron RJ, Neims AH, McManis JS, et al. Synthetic polyamine analogs as antineoplastics. J Med Chem 1988; 31: 1183-90.
-
(1988)
J Med Chem
, vol.31
, pp. 1183-1190
-
-
Bergeron, R.J.1
Neims, A.H.2
McManis, J.S.3
-
169
-
-
34248228763
-
Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
-
Casero RA, Marton LJ. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Dis 2007; 6: 373-90.
-
(2007)
Nat Rev Drug Dis
, vol.6
, pp. 373-390
-
-
Casero, R.A.1
Marton, L.J.2
-
170
-
-
73149118652
-
Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes
-
Huang Y, Stewart TM, Wu Y, et al. Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. Clin Cancer Res 2009; 15: 7217-28.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7217-7228
-
-
Huang, Y.1
Stewart, T.M.2
Wu, Y.3
-
171
-
-
38549141763
-
Synergistic antitumor effects of anthracenylmethyl homospermidine and alphadifluoromethylornithine on promyelocytic leukemia HL60 cells
-
Xie SQ, Liu GC, Ma YF, et al. Synergistic antitumor effects of anthracenylmethyl homospermidine and alphadifluoromethylornithine on promyelocytic leukemia HL60 cells. Toxicol In vitro 2008; 22: 352-8.
-
(2008)
Toxicol In vitro
, vol.22
, pp. 352-358
-
-
Xie, S.Q.1
Liu, G.C.2
Ma, Y.F.3
-
172
-
-
73149104152
-
A putrescine-anthracene conjugate: A paradigm for selective drug delivery
-
Palmer A J, Ghani RA, Kaur N, Phanstiel O, Wallace HM. A putrescine-anthracene conjugate: a paradigm for selective drug delivery. Biochem J 2009; 424: 431-8.
-
(2009)
Biochem J
, vol.424
, pp. 431-438
-
-
Palmer, A.J.1
Ghani, R.A.2
Kaur, N.3
Phanstiel, O.4
Wallace, H.M.5
-
173
-
-
0027511220
-
The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes
-
Guppy M, Greiner E, Brand K. The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes. Eur J Biochem 1993; 212: 95-9.
-
(1993)
Eur J Biochem
, vol.212
, pp. 95-99
-
-
Guppy, M.1
Greiner, E.2
Brand, K.3
-
174
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis RJ, Mancuso A, Daikhin E, et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 2007; 104: 19345-50.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
-
175
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4: 891-9.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
176
-
-
4744341871
-
Advanced cancers: Eradication in all cases using 3-bromopyruvate therapy to deplete ATP
-
Ko YH, Smith BL, Wang Y, et al. Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. Biochem Biophysical Res Commun 2004; 324: 269-75.
-
(2004)
Biochem Biophysical Res Commun
, vol.324
, pp. 269-275
-
-
Ko, Y.H.1
Smith, B.L.2
Wang, Y.3
-
177
-
-
12544256565
-
Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
-
Xu RH, Pelicano H, Zhou Y, et al. Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 2005; 65: 613-21.
-
(2005)
Cancer Res
, vol.65
, pp. 613-621
-
-
Xu, R.H.1
Pelicano, H.2
Zhou, Y.3
-
178
-
-
33947726287
-
Intraarterial therapy with a new potent inhibitor of tumor metabolism (3-bromopyruvate): Identification of therapeutic dose and method of injection in an animal model of liver cancer
-
Vali M, Liapi E, Kowalski J, et al. Intraarterial therapy with a new potent inhibitor of tumor metabolism (3-bromopyruvate): identification of therapeutic dose and method of injection in an animal model of liver cancer. J Vasc Interv Radiol 2007; 18: 95-101.
-
(2007)
J Vasc Interv Radiol
, vol.18
, pp. 95-101
-
-
Vali, M.1
Liapi, E.2
Kowalski, J.3
-
179
-
-
34447513075
-
Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: Novel pathways and targets for anticancer therapeutics
-
Airley RE, Mobasheri A. Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics. Chemotherapy 2007; 53: 233-56.
-
(2007)
Chemotherapy
, vol.53
, pp. 233-256
-
-
Airley, R.E.1
Mobasheri, A.2
-
180
-
-
0036077547
-
Glucose transporters: Expression, regulation and cancer
-
Medina RA, Owen GI. Glucose transporters: expression, regulation and cancer. Biol Res 2002; 35: 9-26.
-
(2002)
Biol Res
, vol.35
, pp. 9-26
-
-
Medina, R.A.1
Owen, G.I.2
-
181
-
-
84864122028
-
Glycolysis inhibitors as a potential therapeutic option to treat aggressive neuroblastoma expressing GLUT1
-
Matsushita K, Uchida K, Saigusa S, et al. Glycolysis inhibitors as a potential therapeutic option to treat aggressive neuroblastoma expressing GLUT1. J Pediatr Surg 2012; 47: 1323-30.
-
(2012)
J Pediatr Surg
, vol.47
, pp. 1323-1330
-
-
Matsushita, K.1
Uchida, K.2
Saigusa, S.3
-
182
-
-
28544444116
-
Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
-
Xu RH, Pelicano H, Zhang H, Giles FJ, Keating MJ, Huang P. Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells. Leukemia 2005; 19: 2153-8.
-
(2005)
Leukemia
, vol.19
, pp. 2153-2158
-
-
Xu, R.H.1
Pelicano, H.2
Zhang, H.3
Giles, F.J.4
Keating, M.J.5
Huang, P.6
-
183
-
-
46649106720
-
Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels
-
Chiara F, Castellaro D, Marin O, et al. Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS One 2008; 3: e1852.
-
(2008)
PLoS One
, vol.3
-
-
Chiara, F.1
Castellaro, D.2
Marin, O.3
-
184
-
-
47749093652
-
Methyl jasmonate binds to and detaches mitochondria-bound hexokinase
-
Goldin N, Arzoine L, Heyfets A, et al. Methyl jasmonate binds to and detaches mitochondria-bound hexokinase. Oncogene 2008; 27: 4636-43.
-
(2008)
Oncogene
, vol.27
, pp. 4636-4643
-
-
Goldin, N.1
Arzoine, L.2
Heyfets, A.3
-
185
-
-
0001601215
-
Effect of 2-deoxyglucose on carbohydrate metabolism: Review of the literature and studies in the rat
-
Brown J. Effect of 2-deoxyglucose on carbohydrate metabolism: review of the literature and studies in the rat. Metabolism 1962; 11: 1098-112.
-
(1962)
Metabolism
, vol.11
, pp. 1098-1112
-
-
Brown, J.1
-
186
-
-
32044448517
-
2-Deoxyglucose: An anticancer and antiviral therapeutic, but not anymore a low glucose mimetic
-
Kang HT, Hwang ES. 2-Deoxyglucose: an anticancer and antiviral therapeutic, but not anymore a low glucose mimetic. Life Sci 2006; 78: 1392-9.
-
(2006)
Life Sci
, vol.78
, pp. 1392-1399
-
-
Kang, H.T.1
Hwang, E.S.2
-
187
-
-
0442313668
-
Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions
-
Maher J, Krishan A, Lampidis T. Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother Pharmacol 2004; 53: 116-22.
-
(2004)
Cancer Chemother Pharmacol
, vol.53
, pp. 116-122
-
-
Maher, J.1
Krishan, A.2
Lampidis, T.3
-
188
-
-
34248142302
-
2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells
-
Simons AL, Ahmad IM, Mattson DM, Dornfeld KJ, Spitz DR. 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Res 2007; 67: 3364-70.
-
(2007)
Cancer Res
, vol.67
, pp. 3364-3370
-
-
Simons, A.L.1
Ahmad, I.M.2
Mattson, D.M.3
Dornfeld, K.J.4
Spitz, D.R.5
-
190
-
-
42249111525
-
2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMPactivated protein kinase signalling activation or glycolysis inhibition
-
Zhong D, Liu X, Schafer-Hales K, et al. 2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMPactivated protein kinase signalling activation or glycolysis inhibition. Mol Cancer Ther 2008; 7: 809-17.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 809-817
-
-
Zhong, D.1
Liu, X.2
Schafer-Hales, K.3
-
191
-
-
33846002728
-
+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
-
+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth. Cancer cell 11: 37-51.
-
Cancer cell
, vol.11
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
-
192
-
-
33646830260
-
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children
-
Stacpoole PW, Kerr DS, Barnes C, et al. Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics 2006; 117: 1519-1531.
-
(2006)
Pediatrics
, vol.117
, pp. 1519-1531
-
-
Stacpoole, P.W.1
Kerr, D.S.2
Barnes, C.3
-
193
-
-
26644441651
-
ATP citrate lyase inhibition can suppress tumor cell growth
-
Hatzivassiliou G, Zhao F, Bauer DE, et al. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 2005; 8: 311-21.
-
(2005)
Cancer Cell
, vol.8
, pp. 311-321
-
-
Hatzivassiliou, G.1
Zhao, F.2
Bauer, D.E.3
-
194
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. ATP-citrate lyase links cellular metabolism to histone acetylation. Sci Signalling 2009; 324: 1076-80.
-
(2009)
Sci Signalling
, vol.324
, pp. 1076-1080
-
-
Wellen, K.E.1
Hatzivassiliou, G.2
Sachdeva, U.M.3
Bui, T.V.4
Cross, J.R.5
Thompson, C.B.6
-
195
-
-
0034652143
-
Subcellular localization of proteasomes and their regulatory complexes in mammalian cells
-
Brooks P, Fuertes G, Murray RZ, et al. Subcellular localization of proteasomes and their regulatory complexes in mammalian cells. Biochem J 2000; 346: 155-61.
-
(2000)
Biochem J
, vol.346
, pp. 155-161
-
-
Brooks, P.1
Fuertes, G.2
Murray, R.Z.3
-
196
-
-
0035736099
-
The proteasome: A new target for novel drug therapies
-
Elliott PJ, Ross JS. The proteasome: a new target for novel drug therapies. Am J Clin Pathol 2001; 116: 637-46.
-
(2001)
Am J Clin Pathol
, vol.116
, pp. 637-646
-
-
Elliott, P.J.1
Ross, J.S.2
-
197
-
-
0030014843
-
In vivo characterization of the proteasome regulator PA28
-
Ahn K, Erlander M, Leturcq D, Peterson PA, Früh K, Yang Y. In vivo characterization of the proteasome regulator PA28. J Biol Chem 1996; 271: 18237-42.
-
(1996)
J Biol Chem
, vol.271
, pp. 18237-18242
-
-
Ahn, K.1
Erlander, M.2
Leturcq, D.3
Peterson, P.A.4
Früh, K.5
Yang, Y.6
-
198
-
-
0033965851
-
The proteasome activator 11 S REG (PA28) and class I antigen presentation
-
Rechsteiner M, Realini C, Ustrell V. The proteasome activator 11 S REG (PA28) and class I antigen presentation. Biochem J 2000; 345: 1-15.
-
(2000)
Biochem J
, vol.345
, pp. 1-15
-
-
Rechsteiner, M.1
Realini, C.2
Ustrell, V.3
-
199
-
-
0036596666
-
Proteasome dynamics during cell cycle in rat Schwann cells
-
Lafarga M, Fernández R, Mayo I, Berciano MT, Castaño JG. Proteasome dynamics during cell cycle in rat Schwann cells. Glia 2002; 38: 313-28.
-
(2002)
Glia
, vol.38
, pp. 313-328
-
-
Lafarga, M.1
Fernández, R.2
Mayo, I.3
Berciano, M.T.4
Castaño, J.G.5
-
200
-
-
0031034160
-
Activation of the cell death program by inhibition of proteasome function
-
Drexler HC. Activation of the cell death program by inhibition of proteasome function. Proc Natl Acad Sci USA 1997; 94: 855-60.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 855-860
-
-
Drexler, H.C.1
-
201
-
-
0033965742
-
Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells
-
Drexler HC, Risau W, Konerding MA. Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells. FASEB J 2000; 14: 65-77.
-
(2000)
FASEB J
, vol.14
, pp. 65-77
-
-
Drexler, H.C.1
Risau, W.2
Konerding, M.A.3
-
203
-
-
0033152760
-
Proteasome inhibitors: A novel class of potent and effective antitumor agents
-
Adams J, Palombella VJ, Sausville EA, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 1999; 59: 2615-22.
-
(1999)
Cancer Res
, vol.59
, pp. 2615-2622
-
-
Adams, J.1
Palombella, V.J.2
Sausville, E.A.3
-
204
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. New Engl JMed 2003; 348: 2609-17.
-
(2003)
New Engl JMed
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
205
-
-
21344469223
-
Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma
-
Jagannath S, Durie BG, Wolf J, et al. Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. Br J Haematol 2005; 129: 776-83.
-
(2005)
Br J Haematol
, vol.129
, pp. 776-783
-
-
Jagannath, S.1
Durie, B.G.2
Wolf, J.3
-
206
-
-
0038189917
-
Rationale for the treatment of solid tumors with the proteasome inhibitor bortezomib
-
Cusack JC. Rationale for the treatment of solid tumors with the proteasome inhibitor bortezomib. Cancer Treat Rev 2003; 29: 21-31.
-
(2003)
Cancer Treat Rev
, vol.29
, pp. 21-31
-
-
Cusack, J.C.1
-
207
-
-
0037514596
-
Clinical update: Proteasome inhibitors in solid tumors
-
Lenz HJ. Clinical update: Proteasome inhibitors in solid tumors. Cancer Treat Rev 2003; 29: 41-8.
-
(2003)
Cancer Treat Rev
, vol.29
, pp. 41-48
-
-
Lenz, H.J.1
-
208
-
-
34447116376
-
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
-
Demo SD, Kirk CJ, Aujay MA, et al. Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res 2007; 67: 6383-91.
-
(2007)
Cancer Res
, vol.67
, pp. 6383-6391
-
-
Demo, S.D.1
Kirk, C.J.2
Aujay, M.A.3
-
209
-
-
36148944490
-
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
-
Kuhn DJ, Chen Q, Voorhees P M, et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 2007; 110: 3281-90.
-
(2007)
Blood
, vol.110
, pp. 3281-3290
-
-
Kuhn, D.J.1
Chen, Q.2
Voorhees, P.M.3
-
210
-
-
84855430944
-
Molecular pathways: Targeting proteasomal protein degradation in cancer
-
Molineaux SM. Molecular pathways: targeting proteasomal protein degradation in cancer. Clin Cancer Res 2012; 18: 15-20.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 15-20
-
-
Molineaux, S.M.1
-
211
-
-
3042577683
-
Approval summary for bortezomib for injection in the treatment of multiple myeloma
-
Bross PF, Kane R, Farrell AT, et al. Approval summary for bortezomib for injection in the treatment of multiple myeloma. Clin Cancer Res 2004; 10: 3954-64.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3954-3964
-
-
Bross, P.F.1
Kane, R.2
Farrell, A.T.3
-
212
-
-
77955450608
-
Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low dose dexamethasone (CRd) in relapsed and refractory multiple myeloma (MM)
-
Niesvizky R, Wang L, Orlowski RZ, et al. Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low dose dexamethasone (CRd) in relapsed and refractory multiple myeloma (MM). Blood 2009; 114: 128-9.
-
(2009)
Blood
, vol.114
, pp. 128-129
-
-
Niesvizky, R.1
Wang, L.2
Orlowski, R.Z.3
-
213
-
-
84864568543
-
Proteasome inhibitors in multiple myeloma: 10 years later
-
Moreau P, Richardson PG, Cavo M, et al. Proteasome inhibitors in multiple myeloma: 10 years later. Blood 2012; 120: 947-59.
-
(2012)
Blood
, vol.120
, pp. 947-959
-
-
Moreau, P.1
Richardson, P.G.2
Cavo, M.3
-
214
-
-
79951684725
-
Marizomib, a proteasome inhibitor for all seasons: Preclinical profile and a framework for clinical trials
-
Baritaki S, Berkers C, Bonavida B, et al. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets 2011; 11: 254-84.
-
(2011)
Curr Cancer Drug Targets
, vol.11
, pp. 254-284
-
-
Baritaki, S.1
Berkers, C.2
Bonavida, B.3
-
215
-
-
79954990288
-
Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs
-
Obaidat A, Weiss J, Wahlgren B, et al. Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs. J Pharmacol Exp Ther 2011; 337: 479-86.
-
(2011)
J Pharmacol Exp Ther
, vol.337
, pp. 479-486
-
-
Obaidat, A.1
Weiss, J.2
Wahlgren, B.3
-
216
-
-
77951682116
-
Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI0052 (marizomib) in a human plasmacytoma xenograft murine model
-
Singh AV, Palladino MA, Lloyd GK, Potts BC, Chauhan D, Anderson KC. Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI0052 (marizomib) in a human plasmacytoma xenograft murine model. Br J Haematol 2010; 149: 550-9.
-
(2010)
Br J Haematol
, vol.149
, pp. 550-559
-
-
Singh, A.V.1
Palladino, M.A.2
Lloyd, G.K.3
Potts, B.C.4
Chauhan, D.5
Anderson, K.C.6
-
217
-
-
77950238258
-
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer
-
Kupperman E, Lee EC, Cao Y, et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res 2010; 70: 1970-80.
-
(2010)
Cancer Res
, vol.70
, pp. 1970-1980
-
-
Kupperman, E.1
Lee, E.C.2
Cao, Y.3
-
218
-
-
80051691845
-
In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells
-
Chauhan D, Tian Z, Zhou B, et al. In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells. Clin Cancer Res 2011; 17: 5311-21.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5311-5321
-
-
Chauhan, D.1
Tian, Z.2
Zhou, B.3
-
219
-
-
78649755360
-
A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
-
Chauhan D, Singh A V, Aujay M, et al. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood 2010; 116: 4906-15.
-
(2010)
Blood
, vol.116
, pp. 4906-4915
-
-
Chauhan, D.1
Singh, A.V.2
Aujay, M.3
-
220
-
-
81155138545
-
A phase I, open-label, doseescalation study of the novel oral proteasome inhibitor (PI) ONX 0912 in patients with advanced refractory or recurrent solid tumors
-
Papadopoulos KP, Mendelson DS, Tolcher AW, Patnaik A, Burris HA, Rasco DW. A phase I, open-label, doseescalation study of the novel oral proteasome inhibitor (PI) ONX 0912 in patients with advanced refractory or recurrent solid tumors. J Clin Oncol 2011; 29.
-
(2011)
J Clin Oncol
, vol.29
-
-
Papadopoulos, K.P.1
Mendelson, D.S.2
Tolcher, A.W.3
Patnaik, A.4
Burris, H.A.5
Rasco, D.W.6
-
221
-
-
70350765046
-
ER stress response, Peroxisome prioliferation, Mitochondrial unfolded protein response and Golgi stress response
-
Yoshida H. ER stress response, Peroxisome prioliferation, Mitochondrial unfolded protein response and Golgi stress response. Life 2009; 61: 871-9.
-
(2009)
Life
, vol.61
, pp. 871-879
-
-
Yoshida, H.1
-
222
-
-
34250745700
-
The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation)
-
Brodsky JL. The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation). Biochem J 2007; 404: 353-63.
-
(2007)
Biochem J
, vol.404
, pp. 353-363
-
-
Brodsky, J.L.1
-
223
-
-
36248949141
-
The endoplasmic reticulum and the unfolded protein response
-
Malhotra JD, Kaufman RJ. The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol 2007 18: 716-31.
-
(2007)
Semin Cell Dev Biol
, vol.18
, pp. 716-731
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
224
-
-
33846548110
-
ER stress and diseases
-
Yoshida H. ER stress and diseases. FEBS J 2007; 274: 630-58.
-
(2007)
FEBS J
, vol.274
, pp. 630-658
-
-
Yoshida, H.1
-
225
-
-
68649102488
-
ER-Golgi network-a future target for anticancer therapy
-
Wlodkowic D, Skommer J, McGuinness D, Hillier C, Darzynkiewicz Z. ER-Golgi network-a future target for anticancer therapy. Leuk Res 2009; 33: 1440-7.
-
(2009)
Leuk Res
, vol.33
, pp. 1440-1447
-
-
Wlodkowic, D.1
Skommer, J.2
McGuinness, D.3
Hillier, C.4
Darzynkiewicz, Z.5
-
226
-
-
77953387854
-
Endoplasmic reticulum stress response in cancer: Molecular mechanism and therapeutic potential
-
Wang G, Yang ZQ, Zhang K. Endoplasmic reticulum stress response in cancer: molecular mechanism and therapeutic potential. Am J Transl Res 2010; 2: 65-74.
-
(2010)
Am J Transl Res
, vol.2
, pp. 65-74
-
-
Wang, G.1
Yang, Z.Q.2
Zhang, K.3
-
227
-
-
34248571826
-
GRP78 induction in cancer: Therapeutic and prognostic implications
-
Lee AS. GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res 2007; 67: 3496-9.
-
(2007)
Cancer Res
, vol.67
, pp. 3496-3499
-
-
Lee, A.S.1
-
229
-
-
0037427412
-
Mechanisms of cytochrome c release by proapoptotic BCL-2 family members
-
Scorrano L, Korsmeyer SJ. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 2003; 304: 437-44.
-
(2003)
Biochem Biophys Res Commun
, vol.304
, pp. 437-444
-
-
Scorrano, L.1
Korsmeyer, S.J.2
-
230
-
-
71749110928
-
Targeting the endoplasmic reticulum-stress response as an anticancer strategy
-
Healy SJ, Gorman AM, Mousavi-Shafaei P, Gupta S, Samali A. Targeting the endoplasmic reticulum-stress response as an anticancer strategy. Eur J Pharmacol 2009; 625: 234-46.
-
(2009)
Eur J Pharmacol
, vol.625
, pp. 234-246
-
-
Healy, S.J.1
Gorman, A.M.2
Mousavi-Shafaei, P.3
Gupta, S.4
Samali, A.5
-
231
-
-
33744539521
-
Proteasome inhibitiors induce a terminal unfolded protein response in multiple myeloma cells
-
Obeng EA, Carlson LM, Gutman DM, et al. Proteasome inhibitiors induce a terminal unfolded protein response in multiple myeloma cells. Blood 2006; 107: 4907-16.
-
(2006)
Blood
, vol.107
, pp. 4907-4916
-
-
Obeng, E.A.1
Carlson, L.M.2
Gutman, D.M.3
-
232
-
-
34948890040
-
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
-
Davenport EL, Moore HE, Dunlop AS, et al. Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood 2007; 110: 2641-49.
-
(2007)
Blood
, vol.110
, pp. 2641-2649
-
-
Davenport, E.L.1
Moore, H.E.2
Dunlop, A.S.3
-
233
-
-
34548827350
-
Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo
-
Gills JJ, LoPiccolo J, Tsurutani J, et al. Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clinical Cancer Res 2007; 13: 5183-94.
-
(2007)
Clinical Cancer Res
, vol.13
, pp. 5183-5194
-
-
Gills, J.J.1
LoPiccolo, J.2
Tsurutani, J.3
-
234
-
-
36348961452
-
HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress
-
Pyrko P, Kardosh A, Wang W, Xiong W, Schönthal AH, Chen TC. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res 2007; 67: 10920-28.
-
(2007)
Cancer Res
, vol.67
, pp. 10920-10928
-
-
Pyrko, P.1
Kardosh, A.2
Wang, W.3
Xiong, W.4
Schönthal, A.H.5
Chen, T.C.6
-
235
-
-
51049124323
-
Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomibinduced apoptosis
-
Kraus M, Malenke E, Gogel J, et al. Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomibinduced apoptosis. Mol Cancer Ther 2008; 7: 1940-8.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1940-1948
-
-
Kraus, M.1
Malenke, E.2
Gogel, J.3
-
236
-
-
0035158741
-
Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts
-
Deng WG, Ruan KH, Du M, Saunders MA, Wu KK. Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts. FASEB J 15: 2463-70.
-
FASEB J
, vol.15
, pp. 2463-2470
-
-
Deng, W.G.1
Ruan, K.H.2
Du, M.3
Saunders, M.A.4
Wu, K.K.5
-
237
-
-
33749460895
-
Epigallocatechin Gallate Overcomes Resistance to Etoposide-Induced Cell Death by Targeting the Molecular Chaperone Glucose-Regulated Protein 78
-
Ermakova SP, Kang BS, Choi BY, et al. Epigallocatechin Gallate Overcomes Resistance to Etoposide-Induced Cell Death by Targeting the Molecular Chaperone Glucose-Regulated Protein 78. Cancer Res 2006; 66: 9260-9.
-
(2006)
Cancer Res
, vol.66
, pp. 9260-9269
-
-
Ermakova, S.P.1
Kang, B.S.2
Choi, B.Y.3
-
238
-
-
0032481676
-
Mechanism for the suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soy
-
Zhou Y, Lee AS. Mechanism for the suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soy. J Natl Cancer Inst 1998; 90: 381-8.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 381-388
-
-
Zhou, Y.1
Lee, A.S.2
-
239
-
-
0037163259
-
Versipelostatin, a novel GRP78/Bip molecular chaperone down-regulator of microbial origin
-
Park HR, Furihata K, Hayakawa Y, Shin-ya K. Versipelostatin, a novel GRP78/Bip molecular chaperone down-regulator of microbial origin. Tetrahedron Lett 2002; 43: 6941-5.
-
(2002)
Tetrahedron Lett
, vol.43
, pp. 6941-6945
-
-
Park, H.R.1
Furihata, K.2
Hayakawa, Y.3
Shin-ya, K.4
-
240
-
-
35548994250
-
Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator
-
Umeda Y, Furihata K, Sakuda S, et al. Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator. Organic Lett 2007; 9: 4239-42.
-
(2007)
Organic Lett
, vol.9
, pp. 4239-4242
-
-
Umeda, Y.1
Furihata, K.2
Sakuda, S.3
-
241
-
-
33845564748
-
Glucose-deprived HT-29 human colon carcinoma cells are sensitive to verrucosidin as a GRP78 down-regulator
-
Park HR, Ryoo IJ, Choo SJ, et al. Glucose-deprived HT-29 human colon carcinoma cells are sensitive to verrucosidin as a GRP78 down-regulator. Toxicol 2007; 229: 253-61.
-
(2007)
Toxicol
, vol.229
, pp. 253-261
-
-
Park, H.R.1
Ryoo, I.J.2
Choo, S.J.3
-
242
-
-
39149109651
-
Etoposideresistant HT29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 downregulator
-
Hwang JH, Kim JY, Cha MR, et al. Etoposideresistant HT29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 downregulator. J Cell Physiol 2008; 215: 243-50.
-
(2008)
J Cell Physiol
, vol.215
, pp. 243-250
-
-
Hwang, J.H.1
Kim, J.Y.2
Cha, M.R.3
-
243
-
-
17044421363
-
Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp
-
Choo SJ, Park HR, Ryoo IJ, et al. Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp. J Antibiot 2005; 58: 210-3.
-
(2005)
J Antibiot
, vol.58
, pp. 210-213
-
-
Choo, S.J.1
Park, H.R.2
Ryoo, I.J.3
-
244
-
-
84873409612
-
Pharmacological targeting of endoplasmic reticulum stress signalling in cancer
-
(2012)
-
Schönthal AH. (2012) Pharmacological targeting of endoplasmic reticulum stress signalling in cancer. Biochem Pharmacol 2012; 85: 653-66.
-
(2012)
Biochem Pharmacol
, vol.85
, pp. 653-666
-
-
Schönthal, A.H.1
-
245
-
-
58049213923
-
Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy
-
Yu DH, Macdonald J, Liu G, et al. Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy. PloS one 2008; 3: e3951.
-
(2008)
PloS one
, vol.3
-
-
Yu, D.H.1
Macdonald, J.2
Liu, G.3
-
246
-
-
77952502347
-
Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity
-
Kim JY, Hwang JH, Cha MR, et al. Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. J Cell Physiol 2010; 224: 33-40.
-
(2010)
J Cell Physiol
, vol.224
, pp. 33-40
-
-
Kim, J.Y.1
Hwang, J.H.2
Cha, M.R.3
-
247
-
-
79951537603
-
Beyond the endoplasmic reticulum: Atypical GPR78 in cell viability, signalling and therapeutic targeting
-
Ni M, Zhang Y, Lee AS. Beyond the endoplasmic reticulum: atypical GPR78 in cell viability, signalling and therapeutic targeting. Biochem J 2011; 434: 181-8.
-
(2011)
Biochem J
, vol.434
, pp. 181-188
-
-
Ni, M.1
Zhang, Y.2
Lee, A.S.3
-
248
-
-
0033903708
-
Brefeldin A induces p53-independent apoptosis in primary cultures of human prostatic cancer cells
-
Wallen E, Sellers RG, Peehl DM. Brefeldin A induces p53-independent apoptosis in primary cultures of human prostatic cancer cells. J Urol 2000; 164: 836-41.
-
(2000)
J Urol
, vol.164
, pp. 836-841
-
-
Wallen, E.1
Sellers, R.G.2
Peehl, D.M.3
-
249
-
-
0030587429
-
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53
-
Shao RG, Shimizu T, Pommier Y. Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53. Exp Cell Res 1996; 227: 190-6.
-
(1996)
Exp Cell Res
, vol.227
, pp. 190-196
-
-
Shao, R.G.1
Shimizu, T.2
Pommier, Y.3
-
250
-
-
78650831339
-
Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stressinduced apoptosis through inhibition of reactive oxygen species production and CHOP induction
-
Choi JH, Choi AY, Yoon H, et al. Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stressinduced apoptosis through inhibition of reactive oxygen species production and CHOP induction. Exp Mol Med 2010; 42: 811-22.
-
(2010)
Exp Mol Med
, vol.42
, pp. 811-822
-
-
Choi, J.H.1
Choi, A.Y.2
Yoon, H.3
-
251
-
-
0042308774
-
Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer
-
Denmeade SR, Jakobsen CM, Janssen S, et al. Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer. J Natl Cancer Inst 2003; 95: 990-1000.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 990-1000
-
-
Denmeade, S.R.1
Jakobsen, C.M.2
Janssen, S.3
-
252
-
-
84863198078
-
Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy
-
Denmeade SR, Mhaka AM, Rosen DM, et al. Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy. Sci Transl Med 2012; 4: 140ra86-140ra86.
-
(2012)
Sci Transl Med
, vol.4
-
-
Denmeade, S.R.1
Mhaka, A.M.2
Rosen, D.M.3
-
253
-
-
84867363671
-
Unfolded protein response to autophagy as a promising druggable target for anticancer therapy
-
Suh DH, Kim MK, Kim HS, Chung HH, Song YS. Unfolded protein response to autophagy as a promising druggable target for anticancer therapy. Ann N Y Acad Sci 2012; 1271: 20-32.
-
(2012)
Ann N Y Acad Sci
, vol.1271
, pp. 20-32
-
-
Suh, D.H.1
Kim, M.K.2
Kim, H.S.3
Chung, H.H.4
Song, Y.S.5
-
254
-
-
0036236186
-
Celecoxib: A selective COX-2 inhibitor with anticancer properties
-
Koki AT, Masferrer JL. Celecoxib: a selective COX-2 inhibitor with anticancer properties. Cancer Control 2002; 9: 28-35.
-
(2002)
Cancer Control
, vol.9
, pp. 28-35
-
-
Koki, A.T.1
Masferrer, J.L.2
-
255
-
-
36448957271
-
Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
-
Schönthal AH. Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy. Br J Cancer 2007; 97: 1465-8.
-
(2007)
Br J Cancer
, vol.97
, pp. 1465-1468
-
-
Schönthal, A.H.1
-
256
-
-
42149155405
-
Carbonic anhydrase inhibition: Insight into non-COX-2 pharmacological effect of some coxibs
-
Dogne JM, Thiry A, Supuran CT. Carbonic anhydrase inhibition: insight into non-COX-2 pharmacological effect of some coxibs. Curr Pharm Des 2008; 14: 679-84.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 679-684
-
-
Dogne, J.M.1
Thiry, A.2
Supuran, C.T.3
-
257
-
-
38849191201
-
Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2, 5-dimethyl-celecoxib
-
Kardosh A, Golden EB, Pyrko P, et al. Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2, 5-dimethyl-celecoxib. Cancer Res 2008; 68: 843-51.
-
(2008)
Cancer Res
, vol.68
, pp. 843-851
-
-
Kardosh, A.1
Golden, E.B.2
Pyrko, P.3
-
258
-
-
39049101494
-
Celecoxib analogs that lack COX-2 inhibitory function: Preclinical development of novel anticancer drugs
-
Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA. Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs. Expert Opin Investig Drugs 2008; 17: 197-208.
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 197-208
-
-
Schönthal, A.H.1
Chen, T.C.2
Hofman, F.M.3
Louie, S.G.4
Petasis, N.A.5
-
259
-
-
20844434173
-
Synergistic interactions between imatinib mesylate and the novel phosphoinositide-dependent kinase-1 inhibitor OSU-03012 in overcoming imatinib mesylate resistance
-
Tseng PH, Lin HP, Zhu J, et al. Synergistic interactions between imatinib mesylate and the novel phosphoinositide-dependent kinase-1 inhibitor OSU-03012 in overcoming imatinib mesylate resistance. Blood 2005; 105: 4021-7.
-
(2005)
Blood
, vol.105
, pp. 4021-4027
-
-
Tseng, P.H.1
Lin, H.P.2
Zhu, J.3
-
260
-
-
33751168744
-
Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor
-
Tseng PH, Wang YC, Weng SC, et al. Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor. Mol Pharmacol 2006; 70: 1534-41.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1534-1541
-
-
Tseng, P.H.1
Wang, Y.C.2
Weng, S.C.3
-
261
-
-
42249092819
-
Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor
-
Weng SC, Kashida Y, Kulp SK, et al. Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. Mol Cancer Thera 2008; 7: 800-8.
-
(2008)
Mol Cancer Thera
, vol.7
, pp. 800-808
-
-
Weng, S.C.1
Kashida, Y.2
Kulp, S.K.3
-
262
-
-
84865300412
-
Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors
-
Thomas S, Sharma N, Golden EB, et al. Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. Cancer Lett 2012; 325: 63-71.
-
(2012)
Cancer Lett
, vol.325
, pp. 63-71
-
-
Thomas, S.1
Sharma, N.2
Golden, E.B.3
-
263
-
-
33847685719
-
Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme
-
Briceno E, Calderon A, Sotelo J. Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme. Surg Neurol 2007; 67: 388-91.
-
(2007)
Surg Neurol
, vol.67
, pp. 388-391
-
-
Briceno, E.1
Calderon, A.2
Sotelo, J.3
-
264
-
-
1842865745
-
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
-
Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, Kondo S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 2004; 11: 448-57.
-
(2004)
Cell Death Differ
, vol.11
, pp. 448-457
-
-
Kanzawa, T.1
Germano, I.M.2
Komata, T.3
Ito, H.4
Kondo, Y.5
Kondo, S.6
-
266
-
-
71749096160
-
Chloroquine and its analogs; a new promise of an old drug for effective and safe cancer therapies
-
Solomon VR, Lee H. Chloroquine and its analogs; a new promise of an old drug for effective and safe cancer therapies. Eur J Pharmacol 2009; 625: 220-33.
-
(2009)
Eur J Pharmacol
, vol.625
, pp. 220-233
-
-
Solomon, V.R.1
Lee, H.2
-
267
-
-
0021040946
-
Lysosomes revisited
-
De Duve C. Lysosomes revisited. Eur J Biochem 1983; 137: 391-7.
-
(1983)
Eur J Biochem
, vol.137
, pp. 391-397
-
-
De Duve, C.1
-
268
-
-
0141907718
-
Destination 'Lysosome': A target organelle for tumour cell killing?
-
Castino R, Démoz M, Isidoro C. Destination 'Lysosome': a target organelle for tumour cell killing? J Mol Recogn 2003; 16: 337-48.
-
(2003)
J Mol Recogn
, vol.16
, pp. 337-348
-
-
Castino, R.1
Démoz, M.2
Isidoro, C.3
-
269
-
-
0036903036
-
Regulated exocytosis: A novel, widely expressed system
-
Borgonovo B, Cocucci E, Racchetti G, Podini P, Bachi A, Meldolesi J. Regulated exocytosis: a novel, widely expressed system. Nat Cell Biol 2002; 4: 955-62.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 955-962
-
-
Borgonovo, B.1
Cocucci, E.2
Racchetti, G.3
Podini, P.4
Bachi, A.5
Meldolesi, J.6
-
270
-
-
0037175388
-
Membrane proximal lysosomes are the major vesicles responsible for calciumdependent exocytosis in nonsecretory cells
-
Jaiswal JK, Andrews NW, Simon SM. Membrane proximal lysosomes are the major vesicles responsible for calciumdependent exocytosis in nonsecretory cells. J Cell Biol 25: 625-35.
-
J Cell Biol
, vol.25
, pp. 625-635
-
-
Jaiswal, J.K.1
Andrews, N.W.2
Simon, S.M.3
-
271
-
-
0027787534
-
Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells
-
Kisen GØ, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993; 14: 2501-05.
-
(1993)
Carcinogenesis
, vol.14
, pp. 2501-2505
-
-
Kisen, G.O.1
Tessitore, L.2
Costelli, P.3
-
272
-
-
17144361820
-
Lysosomes as targets for cancer therapy
-
Fehrenbacher N, Jäättelä M. Lysosomes as targets for cancer therapy. Cancer Res 65: 2993-5.
-
Cancer Res
, vol.65
, pp. 2993-2995
-
-
Fehrenbacher, N.1
Jäättelä, M.2
-
273
-
-
0034930528
-
Towards specific functions of lysosomal cysteine peptidases: Phenotypes of mice deficient for cathepsin B or cathepsin L
-
Reinheckel T, Deussing J, Roth W, Peters C. Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L. Biol Chem 2001; 382: 735-41.
-
(2001)
Biol Chem
, vol.382
, pp. 735-741
-
-
Reinheckel, T.1
Deussing, J.2
Roth, W.3
Peters, C.4
-
274
-
-
0031685364
-
Cysteine proteinases and their endogenous inhibitors: Target proteins for prognosis, diagnosis and therapy in cancer
-
Kos J, Lah TT. Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer. Oncol Rep 1998; 5: 1349-61.
-
(1998)
Oncol Rep
, vol.5
, pp. 1349-1361
-
-
Kos, J.1
Lah, T.T.2
-
277
-
-
2342603891
-
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
-
Joyce JA, Baruch A, Chehade K, et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer cell 2004; 5: 443-53.
-
(2004)
Cancer cell
, vol.5
, pp. 443-453
-
-
Joyce, J.A.1
Baruch, A.2
Chehade, K.3
-
278
-
-
2942718949
-
Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis
-
Lakka SS, Gondi CS, Yanamandra N, et al. Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene 2004; 23: 4681-9.
-
(2004)
Oncogene
, vol.23
, pp. 4681-4689
-
-
Lakka, S.S.1
Gondi, C.S.2
Yanamandra, N.3
-
279
-
-
0942265544
-
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins
-
Cirman T, Orei K, Mazovec GD, et al. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem 2004; 279: 3578-87.
-
(2004)
J Biol Chem
, vol.279
, pp. 3578-3587
-
-
Cirman, T.1
Orei, K.2
Mazovec, G.D.3
-
280
-
-
0038605721
-
Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes
-
Mousavi SA, Brech A, Berg T, Kjeken R. Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes. Biochem J 2003; 372: 861-9.
-
(2003)
Biochem J
, vol.372
, pp. 861-869
-
-
Mousavi, S.A.1
Brech, A.2
Berg, T.3
Kjeken, R.4
-
281
-
-
0037742249
-
Inhibition of phosphatidylinositol 3-kinase sensitises vascular endothelial cells to cytokineinitiated cathepsin-dependent apoptosis
-
Madge LA, Li JH, Choi J, Pober JS. Inhibition of phosphatidylinositol 3-kinase sensitises vascular endothelial cells to cytokineinitiated cathepsin-dependent apoptosis. J Biol Chem 2003; 278: 21295-306.
-
(2003)
J Biol Chem
, vol.278
, pp. 21295-21306
-
-
Madge, L.A.1
Li, J.H.2
Choi, J.3
Pober, J.S.4
-
282
-
-
4344651318
-
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization
-
Nylandsted J, Gyrd-Hansen M, Danielewicz A, et al. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med 2004; 200: 425-35.
-
(2004)
J Exp Med
, vol.200
, pp. 425-435
-
-
Nylandsted, J.1
Gyrd-Hansen, M.2
Danielewicz, A.3
-
283
-
-
0035018235
-
Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells
-
Zang Y, Beard RL, Chandraratna RA, Kang JX. Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells. Cell death and differentiation 2001; 8: 477-85.
-
(2001)
Cell death and differentiation
, vol.8
, pp. 477-485
-
-
Zang, Y.1
Beard, R.L.2
Chandraratna, R.A.3
Kang, J.X.4
-
284
-
-
0037086662
-
Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability
-
Neuzil J, Zhao M, Ostermann G, et al. Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability. Biochem J 2002; 362: 709-15.
-
(2002)
Biochem J
, vol.362
, pp. 709-715
-
-
Neuzil, J.1
Zhao, M.2
Ostermann, G.3
-
287
-
-
14144250911
-
Recent advances with liposomes as pharmaceutical carriers
-
Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005; 4: 145-60.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 145-160
-
-
Torchilin, V.P.1
-
288
-
-
34547657290
-
Enhanced transfection of tumor cells in vivo using "Smart" pH-sensitive TAT-modified pegylated liposomes
-
Kale AA, Torchilin VP. Enhanced transfection of tumor cells in vivo using "Smart" pH-sensitive TAT-modified pegylated liposomes. J Drug Target 2007; 15: 538-45.
-
(2007)
J Drug Target
, vol.15
, pp. 538-545
-
-
Kale, A.A.1
Torchilin, V.P.2
-
289
-
-
27844496561
-
Mixed micelles made of poly(ethylene glycol)-phosphatidylethanolamine conjugate and d-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camtothecin
-
Mu L, Elbayoumi TA, Torchilin VP. Mixed micelles made of poly(ethylene glycol)-phosphatidylethanolamine conjugate and d-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camtothecin. Int J Pharm 2005; 306: 142-9.
-
(2005)
Int J Pharm
, vol.306
, pp. 142-149
-
-
Mu, L.1
Elbayoumi, T.A.2
Torchilin, V.P.3
-
291
-
-
33748494877
-
Liposomes and liposome-like vesicles for drug and DNA delivery to mitochondria
-
Wsissig V, Boddapati SV, Cheng SM, D'Souza GG. Liposomes and liposome-like vesicles for drug and DNA delivery to mitochondria. J Liposome Res 2006; 16: 249-64.
-
(2006)
J Liposome Res
, vol.16
, pp. 249-264
-
-
Wsissig, V.1
Boddapati, S.V.2
Cheng, S.M.3
D'Souza, G.G.4
-
292
-
-
22144455351
-
Mitochondriotropic liposomes
-
Boddapati SV, Tongcharoensirikul P, Hanson RN, D'Souza GG, Torchilin VP, Weissig V. Mitochondriotropic liposomes. J Liposome Res 2005; 15: 49-58.
-
(2005)
J Liposome Res
, vol.15
, pp. 49-58
-
-
Boddapati, S.V.1
Tongcharoensirikul, P.2
Hanson, R.N.3
D'Souza, G.G.4
Torchilin, V.P.5
Weissig, V.6
-
293
-
-
52049115848
-
Organelle-targeted nanocarriers: Specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo
-
Boddapati SV, D'Souza GG, Erdogan S, Torchilin VP, Weissig V. Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo. Nano Lett 2008; 8: 2559-63.
-
(2008)
Nano Lett
, vol.8
, pp. 2559-2563
-
-
Boddapati, S.V.1
D'Souza, G.G.2
Erdogan, S.3
Torchilin, V.P.4
Weissig, V.5
-
294
-
-
34548659249
-
Multifunctional envelope-type nano device for non-viral gene delivery: Concept and application of programmed packaging
-
Kogure K, Akita H, Harashima H. Multifunctional envelope-type nano device for non-viral gene delivery: concept and application of programmed packaging. J Control Release 2007; 122: 246-51.
-
(2007)
J Control Release
, vol.122
, pp. 246-251
-
-
Kogure, K.1
Akita, H.2
Harashima, H.3
-
295
-
-
38949151892
-
Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system
-
Kogure K, Akita H, Yamada Y, Harashima H. Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system. Adv Drug Deliv Rev 2008; 60: 559-71.
-
(2008)
Adv Drug Deliv Rev
, vol.60
, pp. 559-571
-
-
Kogure, K.1
Akita, H.2
Yamada, Y.3
Harashima, H.4
-
296
-
-
51249109260
-
Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases
-
Yamada Y, Harashima H. Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. Adv Drug Del Rev 2008; 60: 1439-62.
-
(2008)
Adv Drug Del Rev
, vol.60
, pp. 1439-1462
-
-
Yamada, Y.1
Harashima, H.2
|