An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 28, 2007, Pages 11832-11837

  Bey, Erik A ^a,b   Bentle, Melissa S ^d   Reinicke, Kathryn E ^e   Dong, Ying ^a,b   Yang, Chin Rang ^b   Girard, Luc ^c   Minna, John D ^c   Bornmann, William G ^f   Gao, Jinming ^b   Boothman, David A ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e CASE WESTERN RESERVE UNIVERSITY   (United States)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

calpain cell death; Apoptosis; DNA repair inhibitor; Non small cell lung cancer; NQO1

Indexed keywords

3 AMINOBENZAMIDE; ADENOSINE TRIPHOSPHATE; BETA LAPACHONE; CALCIUM CHELATING AGENT; DICOUMAROL; DNA; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID ACETOXYMETHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CELL DEATH; CELL SPECIFICITY; CONTROLLED STUDY; DNA DAMAGE; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME BLOOD LEVEL; HUMAN; HUMAN CELL; LD 50; LUNG NON SMALL CELL CANCER; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PULSATILE DRUG RELEASE; RADIOSENSITIVITY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE; CELL LINE, TUMOR; HUMANS; LUNG NEOPLASMS; NAD(P)H DEHYDROGENASE (QUINONE); NAPHTHOQUINONES; POLY(ADP-RIBOSE) POLYMERASES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 34547481318     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0702176104     Document Type: Article

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