Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 49, 2007, Pages 19512-19517

  Nguyen, Mai ^a   Marcellus, Richard C ^c   Roulston, Anne ^c   Watson, Mark ^c   Serfass, Lucile ^c   Murthy Madiraju, S R ^c   Goulet, Daniel ^c   Viallet, Jean ^c   Bélec, Laurent ^c   Billot, Xavier ^c   Acoca, Stephane ^a,d   Purisima, Enrico ^a,d   Wiegmans, Adrian ^e   Cluse, Leonie ^e   Johnstone, Ricky W ^e   Beauparlant, Pierre ^c   Shore, Gordon C ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^d NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^e PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Bak; Bax; Bcl 2; Caspase; Melanoma

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BORTEZOMIB; OBATOCLAX; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL; PROTEIN MCL 1;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROPHOBICITY; MELANOMA; MITOCHONDRIAL MEMBRANE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BORONIC ACIDS; CELL LINE, TUMOR; CYSTEINE PROTEINASE INHIBITORS; DRUG RESISTANCE, NEOPLASM; HUMANS; MELANOMA; MICE; MITOCHONDRIA; NEOPLASM PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRAZINES; PYRROLES;

EID: 37649023004     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0709443104     Document Type: Article

References (45)

1. Cory S, Vaux DL, Strasser A, Harris AW, Adams JM (1999) Cancer Res 59(Suppl 7):1685s-1692s.
2. Korsmeyer SJ (1999) Cancer Res 59(Suppl 7):1693s-1700s.
3. Danial NN, Korsmeyer SJ (2004) Cell 116:205-219.
4. Vaux DL, Cory S, Adams JM (1988) Nature 335:440-442.
5. Reed JC, Cuddy M, Slabiak T, Croce CM, Nowell PC (1988) Nature 336:259-261.
6. McDonnell TJ, Deane N, Platt FM, Nunez G, Jaeger U, McKearn JP, Korsmeyer SJ (1989) Cell 57:79-88.
7. Pelengaris S, Khan M, Evan GI (2002) Cell 109:321-334.
8. Reed JC (2006) Cell Death Differ 13:1378-1386.
9. Adams JM, Cory S (2007) Oncogene 26:1324-1337.
10. Jiang X, Wang X (2004) Annu Rev Biochem 73:87-106.
11. Petros AM, Olejniczak ET, Fesik SW (2004) Biochim Biophys Acta 1644:83-94.
12. Youle RJ (2007) Science 315:776-777.
13. Annis MG, Soucie EL, Dlugosz PJ, Cruz-Aguado JA, Penn LZ, Leber B, Andrews DW (2005) EMBO J 24:2096-2103.
14. Dlugosz PJ, Billen LP, Annis MG, Zhu W, Zhang Z, Lin J, Leber B, Andrews DW (2006) EMBO J 25:2287-2296.
15. Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine, GL, Korsmeyer SJ (2004) Science 305:1466-1470.
16. Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, et al. (2005) Nature 435:677-681.
17. Day CL, Chen L, Richardson SJ, Harrison PJ, Huang DC, Hinds MG (2005) J Biol Chem 280:4738-4744.
18. Cuconati A, Mukherjee C, Perez D, White E (2003) Genes Dev 17:2922-2932.
19. Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang, DC (2005) Genes Dev 19:1294-1305.
20. Nijhawan D, Fang M, Traer E, Zhong Q, Gao W, Du F, Wang X (2003) Genes Dev 17:1475-1486.
21. Zhai D, Jin C, Satterthwait AC, Reed JC (2006) Cell Death Differ 13:1419-1421.
22. Naim M, Bhat S, Rankin KN, Denni S, Chowdhury SF, Siddiqi I, Drabik P, Sulea T, Bayly CI, Jakalian A, Purisima EO (2007) J Chem Inf Model 47:122-133.
23. Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC, et al. (2007) J Med Chem 50:641-662.
24. Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005) Mol Cell 17:393-403.
25. Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ (2002) Cancer Cell 2:183-192.
26. Perez-Galan P, Roue G, Villamor N, Montserrat E, Campo E, Colomer D (2006) Blood 107:257-264.
27. Zha H, Fisk HA, Yaffe MP, Mahajan N, Herman B, Reed JC (1996) Mol Cell Biol 16:6494-6508.
28. Simon JA, Szankasi P, Nguyen DK, Ludlow C, Dunstan HM, Roberts CJ, Jensen EL, Hartwell LH, Friend SH (2000) Cancer Res 60(2):328-333.
29. Degenhardt K, Chen G, Lindsten T, White E (2002) Cancer Cell 2:193-203.
30. Schmitt CA, Fridman JS, Yang M, Baranov E, Hoffman RM, Lowe SW (2002) Cancer Cell 3:289-298.
31. Lindemann RK, Newbold A, Whitecross KF, Cluse LA, Frew AJ, Ellis L, Williams S, Wiegmans AP, Dear AE, Scott CL, et al. (2007) Proc Natl Acad Sci USA 104:8071-8076.
32. Konopleva M, Contractor R, Tsao T, Samudi I, Ruvolo PP, Kitada S, Deng X, Zhai D, Shi YX, Sneed T, et al. (2006) Cancer Cell 10:375-388.
33. van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, et al. (2006) Cancer Cell 10:389-399.
34. Tan TT, Degenhardt K, Nelson DA, Beaudoin B, Nieves-Neira W, Bouillet P, Villunger A, Adams JM, White E (2005) Cancer Cell 7:227-238.
35. Zhong Q, Gao W, Du F, Wang X (2005) Cell 121:1085-1095.
36. Warr MR, Acoca S, Liu Z, Germain M, Watson M, Blanchette M, Wing SS, Shore GC (2005) FEBS Lett 579:5603-5608.
37. Gomez-Bougie P, Wuilleme-Toumi S, Menoret E, Trichet V, Robillard N, Philippe M, Bataille R, Amiot M (2007) Cancer Res 67:5418-5424.
38. Trudel S, Li ZH, Rauw J, Tiedemann RE, Wen XY, Stewart AK (2007) Blood 109:5430-5438.
39. Perez-Galan P, Roue G, Villamor N, Campo E, Colomer D (2007) Blood 109:4441-4449.
40. Qin JZ, Ziffra J, Stennett L, Bodner B, Bonish BK, Chaturvedi V, Bennett F, Pollock PM, Trent JM, Hendrix MJ, et al. (2005) Cancer Res 65:6282-6293.
41. Caravita T, de Fabritiis P, Palumbo A, Amadori S, Boccadoro M (2006) Nat Clin Pract Oncol 3:374-387.
42. Rinkenberger JL, Horning S, Klocke B, Roth K, Korsmeyer SJ (2000) Genes Dev 14:23-27.
43. Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ (2003) Nature 426:671-676.
44. Ruffolo SC, Shore GC (2003) J Biol Chem 278:25039-25045.
45. Johnstone RW, Cretney E, Smyth MJ (1999) Blood 93:1075-1085.