Microdomains of intracellular Ca2+: Molecular determinants and functional consequences

Physiological Reviews

Volumn 86, Issue 1, 2006, Pages 369-408

  Rizzuto, Rosario ^b   Pozzan, Tullio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM CHANNEL; CALCIUM ION; GROWTH FACTOR; HORMONE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; NEUROTRANSMITTER; RYANODINE RECEPTOR; CALCIUM;

CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL DEATH; CELL HETEROGENEITY; CELL MEMBRANE; CELL ORGANELLE; CELL PROLIFERATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CHOREOGRAPHY; CYTOARCHITECTURE; ENDOPLASMIC RETICULUM; ENDOSOME; FUNCTIONAL ASSESSMENT; GOLGI COMPLEX; HOMEOSTASIS; HUMAN; LYSOSOME; MITOCHONDRION; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW; SARCOPLASMIC RETICULUM; SECRETORY GRANULE; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; STRUCTURE ANALYSIS; ANIMAL; CALCIUM SIGNALING; METABOLISM; PHYSIOLOGY;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CELL MEMBRANE; ENDOPLASMIC RETICULUM; HUMANS; MITOCHONDRIA; SARCOPLASMIC RETICULUM;

EID: 33644847375     PISSN: 00319333     EISSN: 15221210     Source Type: Journal    
DOI: 10.1152/physrev.00004.2005     Document Type: Review

References (407)

1. +. J Biol Chem 271: 8513-8516, 1996.
2. Albert AP and Large WA. Inhibitory regulation of constitutive transient receptor potential-like cation channels in rabbit ear artery myocytes. J Physiol 560: 160-180, 2004.
3. 2+-permeable non-selective cation channel in rabbit ear artery myocytes. J Physiol 549: 143-156, 2003.
4. Allbritton NL, Meyer T, and Stryer L. Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate. Science 258: 1812-1815, 1992.
5. 2+ channels: is a unifying mechanism at hand? J Mol Cell Cardiol 33: 639-650, 2001.
6. 2+. J Biol Chem 260: 2719-2727, 1985.
7. 2+ release channels revealed by carbachol uncaging in cell-attached patch pipette. J Biol Chem 278: 20860-20864, 2003.
8. 2+ waves. J Cell Biol 158: 283-292, 2002.
9. 2+ signalling takes the local route. Curr Opin Neurobiol 2: 302-307, 1992.
10. Bading H, Hardingham GE, Johnson CM, and Chawla S. Gene regulation by nuclear and cytoplasmic calcium signals. Biochem Biophys Res Commun 236: 541-543, 1997.
11. Baird GS, Zacharias DA, and Tsien RY. Circular permutation and receptor insertion within green fluorescent proteins. Proc Natl Acad Sci USA 96: 11241-11246, 1999.
12. Balschun D, Wolfer DP, Bertocchini F, Barone V, Conti A, Zuschratter W, Missiaen L, Lipp HP, Frey JU, and Sorrentino V. Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning. EMBO J 18: 5264-5273, 1999.
13. Bannai H, Inoue T, Nakayama T, Hattori M, and Mikoshiba K. Kinesin dependent, rapid, bi-directional transport of ER sub-compartment in dendrites of hippocampal neurons. J Cell Sci 117: 163-175, 2004.
14. 2+ uptake by a subset of mitochondria in hippocampal neurons. Brain Res 993: 124-132, 2003.
15. 2+ binding in ventricular myocardium of neonatal and adult rats. Cell Calcium 23: 433-442, 1998.
16. 2+ homeostasis and apoptosis. EMBO J 23: 1207-1216, 2004.
17. 2+ reporters at the single-cell level. Proc Natl Acad Sci USA 97: 7260-7265, 2000.
18. Beard NA, Laver DR, and Dulhunty AF. Calsequestrin and the calcium release channel of skeletal and cardiac muscle. Prog Biophys Mol Biol 85: 33-69, 2004.
19. 2+ stores. J Invest Dermatol 121: 688-694, 2003.
20. Berlin JR, Bassani JW, and Bers DM. Intrinsic cytosolic calcium buffering properties of single rat cardiac myocytes. Biophys J 67: 1775-1787, 1994.
21. Berridge MJ. Calcium oscillations. J Biol Chem 265: 9583-9586, 1990.
22. Berridge MJ, Bootman MD, and Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4: 517-529, 2003.
23. Beutner D, Voets T, Neher E, and Moser T. Calcium dependence of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse. Neuron 29: 681-690, 2001.
24. Bezzi P, Carmignoto G, Pasti L, Vesce S, Rossi D, Rizzini BL, Pozzan T, and Volterra A. Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature 391: 281-285, 1998.
25. 2+ entry (CCE): interaction between IP3 receptor and TRP links the internal calcium storage compartment to plasma membrane CCE channels. Rec Prog Horm Res 55: 127-162, 2000.
26. 2+ stores. Trends Neurosci 24: 602-608, 2001.
27. 2+ stores in vascular smooth muscle: functional implications. Novartis Found Symp 246: 125-141, 2002.
28. Blondel O, Moody MM, Depaoli AM, Sharp AH, Ross CA, Swift H, and Bell GI. Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells. Proc Natl Acad Sci USA 91: 7777-7781, 1994.
29. 2+ATPase 3 gene. J Biol Chem 279: 24297-24306, 2004.
30. 2+ waves in rat cortical astrocytes. J Cell Biol 145: 795-808, 1999.
31. Bollmann JH and Sakmann B. Control of synaptic strength and timing by the release-site Ca(2+) signal. Nat Neurosci 8: 426-434, 2005.
32. 2+ signals. J Cell Sci 114: 2213-2222, 2001.
33. Bouchard R, Pattarini R, and Geiger JD. Presence and functional significance of presynaptic ryanodine receptors. Prog Neurobiol 69: 391-418, 2003.
34. 2+ concentration in bovine adrenal glomerulosa cells with aequorin targeted to the outer mitochondrial membrane. Biochem J 341: 745-753, 1999.
35. Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewett TE, Bibb JA, Westfall MV, Kranias EG, and Molkentin JD. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med 10: 248-254, 2004.
36. 2+ homeostasis in primary cultures of skeletal muscle myotubes. Mol Biol Cell 8: 129-143, 1997.
37. c): a critical evaluation. J Biol Chem 270: 9896-9903, 1995.
38. 2+ concentration measured with specifically targeted recombinant aequorin. EMBO J 12: 4813-4819, 1993.
39. i signaling dynamics and metabolism by perinuclear mitochondria in mouse parotid acinar cells. J Biol Chem 279: 12909-12917, 2004.
40. 2+ in isolated chromaffin vesicles. Biochemistry 24: 7760-7765, 1985.
41. Cadiou H, Sienaert I, Vanlingen S, Parys JB, Molle G, and Duclohier H. Basic properties of an inositol 1,4,5-trisphosphate-gated channel in carp olfactory cilia. Eur J Neurosci 12: 2805-2811, 2000.
42. 2+-binding proteins. Semin Cell Biol 1: 265-275, 1990.
43. 2+ releasing messengers. EMBO J 21: 909-919, 2002.
44. Carafoli E. Intracellular calcium homeostasis. Annu Rev Biochem 56: 395-433, 1987.
45. Carafoli E and Brini M. Calcium pumps: structural basis for and mechanism of calcium transmembrane transport. Curr Opin Chem Biol 4: 152-161, 2000.
46. 2+ channels. Annu Rev Cell Dev Biol 16: 521-555, 2000.
47. Cavalli AL, O'Brien NW, Barlow SB, Betto R, Glembotski CC, Palade PT, and Sabbadini RA. Expression and functional characterization of SCaMPER: a sphingolipid-modulated calcium channel of cardiomyocytes. Am J Physiol Cell Physiol 284: C780-C790, 2003.
48. 2+ mobilization by ryanodine receptors is due to all-or-none release from functionally discrete intracellular stores. Biochem J 301: 879-883, 1994.
49. i waves in cardiac myocytes. Am J Physiol Cell Physiol 270: C148-C159, 1996.
50. Cheng H, Lederer WJ, and Cannell MB. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science 262: 740-744, 1993.
51. Chini EN, Beers KW, and Dousa TP. Nicotinate adenine dinucleotide phosphate (NAADP) triggers a specific calcium release system in sea urchin eggs. J Biol Chem 270: 3216-3223, 1995.
52. Chow RH, Klingauf J, Heinemann C, Zucker RS, and Neher E. Mechanisms determining the time course of secretion in neuroendocrine cells. Neuron 16: 369-376, 1996.
53. 2+ concentration triggering exocytosis in neuroendocrine cells. Proc Natl Acad Sci USA 91: 12765-12769, 1994.
54. 2+ release is observed in native vesicles. J Membr Biol 135: 49-59, 1993.
55. Clapham DE. Calcium signaling. Cell 80: 259-268, 1995.
56. Clusin WT. Caffeine induces a transient inward current in cultured cardiac cells. Nature 301: 248-250, 1983.
57. 2+ signals. J Biol Chem 276: 26411-26420, 2001.
58. Colosetti P, Tunwell RE, Cruttwell C, Arsanto JP, Mauger JP, and Cassio D. The type 3 inositol 1,4,5-trisphosphate receptor is concentrated at the tight junction level in polarized MDCK cells. J Cell Sci 116: 2791-2803, 2003.
59. Conklin MW, Barone V, Sorrentino V, and Coronado R. Contribution of ryanodine receptor type 3 to Ca(2+) sparks in embryonic mouse skeletal muscle. Biophys J 77: 1394-1403, 1999.
60. 2+ gating of skeletal muscle and cardiac ryanodine receptors. Biophys J 73: 141-156, 1997.
61. Cremona O, Collesi C, Raiteri E, and Benfenati F. Kinetics of neuronal and endocrine secretion. J Endocrinol Invest 27: 128-133, 2004.
62. Criddle DN, Raraty MG, Neoptolemos JP, Tepikin AV, Petersen OH, and Sutton R. Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites. Proc Natl Acad Sci USA 101: 10738-10743, 2004.
63. Csordás G, Thomas AP, and Hajnoczky G. Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria. EMBO J 18: 96-108, 1999.
64. Dalva MB, Takasu MA, Lin MZ, Shamah SM, Hu L, Gale NW, and Greenberg ME. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell 103: 945-956, 2000.
65. Daub B and Ganitkevich VY. An estimate of rapid cytoplasmic calcium buffering in a single smooth muscle cell. Cell Calcium 27: 3-13, 2000.
66. 2+ loads in lizard motor nerve terminals. J Physiol 509: 59-65, 1998.
67. Deisseroth K, Bito H, and Tsien RW. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron 16: 89-101, 1996.
68. Demaurex N and Frieden M. Measurements of the free luminal ER Ca(2+) concentration with targeted "cameleon" fluorescent proteins. Cell Calcium 34: 109-119, 2003.
69. 2+-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses. J Biol Chem 277: 45579-45591, 2002.
70. Dolmetsch R. Excitation-transcription coupling: signaling by ion channels to the nucleus. Science's STKE 2003: PE4, 2003.
71. Dolmetsch RE, Pajvani U, Fife K, Spotts JM, and Greenberg ME. Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science 294: 333-339, 2001.
72. Dolmetsch RE, Xu K, and Lewis RS. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392: 933-936, 1998.
73. Dong H, Light PE, French RJ, and Lytton J. Electrophysiological characterization and ionic stoichiometry of the rat brain K(+)-dependent Na(+)/Ca(2+) exchanger, NCKX2. J Biol Chem 276: 25919-25928, 2001.
74. 2+ release in gastric myocytes from Bufo marinus. J Physiol 522: 375-390, 2000.
75. Duchen MR. Mitochondria and calcium: from cell signalling to cell death. J Physiol 529: 57-68, 2000.
76. Echevarria W, Leite MF, Guerra MT, Zipfel WR, and Nathanson MH. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat Cell Biol 5: 440-446, 2003.
77. Ellenberg J, Siggia ED, Moreira JE, Smith CL, Presley JF, Worman HJ, and Lippincott-Schwartz J. Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein in interphase and mitosis. J Biol Chem 138: 1193-1206, 1997.
78. Emptage N, Bliss TV, and Fine A. Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines. Neuron 22: 115-124, 1999.
79. Fabiato A. Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. J Gen Physiol 85: 247-289, 1985.
80. Fadool DA and Ache BW. Plasma membrane inositol 1,4,5-trisphosphate-activated channels mediate signal transduction in lobster olfactory receptor neurons. Neuron 9: 907-918, 1992.
81. 2+ entry. J Biol Chem 273: 9297-9305, 1998.
82. Fasolato C and Pozzan T. Effect of membrane potential on divalent cation transport catalyzed by the "electroneutral" ionophores A23187 and ionomycin. J Biol Chem 264: 19630-19636, 1989.
83. 2+ accumulation, storage and release. J Biol Chem 267: 20159-20167, 1991.
84. Felder E and Franzini-Armstrong C. Type 3 ryanodine receptors of skeletal muscle are segregated in a parajunctional position. Proc Natl Acad Sci USA 99: 1695-1700, 2002.
85. 2+-dependent and lacks a direct influence of presynaptic membrane potential. Proc Natl Acad Sci USA 100: 15200-15205, 2003.
86. Ferguson GD and Storm DR. Why calcium-stimulated adenylyl cyclases? Physiology 19: 271-276, 2004.
87. Feron O. Intracellular localization and activation of endothelial nitric oxide synthase. Curr Opin Nephrol Hypertens 8: 55-59, 1999.
88. Feron O and Kelly RA. The caveolar paradox: suppressing, inducing, and terminating eNOS signaling. Circ Res 88: 129-131, 2001.
89. 2+ sensors into the mitochondrial matrix. Cell Calcium 37: 129-136, 2005.
90. Filippin L, Magalhães PJ, Di Benedetto G, Colella M, and Pozzan T. Stable interactions between mitochondria and endoplasmic reticulum allow rapid accumulation of calcium in a subpopulation of mitochondria. J Biol Chem 278: 39224-39234, 2003.
91. Fill M and Copello JA. Ryanodine receptor calcium release channels. Physiol Rev 82: 893-922, 2002.
92. 2+ channels: one switch. J Physiol 554: 275-283, 2004.
93. 2+ release in mouse oocytes and embryos. Mol Biol Cell 14: 288-301, 2003.
94. Fitzpatrick S and Waisman DM. The uptake of calcium by isolated chromaffin granules of the adrenal medulla. Mol Cell Biochem 155: 121-130, 1996.
95. Fleet A, Ellis-Davies G, and Bolsover S. Calcium buffering capacity of neuronal cell cytosol measured by flash photolysis of calcium buffer NP-EGTA. Biochem Biophys Res Commun 250: 786-790, 1998.
96. Franck JP, Morrissette J, Keen JE, Londraville RL, Beamsley M, and Block BA. Cloning and characterization of fiber type-specific ryanodine receptor isoforms in skeletal muscles of fish. Am J Physiol Cell Physiol 275: C401-C415, 1998.
97. Franzini-Armstrong C and Protasi F. Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions. Physiol Rev 77: 699-729, 1997.
98. 2+ release units in skeletal and cardiac muscle. Ann NY Acad Sci 853: 20-30, 1998.
99. Franzini-Armstrong C, Protasi F, and Ramesh V. Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles. Biophys J 77: 1528-1539, 1999.
100. Friel DD. Mitochondria as regulators of stimulus-evoked calcium signals in neurons. Cell Calcium 28: 307-316, 2000.
101. Fujimoto T, Miyawaki A, and Mikoshiba K. Inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae is linked to actin filaments. J Cell Sci 108: 7-15, 1995.
102. Fukushi Y, Kato I, Takasawa S, Sasaki T, Ong BH, Sato M, Ohsaga A, Sato K, Shirato K, Okamoto H, and Maruyama Y. Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca(2+) signaling using CD38 knockout mice. J Biol Chem 276: 649-655, 2001.
103. 2+ release channels are differentially expressed in rabbit brain. J Neurosci 14: 4794-4805, 1994.
104. Furuichi T, Yoshikawa S, Miyawaki A, Wada K, Maeda N, and Mikoshiba K. Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature 342: 32-38, 1989.
105. Futatsugi A, Kato K, Ogura H, Li ST, Nagata E, Kuwajima G, Tanaka K, Itohara S, and Mikoshiba K. Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3. Neuron 24: 701-713, 1999.
106. Galione A and Churchill GC. Interactions between calcium release pathways: multiple messengers and multiple stores. Cell Calcium 32: 343-354, 2002.
107. Gatti G, Podini P, and Meldolesi J. Overexpression of calsequestrin in L6 myoblasts: formation of endoplasmic reticulum subdomains and their evolution into discrete vacuoles where aggregates of the protein are specifically accumulated. Mol Biol Cell 8: 1789-1803, 1997.
108. Gatti G, Trifari S, Mesaeli N, Parker JM, Michalak M, and Meldolesi J. Head-to-tail oligomerization of calsequestrin: a novel mechanism for heterogeneous distribution of endoplasmic reticulum luminal proteins. J Cell Biol 154: 525-534, 2001.
109. Gelebart P, Martin V, Enouf J, and Papp B. Identification of a new SERCA2 splice variant regulated during monocytic differentiation. Biochem Biophys Res Commun 303: 676-684, 2003.
110. 2+ from a thapsigargin-insensitive pool. Biochem J 315: 721-725, 1996.
111. George CH, Kendall JM, Campbell AK, and Evans WH. Connexin-aequorin chimerae report cytoplasmic calcium environments along trafficking pathways leading to gap junction biogenesis in living COS-7 cells. J Biol Chem 273: 29822-29829, 1998.
112. Gerasimenko J, Maruyama Y, Tepikin A, Petersen OH, and Gerasimenko O. Calcium signalling in and around the nuclear envelope. Biochem Soc Trans 31: 76-78, 2003.
113. 2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. J Cell Biol 163: 271-282, 2003.
114. Gerasimenko JV, Tepikin AV, Petersen OH, and Gerasimenko OV. Calcium uptake via endocytosis with rapid release from acidifying endosomes. Curr Biol 8: 1335-1338, 1998.
115. 2+ from single isolated pancreatic zymogen granules. Cell 84: 473-480, 1996.
116. Ghosh TK, Bian J, and Gill DL. Intracellular calcium release mediated by sphingosine derivatives generated in cells. Science 248: 1653-1656, 1990.
117. Giannini G, Conti A, Mammarella S, Scrobogna M, and Sorrentino V. The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues. J Cell Biol 128: 893-904, 1995.
118. 2+ current ICRAC. EMBO J 19: 6401-6407, 2000.
119. i and cell shape, polarity, and locomotion by InsP3, DAG, and protein kinase C in newt eosinophils. J Cell Biol 127: 489-503, 1994.
120. Girard T, Cavagna D, Padovan E, Spagnoli G, Urwyler A, Zorzato F, and Treves S. B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators. J Biol Chem 276: 48077-48082, 2001.
121. Goldberg MW and Allen TD. Structural and functional organization of the nuclear envelope. Curr Opin Cell Biol 7: 301-309, 1995.
122. 2+ stores in sarcoplasmic and endoplasmic reticulum. Science 275: 1643-1648, 1997.
123. Gomez AM, Valdivia HH, Cheng H, Lederer MR, Santana LF, Cannell MB, McCune SA, Altschuld RA, and Lederer WJ. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276: 800-806, 1997.
124. 2+-induced interaction that results in red shift of GFP absorption and efficient bioluminescence energy transfer. Biochem Biophys Res Commun 320: 703-711, 2004.
125. Gorza L, Schiaffino S, and Volpe P. Inositol 1,4,5-trisphosphate receptor in heart: evidence for its concentration in Purkinje myocytes of the conduction system. J Cell Biol 121: 345-353, 1993.
126. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
127. Guerini D, Garcia-Martin E, Zecca A, Guidi F, and Carafoli E. The calcium pump of the plasma membrane: membrane targeting, calcium binding sites, tissue-specific isoform expression. Acta Physiol Scand 643: 265-273, 1998.
128. Gunteski-Hamblin AM, Clarke DM, and Shull GE. Molecular cloning and tissue distribution of alternatively spliced mRNAs encoding possible mammalian homologues of the yeast secretory pathway calcium pump. Biochemistry 31: 7600-7608, 1992.
129. 2+ sensing sites. Biophys J 75: 2801-2810, 1998.
130. 2+ release in heart. Science 260: 807-809, 1993.
131. Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, Fan GC, Tsiapras D, Hahn HS, Adamopoulos S, Liggett SB, Dorn GW II, MacLennan DH, Kremastinos DT, and Kranias EG. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest 111: 869-876, 2003.
132. 2+. J Biol Chem 274: 14157-14162, 1999.
133. Hajnóczky G, Robb-Gaspers LD, Seitz MB, and Thomas AP. Decoding of cytosolic calcium oscillations in the mitochondria. Cell 82: 415-424, 1995.
134. 2+ transport. J Bioenerg Biomembr 26: 495-508, 1994.
135. Hardingham GE, Chawla S, Johnson CM, and Bading H. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature 385: 260-265, 1997.
136. Hardingham GE, Cruzalegui FH, Chawla S, and Bading H. Mechanisms controlling gene expression by nuclear calcium signals. Cell Calcium 23: 131-134, 1998.
137. Hardingham GE, Fukunaga Y, and Bading H. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5: 405-414, 2002.
138. Haug-Collet K, Pearson B, Webel R, Szerencsei RT, Winkfein RJ, Schnetkamp PP, and Colley NJ. Cloning and characterization of a potassium-dependent sodium/calcium exchanger in Drosophila. J Cell Biol 147: 659-670, 1999.
139. Heidelberger R, Heinemann C, Neher E, and Matthews G. Calcium dependence of the rate of exocytosis in a synaptic terminal. Nature 371: 513-515, 1994.
140. Heim N and Griesbeck O. Genetically encoded indicators of cellular calcium dynamics based on troponin C and green fluorescent protein. J Biol Chem 279: 14280-14286, 2004.
141. 2+ concentration. J Biol Chem 270: 4959-4962, 1995.
142. Higo T, Hattori M, Nakamura T, Natsume T, Michikawa T, and Mikoshiba K. Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. Cell 120: 85-98, 2005.
143. Hirata Y, Kiuchi K, and Nagatsu T. Manganese mimics the action of 1-methyl-4-phenylpyridinium ion, a dopaminergic neurotoxin, in rat striatal tissue slices. Neurosci Lett 311: 53-56, 2001.
144. Hohenegger M, Suko J, Gscheidlinger R, Drobny H, and Zidar A. Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor. Biochem J 367: 423-431, 2002.
145. Hong K, Nishiyama M, Henley J, Tessier-Lavigne M, and Poo M. Calcium signalling in the guidance of nerve growth by netrin-1. Nature 403: 93-98, 2000.
146. Hoth M, Fanger CM, and Lewis RS. Mitochondrial regulation of store-operated calcium signaling in T lymphocytes. J Cell Biol 137: 633-648, 1997.
147. Houten SM, and Auwerx J. PGC1alpha: turbocharging mitochondria. Cell 119: 5-7, 2004.
148. Hu Z, Bonifas JM, Beech J, Bench G, Shigihara T, Ogawa H, Ikeda S, Mauro T, and Epstein EH Jr. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease. Nat Genet 24: 61-65, 2000.
149. 2+ stores in rat adrenal chromaffin cells. Cell Calcium 33: 19-26, 2003.
150. 2+ waves sneaking under the plasma membrane in endothelial cells. Circ Res 95: 11-21, 2004.
151. Isshiki M, Ying YS, Fujita T, and Anderson RG. A molecular sensor detects signal transduction from caveolae in living cells. J Biol Chem 277: 43389-43398, 2002.
152. Itagaki K and Hauser CJ. Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry. J Biol Chem 278: 27540-27547, 2003.
153. 2+ and sustained opening of the permeability transition pore. J Cell Sci 115: 1175-1188, 2002.
154. Jacobson J and Duchen MR. "What nourishes me, destroys me": towards a new mitochondrial biology. Cell Death Differ 8: 963-966, 2001.
155. 2+ channels, cytoplasmic messengers and proteins of the synaptic vesicle release complex. Trends Pharmacol Sci 22: 519-525, 2001.
156. Jouaville LS, Ichas F, Holmuhamedov EL, Camacho P, and Lechleiter JD. Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes. Nature 377: 438-441, 1995.
157. Jouaville LS, Pinton P, Bastianutto C, Rutter GA, and Rizzuto R. Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc Natl Acad Sci USA 96: 13807-13812, 1999.
158. Karbowski M and Youle RJ. Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ 10: 870-880, 2003.
159. Kass RS, Lederer WJ, Tsien RW, and Weingart R. Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres. J Physiol 281: 187-208, 1978.
160. 2+-dependent cell death in rat pancreatic acinar cells. Gastroenterology 122: 1941-1953, 2002.
161. Kirichok Y, Krapivinsky G, and Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. Nature 427: 360-364, 2004.
162. 2+ sensor for neurotransmitter release. Trends Neurosci 26: 413-422, 2003.
163. Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, and Greenberg ME. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron 34: 221-233, 2002.
164. Kovalchuk Y, Eilers J, Lisman J, and Konnerth A. NMDA receptor-mediated subthreshold Ca(2+) signals in spines of hippocampal neurons. J Neurosci 20: 1791-1799, 2000.
165. 2+ stores for inositol 1,4,5-trisphosphate, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate in permeabilized pancreatic acinar cells from mouse. J Biol Chem 277: 11696-11702, 2002.
166. 2+ by isolated secretory vesicles from adrenal medulla. Biochim Biophys Acta 691: 61-70, 1982.
167. Kuno M and Gardner P. Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes. Nature 326: 301-304, 1987.
168. Kuwajima G, Futatsugi A, Niinobe M, Nakanishi S, and Mikoshiba K. Two types of ryanodine receptors in mouse brain: skeletal muscle type exclusively in Purkinje cells and cardiac muscle type in various neurons. Neuron 9: 1133-1142, 1992.
169. 2+ homeostasis in the agonist-sensitive internal store: functional interactions between mitochondria and the ER measured in situ in intact cells. J Cell Biol 142: 1235-1243, 1998.
170. LaPointe P, Gurkan C, and Balch WE. Mise en place - this bud's for the Golgi. Mol Cell 14: 413-414, 2004.
171. Lasorsa FM, Pinton P, Palmieri L, Fiermonte G, Rizzuto R, and Palmieri F. Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells. J Biol Chem 278: 38686-38692, 2003.
172. Lawrie AM, Rizzuto R, Pozzan T, and Simpson AWM. A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells. J Biol Chem 271: 10753-10759, 1996.
173. 2+-binding protein 1. Nat Neurosci 5: 210-217, 2002.
174. Lee HC. Calcium signaling: NAADP ascends as a new messenger. Curr Biol 13: R186-R188, 2003.
175. Lee HC. Multiple calcium stores: separate but interacting. Science's STKE 2000: PE1, 2000.
176. 2+ stores: a perspective from cyclic ADP-ribose and NAADP. Curr Mol Med 4: 227-237, 2004.
177. Lee HC and Aarhus R. A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose. J Biol Chem 270: 2152-2157, 1995.
178. i waves. J Biol Chem 272: 15771-15776, 1997.
179. i waves. J Biol Chem 272: 15765-15770, 1997.
180. 2+ waves require sequential activation of inositol trisphosphate receptors and ryanodine receptors in pancreatic acini. Gastroenterology 122: 415-427, 2002.
181. 2-production in human neutrophils. J Cell Biol 99: 1212-1220, 1984.
182. Li HS and Montell C. TRP and the PDZ protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells. J Cell Biol 150: 1411-1422, 2000.
183. 2+ signaling complexes in plasma membrane microdomains of polarized cells. J Biol Chem 279: 27837-27840, 2004.
184. 2+ channel family. Neuron 39: 951-960, 2003.
185. 2+ entry. J Biol Chem 275: 17979-17985, 2000.
186. + current in guinea-pig cardiac myocytes. J Physiol 542: 383-393, 2002.
187. Lippincott-Schwartz J and Patterson GH. Development and use of fluorescent protein markers in living cells. Science 300: 87-91, 2003.
188. 2+ channels in sympathetic neurons. Neuron 1: 355-365, 1988.
189. Lipscombe D, Madison DV, Poenie M, Reuter H, Tsien RY, and Tsien RW. Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons. Proc Natl Acad Sci USA 85: 2398-2402, 1988.
190. Lischka FW, Zviman MM, Teeter JH, and Restrepo D. Characterization of inositol-1,4,5-trisphosphate-gated channels in the plasma membrane of rat olfactory neurons. Biophys J 76: 1410-1422, 1999.
191. 2+ current (ISOC) in liver cells: a role for calmodulin. J Physiol 558: 85-97, 2004.
192. Llinas R, Sugimori M, and Silver RB. Microdomains of high calcium concentration in a presynaptic terminal. Science 256: 677-679, 1992.
193. Lomax RB, Camello C, Van Coppenolle F, Petersen OH, and Tepikin AV. Basal and physiological Ca(2+) leak from the endoplasmic reticulum of pancreatic acinar cells. Second messenger-activated channels and translocons. J Biol Chem 277: 26479-26485, 2002.
194. Lytton J, Westlin M, Burk SE, Shull GE, and MacLennan DH. Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. J Biol Chem 267: 14483-14489, 1992.
195. Mackenzie L, Bootman MD, Laine M, Berridge MJ, Thuring J, Holmes A, Li WH, and Lipp P. The role of inositol 1,4,5-trisphosphate receptors in Ca(2+) signalling and the generation of arrhythmias in rat atrial myocytes. J Physiol 541: 395-409, 2002.
196. MacLennan DH and Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4: 566-577, 2003.
197. Mak DO and Foskett JK. Single-channel inositol 1,4,5-trisphosphate receptor currents revealed by patch clamp of isolated Xenopus oocyte nuclei. J Biol Chem 269: 29375-29378, 1994.
198. Mak DO and Foskett JK. Single-channel kinetics, inactivation, and spatial distribution of inositol trisphosphate (IP3) receptors in Xenopus oocyte nucleus. J Gen Physiol 109: 571-587, 1997.
199. 2+ release-mediating protein from endoplasmic reticulum. Proc Natl Acad Sci USA 93: 1993-1996, 1996.
200. Marchant J, Callamaras N, and Parker I. Initiation of IP(3)-mediated Ca(2+) waves in Xenopus oocytes. EMBO J 18: 5285-5299, 1999.
201. 2+-regulated photoproteins. Biochemistry 41: 2227-2236, 2002.
202. 2+ beneath the plasma membrane of living A7r5 cells. EMBO J 16: 1575-1581, 1997.
203. 2+ATPases: a plural, species-specific, and multiple hypertension-regulated expression system. Hypertension 35: 91-102, 2000.
204. 2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family. J Biol Chem 277: 24442-24452, 2002.
205. Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, and Marks AR. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101: 365-376, 2000.
206. McCormack JG, Halestrap AP, and Denton RM. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev 70: 391-425, 1990.
207. Meinrenken CJ, Borst JG, and Sakmann B. Calcium secretion coupling at calyx of Held governed by nonuniform channel-vesicle topography. J Neurosci 22: 1648-1667, 2002.
208. 2+ signal for phasic transmitter release at the rat calyx of Held. J Physiol 547: 665-689, 2003.
209. 2+ release channels and their regulation by endogenous effectors. Annu Rev Physiol 56: 485-508, 1994.
210. 2+ current through cardiac ryanodine receptor channels under quasi-physiological ionic conditions. J Gen Physiol 113: 177-186, 1999.
211. 2+ store: a view from the lumen. Trends Biochem Sci 23: 10-14, 1998.
212. 2+ stores has a key role in nonmuscle cell signaling and function. J Cell Biol 142: 1395-1398, 1998.
213. 2+ influx at the plasma membrane: voltage-, receptor-, and second messenger-operated channels. Exp Cell Res 171: 271-283, 1987.
214. Mignery GA, Sudhof TC, Takei K, and De Camilli P. Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor. Nature 342: 192-195, 1989.
215. Milner RE, Famulski KS, and Michalak M. Calcium binding proteins in the sarcoplasmic/endoplasmic reticulum of muscle and nonmuscle cells. Mol Cell Biochem 112: 1-13, 1992.
216. 2+ store. J Biol Chem 276: 39161-39170, 2001.
217. Missiaen L, Van Acker K, Van Baelen K, Raeymaekers L, Wuytack F, Parys JB, De Smedt H, Vanoevelen J, Dode L, Rizzuto R, and Callewaert G. Calcium release from the Golgi apparatus and the endoplasmic reticulum in HeLa cells stably expressing targeted aequorin to these compartments. Cell Calcium 36: 479-487, 2004.
218. 2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). J Biol Chem 278: 11057-11064, 2003.
219. 2+ store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera. J Cell Biol 155: 41-51, 2001.
220. 2+ homeostasis revealed by RNA silencing. Diabetes 53: 393-400, 2004.
221. 2+ measurements using improved cameleons. Proc Natl Acad Sci USA 96: 2135-2140, 1999.
222. 2+ based on green fluorescent proteins and calmodulin. Nature 388: 882-887, 1997.
223. 2+ entry through basal membrane patch. Cell 88: 49-55, 1997.
224. Mogelsvang S, Marsh BJ, Ladinsky MS, and Howell KE. Predicting function from structure: 3D structure studies of the mammalian Golgi complex. Traffic 5: 338-345, 2004.
225. 2+-sensitive adenylyl cyclases, key integrators of cellular signalling. Life Sci 62: 1647-1652, 1998.
226. Montell C. Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Sci STKE 2001: RE1, 2001.
227. Montell C, Birnbaumer L, and Flockerzi V. The TRP channels, a remarkably functional family. Cell 108: 595-598, 2002.
228. 2+] after chromaffin cell stimulation. Eur J Neurosci 13: 2247-2254, 2001.
229. 2+ transients that modulate secretion. Nat Cell Biol 2: 57-61, 2000.
230. 2+] subcompartments in intact HeLa cells. J Cell Biol 139: 601-611, 1997.
231. 2+ concentration in the endoplasmic reticulum of intact cells. EMBO J 14: 5467-5475, 1995.
232. 2+ uniporter revealed by the p38 mitogen-activated protein kinase inhibitor SB202190. FASEB J 16: 1955-1957, 2002.
233. Mori F, Fukaya M, Abe H, Wakabayashi K, and Watanabe M. Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain. Neurosci Lett 285: 57-60, 2000.
234. Morrissette J, Xu L, Nelson A, Meissner G, and Block BA. Characterization of RyR1-slow, a ryanodine receptor specific to slow-twitch skeletal muscle. Am J Physiol Regul Integr Comp Physiol 279: R1889-R1898, 2000.
235. Muallem S. Calcium transport pathways of pancreatic acinar cells. Annu Rev Physiol 51: 83-105, 1989.
236. Murayama T and Ogawa Y. RyR1 exhibits lower gain of CICR activity than RyR3 in the SR: evidence for selective stabilization of RyR1 channel. Am J Physiol Cell Physiol 287: C36-C45, 2004.
237. 2+ release between α- and β-RyR. J Biol Chem 276: 2953-2960, 2001.
238. Nabauer M, Callewaert G, Cleemann L, and Morad M. Regulation of calcium release is gated by calcium current, not gating charge, in cardiac myocytes. Science 244: 800-803, 1989.
239. 2+. Proc Natl Acad Sci USA 98: 3197-3202, 2001.
240. 2+ by circularly permuted yellow fluorescent proteins. Proc Natl Acad Sci USA 101: 10554-10559, 2004.
241. 2+-sensitive adenylyl cyclase/aequorin chimera. J Biol Chem 272: 18093-18097, 1997.
242. 2+ probe composed of a single green fluorescent protein. Nat Biotechnol 19: 137-141, 2001.
243. 2+ binding in bovine chromaffin cells. Biophys J 75: 1635-1647, 1998.
244. 2+] at the mouth of a calcium channel. J Neurosci 17: 6961-6973, 1997.
245. 2+ wave trigger zone of pancreatic acinar cells. J Biol Chem 269: 4693-4696, 1994.
246. 2+ microdomains: new tools for understanding their roles in neurotransmitter release. Neuron 20: 389-399, 1998.
247. 2+ signals evoked by coincident EPSPs and backpropagating action potentials in spiny stellate cells of layer 4 in the juvenile rat somatosensory barrel cortex. J Neurosci 24: 1689-1699, 2004.
248. 2+. Nature 395: 908-912, 1998.
249. Nilius B (Editor). TRP channels: facts, fiction, challenges (Special Issue). Cell Calcium 33: 293-558, 2003.
250. Nixon GF, Mignery GA, and Somlyo AV. Immunogold localization of inositol 1,4,5-trisphosphate receptors and characterization of ultrastructural features of the sarcoplasmic reticulum in phasic and tonic smooth muscle. J Muscle Res Cell Motil 15: 682-700, 1994.
251. 2+ release channels. Cell Calcium 19: 375-381, 1996.
252. 2+ dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol 66: 1335-1340, 2003.
253. Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, and Korsmeyer SJ. Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci USA 102: 105-110, 2005.
254. 2+ releasing action of cyclic adenosine diphosphate-ribose in guinea-pig adrenal chromaffin cells. Neurosci Lett 326: 167-170, 2002.
255. Orrenius S, Zhivotovsky B, and Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 4: 552-565, 2003.
256. - current recording in single pancreatic acinar cells. EMBO J 9: 697-704, 1990.
257. 2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum. J Biol Chem 265: 13472-13483, 1990.
258. Palade GE. The endoplasmic reticulum. J Biophys Biochem Cytol 2: 85-98, 1956.
259. Palade GE. Studies on the endoplasmic reticulum. II. Simple dispositions in cells in situ. J Biophys Biochem Cytol 1: 567-582, 1955.
260. Palade GE and Porter KR. Studies on the endoplasmic reticulum. I. Its identification in cells in situ. J Exp Med 100: 641-656, 1954.
261. Parekh AB. Slow feedback inhibition of calcium release-activated calcium current by calcium entry. J Biol Chem 273: 14925-14932, 1998.
262. 2+ movements and equilibration. EMBO J 19: 5729-5739, 2000.
263. Parker AK, Gergely FV, and Taylor CW. Targeting of inositol 1,4,5-trisphosphate receptors to the endoplasmic reticulum by multiple signals within their transmembrane domains. J Biol Chem 279: 23797-23805, 2004.
264. Parker I and Ivorra I. Localized all-or-none calcium liberation by inositol trisphosphate. Science 250: 977-979, 1990.
265. 2+ transients associated with openings of inositol trisphosphate-gated channels in Xenopus oocytes. J Physiol 491: 663-668, 1996.
266. 2+ release from chloroquine-sensitive and -insensitive intracellular stores in the intraerythrocytic stage of the malaria parasite P. chabaudi. Biochem Biophys Res Commun 245: 155-160, 1998.
267. Pasti L, Pozzan T, and Carmignoto G. Long-lasting changes of calcium oscillations in astrocytes. A new form of glutamate-mediated plasticity. J Biol Chem 270: 15203-15210, 1995.
268. Pasti L, Volterra A, Pozzan T, and Carmignoto G. Intracellular calcium oscillations in astrocytes: a highly plastic, bidirectional form of communication between neurons and astrocytes in situ. J Neurosci 17: 7817-7830, 1997.
269. Patel S, Joseph SK, and Thomas AP. Molecular properties of inositol 1,4,5-trisphosphate receptors. Cell Calcium 25: 247-264, 1999.
270. Patterson RL, Boehning D, and Snyder SH. Inositol 1,4,5-trisphosphate receptors as signal integrators. Annu Rev Biochem 73: 437-465, 2004.
271. Petersen OH. Local calcium spiking in pancreatic acinar cells. Ciba Found Symp 188: 85-103, 1995.
272. Petersen OH, Burdakov D, and Tepikin AV. Polarity in intracellular calcium signaling. Bioessays 21: 851-860, 1999.
273. Petersen OH, Gerasimenko OV, Gerasimenko JV, Mogami H, and Tepikin AV. The calcium store in the nuclear envelope. Cell Calcium 23: 87-90, 1998.
274. Petkov GV, Heppner TJ, Bonev AD, Herrera GM, and Nelson MT. Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder. Am J Physiol Regul Integr Comp Physiol 280: R1427-R1433, 2001.
275. Pezzati R, Bossi M, Podini P, Meldolesi J, and Grohovaz F. High-resolution calcium mapping of the endoplasmic reticulum-Golgi-exocytic membrane system. Electron energy loss imaging analysis of quick frozen-freeze dried PC12 cells. Mol Biol Cell 8: 1501-1512, 1997.
276. Pezzati R, Meldolesi J, and Grohovaz F. Ultra rapid calcium events in electrically stimulated frog nerve terminals. Biochem Biophys Res Commun 285: 724-727, 2001.
277. Philipson KD and Nicoll DA. Sodium-calcium exchange: a molecular perspective. Annu Rev Physiol 62: 111-133, 2000.
278. 2+ exchange molecule: an overview. Ann NY Acad Sci 976: 1-10, 2002.
279. Pieper AA, Brat DJ, O'Hearn E, Krug DK, Kaplin AI, Takahashi K, Greenberg JH, Ginty D, Molliver ME, and Snyder SH. Differential neuronal localizations and dynamics of phosphorylated and unphosphorylated type 1 inositol 1,4,5-trisphosphate receptors. Neuroscience 102: 433-444, 2001.
280. 2+ influx in Bcl-2-overexpressing cells. J Cell Biol 148: 857-862, 2000.
281. 2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J 20: 2690-2701, 2001.
282. 2+ signals by protein kinase C isozymes. J Cell Biol 165: 223-232, 2004.
283. 2+ store, with functional properties distinct from those of the endoplasmic reticulum. EMBO J 17: 5298-5308, 1998.
284. Pinton P, Tsuboi T, Ainscow EK, Pozzan T, Rizzuto R, and Rutter GA. Dynamics of glucose-induced membrane recruitment of protein kinase C β II in living pancreatic islet β-cells. J Biol Chem 277: 37702-37710, 2002.
285. Pivovarova NB, Hongpaisan J, Andrews SB, and Friel DD. Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: spatial and temporal characteristics. J Neurosci 19: 6372-6384, 1999.
286. Pizzo P, Fasolato C, and Pozzan T. Dynamic properties of an inositol 1,4,5-trisphosphate- and thapsigargin-insensitive calcium pool in mammalian cell lines. J Cell Biol 138: 355-366, 1997.
287. Poch E, Leach S, Snape S, Cacic T, MacLennan DH, and Lytton J. Functional characterization of alternatively spliced human SERCA3 transcripts. Am J Physiol Cell Physiol 275: C1449-C1458, 1998.
288. i in individual cytolytic T cells and targets. EMBO J 6: 2223-2232, 1987.
289. Porter KR and Palade GE. Studies on the endoplasmic reticulum. III. Its form and distribution in striated muscle cells. J Biophys Biochem Cytol 3: 269-300, 1957.
290. Posterino GS and Lamb GD. Investigation of the effect of inositol trisphosphate in skinned skeletal muscle fibres with functional excitation-contraction coupling. J Muscle Res Cell Motil 19: 67-74, 1998.
291. Pozzan T, Rizzuto R, Volpe P, and Meldolesi J. Molecular and cellular physiology of intracellular calcium stores. Physiol Rev 74: 595-636, 1994.
292. 2+ transport by isolated organelles of a rat insulinoma. Studies with endoplasmic reticulum and secretory granules. J Biol Chem 259: 10118-10123, 1984.
293. 2+ by isolated organelles from a rat insulinoma. J Biol Chem 259: 14054-14058, 1984.
294. Prinsen CF, Szerencsei RT, and Schnetkamp PP. Molecular cloning and functional expression of the potassium-dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors. J Neurosci 20: 1424-1434, 2000.
295. Proenza C, O'Brien J, Nakai J, Mukherjee S, Allen PD, and Beam KG. Identification of a region of RyR1 that participates in allosteric coupling with the alpha(1S) (Ca(V)1.1) II-III loop. J Biol Chem 277: 6530-6535, 2002.
296. Pryor PR, Mullock BM, Bright NA, Gray SR, and Luzio JP. The role of intraorganellar Ca(2+) in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. J Cell Biol 149: 1053-1062, 2000.
297. Quednau BD, Nicoll DA, and Philipson KD. The sodium/calcium exchanger family-SLC8. Pflügers Arch 447: 543-548, 2004.
298. 2+ binding proteins of the sarcoplasmic reticulum of striated muscle in the endoplasmic reticulum of pig smooth muscles. Cell Calcium 14: 581-589, 1993.
299. Raraty M, Ward J, Erdemli G, Vaillant C, Neoptolemos JP, Sutton R, and Petersen OH. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proc Natl Acad Sci USA 97: 13126-13131, 2000.
300. Ravazzola M, Halban PA, and Orci L. Inositol 1,4,5-trisphosphate receptor subtype 3 in pancreatic islet cell secretory granules revisited. Proc Natl Acad Sci USA 93: 2745-2748, 1996.
301. Rink TJ and Pozzan T. Using quin2 in cell suspensions. Cell Calcium 6: 133-144, 1985.
302. Rios E and Brum G. Involvement of dihydropyridine receptors in excitation-contraction coupling in skeletal muscle. Nature 325: 717-720, 1987.
303. 2+ homeostasis in intact cells. J Cell Biol 126: 1183-1194, 1994.
304. Rizzuto R, Bernardi P, and Pozzan T. Mitochondria as all-round players of the calcium game. J Physiol 529: 37-47, 2000.
305. 2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science 262: 744-747, 1993.
306. 2+ liaison. Science's STKE 2004: re1, 2004.
307. 2+ responses. Science 280: 1763-1766, 1998.
308. Rizzuto R, Pinton P, Ferrari D, Chami M, Szabadkai G, Magalhães PJ, Di Virgilio F, and Pozzan T. Calcium and apoptosis: facts and hypotheses. Oncogene 22: 8619-8627, 2003.
309. Rizzuto R and Pozzan T. When calcium goes wrong: genetic alterations of a ubiquitous signaling route. Nat Genet 34: 135-141, 2003.
310. 2+ revealed by specifically targeted recombinant aequorin. Nature 358: 325-327, 1992.
311. 2+ revealed by specifically targeted recombinant aequorin. Nature 358: 325-327, 1992.
312. Robb-Gaspers LD, Burnett P, Rutter GA, Denton RM, Rizzuto R, and Thomas AP. Integrating cytosolic calcium signals into mitochondrial metabolic responses. EMBO J 17: 4987-5000, 1998.
313. 2+] in cardiac cells. EMBO J 20: 4998-5007, 2001.
314. 2+-regulated exocytic vesicles in fibroblasts and epithelial cells. J Cell Biol 137: 93-104, 1997.
315. 2+-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence. A new class of fluorescent indicators. J Biol Chem 272: 13270-13274, 1997.
316. 2+ handling. J Biol Chem 271: 29304-29311, 1996.
317. Rosemblit N, Moschella MC, Ondriasa E, Gutstein DE, Ondrias K, and Marks AR. Intracellular calcium release channel expression during embryogenesis. Dev Biol 206: 163-177, 1999.
318. Rosenzweig SA, Miller LJ, and Jamieson JD. Identification and localization of cholecystokinin-binding sites on rat pancreatic plasma membranes and acinar cells: a biochemical and autoradiographic study. J Cell Biol 96: 1288-1297, 1983.
319. Ross CA, Meldolesi J, Milner TA, Satoh T, Supattapone S, and Snyder SH. Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons. Nature 339: 468-470, 1989.
320. Rossi R, Bottinelli R, Sorrentino V, and Reggiani C. Response to caffeine and ryanodine receptor isoforms in mouse skeletal muscles. Am J Physiol Cell Physiol 281: C585-C594, 2001.
321. 2+ uptake into mitochondria of mouse skeletal muscle during contraction. J Cell Biol 166: 527-536, 2004.
322. 2+ ATPase family. Cell 58: 133-145, 1989.
323. Santella L, De Riso L, Gragnaniello G, and Kyozuka K. Separate activation of the cytoplasmic and nuclear calcium pools in maturing starfish oocytes. Biochem Biophys Res Commun 252: 1-4, 1998.
324. Satoh T, Ross CA, Villa A, Supattapone S, Pozzan T, Snyder SH, and Meldolesi J. The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment. J Cell Biol 111: 615-624, 1990.
325. Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U, Kranias EG, MacLennan DH, Seidman JG, and Seidman CE. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science 299: 1410-1413, 2003.
326. Schneggenburger R and Neher E. Intracellular calcium dependence of transmitter release rates at a fast central synapse. Nature 406: 889-893, 2000.
327. 2+ channel activated by sphingosylphosphocholine. Biochem J 362: 183-189, 2002.
328. 2+: a control point for apoptosis. Science 300: 135-139, 2003.
329. Sei Y, Gallagher KL, and Basile AS. Skeletal muscle type ryanodine receptor is involved in calcium signaling in human B lymphocytes. J Biol Chem 274: 5995-6002, 1999.
330. Sharp AH, Nucifora FC Jr, Blondel O, Sheppard CA, Zhang C, Snyder SH, Russell JT, Ryugo DK, and Ross CA. Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain. J Comp Neurol 406: 207-220, 1999.
331. Sharp AH, Snyder SH, and Nigam SK. Inositol 1,4,5-trisphosphate receptors. Localization in epithelial tissue. J Biol Chem 267: 7444-7449, 1992.
332. Shaul PW, Smart EJ, Robinson LJ, German Z, Yuhanna IS, Ying Y, Anderson RG, and Michel T. Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem 271: 6518-6522, 1996.
333. 2+ waves in cultured astrocytes. J Neurochem 68: 2317-2327, 1997.
334. Shuai JW and Jung P. Optimal ion channel clustering for intracellular calcium signaling. Proc Natl Acad Sci USA 100: 506-510, 2003.
335. 2+ release channels. Phys Rev E Stat Nonlin Soft Matter Phys 67: 031905, 2003.
336. Shuai JW and Jung P. Stochastic properties of Ca(2+) release of inositol 1,4,5-trisphosphate receptor clusters. Biophys J 83: 87-97, 2002.
337. Shuttleworth TJ, Thompson JL, and Mignen O. ARC channels: a novel pathway for receptor-activated calcium entry. Physiology 19: 355-361, 2004.
338. 2+ waves in cultured oligodendrocytes. J Biol Chem 271: 33493-33501, 1996.
339. 2+-release microdomains in cultured glia. Biochem J 325: 239-247, 1997.
340. 2+ influx. Mol Cell 15: 635-646, 2004.
341. 2+. J Membr Biol 159: 179-185, 1997.
342. Smith KE, Gu C, Fagan KA, Hu B, and Cooper DM. Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry. J Biol Chem 277: 6025-6031, 2002.
343. 2+ sparks: an investigative mathematical model of calcium-induced calcium release. Biophys J 83: 59-78, 2002.
344. 2+ signal transduction. Trends Pharmacol Sci 24: 167-171, 2003.
345. Sorensen JB. Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles. Pflügers Arch 448: 347-362, 2004.
346. Sorrentino V. Molecular determinants of the structural and functional organization of the sarcoplasmic reticulum. Biochim Biophys Acta 1742: 113-118, 2004.
347. Sorrentino V. Ryanodine Receptors. Boca Raton, FL: CRC, 1995.
348. Sorrentino V and Reggiani C. Expression of the ryanodine receptor type 3 in skeletal muscle. A new partner in excitation-contraction coupling? Trends Cardiovasc Med 9: 54-61, 1999.
349. Sorrentino V and Volpe P. Ryanodine receptors: how many, where and why? Trends Pharmacol Sci 141: 98-103, 1993.
350. Spat A, Pitter JG, Rohacs T, and Szabadkai G. Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells. News Physiol Sci 16: 197-200, 2001.
351. 2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306: 67-68, 1983.
352. Strehler EE and Treiman M. Calcium pumps of plasma membrane and cell interior. Curr Mol Med 4: 323-335, 2004.
353. Strehler EE and Zacharias DA. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol Rev 81: 21-50, 2001.
354. 2+ signaling in maturing and fertilized oocytes of marine protostome worms: the roles of MAPKs and MPF. Development 130: 2867-2879, 2003.
355. Sudhof TC. The synaptic vesicle cycle. Annu Rev Neurosci 27: 509-547, 2004.
356. Sun XH, Protasi F, Takahashi M, Takeshima H, Ferguson DG, and Franzini-Armstrong C. Molecular architecture of membranes involved in excitation-contraction coupling of cardiac muscle. J Cell Biol 129: 659-671, 1995.
357. Sutko JL, Ito K, and Kenyon JL. Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle. Federation Proc 44: 2984-2988, 1985.
358. Sutton KG, McRory JE, Guthrie H, Murphy TH, and Snutch TP. P/Q-type calcium channels mediate the activity-dependent feedback of syntaxin-1A. Nature 401: 800-804, 1999.
359. 2+ at low submicromolar concentration stimulates mitochondrial metabolism in rat luteal cells. Pflügers Arch 441: 678-685, 2001.
360. 2+-mediated apoptosis. Mol Cell 16: 59-68, 2004.
361. Szalai G, Csordas G, Hantash BM, Thomas AP, and Hajnoczky G. Calcium signal transmission between ryanodine receptors and mitochondria. J Biol Chem 275: 15305-15313, 2000.
362. Szalai G, Krishnamurthy R, and Hajnoczky G. Apoptosis driven by IP(3)-linked mitochondrial calcium signals. EMBO J 18: 6349-6361, 1999.
363. Taddei A, Hediger F, Neumann FR, and Gasser SM. The function of nuclear architecture: a genetic approach. Annu Rev Genet 38: 305-345, 2004.
364. Takasu MA, Dalva MB, Zigmond RE, and Greenberg ME. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science 295: 491-495, 2002.
365. 2+-ATPase, and calsequestrin. J Neurosci 12: 489-505, 1992.
366. Tang YG and Zucker RS. Mitochondrial involvement in post-tetanic potentiation of synaptic transmission. Neuron 18: 483-491, 1997.
367. Tanimura A, Tojyo Y, and Turner RJ. Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins. J Biol Chem 275: 27488-27493, 2000.
368. 2+. Cell Calcium 32: 321-334, 2002.
369. 2+ release sites in non-excitable cells. Curr Biol 10: 8-15, 2000.
370. 2+ oscillations in exocrine cells evoked by agonists and inositol trisphosphate. Cell 74: 661-668, 1993.
371. 2+ channel. J Biol Chem 278: 49699-49706, 2003.
372. 2+ signals. EMBO J 18: 4999-5008, 1999.
373. Tiso N, Salamon M, Bagattin A, Danieli GA, Argenton F, and Bortolussi M. The binding of the RyR2 calcium channel to its gating protein FKBP12.6 is oppositely affected by ARVD2 and VTSIP mutations. Biochem Biophys Res Commun 299: 594-598, 2002.
374. Tiso N, Stephan DA, Nava A, Bagattin A, Devaney JM, Stanchi F, Larderet G, Brahmbhatt B, Brown K, Bauce B, Muriago M, Basso C, Thiene G, Danieli GA, and Rampazzo A. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Hum Mol Genet 10: 189-194, 2001.
375. Tsugorka A, Rios E, and Blatter LA. Imaging elementary events of calcium release in skeletal muscle cells. Science 269: 1723-1726, 1995.
376. Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, and Worley PF. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23: 583-592, 1999.
377. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, and Worley PF. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21: 717-726, 1998.
378. 2+ and phosphorylation. Science 267: 1997-2000, 1995.
379. 2+ pumps in the Golgi apparatus. Biochim Biophys Acta 1742: 103-112, 2004.
380. 2+ accumulation in the Golgi apparatus of HeLa cells assessed via RNA-mediated interference. Biochem Biophys Res Commun 306: 430-436, 2003.
381. 2+ store. Cell Calcium 35: 115-121, 2004.
382. Vasu SK and Forbes DJ. Nuclear pores and nuclear assembly. Curr Opin Cell Biol 13: 363-375, 2001.
383. Vergara J, Tsien RY, and Delay M. Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle. Proc Natl Acad Sci USA 82: 6352-6356, 1985.
384. Verkhratsky A. Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol Rev 85: 201-279, 2005.
385. Vermassen E, Parys JB, and Mauger JP. Subcellular distribution of the inositol 1,4,5-trisphosphate receptors: functional relevance and molecular determinants. Biol Cell 96: 3-17, 2004.
386. Viard P, Butcher AJ, Halet G, Davies A, Nurnberg B, Heblich F, and Dolphin AC. PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nat Neurosci 7: 939-946, 2004.
387. 2+ ATPase and of the ER lumenal protein, Bip. J Cell Biol 113: 779-791, 1991.
388. 2+ homeostasis. J Cell Biol 121: 1041-1051, 1993.
389. Volpe P, Martini A, Furlan S, and Meldolesi J. Calsequestrin is a component of smooth muscles: the skeletal- and cardiac-muscle isoforms are both present, although in highly variable amounts and ratios. Biochem J 301: 465-469, 1994.
390. Volpe P, Salviati G, Di Virgilio F, and Pozzan T. Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle. Nature 316: 347-349, 1985.
391. 2+ stores in chicken Purkinje neurons. EMBO J 10: 3183-3189, 1991.
392. Voronina S, Longbottom R, Sutton R, Petersen OH, and Tepikin A. Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology. J Physiol 540: 49-55, 2002.
393. 125I-cholecystokinin in pancreatic acini. Am J Physiol Gastrointest Liver Physiol 243: G291-G296, 1982.
394. 2+ signals in pancreatic acinar and beta cells. J Biol Chem 279: 7234-7240, 2004.
395. 2+ exchanger and protein kinase C. J Cell Biol 163: 511-523, 2003.
396. 2+ evoked by inositol trisphosphate in Xenopus oocytes. J Physiol 482: 533-553, 1995.
397. 2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messenger. Cell 98: 475-485, 1999.
398. Yasuda R, Nimchinsky EA, Scheuss V, Pologruto TA, Oertner TG, Sabatini BL, and Svoboda K. Imaging calcium concentration dynamics in small neuronal compartments. Sci STKE 2004: pl5, 2004.
399. 2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. J Biol Chem 275: 38532-38539, 2000.
400. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, and Worley PF. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114: 777-789, 2003.
401. Yule DI, Ernst SA, Ohnishi H, and Wojcikiewicz RJ. Evidence that zymogen granules are not a physiologically relevant calcium pool. Defining the distribution of inositol 1,4,5-trisphosphate receptors in pancreatic acinar cells. J Biol Chem 272: 9093-9098, 1997.
402. 2+ release channels by Gβγ. Curr Biol 13: 872-876, 2003.
403. Zhao W, Frank KF, Chu G, Gerst MJ, Schmidt AG, Ji Y, Periasamy M, and Kranias EG. Combined phospholamban ablation and SERCA1a overexpression result in a new hyperdynamic cardiac state. Cardiovasc Res 57: 71-81, 2003.
404. Zhou Z and Neher E. Mobile and immobile calcium buffers in bovine adrenal chromaffin cells. J Physiol 469: 245-273, 1993.
405. 2+ oscillations in permeabilized blowfly salivary gland cells: contribution of mitochondria. J Physiol 525 3: 707-719, 2000.
406. Zitt C, Obukhov AG, Strubing C, Zobel A, Kalkbrenner F, Luckhoff A, and Schultz G. Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J Cell Biol 138: 1333-1341, 1997.
407. Zweifach A and Lewis RS. Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback. J Gen Physiol 105: 209-226, 1995.