Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion

Apoptosis

Volumn 14, Issue 2, 2009, Pages 191-202

  Mullauer, Franziska B ^a   Kessler, Jan H ^a,b   Medema, Jan Paul ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bak; Bax; Bcl 2 family; Betulinic acid; Cell death; Cytochrome c release

Indexed keywords

BETULIC ACID; CYCLOSPORIN A; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CELL MEMBRANE PERMEABILITY; DNA FRAGMENTATION; EMBRYO; ENZYME ACTIVATION; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INCUBATION TIME; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; WILD TYPE;

ANIMALS; APOPTOSIS; APOPTOSOMES; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CYTOCHROMES C; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; TRITERPENES;

EID: 58849088375     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-008-0290-x     Document Type: Article

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