메뉴 건너뛰기




Volumn 120, Issue 5, 2012, Pages 947-959

Proteasome inhibitors in multiple myeloma: 10 Years later

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CARFILZOMIB; CYCLOPHOSPHAMIDE; DELANZOMIB; DEXAMETHASONE; DOXORUBICIN; HISTONE DEACETYLASE INHIBITOR; IMMUNOMODULATING AGENT; IXAZOMIB CITRATE; LENALIDOMIDE; MELPHALAN; MONOCLONAL ANTIBODY; PANOBINOSTAT; PERIFOSINE; PREDNISONE; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN KINASE B INHIBITOR; SALINOSPORAMIDE A; THALIDOMIDE; VINCRISTINE; VORINOSTAT;

EID: 84864568543     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-04-403733     Document Type: Review
Times cited : (425)

References (100)
  • 1
    • 0037852202 scopus 로고    scopus 로고
    • The proteasome: Structure, function, and role in the cell
    • Adams J. The proteasome: structure, function, and role in the cell. Cancer Treat Rev. 2003;29(Suppl 1):3-9. (Pubitemid 36626287)
    • (2003) Cancer Treatment Reviews , vol.29 , Issue.SUPPL. 1 , pp. 3-9
    • Adams, J.1
  • 2
    • 0028018268 scopus 로고
    • The ubiquitin-proteasome proteolytic pathway
    • DOI 10.1016/0092-8674(94)90396-4
    • Ciechanover A. The ubiquitin-proteasome proteolytic pathway. Cell. 1994;79(1):13-21. (Pubitemid 24309509)
    • (1994) Cell , vol.79 , Issue.1 , pp. 13-21
    • Ciechanover, A.1
  • 3
    • 0032535483 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway: On protein death and cell life
    • DOI 10.1093/emboj/17.24.7151
    • Ciechanover A. The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J. 1998;17(24):7151-7160. (Pubitemid 29002684)
    • (1998) EMBO Journal , vol.17 , Issue.24 , pp. 7151-7160
    • Ciechanover, A.1
  • 5
    • 33744539521 scopus 로고    scopus 로고
    • Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
    • DOI 10.1182/blood-2005-08-3531
    • Obeng EA, Carlson LM, Gutman DM, et al. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood. 2006;107(12):4907-4916. (Pubitemid 43882644)
    • (2006) Blood , vol.107 , Issue.12 , pp. 4907-4916
    • Obeng, E.A.1    Carlson, L.M.2    Gutman, D.M.3    Harrington Jr., W.J.4    Lee, K.P.5    Boise, L.H.6
  • 6
    • 0033178142 scopus 로고    scopus 로고
    • Proteasome inhibitors as potential novel anticancer agents
    • DOI 10.1054/drup.1999.0095
    • Dou QP, Li B. Proteasome inhibitors as potential novel anticancer agents. Drug Resist Updat. 1999;2(4):215-223. (Pubitemid 29526245)
    • (1999) Drug Resistance Updates , vol.2 , Issue.4 , pp. 215-223
    • Dou, Q.P.1    Li, B.2
  • 7
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: A suitable antineoplastic target
    • Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer. 2004;4(5):349-360. (Pubitemid 38579481)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.5 , pp. 349-360
    • Adams, J.1
  • 8
    • 77649237033 scopus 로고    scopus 로고
    • Building on bortezomib: Second-generation proteasome inhibitors as anticancer therapy
    • Dick LR, Fleming PE. Building on bortezomib: second-generation proteasome inhibitors as anticancer therapy. Drug Discov Today. 2010;15(5):243-249.
    • (2010) Drug Discov Today , vol.15 , Issue.5 , pp. 243-249
    • Dick, L.R.1    Fleming, P.E.2
  • 9
    • 83655198773 scopus 로고    scopus 로고
    • Emerging role of carfilzomib in treatment of relapsed and refractory lymphoid neoplasms and multiple myeloma
    • Jain S, Diefenbach C, Zain J, O'Connor OA. Emerging role of carfilzomib in treatment of relapsed and refractory lymphoid neoplasms and multiple myeloma. Core Evid. 2011;6:43-57.
    • (2011) Core Evid , vol.6 , pp. 43-57
    • Jain, S.1    Diefenbach, C.2    Zain, J.3    O'Connor, O.A.4
  • 10
    • 77950238258 scopus 로고    scopus 로고
    • Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer
    • Kupperman E, Lee EC, Cao Y, et al. Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res. 2010;70(5):1970- 1980.
    • (2010) Cancer Res , vol.70 , Issue.5 , pp. 1970-1980
    • Kupperman, E.1    Lee, E.C.2    Cao, Y.3
  • 11
    • 26844452967 scopus 로고    scopus 로고
    • Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy
    • Boccadoro M, Morgan G, Cavenagh J. Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. Cancer Cell Int. 2005;5(1):18.
    • (2005) Cancer Cell Int , vol.5 , Issue.1 , pp. 18
    • Boccadoro, M.1    Morgan, G.2    Cavenagh, J.3
  • 12
    • 77956108780 scopus 로고    scopus 로고
    • Enhancing activity and overcoming chemoresistance in hematologic malignancies with bortezomib: Preclinical mechanistic studies
    • Reddy N, Czuczman MS. Enhancing activity and overcoming chemoresistance in hematologic malignancies with bortezomib: preclinical mechanistic studies. Ann Oncol. 2010;21(9):1756-1764.
    • (2010) Ann Oncol , vol.21 , Issue.9 , pp. 1756-1764
    • Reddy, N.1    Czuczman, M.S.2
  • 13
    • 81055149914 scopus 로고    scopus 로고
    • Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma
    • Hideshima T, Richardson PG, Anderson KC. Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma. Mol Cancer Ther. 2011;10(11):2034-2042.
    • (2011) Mol Cancer Ther , vol.10 , Issue.11 , pp. 2034-2042
    • Hideshima, T.1    Richardson, P.G.2    Anderson, K.C.3
  • 14
    • 77955729630 scopus 로고    scopus 로고
    • Combination therapy of bortezomib with novel targeted agents: An emerging treatment strategy
    • .Wright JJ. Combination therapy of bortezomib with novel targeted agents: an emerging treatment strategy. Clin Cancer Res. 2010;16(16):4094-4104.
    • (2010) Clin Cancer Res , vol.16 , Issue.16 , pp. 4094-4104
    • Wright, J.J.1
  • 15
    • 84862841567 scopus 로고    scopus 로고
    • Impact of bortezomib on bone health in myeloma: A review of current evidence
    • published online ahead of print January 6, 2012. doi:10.1016/j.ctrv.2011. 12.007
    • Zangari M, Terpos E, Zhan F, Tricot G. Impact of bortezomib on bone health in myeloma: a review of current evidence [published online ahead of print January 6, 2012]. Cancer Treat Rev. doi:10.1016/j.ctrv.2011.12.007.
    • Cancer Treat Rev
    • Zangari, M.1    Terpos, E.2    Zhan, F.3    Tricot, G.4
  • 16
    • 41949110089 scopus 로고    scopus 로고
    • CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
    • Piva R, Ruggeri B, Williams M, et al. CEP-18770: a novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood. 2008;111(5):2765-2775.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2765-2775
    • Piva, R.1    Ruggeri, B.2    Williams, M.3
  • 18
    • 79955498420 scopus 로고    scopus 로고
    • Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: A link to clinical adverse events
    • Arastu-Kapur S, Anderl JL, Kraus M, et al. Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res. 2011;17(9):2734-2743.
    • (2011) Clin Cancer Res , vol.17 , Issue.9 , pp. 2734-2743
    • Arastu-Kapur, S.1    Anderl, J.L.2    Kraus, M.3
  • 20
    • 78649755360 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
    • Chauhan D, Singh AV, Aujay M, et al. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood. 2010;116(23):4906-4915.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4906-4915
    • Chauhan, D.1    Singh, A.V.2    Aujay, M.3
  • 21
    • 84862669447 scopus 로고    scopus 로고
    • Epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable ONX 0912 have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects
    • abstract. Abstract 2906
    • Hurchla MA, Garcia-Gomez A, Hornick MC, et al. Epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable ONX 0912 have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):1253. Abstract 2906.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 1253
    • Hurchla, M.A.1    Garcia-Gomez, A.2    Hornick, M.C.3
  • 23
    • 79951684725 scopus 로고    scopus 로고
    • Marizomib, a proteasome inhibitor for all seasons: Preclinical profile and a framework for clinical trials
    • Potts C, Albitar X, Anderson C, et al. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets. 2011;11(3):254-284.
    • (2011) Curr Cancer Drug Targets , vol.11 , Issue.3 , pp. 254-284
    • Potts, C.1    Albitar, X.2    Anderson, C.3
  • 29
    • 54849413402 scopus 로고    scopus 로고
    • Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma
    • Jagannath S, Barlogie B, Berenson JR, et al. Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma. Br J Haematol. 2008;143(4):537-540.
    • (2008) Br J Haematol , vol.143 , Issue.4 , pp. 537-540
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.R.3
  • 33
    • 39749107470 scopus 로고    scopus 로고
    • Effect of an experimental proteasome inhibitor on the cytoskeleton, cytosolic protein turnover, and induction in the neuronal cells in vitro
    • Csizmadia V, Raczynski A, Csizmadia E, et al. Effect of an experimental proteasome inhibitor on the cytoskeleton, cytosolic protein turnover, and induction in the neuronal cells in vitro. Neurotoxicology. 2008;29(2):232-243.
    • (2008) Neurotoxicology , vol.29 , Issue.2 , pp. 232-243
    • Csizmadia, V.1    Raczynski, A.2    Csizmadia, E.3
  • 35
    • 78049528177 scopus 로고    scopus 로고
    • Treatment-related peripheral neuropathy in multiple myeloma: The challenge continues
    • Delforge M, Blade J, Dimopoulos MA, et al. Treatment-related peripheral neuropathy in multiple myeloma: the challenge continues. Lancet Oncol. 2010;11(11):1086-1095.
    • (2010) Lancet Oncol , vol.11 , Issue.11 , pp. 1086-1095
    • Delforge, M.1    Blade, J.2    Dimopoulos, M.A.3
  • 36
    • 76549137222 scopus 로고    scopus 로고
    • Peripheral neuropathy and new treatments for multiple myeloma: Background and practical recommendations
    • Mohty B, El-Cheikh J, Yakoub-Agha I, et al. Peripheral neuropathy and new treatments for multiple myeloma: background and practical recommendations. Haematologica. 2010;95(2):311-319.
    • (2010) Haematologica , vol.95 , Issue.2 , pp. 311-319
    • Mohty, B.1    El-Cheikh, J.2    Yakoub-Agha, I.3
  • 37
    • 84859632261 scopus 로고    scopus 로고
    • Management of treatment-emergent peripheral neuropathy in multiple myeloma
    • Richardson PG, Delforge M, Beksac M, et al. Management of treatment-emergent peripheral neuropathy in multiple myeloma. Leukemia. 2012;26(4):595-608.
    • (2012) Leukemia , vol.26 , Issue.4 , pp. 595-608
    • Richardson, P.G.1    Delforge, M.2    Beksac, M.3
  • 39
    • 78649681350 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly bortezomib in multiple myeloma patients
    • Bringhen S, Larocca A, Rossi D, et al. Efficacy and safety of once-weekly bortezomib in multiple myeloma patients. Blood. 2010;116(23):4745-4753.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4745-4753
    • Bringhen, S.1    Larocca, A.2    Rossi, D.3
  • 40
    • 77957344540 scopus 로고    scopus 로고
    • Bortezomib, melphalan, and prednisone versus bortezomib, thalidomide, and prednisone as induction therapy followed by maintenance treatment with bortezomib and thalidomide versus bortezomib and prednisone in elderly patients with untreated multiple myeloma: A randomised trial
    • Mateos MV, Oriol A, Martinez-Lopez J, et al. Bortezomib, melphalan, and prednisone versus bortezomib, thalidomide, and prednisone as induction therapy followed by maintenance treatment with bortezomib and thalidomide versus bortezomib and prednisone in elderly patients with untreated multiple myeloma: a randomised trial. Lancet Oncol. 2010;11(10):934-941.
    • (2010) Lancet Oncol , vol.11 , Issue.10 , pp. 934-941
    • Mateos, M.V.1    Oriol, A.2    Martinez-Lopez, J.3
  • 41
    • 78650993336 scopus 로고    scopus 로고
    • Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: A randomized controlled trial
    • Palumbo A, Bringhen S, Rossi D, et al. Bortezomib-melphalan-prednisone- thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: a randomized controlled trial. J Clin Oncol. 2010;28(34):5101-5109.
    • (2010) J Clin Oncol , vol.28 , Issue.34 , pp. 5101-5109
    • Palumbo, A.1    Bringhen, S.2    Rossi, D.3
  • 42
    • 79955461011 scopus 로고    scopus 로고
    • Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: A randomised, phase 3, non-inferiority study
    • Moreau P, Pylypenko H, Grosicki S, et al. Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study. Lancet Oncol. 2011;12(5):431-440.
    • (2011) Lancet Oncol , vol.12 , Issue.5 , pp. 431-440
    • Moreau, P.1    Pylypenko, H.2    Grosicki, S.3
  • 45
    • 57349171505 scopus 로고    scopus 로고
    • Prospective comparison of subcutaneous versus intravenous administration of bortezomib in patients with multiple myeloma
    • Moreau P, Coiteux V, Hulin C, et al. Prospective comparison of subcutaneous versus intravenous administration of bortezomib in patients with multiple myeloma. Haematologica. 2008;93(12):1908-1911.
    • (2008) Haematologica , vol.93 , Issue.12 , pp. 1908-1911
    • Moreau, P.1    Coiteux, V.2    Hulin, C.3
  • 46
    • 79952105543 scopus 로고    scopus 로고
    • Bortezomib retreatment in relapsed multiple myeloma: Results from a retrospective multicentre survey in Germany and Switzerland
    • Hrusovsky I, Emmerich B, von Rohr A, et al. Bortezomib retreatment in relapsed multiple myeloma: results from a retrospective multicentre survey in Germany and Switzerland. Oncology. 2010;79(3-4):247-254.
    • (2010) Oncology , vol.79 , Issue.3-4 , pp. 247-254
    • Hrusovsky, I.1    Emmerich, B.2    Von Rohr, A.3
  • 47
    • 79955565391 scopus 로고    scopus 로고
    • Efficacy and safety of retreatment with bortezomib in patients with multiple myeloma: Interim results from RETRIEVE, a prospective international phase 2 study
    • abstract. Abstract 0377
    • Petrucci MT, Blau I, Corradini P, et al. Efficacy and safety of retreatment with bortezomib in patients with multiple myeloma: interim results from RETRIEVE, a prospective international phase 2 study [abstract]. Haematologica. 2010;95(s2):152. Abstract 0377.
    • (2010) Haematologica , vol.95 , Issue.S2 , pp. 152
    • Petrucci, M.T.1    Blau, I.2    Corradini, P.3
  • 49
    • 20144387627 scopus 로고    scopus 로고
    • Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies
    • Orlowski RZ, Voorhees PM, Garcia RA, et al. Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood. 2005;105(8):3058-3065.
    • (2005) Blood , vol.105 , Issue.8 , pp. 3058-3065
    • Orlowski, R.Z.1    Voorhees, P.M.2    Garcia, R.A.3
  • 51
    • 33646003521 scopus 로고    scopus 로고
    • Bortezomib interactions with chemotherapy agents in acute leukemia in vitro
    • Horton TM, Gannavarapu A, Blaney SM, et al. Bortezomib interactions with chemotherapy agents in acute leukemia in vitro. Cancer Chemother Pharmacol. 2006;58(1):13-23.
    • (2006) Cancer Chemother Pharmacol , vol.58 , Issue.1 , pp. 13-23
    • Horton, T.M.1    Gannavarapu, A.2    Blaney, S.M.3
  • 53
    • 58149086029 scopus 로고    scopus 로고
    • High response rate to bortezomib with or without dexamethasone in patients with relapsed or refractory multiple myeloma: Results of a global phase 3b expanded access program
    • Mikhael JR, Belch AR, Prince HM, et al. High response rate to bortezomib with or without dexamethasone in patients with relapsed or refractory multiple myeloma: results of a global phase 3b expanded access program. Br J Haematol. 2009;144(2):169-175.
    • (2009) Br J Haematol , vol.144 , Issue.2 , pp. 169-175
    • Mikhael, J.R.1    Belch, A.R.2    Prince, H.M.3
  • 54
    • 84864552757 scopus 로고    scopus 로고
    • Bortezomib (VELCADE)-thalidomide-dexamethasone (VTD) is superior to thalidomide-dexamethasone (TD) in patients with multiple myeloma (MM) progressing or relapsing after autologous transplantation
    • abstract. Abstract 1008
    • Garderet L, Iacobelli S, Moreau P, et al. Bortezomib (VELCADE)- thalidomide-dexamethasone (VTD) is superior to thalidomide-dexamethasone (TD) in patients with multiple myeloma (MM) progressing or relapsing after autologous transplantation [abstract]. Haematologica. 2011;96(s2):420-421. Abstract 1008.
    • (2011) Haematologica , vol.96 , Issue.S2 , pp. 420-421
    • Garderet, L.1    Iacobelli, S.2    Moreau, P.3
  • 55
    • 84859719940 scopus 로고    scopus 로고
    • Vantage 088. Vorinostat in combination with bortezomib in patients with relapsed/refractory multiple myeloma: Results of a global, randomized phase 3 trial
    • abstract. Abstract 811
    • Dimopoulos MA, Jagannath S, Yoon S-S, et al. Vantage 088. Vorinostat in combination with bortezomib in patients with relapsed/refractory multiple myeloma: results of a global, randomized phase 3 trial [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):368-369. Abstract 811.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 368-369
    • Dimopoulos, M.A.1    Jagannath, S.2    Yoon, S.-S.3
  • 56
    • 79952720734 scopus 로고    scopus 로고
    • Treatment options for relapsed and refractory multiple myeloma
    • Lonial S, Mitsiades CS, Richardson PG. Treatment options for relapsed and refractory multiple myeloma. Clin Cancer Res. 2011;17(6):1264-1277.
    • (2011) Clin Cancer Res , vol.17 , Issue.6 , pp. 1264-1277
    • Lonial, S.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 57
    • 33748287079 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: Results of a multicenter phase 1/2 study
    • Mateos MV, Hernandez JM, Hernandez MT, et al. Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study. Blood. 2006;108(7):2165-2172.
    • (2006) Blood , vol.108 , Issue.7 , pp. 2165-2172
    • Mateos, M.V.1    Hernandez, J.M.2    Hernandez, M.T.3
  • 59
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel JF, Schlag R, Khuageva NK, et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med. 2008;359(9):906-917.
    • (2008) N Engl J Med , vol.359 , Issue.9 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 60
    • 77952310929 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: Updated follow-up and impact of subsequent therapy in the phase III VISTA trial
    • Mateos MV, Richardson PG, Schlag R, et al. Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: updated follow-up and impact of subsequent therapy in the phase III VISTA trial. J Clin Oncol. 2010;28(13):2259-2266.
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2259-2266
    • Mateos, M.V.1    Richardson, P.G.2    Schlag, R.3
  • 61
    • 84858791957 scopus 로고    scopus 로고
    • Continued overall survival benefit after 5 years'follow-up with bortezomib-melphalan-prednisone (VMP) versus melphalan-prednisone (MP) in patients with previously untreated multiple myeloma, and no increased risk of second primary malignancies: Final results of the phase 3 VISTA trial
    • abstract. Abstract 476
    • San Miguel JF, Schlag R, Khuageva NK, et al. Continued overall survival benefit after 5 years'follow-up with bortezomib-melphalan-prednisone (VMP) versus melphalan-prednisone (MP) in patients with previously untreated multiple myeloma, and no increased risk of second primary malignancies: final results of the phase 3 VISTA trial [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):221-222. Abstract 476.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 221-222
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 62
    • 84861620759 scopus 로고    scopus 로고
    • Maintenance therapy with bortezomib plus thalidomide (VT) or bortezomib plus prednisone (VP) in elderly myeloma patients included in the GEM2005MAS65 Spanish randomized trial
    • abstract. Abstract 477
    • Mateos MV, Oriol A, Teruel AI, et al. Maintenance therapy with bortezomib plus thalidomide (VT) or bortezomib plus prednisone (VP) in elderly myeloma patients included in the GEM2005MAS65 Spanish randomized trial [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):222. Abstract 477.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 222
    • Mateos, M.V.1    Oriol, A.2    Teruel, A.I.3
  • 63
    • 76349087848 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone can improve stem cell collection and overcome the need for additional chemotherapy before autologous transplant in patients with myeloma
    • Corso A, Barbarano L, Mangiacavalli S, et al. Bortezomib plus dexamethasone can improve stem cell collection and overcome the need for additional chemotherapy before autologous transplant in patients with myeloma. Leuk Lymphoma. 2010;51(2):236-242.
    • (2010) Leuk Lymphoma , vol.51 , Issue.2 , pp. 236-242
    • Corso, A.1    Barbarano, L.2    Mangiacavalli, S.3
  • 65
    • 75149147388 scopus 로고    scopus 로고
    • Extended follow-up of a phase 2 trial of bortezomib alone and in combination with dexamethasone for the frontline treatment of multiple myeloma
    • Jagannath S, Durie BG, Wolf JL, et al. Extended follow-up of a phase 2 trial of bortezomib alone and in combination with dexamethasone for the frontline treatment of multiple myeloma. Br J Haematol. 2009;146(6):619-626.
    • (2009) Br J Haematol , vol.146 , Issue.6 , pp. 619-626
    • Jagannath, S.1    Durie, B.G.2    Wolf, J.L.3
  • 66
    • 78049488759 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stemcell transplantation in newly diagnosed multiple myeloma: Results of the IFM 2005-01 phase III trial
    • Harousseau JL, Attal M, Avet-Loiseau H, et al. Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stemcell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial. J Clin Oncol. 2010;28(30):4621-4629.
    • (2010) J Clin Oncol , vol.28 , Issue.30 , pp. 4621-4629
    • Harousseau, J.L.1    Attal, M.2    Avet-Loiseau, H.3
  • 67
    • 34250630470 scopus 로고    scopus 로고
    • Bortezomib in combination with thalidomide-dexamethasone for previously untreated multiple myeloma
    • DOI 10.1080/10245330701214236, PII 779391625
    • .Wang M, Giralt S, Delasalle K, Handy B, Alexanian R. Bortezomib in combination with thalidomide-dexamethasone for previously untreated multiple myeloma. Hematology. 2007;12(3):235-239. (Pubitemid 46930250)
    • (2007) Hematology , vol.12 , Issue.3 , pp. 235-239
    • Wang, M.1    Giralt, S.2    Delasalle, K.3    Handy, B.4    Alexanian, R.5
  • 68
    • 77649092410 scopus 로고    scopus 로고
    • Phase II trial of combination therapy with bortezomib, pegylated liposomal doxorubicin, and dexamethasone in patients with newly diagnosed myeloma
    • Jakubowiak AJ, Kendall T, Al-Zoubi A, et al. Phase II trial of combination therapy with bortezomib, pegylated liposomal doxorubicin, and dexamethasone in patients with newly diagnosed myeloma. J Clin Oncol. 2009;27(30):5015-5022.
    • (2009) J Clin Oncol , vol.27 , Issue.30 , pp. 5015-5022
    • Jakubowiak, A.J.1    Kendall, T.2    Al-Zoubi, A.3
  • 70
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S, et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood. 2010;116(5):679-686.
    • (2010) Blood , vol.116 , Issue.5 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 71
    • 77951453409 scopus 로고    scopus 로고
    • Once-versus twice-weekly bortezomib induction therapy with CyBorD in newly diagnosed multiple myeloma
    • Reeder CB, Reece DE, Kukreti V, et al. Once-versus twice-weekly bortezomib induction therapy with CyBorD in newly diagnosed multiple myeloma. Blood. 2010;115(16):3416-3417.
    • (2010) Blood , vol.115 , Issue.16 , pp. 3416-3417
    • Reeder, C.B.1    Reece, D.E.2    Kukreti, V.3
  • 72
    • 78650303860 scopus 로고    scopus 로고
    • Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: A randomised phase 3 study
    • Cavo M, Tacchetti P, Patriarca F, et al. Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study. Lancet. 2010;376(9758):2075-2085.
    • (2010) Lancet , vol.376 , Issue.9758 , pp. 2075-2085
    • Cavo, M.1    Tacchetti, P.2    Patriarca, F.3
  • 73
    • 82155178738 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma
    • Moreau P, Avet-Loiseau H, Facon T, et al. Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma. Blood. 2011;118(22):5752-5758.
    • (2011) Blood , vol.118 , Issue.22 , pp. 5752-5758
    • Moreau, P.1    Avet-Loiseau, H.2    Facon, T.3
  • 74
    • 84859268120 scopus 로고    scopus 로고
    • Results of pre- And post-autologous stem cell transplantation (ASCT) with three induction regimens in multiple myeloma (MM): Superiority of VTD (bortezomib/thalidomide/dexamethasone) over TD and VBMCP/VBAD plus bortezomib (VBMCP/VBAD/V)
    • abstract. Abstract P-138
    • Rosiñol L, Cibeira MT, Mateos MV, et al. Results of pre- and post-autologous stem cell transplantation (ASCT) with three induction regimens in multiple myeloma (MM): superiority of VTD (bortezomib/thalidomide/ dexamethasone) over TD and VBMCP/VBAD plus bortezomib (VBMCP/VBAD/V) [abstract]. Haematologica. 2011;96(s1):S69. Abstract P-138.
    • (2011) Haematologica , vol.96 , Issue.S1
    • Rosiñol, L.1    Cibeira, M.T.2    Mateos, M.V.3
  • 75
    • 79952790841 scopus 로고    scopus 로고
    • HOVON-65/GMMG-HD4 randomized phase III trial comparing bortezomib, doxorubicin, dexamethasone (PAD) vs VAD followed by high-dose melphalan (HDM) and maintenance with bortezomib or thalidomide in patients with newly diagnosed multiple myeloma (MM)
    • abstract. Abstract 40
    • Sonneveld P, Schmidt-Wolf I, van der Holt B, et al. HOVON-65/GMMG-HD4 randomized phase III trial comparing bortezomib, doxorubicin, dexamethasone (PAD) vs VAD followed by high-dose melphalan (HDM) and maintenance with bortezomib or thalidomide in patients with newly diagnosed multiple myeloma (MM) [abstract]. Blood (ASH Annual Meeting Abstracts). 2010;116(21):23-24. Abstract 40.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , Issue.21 , pp. 23-24
    • Sonneveld, P.1    Schmidt-Wolf, I.2    Van Der Holt, B.3
  • 76
    • 79959398524 scopus 로고    scopus 로고
    • International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantation
    • Cavo M, Rajkumar SV, Palumbo A, et al. International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantation. Blood. 2011;117(23):6063- 6073.
    • (2011) Blood , vol.117 , Issue.23 , pp. 6063-6073
    • Cavo, M.1    Rajkumar, S.V.2    Palumbo, A.3
  • 77
    • 74949119502 scopus 로고    scopus 로고
    • Bortezomib and high-dose melphalan as conditioning regimen before autologous stem cell transplantation in patients with de novo multiple myeloma: A phase 2 study of the Intergroupe Francophone du Myelome (IFM)
    • Roussel M, Moreau P, Huynh A, et al. Bortezomib and high-dose melphalan as conditioning regimen before autologous stem cell transplantation in patients with de novo multiple myeloma: a phase 2 study of the Intergroupe Francophone du Myelome (IFM). Blood. 2010;115(1):32-37.
    • (2010) Blood , vol.115 , Issue.1 , pp. 32-37
    • Roussel, M.1    Moreau, P.2    Huynh, A.3
  • 78
    • 77958065790 scopus 로고    scopus 로고
    • A phase I/II trial combining high-dose melphalan and autologous transplant with bortezomib for multiple myeloma: A dose- And schedule-finding study
    • Lonial S, Kaufman J, Tighiouart M, et al. A phase I/II trial combining high-dose melphalan and autologous transplant with bortezomib for multiple myeloma: a dose- and schedule-finding study. Clin Cancer Res. 2010;16(20):5079-5086.
    • (2010) Clin Cancer Res , vol.16 , Issue.20 , pp. 5079-5086
    • Lonial, S.1    Kaufman, J.2    Tighiouart, M.3
  • 79
    • 83655174029 scopus 로고    scopus 로고
    • Improved progression-free survival with bortezomib consolidation after high dose melphalan: Results of a randomized phase III trial abstract
    • Abstract O-11
    • Mellqvist UH, Gimsing P, Hjertner O, et al. Improved progression-free survival with bortezomib consolidation after high dose melphalan: results of a randomized phase III trial [abstract]. Haematologica. 2011;96(s1):S31. Abstract O-11.
    • (2011) Haematologica , vol.96 , Issue.S1
    • Mellqvist, U.H.1    Gimsing, P.2    Hjertner, O.3
  • 80
    • 77951625298 scopus 로고    scopus 로고
    • Major tumor shrinking and persistent molecular remissions after consolidation with bortezomib, thalidomide, and dexamethasone in patients with autografted myeloma
    • Ladetto M, Pagliano G, Ferrero S, et al. Major tumor shrinking and persistent molecular remissions after consolidation with bortezomib, thalidomide, and dexamethasone in patients with autografted myeloma. J Clin Oncol. 2010;28(12):2077-2084.
    • (2010) J Clin Oncol , vol.28 , Issue.12 , pp. 2077-2084
    • Ladetto, M.1    Pagliano, G.2    Ferrero, S.3
  • 81
    • 84864562565 scopus 로고    scopus 로고
    • Long-term results of the GIMEMA VTD consolidation trial in autografted multiple myeloma patients (VEL-03-096): Impact of minimal residual disease detection by real time quantitative PCR on late recurrences and overall survival
    • abstract. Abstract 827
    • Ladetto M, Ferrero S, Drandi D, et al. Long-term results of the GIMEMA VTD consolidation trial in autografted multiple myeloma patients (VEL-03-096): impact of minimal residual disease detection by real time quantitative PCR on late recurrences and overall survival [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):376-377. Abstract 827.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 376-377
    • Ladetto, M.1    Ferrero, S.2    Drandi, D.3
  • 82
    • 84862702124 scopus 로고    scopus 로고
    • Superior complete response rate (CR) and progressionfree survival (PFS) with bortezomib-thalidomide-dexamethasone (VTD) versus thalidomidedexamethasone (TD) as consolidation therapy after autologous stem-cell transplantation (ASCT) in multiple myeloma (MM)
    • abstract. Abstract 1871
    • Cavo M, Pantani L, Patriarca F, et al. Superior complete response rate (CR) and progressionfree survival (PFS) with bortezomib-thalidomide- dexamethasone (VTD) versus thalidomidedexamethasone (TD) as consolidation therapy after autologous stem-cell transplantation (ASCT) in multiple myeloma (MM) [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):816. Abstract 1871.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 816
    • Cavo, M.1    Pantani, L.2    Patriarca, F.3
  • 83
    • 84856949640 scopus 로고    scopus 로고
    • Sequential bortezomib, dexamethasone, and thalidomide maintenance therapy after single autologous peripheral stem cell transplantation in patients with multiple myeloma
    • Sahebi F, Frankel PH, Farol L, et al. Sequential bortezomib, dexamethasone, and thalidomide maintenance therapy after single autologous peripheral stem cell transplantation in patients with multiple myeloma. Biol Blood Marrow Transplant. 2012;18(3):486-492.
    • (2012) Biol Blood Marrow Transplant , vol.18 , Issue.3 , pp. 486-492
    • Sahebi, F.1    Frankel, P.H.2    Farol, L.3
  • 84
    • 84862656849 scopus 로고    scopus 로고
    • A phase III PETHEMA/GEM randomized trial of postransplant (ASCT) maintenance in multiple myeloma: Superiority of bortezomib/thalidomide compared with thalidomide and alfa-2b interferon
    • abstract. Abstract 3962
    • Rosiñol L, Cibeira MT, Mateos MV, et al. A phase III PETHEMA/GEM randomized trial of postransplant (ASCT) maintenance in multiple myeloma: superiority of bortezomib/thalidomide compared with thalidomide and alfa-2b interferon [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):1694-1695. Abstract 3962.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 1694-1695
    • Rosiñol, L.1    Cibeira, M.T.2    Mateos, M.V.3
  • 85
    • 84862507585 scopus 로고    scopus 로고
    • An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
    • published online ahead of print May 3, 2012 doi:10.1182/blood-2012-03- 414359
    • Vij R, Wang M, Kaufman JL, et al. An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma [published online ahead of print May 3, 2012]. Blood. doi:10.1182/blood-2012-03-414359.
    • Blood
    • Vij, R.1    Wang, M.2    Kaufman, J.L.3
  • 86
    • 78649237411 scopus 로고    scopus 로고
    • Results of an ongoing open-label, phase II study of carfilzomib in patients with relapsed and/or refractory multiple myeloma (R/R MM)
    • abstract. Abstract 8000
    • Vij R, Siegel DS, Kaufman JL, et al. Results of an ongoing open-label, phase II study of carfilzomib in patients with relapsed and/or refractory multiple myeloma (R/R MM) [abstract]. J Clin Oncol. 2010;28(15s):573s. Abstract 8000.
    • (2010) J Clin Oncol , vol.28 , Issue.15
    • Vij, R.1    Siegel, D.S.2    Kaufman, J.L.3
  • 87
    • 84859760906 scopus 로고    scopus 로고
    • Integrated safety from phase 2 studies of monotherapy carfilzomib in patients with relapsed and refractory multiple myeloma (MM): An updated analysis
    • abstract. Abstract 1876
    • Singhal S, Siegel DS, Martin T, et al. Integrated safety from phase 2 studies of monotherapy carfilzomib in patients with relapsed and refractory multiple myeloma (MM): an updated analysis [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):819. Abstract 1876.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 819
    • Singhal, S.1    Siegel, D.S.2    Martin, T.3
  • 88
    • 79955511317 scopus 로고    scopus 로고
    • Results of PX-171-003-A1, an open-label, single-arm, phase 2 (ph 2) study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM)
    • abstract. Abstract 985
    • Siegel DS, Martin T, Wang M, et al. Results of PX-171-003-A1, an open-label, single-arm, phase 2 (ph 2) study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM) [abstract]. Blood (ASH Annual Meeting Abstracts). 2010;116(21):433. Abstract 985.
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , Issue.21 , pp. 433
    • Siegel, D.S.1    Martin, T.2    Wang, M.3
  • 89
    • 84862642342 scopus 로고    scopus 로고
    • Responses to single-agent carfilzomib (CFZ) are not affected by cytogenetics in patients (pts) with relapsed and refractory multiple myeloma (R/R MM)
    • abstract. Abstract 117
    • Jakubowiak AJ, Martin T, Singhal S, et al. Responses to single-agent carfilzomib (CFZ) are not affected by cytogenetics in patients (pts) with relapsed and refractory multiple myeloma (R/R MM) [abstract]. Ann Oncol. 2011;22(Suppl 4):iv122. Abstract 117.
    • (2011) Ann Oncol , vol.22 , Issue.SUPPL. 4
    • Jakubowiak, A.J.1    Martin, T.2    Singhal, S.3
  • 90
    • 77955450608 scopus 로고    scopus 로고
    • Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low dose dexamethasone (CRd) in relapsed and refractory multiple myeloma (MM)
    • abstract. Abstract 304
    • Niesvizky R, Wang L, Orlowski RZ, et al. Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low dose dexamethasone (CRd) in relapsed and refractory multiple myeloma (MM) [abstract]. Blood (ASH Annual Meeting Abstracts). 2009;114(22):128-129. Abstract 304.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , Issue.22 , pp. 128-129
    • Niesvizky, R.1    Wang, L.2    Orlowski, R.Z.3
  • 91
    • 84864568291 scopus 로고    scopus 로고
    • Carfilzomib combined with thalidomide and dexamethasone (CARTHADEX) as induction treatment prior to high-dose melphalan (HDM) in newly diagnosed patients with multiple myeloma (MM): A trial of the European Myeloma Network EMN
    • abstract. Abstract 633
    • Sonneveld P, Hacker E, Zweegman S, et al. Carfilzomib combined with thalidomide and dexamethasone (CARTHADEX) as induction treatment prior to high-dose melphalan (HDM) in newly diagnosed patients with multiple myeloma (MM): a trial of the European Myeloma Network EMN [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):290. Abstract 633.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 290
    • Sonneveld, P.1    Hacker, E.2    Zweegman, S.3
  • 92
    • 84857261392 scopus 로고    scopus 로고
    • Final results of a frontline phase 1/2 study of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) in multiple myeloma (MM)
    • abstract. Abstract 631
    • Jakubowiak AJ, Dytfeld D, Jagannath S, et al. Final results of a frontline phase 1/2 study of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) in multiple myeloma (MM) [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(12):288-289. Abstract 631.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.12 , pp. 288-289
    • Jakubowiak, A.J.1    Dytfeld, D.2    Jagannath, S.3
  • 93
    • 84857919694 scopus 로고    scopus 로고
    • Phase 1 clinical evaluation of twice-weekly marizomib (NPI-0052), a novel proteasome inhibitor, in patients with relapsed/refractory multiple myeloma (MM)
    • abstract. Abstract 302
    • Richardson PG, Spencer A, Cannell P, et al. Phase 1 clinical evaluation of twice-weekly marizomib (NPI-0052), a novel proteasome inhibitor, in patients with relapsed/refractory multiple myeloma (MM) [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):140-141. Abstract 302.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 140-141
    • Richardson, P.G.1    Spencer, A.2    Cannell, P.3
  • 94
    • 84872218337 scopus 로고    scopus 로고
    • MLN9708, a novel, investigational proteasome inhibitor, in patients with relapsed/refractory lymphoma: Results of a phase 1 dose-escalation study
    • abstract. Abstract 2672
    • Assouline S, Chang J, Rifkin R, et al. MLN9708, a novel, investigational proteasome inhibitor, in patients with relapsed/refractory lymphoma: results of a phase 1 dose-escalation study [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):1148. Abstract 2672.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 1148
    • Assouline, S.1    Chang, J.2    Rifkin, R.3
  • 95
    • 84863643928 scopus 로고    scopus 로고
    • Phase 1/2 study of oral MLN9708, a novel, investigational proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma (MM)
    • abstract. Abstract 479
    • Berdeja JG, Richardson PG, Lonial S, et al. Phase 1/2 study of oral MLN9708, a novel, investigational proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma (MM) [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):223. Abstract 479.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 223
    • Berdeja, J.G.1    Richardson, P.G.2    Lonial, S.3
  • 96
    • 84862697766 scopus 로고    scopus 로고
    • Weekly dosing of the investigational oral proteasome inhibitor MLN9708 in patients with relapsed and/or refractory multiple myeloma: Results from a phase 1 dose-escalation study
    • abstract. Abstract 816
    • Kumar S, Bensinger WI, Reeder CB, et al. Weekly dosing of the investigational oral proteasome inhibitor MLN9708 in patients with relapsed and/or refractory multiple myeloma: results from a phase 1 dose-escalation study [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):371-372. Abstract 816.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 371-372
    • Kumar, S.1    Bensinger, W.I.2    Reeder, C.B.3
  • 97
    • 84862644984 scopus 로고    scopus 로고
    • Investigational agent MLN9708, an oral proteasome inhibitor, in patients (pts) with relapsed and/or refractory multiple myeloma (MM): Results from the expansion cohorts of a phase 1 dose-escalation study
    • abstract. Abstract 301
    • Richardson PG, Baz R, Wang L, et al. Investigational agent MLN9708, an oral proteasome inhibitor, in patients (pts) with relapsed and/or refractory multiple myeloma (MM): results from the expansion cohorts of a phase 1 dose-escalation study [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):140. Abstract 301.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 140
    • Richardson, P.G.1    Baz, R.2    Wang, L.3
  • 99
    • 84862696861 scopus 로고    scopus 로고
    • Efficacy and safety of three bortezomib-based combinations in elderly, newly diagnosed multiple myeloma patients: Results from all randomized patients in the community-based, phase 3b UPFRONT study
    • abstract. Abstract 478
    • Niesvizky R, Flinn IW, Rifkin R, et al. Efficacy and safety of three bortezomib-based combinations in elderly, newly diagnosed multiple myeloma patients: results from all randomized patients in the community-based, phase 3b UPFRONT study [abstract]. Blood (ASH Annual Meeting Abstracts). 2011;118(21):222-223. Abstract 478.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , Issue.21 , pp. 222-223
    • Niesvizky, R.1    Flinn, I.W.2    Rifkin, R.3
  • 100
    • 70349643684 scopus 로고    scopus 로고
    • Final results of PX-171-003-A0, part 1 of an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM)
    • abstract. Abstract 8504
    • Jagannath S, Vij R, Stewart AK, et al. Final results of PX-171-003-A0, part 1 of an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM) [abstract]. J Clin Oncol. 2009;27(15s):435s. Abstract 8504.
    • (2009) J Clin Oncol , vol.27 , Issue.15
    • Jagannath, S.1    Vij, R.2    Stewart, A.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.