Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions

Cancer Chemotherapy and Pharmacology

Volumn 53, Issue 2, 2004, Pages 116-122

  Maher, Johnathan C ^a   Krishan, Awtar ^a   Lampidis, Theodore J ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

2 Deoxy D glucose; Glycolysis; Hypoxia; Osteosarcoma; Oxidative phosphorylation

Indexed keywords

DEOXYGLUCOSE; RHODAMINE 123;

AEROBIC CAPACITY; ANAEROBIC CAPACITY; ARTICLE; CANCER MODEL; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; FLOW CYTOMETRY; GENE CONSTRUCT; HUMAN; HUMAN CELL; HYPOXIC CELL; MITOSIS INHIBITION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; TUMOR CELL;

AEROBIOSIS; ANTIMETABOLITES, ANTINEOPLASTIC; BONE NEOPLASMS; CELL COUNT; CELL CYCLE; CELL DEATH; CELL HYPOXIA; COLORING AGENTS; DEOXYGLUCOSE; DNA, NEOPLASM; FLOW CYTOMETRY; HUMANS; OSTEOSARCOMA; TRYPAN BLUE;

EID: 0442313668     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-003-0724-7     Document Type: Article

References (25)

1. Arbuckle MI, Kane S, Porter LM, Seatter MJ, Gould GW (1996) Structure-function analysis of liver-type (GLUT2) and brain-type (GLUT3) glucose transporters: expression of chimeric transporters in Xenopus oocytes suggests an important role for putative transmembrane helix 7 in determining substrate selectivity. Biochemistry 35:16519
2. Bell SE, Quinn DM, Kellett GL, Warr JR (1998) 2-Deoxy-D-glucose preferentially kills multidrug-resistant human KB carcinoma cell lines by apoptosis. Br J Cancer 78:1464
3. Boros LG, Brandes JL, Yusuf FI, Cascante M, Williams RD, Schirmer WJ (1998) Inhibition of the oxidative and nonoxidative pentose phosphate pathways by somatostatin: a possible mechanism of antitumor action. Med Hypotheses 50:501
4. Brown J (1962) Effects of 2-deoxyglucose on carbohydrate metabolism: review of the literature and studies in the rat. Metabolism 11:1098
5. Hankinson O (1979) Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase. Proc Natl Acad Sci U S A 76:373
6. 0 tumor cells: a model for studying whether mitochondria are targets for rhodamine 123, doxorubicin and other drugs. Biochem Pharmacol 60:1897
7. Hume DA, Radik JL, Ferber E, Weidemann MJ (1978) Aerobic glycolysis and lymphocyte transformation. Biochem J 174:703
8. Gould GW, Holman GD (1993) The glucose transporter family: structure, function and tissue-specific expression. Biochem J 295:329
9. King MP, Attardi G (1989) Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 248:500
10. Krishan A, Paika K, Frei E (1975) Cytofluorometric studies on the action of podophyllotoxin and epipodophyllotoxins (VM-26, VP-16-213) on the cell cycle traverse of human lymphoblasts. J Cell Biol 66:521
11. LaManna JC, Lust D (1997) Nutrient consumption and metabolic perturbations. Neurosurg Clin N Am 8:145-163
12. Lampidis TJ, Salet C, Moreno G, Chen LB (1984) Effects of the mitochondrial probe rhodamine 123 and related analogs on the function and viability of pulsating myocardial cells in culture. Agents Actions 14:751
13. Liu H, Hu YP, Savaraj N, Priebe W, Lampidis TJ (2001) Hypersensitization of tumor cells to glycolytic inhibitors. Biochemistry 40:5542
14. Liu H, Hu YP, Savaraj N, Priebe W, Lampidis TJ (2002) Hypoxia increases tumor cell sensitivity to glycolytic inhibitors a strategy for solid tumor therapy (model C). Biochem Pharmacol 64:1746
15. Maxwell PH, Pugh CW, Ratcliffe PJ (1993) Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: evidence for a widespread oxygen sensing mechanism. Proc Natl Acad Sci U S A 90:2423
16. Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Ratcliffe PJ (1997) Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci U S A 94:8104
17. Maxwell PH, Pugh CW, Ratcliffe PJ (2001) Activation of the HIF pathway in cancer. Curr Opin Genet Dev 11:93
18. McKeehan WL (1982) Glycolysis, glutaminolysis and cell proliferation. Cell Biol Int Rep 6:635
19. Modica-Napolitano JS, Weiss MJ, Chen LB, Aprille JR (1984) Rhodamine 123 inhibits bioenergetic function in isolated rat liver mitochondria. Biochem Biophys Res Commun 118:717
20. Reitzer LJ, Wice BM, Kennell D (1980) The pentose cycle: control and essential function in HeLa cell nucleic acid synthesis. J Biol Chem 255:5616
21. Semenza GL (2000) HIF: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88:1474
22. Sumbilla CM, Zielke CL, Reed DW, Ozand PT, Zielke RH (1981) Comparison of the oxidation of glutamine, glucose, ketone bodies and fatty acids by human diploid fibroblasts. Biochim Biophys Acta 675:301
23. Vaux EC, Metzen E, Yeates KM, Ratcliffe PJ (2001) Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood 98:296
24. Wang GL, Jiang B, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 92:5510
25. Wood SM, Gleadle JM, Pugh CW, Hankinson O, Ratcliffe PJ (1996) The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. J Biol Chem 271:15117