Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy

PLoS ONE

Volumn 3, Issue 12, 2008, Pages

  Yu, De Hua ^a   Mcdonald, James ^a   Liu, Guohong ^a   Lee, Amy S ^a,b   Ly, Mimi ^a   Davis, Timothy ^a   Ke, Ning ^a   Zhou, Demin ^a   Wong Staal, Flossie ^a   Li, Qi Xiang ^a  

^a iTherX Pharmaceuticals Inc   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CALCIMYCIN; DEOXYGLUCOSE; DOXORUBICIN; GLUCOSE; PYRVINIUM EMBONATE; TUNICAMYCIN; X BOX BINDING PROTEIN 1; ANTINEOPLASTIC AGENT; CHAPERONE; DNA BINDING PROTEIN; GLUCOSE REGULATED PROTEINS; GLUCOSE-REGULATED PROTEINS; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; MEMBRANE PROTEIN; MOLECULAR CHAPERONE GRP78; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CELL DEATH; CELL PROTECTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG TARGETING; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOGLYCEMIA; IN VIVO STUDY; MOUSE; NONHUMAN; TRANSGENE; UNFOLDED PROTEIN RESPONSE; XENOGRAFT; ANIMAL; CELL ADHESION; CELL PROLIFERATION; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; GLYCOLYSIS; METABOLISM; NUDE MOUSE; PROTEIN FOLDING; TRANSCRIPTION INITIATION; TUMOR CELL LINE; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL ADHESION; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; DOWN-REGULATION; DOXORUBICIN; DRUG SYNERGISM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; GLYCOLYSIS; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYPOGLYCEMIA; MEMBRANE PROTEINS; MICE; MICE, NUDE; MOLECULAR CHAPERONES; PROTEIN FOLDING; PYRVINIUM COMPOUNDS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 58049213923     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003951     Document Type: Article

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