Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 21295-21306

  Madge, Lisa A ^b   Li, Jie Hui ^b   Choi, Jaehyuk ^b   Pober, Jordan S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; CONDENSATION; DEGRADATION; DNA; TUMORS;

CELL DEATH;

ENZYME INHIBITION;

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE; CASPASE 8; CASPASE INHIBITOR; CATHEPSIN; CATHEPSIN B; CYCLOHEXIMIDE; CYTOKINE; DNA FRAGMENT; ENZYME INHIBITOR; FLICE INHIBITORY PROTEIN; INHIBITOR PROTEIN; INTERLEUKIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; CYTOLYSIS; DNA DEGRADATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LYSOSOME; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SENSITIZATION; VASCULAR ENDOTHELIUM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARRIER PROTEINS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CATHEPSIN B; CELL NUCLEUS; CELLS, CULTURED; CHROMONES; CYCLOHEXIMIDE; CYSTEINE PROTEINASE INHIBITORS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-1; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MORPHOLINES; PROTEIN SYNTHESIS INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RETROVIRIDAE; TRANSDUCTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS;

EID: 0037742249     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212837200     Document Type: Article

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