Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells

Journal of Cell Biology

Volumn 152, Issue 2, 2001, Pages 237-250

  Shimizu, Shigeomi ^a,b   Matsuoka, Yosuke ^b   Shinohara, Yasuo ^c   Yoneda, Yoshihiro ^b   Tsujimoto, Yoshihide ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Apoptosis; Bax; Bcl 2; Cytochrome c; VDAC

Indexed keywords

ANION CHANNEL; ANTIBODY; CYTOCHROME C; ETOPOSIDE; PACLITAXEL; PROTEIN BAK; PROTEIN BAX; PROTEIN BID; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE; HEMOLYSIS; HUMAN; HUMAN CELL; MAMMAL CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CYTOCHROME C GROUP; ERYTHROCYTES; ETOPOSIDE; HELA CELLS; HUMANS; ION CHANNELS; MAMMALS; MEMBRANE PROTEINS; MITOCHONDRIA; MITOCHONDRIA, LIVER; MOLECULAR SEQUENCE DATA; PACLITAXEL; PORINS; PROTEIN CONFORMATION; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, INBRED STRAINS; RECOMBINANT PROTEINS; STAUROSPORINE; TRANSFECTION; VOLTAGE-DEPENDENT ANION CHANNELS;

ANIMALIA; MAMMALIA;

EID: 0035931765     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.2.237     Document Type: Article

References (52)

1. The Bcl-2 protein family: Arbiters of cell survival
2. Inhibition of Bax channel-forming activity by Bcl-2
3. Studies on human porin. VI. Production and characterization of eight monoclonal mouse antibodies against the human VDAC "Porin 31HL" and their application for histotopological studies in human skeletal muscle
4. Bax, but not BclxL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations
5. Studies on human porin. VII. The channel properties of the human B-lymphocyte membrane-derived "Porin 31HL" are similar to those of mitochondrial porins
6. Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane
7. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
8. Evidence for secretory pathway localization of a voltage-dependent anion channel isoform
9. Studies on human porin. VIII. Expression of "Porin 31HL" channels in the plasmalemma of the acute-lymphoblastic-leukemia cell line KM3 as revealed by light- and electron-microscopy
10. Voltage gating in the mitochondrial channel, VDAC
11. Transmembrane arrangement of mitochondrial porin or voltage-dependent anion channel (VDAC)
12. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
13. 2+ ions
14. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
15. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL
16. Mitochondria and apoptosis
17. A monoclonal antibody to the COOH-terminal acidic portion of Ran inhibits both the recycling of Ran and nuclear protein import in living cells
18. Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins
19. In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import
20. Bax directly induces release of cytochrome c from isolated mitochondria
21. The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol
22. The destabilization of lipid membranes induced by the C-terminal fragment of caspase 8-cleaved Bid is inhibited by the N-terminal fragment
23. In vitro and in vivo protein-DNA interactions on the rat erythroid-specific L′ pyruvate kinase gene promoter
24. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
25. Exogenous histone H1 injection into mitotic cells disrupts synchronous progression of mitotic events by delaying chromosome decondensation
26. Identification of the cDNA for human red blood cell-specific hexokinase isozyme
27. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
28. Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2
29. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition
30. Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore
31. BAX-dependent transport of cytochrome c reconstituted in pure liposomes
32. Ion channel activity of the BH3 only Bcl-2 family member, BID
33. Pro-apoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate VDAC activity
34. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux
35. Bcl-2 family of proteins target mitochondrial channel VDAC to regulate apoptogenic cytochrome c release
36. Electrophysiological study of a novel large pore formed by Bax and VDAC, which is permeable to cytochrome c
37. BH4 domain of anti-apoptotic Bcl-2 family members closes VDAC and inhibits apoptotic mitochondrial changes and cell death
38. L independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator
39. Indications of a common folding pattern for VDAC channels from all sources
40. Caspases: Enemies within
41. Studies on human porin XXI: Gadolinium opens Up cell membrane standing porin channels making way for the osmolytes chloride or taurine-A putative approach to activate the alternate chloride channel in cystic fibrosis
42. Role of Bcl-2 family proteins in apoptosis: Apoptosomes or mitochondria?
43. Bcl-2 family: Life-or-death switch
44. VDAC regulation by the Bcl-2 family of proteins
45. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
46. Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange
47. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival
48. Identification of DIABLO, a mammalian protein that promotes apoptasis by binding to and antagonizing IAP proteins
49. BID: A novel BH3 domain-only death agonist
50. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
51. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases
52. The mitochondrial permeability transition