2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition

Molecular Cancer Therapeutics

Volumn 7, Issue 4, 2008, Pages 809-817

  Zhong, Diansheng ^a,b   Liu, Xiuju ^a   Schafer Hales, Katherine ^a   Marcus, Adam I ^a   Khuri, Fadlo R ^a   Sun, Shi Yong ^a   Zhou, Wei ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; DEOXYGLUCOSE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE LKB1; SERINE; THREONINE; TRANSCRIPTION FACTOR FKHRL1;

ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLYCOLYSIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; ANTIMETABOLITES; BLOTTING, WESTERN; DEOXYGLUCOSE; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; GLYCOGEN SYNTHASE KINASE 3; GLYCOLYSIS; HUMANS; LUCIFERASES; MULTIENZYME COMPLEXES; NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 42249111525     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-0559     Document Type: Article

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