Adrenergic signaling and oxidative stress: A role for sirtuins?

Frontiers in Physiology

Volumn 4 NOV, Issue , 2013, Pages

  Corbi, Graziamaria ^a   Conti, Valeria ^b   Russomanno, Giusy ^b   Longobardi, Giancarlo ^c   Furgi, Giuseppe ^c   Filippelli, Amelia ^b   Ferrara, Nicola ^c,d  

^a UNIVERSITY OF MOLISE   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c IRCCS   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

adrenergic system; Exercise training; GRK2; Heart failure; Oxidative stress; Reactive oxygen species; Sirtuins

Indexed keywords

ANTIOXIDANT; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARDIOVASCULAR AGENT; FATTY ACID; G PROTEIN COUPLED RECEPTOR KINASE 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESVERATROL; SIRTUIN; SIRTUIN 1; SIRTUIN 3; SIRTUIN 6; SOMATOMEDIN C; SRT 2104; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; CARDIOVASCULAR DISEASE; CELL SURVIVAL; CELLULAR STRESS RESPONSE; DEACETYLATION; DISEASE COURSE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXERCISE; HEART DILATATION; HEART DISEASE; HEART FAILURE; HUMAN; INSULIN SENSITIVITY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 84889659347     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2013.00324     Document Type: Review

References (198)

1. Accili, D., de Cabo, R., and Sinclair, D. A. (2011). An unSIRTain role in longevity. Nat. Med. 17, 1350-1351. doi: 10.1038/nm1111-1350
2. Alcendor, R. R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., et al. (2007). Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ. Res. 100, 1512-1521. doi: 10.1161/01.RES.0000267723.65696.4a
3. Alcendor, R. R., Kirshenbaum, L. A., Imai, S., Vatner, S. F., and Sadoshima, J. (2004). Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ. Res. 95, 971-980. doi: 10.1161/01.RES.0000147557.75257.ff
4. Andersson, D. C., Fauconnier, J., Yamada, T., Lacampagne, A., Zhang, S. J., Katz, A., et al. (2011). Mitochondrial production of reactive oxygen species contributes to the ß-adrenergic stimulation of mouse cardiomycytes. J. Physiol. 589, 1791-1801. doi: 10.1113/jphysiol.2010.202838
5. Anversa, P., Hiler, B., Ricci, R., Guideri, G., and Olivetti, G. (1986). Myocyte cell loss and myocyte hypertrophy in the aging rat heart. J. Am. Coll. Cardiol. 8, 1441-1448. doi: 10.1016/S0735-1097(86)80321-7
6. Arrick, D. M., Sharpe, G. M., Sun, H., and Mayhan, W. G. (2008). Losartan improves impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type 1 diabetic rats. Brain Res. 1209, 128-135. doi: 10.1016/j.brainres.2008.03.020
7. Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., et al. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342. doi: 10.1038/nature05354
8. Besse, S., Robert, V., Assayag, P., Delcayre, C., and Swynghedauw, B. (1994a). Nonsynchronous changes in myocardial collagen mRNA and protein during aging: effect of DOCA-salt hypertension. Am. J. Physiol. 267, H2237-H2244.
9. Besse, S., Delcayre, C., Chevalier, B., Hardouin, S., Heymes, C., Bourgeois, F., et al. (1994b). Is the senescent heart overloaded and already failing? Cardiovasc. Drugs Ther. 8, 581-587. doi: 10.1007/BF00877412
10. Bezstarosti, K., Das, S., Lamers, J. M., and Das, D. K. (2006). Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol. J. Cell. Mol. Med. 10, 896-907. doi: 10.1111/j.1582-4934.2006.tb00533.x
11. Bianco, A., Mazzarella, G., Turchiarelli, V., Nigro, E., Corbi, G., Scudiero, O., et al. (2013). Adiponectin: an attractive marker for metabolic disorders in Chronic Obstructive Pulmonary Disease (COPD). Nutrients 5, 4115-4125. doi: 10.3390/nu5104115
12. Bohm, M. (1995). Alterations of beta-adrenoceptor-G-protein-regulated adenylyl cyclase in heart failure. Mol. Cell Biochem. 147, 147-160. doi: 10.1007/BF00944795
13. Breen, D. M., Sanli, T., Giacca, A., and Tsiani, E. (2008). Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK. Biochem. Biophys. Res. Commun. 374, 117-122. doi: 10.1016/j.bbrc.2008.06.104
14. Bristow, M. R., Hershberger, R. E., Port, J. D., Gilbert, E. M., Sandoval, A., Rasmussen, R., et al. (1990). Beta-adrenergic pathways in nonfailing and failing human ventricular myocardium. Circulation 82, I12-I25.
15. Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., et al. (2004). Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015. doi: 10.1126/science.1094637
16. Cannavo, A., Rengo, G., Liccardo, D., Pagano, G., Zincarelli, C., De Angelis, M. C., et al. (2013a). ß 1-Adrenergic receptor and Sphingosine-1-Phosphate Receptor 1 reciprocal down-regulation influences cardiac hypertrophic response and progression toward heart failure: protective role of S1PR1 cardiac gene therapy. Circulation 128, 1612-1622. doi: 10.1161/CIRCULATIONAHA.113.002659
17. Cannavo, A., Rengo, G., Liccardo, D., Pironti, G., Scimia, M. C., Scudiero, L., et al. (2013b). Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation. Apoptosis 18, 1252-1261. doi: 10.1007/s10495-013-0876-9
18. Cant, S. H., and Pitcher, J. A. (2005). G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton. Mol. Biol. Cell 16, 3088-3099. doi: 10.1091/mbc.E04-10-0877
19. Cantó, C., and Auwerx, J. (2012). Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol. Rev. 64, 166-187. doi: 10.1124/pr.110.003905
20. Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., et al. (2009). AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458, 1056-1060. doi: 10.1038/nature07813
21. Cardus, A., Uryga, A. K., Walters, G., and Erusalimsky, J. D. (2013). SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. Cardiovasc. Res. 97, 571-579. doi: 10.1093/cvr/cvs352
22. Cesselli, D., Jakoniuk, I., Barlucchi, L., Beltrami, A. P., Hintze, T. H., Nadal-Ginard, B., et al. (2001). Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ. Res. 89, 279-286. doi: 10.1161/hh1501.094115
23. Chakraborti, S., Chakraborti, T., and Shaw, G. (2000). Beta-adrenergic mechanisms in cardiac diseases: a perspective. Cell Signal. 12, 499-513. doi: 10.1016/S0898-6568(00)00087-5
24. Chan, A. Y., Dolinsky, V. W., Soltys, C. L., Viollet, B., Baksh, S., Light, P. E., et al. (2008). Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt. J. Biol. Chem. 283, 24194-24201. doi: 10.1074/jbc.M802869200
25. Chao, L. C., and Tontonoz, P. (2012). SIRT1 regulation-it ain't all NAD. Mol. Cell. 45, 9-11. doi: 10.1016/j.molcel.2011.12.017
26. Chen, C. H., Sun, L., and Mochly-Rosen, D. (2010). Mitochondrial aldehyde dehydrogenase and cardiac diseases. Cardiovasc. Res. 88, 51-57. doi: 10.1093/cvr/cvq192
27. Chen, E. P., Bittner, H. B., Davis, R. D., Folz, R. J., and Van Trigt, P. (1996). Extracellular superoxide dismutase transgene overexpression preserves postischemic myocardial function in isolated murine hearts. Circulation 94, II412-II417.
28. Chen, M., Sato, P. Y., Chuprun, J. K., Peroutka, R. J., Otis, N. J., Ibetti, J., et al. (2013). Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Circ. Res. 112, 1121-1134. doi: 10.1161/CIRCRESAHA.112.300754
29. Cho, M. C., Rao, M., Koch, W. J., Thomas, S. A., Palmiter, R. D., and Rockman, H. A. (1999). Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. Circulation 99, 2702-2707. doi: 10.1161/01.CIR.99.20.2702
30. Chuang, T. T., LeVine, H. 3rd., and De Blasi, A. (1995). Phosphorylation and activation of beta-adrenergic receptor kinase by protein kinase C. J. Biol. Chem. 270, 18660-18665. doi: 10.1074/jbc.270.31.18660
31. Ciccarelli, M., Chuprun, J. K., Rengo, G., Gao, E., Wei, Z., Peroutka, R. J., et al. (2011). G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation 123, 1953-1962. doi: 10.1161/CIRCULATIONAHA.110.988642
32. Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., et al. (2004). Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305, 390-392. doi: 10.1126/science.1099196
33. Conrad, M., Jakupoglu, C., Moreno, S. G., Lippl, S., Banjac, A., Schneider, M., et al. (2004). Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol. Cell. Biol. 24, 9414-9423. doi: 10.1128/MCB.24.21.9414-9423.2004
34. Conti, V., Corbi, G., Russomanno, G., Simeon, V., Ferrara, N., Filippelli, W., et al. (2012a). Oxidative stress effects on endothelial cells treated with different athletes' sera. Med. Sci. Sports Exerc. 44, 39-49. doi: 10.1249/MSS.0b013e318227f69c
35. Conti, V., Russomanno, G., Corbi, G., and Filippelli, A. (2012b). Exercise training in aging and diseases. Transl. Med. UniSa. 3, 74-80. Available online at: http://hdl.handle.net/10556/629
36. Conti, V., Russomanno, G., Corbi, G., Guerra, G., Grasso, C., Filippelli, W., et al. (2013). Aerobic training workload affects human endothelial cells redox homeostasis. Med. Sci. Sports Exerc. 45, 644-653. doi: 10.1249/MSS.0b013e318279fb59
37. Copps, K. D., and White, M. F. (2012). Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia 55, 2565-2582. doi: 10.1007/s00125-012-2644-8
38. Corbi, G. M., Carbone, S., Ziccardi, P., Giugliano, G., Marfella, R., Nappo, F., et al. (2002). FFAs and QT intervals in obese women with visceral adiposity: effects of sustained weight loss over 1 year. J. Clin. Endocrinol. Metab. 87, 2080-2083. doi: 10.1210/jc.87.5.2080
39. Corbi, G., Acanfora, D., Iannuzzi, G. L., Longobardi, G., Cacciatore, F., Furgi, G., et al. (2008). Hypermagnesemia predicts mortality in elderly with congestive heart disease: relationship with laxative and antacid use. Rejuvenation Res. 11, 129-138. doi: 10.1089/rej.2007.0583
40. Corbi, G., Bianco, A., Turchiarelli, V., Cellurale, M., Fatica, F., Daniele, A., et al. (2013). Potential mechanisms linking atherosclerosis and increased cardiovascular risk in COPD: focus on sirtuins. Int. J. Mol. Sci. 14, 12696-12713. doi: 10.3390/ijms140612696
41. Corbi, G., Conti, V., Scapagnini, G., Filippelli, A., and Ferrara, N. (2012a). Role of sirtuins, calorie restriction and physical activity in aging. Front. Biosci. (Elite Ed). 4, 768-778. doi: 10.2741/E417
42. Corbi, G., Conti, V., Russomanno, G., Rengo, G., Vitulli, P., Ciccarelli, A. L., et al. (2012b). Is physical activity able to modify oxidative damage in cardiovascular aging? Oxid. Med. Cell. Longev. 2012:728547. doi: 10.1155/2012/728547
43. Dai, D. F., Santana, L. F., Vermulst, M., Tomazela, D. M., Emond, M. J., MacCoss, M. J., et al. (2009). Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation 119, 2789-2797. doi: 10.1161/CIRCULATIONAHA.108.822403
44. Das, S., Fraga, C. G., and Das, D. K. (2006). Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkappaB. Free Radic. Res. 40, 1066-1075. doi: 10.1080/10715760600833085
45. Davies, K. J. (1995). Oxidative stress: the paradox of aerobic life. Biochem. Soc. Symp. 61, 1-31.
46. Deibert, D. C., and DeFronzo, R. A. (1980). Epinephrine-induced insulin resistance in man. J. Clin. Invest. 65, 717-721. doi: 10.1172/JCI109718
47. Di Lisa, F., Kaludercic, N., and Paolocci, N. (2011). ß2-Adrenoceptors, NADPH oxidase, ROS and p38 MAPK: another 'radical' road to heart failure? Br. J. Pharmacol. 162, 1009-1011. doi: 10.1111/j.1476-5381.2010.01130.x
48. Dioum, E. M., Chen, R., Alexander, M. S., Zhang, Q., Hogg, R. T., Gerard, R. D., et al. (2009). Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 324, 1289-1293. doi: 10.1126/science.1169956
49. Dolinsky, V. W., Chan, A. Y., Robillard Frayne, I., Light, P. E., Des Rosiers, C., and Dyck, J. R. (2009). Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1. Circulation 119, 1643-1652. doi: 10.1161/CIRCULATIONAHA.108.787440
50. Drake, M. T., Violin, J. D., Whalen, E. J., Wisler, J. W., Shenoy, S. K., and Lefkowitz, R. J. (2008). b-arrestin-biased agonism at the b2-adrenergic receptor. J. Biol. Chem. 283, 5669-5676. doi: 10.1074/jbc.M708118200
51. Dröge, W. (2002). Free radicals in the physiological control of cell function. Physiol. Rev. 82, 47-95. doi: 10.1152/physrev.00018.2001
52. Du, J., Zhou, Y., Su, X., Yu, J. J., Khan, S., Jiang, H., et al. (2011). SIRT5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 334, 806-809. doi: 10.1126/science.1207861
53. Eskildsen-Helmond, Y. E., Bezstarosti, K., Dekkers, D. H., van Heugten, H. A., and Lamers, J. M. (1997). Cross-talk between receptor-mediated phospholipase C-beta and D via protein kinase C as intracellular signal possibly leading to hypertrophy in serum-free cultured cardiomyocytes. J. Mol. Cell. Cardiol. 29, 2545-2559. doi: 10.1006/jmcc.1997.0491
54. Evron, T., Daigle, T. L., and Caron, M. G. (2012). GRK2: multiple roles beyond G protein-coupled receptor desensitization. Trends Pharmacol. Sci. 33, 154-164. doi: 10.1016/j.tips.2011.12.003
55. Feldman, D. S., Elton, T. S., Sun, B., Martin, M. M., and Ziolo, M. T. (2008). Mechanisms of disease: detrimental adrenergic signaling in acute decompensated heart failure. Nat. Clin. Pract. Cardiovasc. Med. 5, 208-218. doi: 10.1038/ncpcardio1127
56. Femminella, G. D., Rengo, G., Pagano, G., de Lucia, C., Komici, K., Parisi, V., et al. (2013). ß-adrenergic receptors and G protein-coupled receptor kinase-2 in Alzheimer's disease: a new paradigm for prognosis and therapy? J. Alzheimers Dis. 34, 341-347. doi: 10.3233/JAD-121813
57. Ferguson, S. S., Downey, W. E. 3rd., Colapietro, A. M., Barak, L. S., Ménard, L., and Caron, M. G. (1996). Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 271, 363-366. doi: 10.1126/science.271.5247.363
58. Ferrara, N., Abete, P., Corbi, G., Paolisso, G., Longobardi, G., Calabrese, C., et al. (2005). Insulin-induced changes in beta-adrenergic response: an experimental study in the isolated rat papillary muscle. Am. J. Hypertens. 18, 348-353. doi: 10.1016/j.amjhyper.2004.10.006
59. Ferrara, N., Corbi, G., Bosimini, E., Cobelli, F., Furgi, G., Giannuzzi, P., et al. (2006). Cardiac rehabilitation in the elderly: patient selection and outcomes. Am. J. Geriatr. Cardiol. 15, 22-27. doi: 10.1111/j.1076-7460.2006.05289.x
60. Ferrara, N., Davia, K., Abete, P., Rengo, F., and Harding, S. E. (1997). Alterations in beta-adrenoceptor mechanisms in the aging heart. Relationship with heart failure. Aging (Milano). 9, 391-403.
61. Ferrara, N., Rinaldi, B., Corbi, G., Conti, V., Stiuso, P., Boccuti, S., et al. (2008). Exercise training promotes SIRT1 activity in aged rats. Rejuvenation Res. 11, 139-150. doi: 10.1089/rej.2007.0576
62. Finkel, T. (1999). Signal transduction by reactive oxygen species in non-phagocytic cells. J. Leukoc. Biol. 65, 337-340.
63. Finkel, T., Deng, C. X., and Mostoslavsky, R. (2009). Recent progress in the biology and physiology of sirtuins. Nature 460, 587-591. doi: 10.1038/nature08197
64. Finley, L. W., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., et al. (2011). SIRT3 opposes reprogramming of cancer cell metabolism through HIF1a destabilization. Cancer Cell. 19, 416-428. doi: 10.1016/j.ccr.2011.02.014
65. Ford, E., Voit, R., Liszt, G., Magin, C., Grummt, I., and Guarente, L. (2006). Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 20, 1075-1080. doi: 10.1101/gad.1399706
66. Garcia-Guerra, L., Nieto-Vazquez, I., Vila-Bedmar, R., Jurado-Pueyo, M., Zalba, G., Díez, J., et al. (2010). G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity. Diabetes 59, 2407-2417. doi: 10.2337/db10-0771
67. Garcia Soriano, F., Viràg, L., and Szabo, C. (2001). Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation. J. Mol. Med. 79, 437-448. doi: 10.1007/s001090100236
68. Gerhart-Hines, Z., Dominy, J. E. Jr., Blättler, S. M., Jedrychowski, M. P., Banks, A. S., Lim, J. H., et al. (2011). The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol. Cell. 44, 851-863. doi: 10.1016/j.molcel.2011.12.005
69. Gerhart-Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S. H., Mostoslavsky, R., et al. (2007). Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 26, 1913-1923. doi: 10.1038/sj.emboj.7601633
70. Giordano, F. J. (2005). Oxygen, oxidative stress, hypoxia, and heart failure. J. Clin. Invest. 115, 500-508. doi: 10.1172/JCI200524408
71. Gong, K., Li, Z., Xu, M., Du, J., Lv, Z., and Zhang, Y. (2008). A novel protein kinase A-independent, b-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by b2-adrenergic receptors. J. Biol. Chem. 283, 29028-29036. doi: 10.1074/jbc.M801313200
72. Griendling, K. K., and FitzGerald, G. A. (2003). Oxidative stress and cardiovascular injury: part I: basic mechanisms and in vivo monitoring of ROS. Circulation. 108, 1912-1916. doi: 10.1161/01.CIR.0000093660.86242.BB
73. Griendling, K. K., Sorescu, D., and Ushio-Fukai, M. (2000). NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 86, 494-501. doi: 10.1161/01.RES.86.5.494
74. Gros, R., Benovic, J. L., Tan, C. M., and Feldman, R. D. (1997). G-protein-coupled receptor kinase activity is increased in hypertension. J. Clin. Invest. 99, 2087-2093. doi: 10.1172/JCI119381
75. Grubisha, O., Smith, B. C., and Denu, J. M. (2005). Small molecule regulation of Sir2 protein deacetylases. FEBS J. 272, 4607-4616. doi: 10.1111/j.1742-4658.2005.04862.x
76. Guarente, L. (2011). Franklin H. Epstein Lecture: sirtuins, aging, and medicine. N. Engl. J. Med. 364, 2235-2244. doi: 10.1056/NEJMra1100831
77. Hafner, A. V., Dai, J., Gomes, A. P., Xiao, C. Y., Palmeira, C. M., Rosenzweig, A., et al., (2010). Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY). 2, 914-923. doi: 10.3410/f.7816956.8154054
78. Haigis, M. C., and Sinclair, D. A. (2010). Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 5, 253-295. doi: 10.1146/annurev.pathol.4.110807.092250
79. Hariharan, N., Maejima, Y., Nakae, J., Paik, J., Depinho, R. A., and Sadoshima, J. (2010). Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes. Circ. Res. 107, 1470-1482. doi: 10.1161/CIRCRESAHA.110.227371
80. Hirotani, S., Otsu, K., Nishida, K., Higuchi, Y., Morita, T., Nakayama, H., et al. (2002). Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonistinduced cardiomyocyte hypertrophy. Circulation 105, 509-515. doi: 10.1161/hc0402.102863
81. Hisahara, S., Chiba, S., Matsumoto, H., Tanno, M., Yagi, H., Shimohama, S., et al. (2008). Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. Proc. Natl. Acad. Sci. U.S.A. 105, 15599-15604. doi: 10.1073/pnas.0800612105
82. Ho, Y. S., Magnenat, J. L., Gargano, M., and Cao, J. (1998). The nature of antioxidant defense mechanisms: a lesson from transgenic studies. Environ. Health Perspect. 106, 1219-1228.
83. Hsu, T. C., Young, M. R., Cmarik, J., and Colburn, N. H. (2000). Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free Radic. Biol. Med. 28, 1338-1348. doi: 10.1016/S0891-5849(00)00220-3
84. Hua, Y., Zhang, Y., Ceylan-Isik, A. F., Wold, L. E., Nunn, J. M., and Ren, J. (2011). Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy. Basic Res. Cardiol. 106, 1173-1191. doi: 10.1007/s00395-011-0222-8
85. Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., et al. (1999). Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Circ. Res. 85, 357-363. doi: 10.1161/01.RES.85.4.357
86. Kahsai, A. W., Zhu, S., and Fenteany, G. (2010). G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. Biochim. Biophys. Acta. 1803, 300-310. doi: 10.1016/j.bbamcr.2009.11.002
87. Kawano, S. (1998). Dual mechanisms of Mg2+ block of ryanodine receptor Ca2+ release channel from cardiac sarcoplasmic reticulum. Receptors Channels 5, 405-416.
88. Klima, M., Burns, T. R., and Chopra, A. (1990). Myocardial fibrosis in the elderly. Arch. Pathol. Lab. Med. 114, 938-942.
89. Knight, J. A. (2000). The biochemistry of aging. Adv. Clin. Chem. 35, 1-62. doi: 10.1016/S0065-2423(01)35014-X
90. Kohen, R., and Nyska, A. (2002). Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol. Pathol. 30, 620-650. doi: 10.1080/01926230290166724
91. Kohno, M., Yasunari, K., Murakawa, K., Yokokawa, K., Horio, T., Fukui, T., et al. (1990). Plasma immunoreactive endothelin in essential hypertension. Am. J. Med. 88, 614-618. doi: 10.1016/0002-9343(90)90527-K
92. Koss, K. L., and Grubbs, R. D. (1994). Elevated extracellular Mg2+ increases Mg2+ buffering through a Ca-dependent mechanism in cardiomyocytes. Am. J. Physiol. 267, C633-C641.
93. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., et al. (2006). Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1a. Cell 127, 1109-1122. doi: 10.1016/j.cell.2006.11.013
94. Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., et al. (2008). A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc. Natl. Acad. Sci. U.S.A. 105, 3374-3379. doi: 10.1073/pnas.0712145105
95. Li, L., Zhang, H. N., Chen, H. Z., Gao, P., Zhu, L. H., Li, H. L., et al. (2011). SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circ. Res. 108, 1180-1189. doi: 10.1161/CIRCRESAHA.110.237875
96. Li, Y., Huang, T. T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., et al. (1995). Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11, 376-381. doi: 10.1038/ng1295-376
97. Loch, T., Vakhrusheva, O., Piotrowska, I., Ziolkowski, W., Ebelt, H., Braun, T., et al. (2009). Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice. Cardiovasc. Res. 82, 448-457. doi: 10.1093/cvr/cvp092
98. Lombard, D. B., Alt, F. W., Cheng, H. L., Bunkenborg, J., Streeper, R. S., Mostoslavsky, R., et al. (2007). Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell. Biol. 27, 8807-8814. doi: 10.1128/MCB.01636-07
99. Lombardi, M. S., Kavelaars, A., Penela, P., Scholtens, E. J., Roccio, M., Schmidt, R. E., et al. (2002). Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism. Mol. Pharmacol. 62, 379-388. doi: 10.1124/mol.62.2.379
100. Lu, Z., Bourdi, M., Li, J. H., Aponte, A. M., Chen, Y., Lombard, D. B., et al. (2011). SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity. EMBO Rep. 12, 840-846. doi: 10.1038/embor.2011.121
101. Machida, Y., Kubota, T., Kawamura, N., Funakoshi, H., Ide, T., Utsumi, H., et al. (2003). Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium. Am. J. Physiol. Heart Circ. Physiol. 284, H449-H455.
102. Mann, D. L., and Bristow, M. R. (2005). Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation 111, 2837-2849. doi: 10.1161/CIRCULATIONAHA.104.500546
103. Marciano, C., Galderisi, M., Gargiulo, P., Acampa, W., D'Amore, C., Esposito, R., et al. (2012). Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease. Eur. J. Nucl. Med. Mol. Imaging 39, 1199-1206. doi: 10.1007/s00259-012-2117-9
104. Martin, J. L., Mestril, R., Hilal-Dandan, R., Brunton, L. L., and Dillmann, W. H. (1997). Small heat shock proteins and protection against ischemic injury in cardiac myocytes. Circulation 96, 4343-4348. doi: 10.1161/01.CIR.96.12.4343
105. McAlees, J. W., and Sanders, V. M. (2009). Hematopoietic protein tyrosine phosphatase mediates b2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes. Mol. Cell. Biol. 29, 675-686. doi: 10.1128/MCB.01466-08
106. Merksamer, P. I., Liu, Y., He, W., Hirschey, M. D., Chen, D., and Verdin, E. (2013). The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY) 5, 144-150. Available online at: http://www.impactaging.com/papers/v5/n3/full/100544.html
107. Michishita, E., Park, J. Y., Burneskis, J. M., Barrett, J. C., and Horikawa, I. (2005). Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell. 16, 4623-4635. doi: 10.1091/mbc.E05-01-0033
108. Miyazaki, R., Ichiki, T., Hashimoto, T., Inanaga, K., Imayama, I., Sadoshima, J., et al. (2008). SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 28, 1263-1269. doi: 10.1161/ATVBAHA.108.166991
109. Molenaar, P., Savarimuthu, S. M., Sarsero, D., Chen, L., Semmler, A. B., Carle, A., et al. (2007). (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling. Naunyn Schmiedebergs Arch. Pharmacol. 375, 11-28. doi: 10.1007/s00210-007-0138-x
110. Nadtochiy, S. M., Yao, H., McBurney, M. W., Gu, W., Guarente, L., Rahman, I., et al. (2011). SIRT1-mediated acute cardioprotection. Am. J. Physiol. Heart Circ. Physiol. 301, H1506-1512. doi: 10.1152/ajpheart.00587.2011
111. Naga Prasad, S. V., Barak, L. S., Rapacciuolo, A., Caron, M. G., and Rockman, H. A. (2001). Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. J. Biol. Chem. 276, 18953-18959. doi: 10.1074/jbc.M102376200
112. Naga Prasad, S. V., Laporte, S. A., Chamberlain, D., Caron, M. G., Barak, L., and Rockman, H. A. (2002). Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J. Cell. Biol. 158, 563-575. doi: 10.1083/jcb.200202113
113. Nakamura, K., Fushimi, K., Kouchi, H., Mihara, K., Miyazaki, M., Ohe, T., et al. (1998). Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation. 98, 794-799. doi: 10.1161/01.CIR.98.8.794
114. Nasrin, N., Kaushik, V. K., Fortier, E., Wall, D., Pearson, K. J., de Cabo, R., et al. (2009). JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS ONE 4:e8414. doi: 10.1371/journal.pone.0008414
115. Navarro-Arévalo, A., Cañavate, C., and Sánchez-del-Pino, M. J. (1999). Myocardial and skeletal muscle aging and changes in oxidative stress in relationship to rigorous exercise training. Mech. Ageing Dev. 108, 207-217. doi: 10.1016/S0047-6374(99)00013-5
116. Nishida, M., Maruyama, Y., Tanaka, R., Kontani, K., Nagao, T., and Kurose, H. (2000). G alpha(i) and G alpha(o) are target proteins of reactive oxygen species. Nature. 408, 492-495. doi: 10.1038/35044120
117. Oellerich, M. F., and Potente, M. (2012). FOXOs and sirtuins in vascular growth, maintenance, and aging. Circ. Res. 110, 1238-1251. doi: 10.1161/CIRCRESAHA.111.246488
118. Opie, L. H., and Lecour, S. (2007). The red wine hypothesis: from concepts to protective signalling molecules. Eur. Heart J. 28, 1683-1693. doi: 10.1093/eurheartj/ehm149
119. Ota, H., Akishita, M., Eto, M., Iijima, K., Kaneki, M., and Ouchi, Y. (2007). Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J. Mol. Cell. Cardiol. 43, 571-579. doi: 10.1016/j.yjmcc.2007.08.008
120. Packer, M. (1998). Beta-blockade in heart failure. Basic concepts and clinical results. Am. J. Hypertens. 11, 23S-37S. doi: 10.1016/S0895-7061(97)00425-1
121. Paolillo, S., Rengo, G., Pagano, G., Pellegrino, T., Savarese, G., Femminella, G. D., et al. (2013). Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study. Diabetes Care. 36, 2395-2401. doi: 10.2337/dc12-2147
122. Penela, P., Ruiz-Gómez, A., Castaño, J. G., and Mayor, F. Jr. (1998). Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway. J. Biol. Chem. 273, 35238-35244. doi: 10.1074/jbc.273.52.35238
123. Perrino, C., Naga Prasad, S. V., Schroder, J. N., Hata, J. A., Milano, C., and Rockman, H. A. (2005). Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex. Circulation. 111, 2579-2587. doi: 10.1161/CIRCULATIONAHA.104.508796
124. Pierce, K. L., Premont, R. T., and Lefkowitz, R. J. (2002). Seven-transmembrane receptors. Nat. Rev. Mol. Cell. Biol. 3, 639-650. doi: 10.1038/nrm908
125. Pillai, J. B., Isbatan, A., Imai, S., and Gupta, M. P. (2005). Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. J. Biol. Chem. 80, 43121-43130. doi: 10.1074/jbc.M506162200
126. Pitcher, J. A., Freedman, N. J., and Lefkowitz, R. J. (1998a). G protein-coupled receptor kinases. Annu. Rev. Biochem. 67, 653-692. doi: 10.1146/annurev.biochem.67.1.653
127. Pitcher, J. A., Hall, R. A., Daaka, Y., Zhang, J., Ferguson, S. S., Hester, S., et al. (1998b). The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. J. Biol. Chem. 273, 12316-12324. doi: 10.1074/jbc.273.20.12316
128. Porcu, M., and Chiarugi, A. (2005). The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends Pharmacol. Sci. 26, 94-103. doi: 10.1016/j.tips.2004.12.009
129. Post, S. R., Hammond, H. K., and Insel, P. A. (1999). Beta-adrenergic receptors and receptor signaling in heart failure. Annu. Rev. Pharmacol. Toxicol. 39, 343-601. doi: 10.1146/annurev.pharmtox.39.1.343
130. Rane, S., He, M., Sayed, D., Yan, L., Vatner, D., and Abdellatif, M. (2010). An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p. Cell Signal. 22, 1054-1062. doi: 10.1016/j.cellsig.2010.02.008
131. Remacle, J., Raes, M., Toussaint, O., Renard, P., and Rao, G. (1995). Low levels of reactive oxygen species as modulators of cell function. Mutat. Res. 316, 103-122. doi: 10.1016/0921-8734(95)90004-7
132. Rengo, G., Cannavo, A., Liccardo, D., Zincarelli, C., de Lucia, C., Pagano, G., et al. (2013a). Vascular endothelial growth factor blockade prevents the beneficial effects of ß-blocker therapy on cardiac function, angiogenesis and remodeling in heart failure. Circ. Heart Fail. doi: 10.1161/CIRCHEARTFAILURE.113.000329. [Epub ahead of print].
133. Rengo, G., Pagano, G., Squizzato, A., Moja, L., Femminella, G. D., de Lucia, C., et al. (2013b). Oral anticoagulation therapy in heart failure patients in sinus rhythm: a systematic review and meta-analysis. PLoS ONE. 8:e52952. doi: 10.1371/journal.pone.0052952
134. Rengo, G., Galasso, G., Femminella, G. D., Parisi, V., Zincarelli, C., Pagano, G., et al. (2013c). Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure. Eur. J. Prev. Cardiol. doi: 10.1177/2047487313491656. [Epub ahead of print].
135. Rengo, G., Leosco, D., Zincarelli, C., Marchese, M., Corbi, G., Liccardo, D., et al. (2010). Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure. Am. J. Physiol. Heart Circ. Physiol. 298, H2032-H2038. doi: 10.1152/ajpheart.00702.2009
136. Rengo, G., Perrone-Filardi, P., Femminella, G. D., Liccardo, D., Zincarelli, C., de Lucia, C., et al. (2012a). Targeting the ß-adrenergic receptor system through G-protein-coupled receptor kinase 2: a new paradigm for therapy and prognostic evaluation in heart failure: from bench to bedside. Circ. Heart Fail. 5, 385-391. doi: 10.1161/CIRCHEARTFAILURE.112.966895
137. Rengo, G., Zincarelli, C., Femminella, G. D., Liccardo, D., Pagano, G., de Lucia, C., et al. (2012b). Myocardial ß(2) -adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure. Br. J. Pharmacol. 166, 2348-2361. doi: 10.1111/j.1476-5381.2012.01954.x
138. Rengo, G., Lymperopoulos, A., Zincarelli, C., Femminella, G., Liccardo, D., Pagano, G., et al. (2012c). Blockade of ß-adrenoceptors restores the GRK2-mediated adrenal a(2) -adrenoceptor-catecholamine production axis in heart failure. Br. J. Pharmacol. 166, 2430-2440. doi: 10.1111/j.1476-5381.2012.01972.x
139. Rinaldi, B., Corbi, G., Boccuti, S., Filippelli, W., Rengo, G., Leosco, D., et al. (2006). Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart. Exp. Gerontol. 41, 764-770. doi: 10.1016/j.exger.2006.05.008
140. Rockman, H. A., Koch, W. J., and Lefkowitz, R. J. (2002). Seven-transmembrane-spanning receptors and heart function. Nature. 415, 206-212. doi: 10.1038/415206a
141. Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., and Puigserver, P. (2005). Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434, 113-118. doi: 10.1038/nature03354
142. Sabri, A., Hughie, H. H., and Lucchesi, P. A. (2003). Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes. Antioxid. Redox Signal. 5, 731-740. doi: 10.1089/152308603770380034
143. Salazar, N. C., Vallejos, X., Siryk, A., Rengo, G., Cannavo, A., Liccardo, D., et al. (2013). GRK2 blockade with betaARKct is essential for cardiac beta2-adrenergic receptor signaling towards increased contractility. Cell. Commun. Signal. 11, 2348-2361. doi: 10.1186/1478-811X-11-64
144. Salcedo, A., Mayor, F. Jr, and Penela, P. (2006). Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J. 25, 4752-4762. doi: 10.1038/sj.emboj.7601351
145. Santulli, G., Campanile, A., Spinelli, L., Assante di Panzillo, E., Ciccarelli, M., Trimarco, B., et al. (2011). G protein-coupled receptor kinase 2 in patients with acute myocardial infarction. Am. J. Cardiol. 107, 1125-1130. doi: 10.1016/j.amjcard.2010.12.006
146. Santulli, G., Trimarco, B., and Iaccarino, G. (2013). G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms. High Blood Press. Cardiovasc. Prev. 20, 5-12. doi: 10.1007/s40292-013-0001-8
147. Sawyer, D. B., Siwik, D. A., Xiao, L., Pimentel, D. R., Singh, K., and Colucci, W. S. (2002). Role of oxidative stress in myocardial hypertrophy and failure. J. Mol. Cell. Cardiol. 34, 379-388. doi: 10.1006/jmcc.2002.1526
148. Schieven, G. L., Kirihara, J. M., Myers, D. E., Ledbetter, J. A., and Uckun, F. M. (1993). Reactive oxygen intermediates activate NF-kappa B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes. Blood. 82, 1212-1220.
149. Schlicker, C., Gertz, M., Papatheodorou, P., Kachholz, B., Becker, C. F., and Steegborn, C. (2008). Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J. Mol. Biol. 382, 790-801. doi: 10.1016/j.jmb.2008.07.048
150. Schreck, R., Rieber, P., and Baeuerle, P. A. (1991). Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J. 10, 2247-2258.
151. Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., et al. (2005). Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 308, 1909-1911. doi: 10.1126/science.1106653
152. Schug, T. T., and Li, X. (2010). Surprising sirtuin crosstalk in the heart. Aging (Albany NY). 2, 129-132. Available online at: http://www.impactaging.com/papers/v2/n3/full/100128.html
153. Scortegagna, M., Ding, K., Oktay, Y., Gaur, A., Thurmond, F., Yan, L. J., et al. (2003). Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat. Genet. 35, 331-340. doi: 10.1038/ng1266
154. Seddon, M., Looi, Y. H., and Shah, A. M. (2007). Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart. 93, 903-907. doi: 10.1136/hrt.2005.068270
155. Sethi, R., Saini, H. K., Guo, X., Wang, X., Elimban, V., and Dhalla, N. S. (2007). Dependence of changes in beta-adrenoceptor signal transduction on type and stage of cardiac hypertrophy. J. Appl. Physiol. 102, 978-984. doi: 10.1152/japplphysiol.00921.2006
156. Shinmura, K., Tamaki, K., Sano, M., Nakashima-Kamimura, N., Wolf, A. M., Amo, T., et al. (2011). Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain. Circ. Res. 109, 396-406. 92. doi: 10.1161/CIRCRESAHA.111.243097
157. Singal, P. K., Petkau, A., Gerrard, J. M., Hrushovetz, S., and Foerster, J. (1988). Free radicals in health and disease. Mol. Cell. Biochem. 84, 121-122. doi: 10.1007/BF00421045
158. Sorescu, D., and Griendling, K. K. (2002). Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure. Congest Heart Fail. 8, 132-140. doi: 10.1111/j.1527-5299.2002.00717.x
159. Stein, S., and Matter, C. M. (2011). Protective roles of SIRT1 in atherosclerosis. Cell Cycle. 10, 640-647. doi: 10.4161/cc.10.4.14863
160. Stiles, G. L., Caron, M. G., and Lefkowitz, R. J. (1984). Beta-adrenergic receptors: biochemical mechanisms of physiological regulation. Physiol. Rev. 64, 661-743.
161. Suematsu, N., Tsutsui, H., Wen, J., Kang, D., Ikeuchi, M., Ide, T., et al. (2003). Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes. Circulation. 107, 1418-1423. doi: 10.1161/01.CIR.0000055318.09997.1F
162. Sulaiman, M., Matta, M. J., Sunderesan, N. R., Gupta, M. P., Periasamy, M., and Gupta, M. (2010). Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol. 29, H833-H843. doi: 10.1152/ajpheart.00418.2009
163. Sun, C., Zhang, F., Ge, X., Yan, T., Chen, X., Shi, X., et al. (2007). SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 6, 307-319. doi: 10.1016/j.cmet.2007.08.014
164. Sunagawa, K. (2008). SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 28, 1263-1269. doi: 10.1161/ATVBAHA.108.166991
165. Sundaresan, N. R., Gupta, M., Kim, G., Rajamohan, S. B., Isbatan, A., and Gupta, M. P. (2009). Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J. Clin. Invest. 119, 2758-2771. doi: 10.1172/JCI39162
166. Sundaresan, N. R., Samant, S. A., Pillai, V. B., Rajamohan, S. B., and Gupta, M. P. (2008). SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol. Cell. Biol. 28, 6384-6401. doi: 10.1128/MCB.00426-08
167. Takeda, S., Kadowaki, S., Haga, T., Takaesu, H., and Mitaku, S. (2002). Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. 520, 97-101. doi: 10.1016/S0014-5793(02)02775-8
168. Tang, Y., Xu, J., Qu, W., Peng, X., Xin, P., Yang, X., et al. (2012). Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms. J. Nutr. Biochem. 23, 1410-1416. doi: 10.1016/j.jnutbio.2011.08.008
169. Tanno, M., Kuno, A., Horio, Y., and Miura, T. (2012). Emerging beneficial roles of sirtuins in heart failure. Basic Res. Cardiol 107, 273. doi: 10.1007/s00395-012-0273-5
170. Tanno, M., Kuno, A., Yano, T., Miura, T., Hisahara, S., Ishikawa, S., et al. (2010). Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J. Biol. Chem. 285, 8375-8382. doi: 10.1074/jbc.M109.090266
171. Tanno, M., Sakamoto, J., Miura, T., Shimamoto, K., and Horio, Y. (2007). Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J. Biol. Chem. 282, 6823-6832. doi: 10.1074/jbc.M609554200
172. Tavares, M., Rezlan, E., Vostroknoutova, I., Khouadja, H., and Mebazaa, A. (2008). New pharmacologic therapies for acute heart failure. Crit. Care Med. 36, S112-120. doi: 10.1097/01.CCM.0000296810.74724.8D
173. Thandapilly, S. J., Louis, X. L., Yang, T., Stringer, D. M., Yu, L., Zhang, S., et al. (2011). Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway. Eur. J. Pharmacol. 668, 217-224. doi: 10.1016/j.ejphar.2011.06.042
174. Thandapilly, S. J., Wojciechowski, P., Behbahani, J., Louis, X. L., Yu, L., Juric, D., et al. (2010). Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the SHR without lowering blood pressure. Am. J. Hypertens. 23, 192-196. doi: 10.1038/ajh.2009.228
175. Thannickal, V. J., and Fanburg, B. L. (2000). Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell Mol. Physiol. 279, L1005-L1028.
176. Tilley, D. G., Kim, I. M., Patel, P. A., Violin, J. D., and Rockman, H. A. (2009). b-Arrestin mediates b1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling. J. Biol. Chem. 284, 20375-20386. doi: 10.1074/jbc.M109.005793
177. Turpaev, K. T. (2002). Reactive oxygen species and regulation of gene expression. Biochemistry Mosc. 67, 281-292. doi: 10.1023/A:1014819832003
178. Ungerer, M., Parruti, G., Böhm, M., Puzicha, M., DeBlasi, A., Erdmann, E., et al. (1994). Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. Circ. Res. 74, 206-213. doi: 10.1161/01.RES.74.2.206
179. Usui, I., Imamura, T., Babendure, J. L., Satoh, H., Lu, J. C., Hupfeld, C. J., et al. (2005). G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Mol. Endocrinol. 19, 2760-2768. doi: 10.1210/me.2004-0429
180. Usui, I., Imamura, T., Satoh, H., Huang, J., Babendure, J. L., Hupfeld, C. J., et al. (2004). GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J. 23, 2821-2829. doi: 10.1038/sj.emboj.7600297
181. Vakhrusheva, O., Smolka, C., Gajawada, P., Kostin, S., Boettger, T., Kubin, T., et al. (2008). Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res. 102, 703-710. doi: 10.1161/CIRCRESAHA.107.164558
182. Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., and Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell. Biol. 39, 44-84. doi: 10.1016/j.biocel.2006.07.001
183. van der Horst, A., Tertoolen, L. G., de Vries-Smits, L. M., Frye, R. A., Medema, R. H., and Burgering, B. M. (2004). FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J. Biol. Chem. 279, 28873-28879. doi: 10.1074/jbc.M401138200
184. Varma, S. D. (1991). Devamanoharan PS hydrogen peroxide in human blood. Free Radic. Res. Commun. 14, 125-131. doi: 10.3109/10715769109094124
185. Venkatasubramanian, S., Noh, R. M., Daga, S., Langrish, J. P., Joshi, N. V., Mills, N. L., et al. (2013). Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers. J. Am. Heart. Assoc. 2:e000042. doi: 10.1161/JAHA.113.000042
186. von Harsdorf, R., Li, P. F., and Dietz, R. (1999). Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation 99, 2934-2941. doi: 10.1161/01.CIR.99.22.2934
187. Vroon, A., Lombardi, M. S., Kavelaars, A., and Heijnen, C. J. (2007). Taxol normalizes the impaired agonist-induced beta2-adrenoceptor internalization in splenocytes from GRK2+/- mice. Eur. J. Pharmacol. 560, 9-16. doi: 10.1016/j.ejphar.2007.01.007
188. Wallace, D. C. (2001). Mouse models for mitochondrial disease. Am. J. Med. Genet. 106, 71-93. doi: 10.1002/ajmg.1393
189. Westerheide, S. D., Anckar, J., Stevens, S.M. Jr, Sistonen, L., and Morimoto, R. I. (2009). Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science. 323, 1063-1066. doi: 10.1126/science.1165946
190. Wu, H. M., Chi, K. H., and Lin, W. W. (2002). Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production. FEBS Lett. 526, 101-105. doi: 10.1016/S0014-5793(02)03151-4
191. Xu, Q., Dalic, A., Fang, L., Kiriazis, H., Ritchie, R. H., Sim, K., et al. (2011). Myocardial oxidative stress contributes to transgenic ß2-adrenoceptor activation-induced cardiomyopathy and heart failure. Br. J. Pharmacol. 162, 1012-1028. doi: 10.1111/j.1476-5381.2010.01043.x
192. Yatabe, M. S., Yatabe, J., Yoneda, M., Watanabe, T., Otsuki, M., Felder, R. A., et al. (2010). Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and decreased suppression of circulating renin activity in lean patients with essential hypertension. Am. J. Clin. Nutr. 92, 77-82. doi: 10.3945/ajcn.2009.29028
193. Yen, H. C., Oberley, T. D., Vichitbandha, S., Ho, Y. S., and St Clair, D. K. (1996). The protective role of manganese superoxide dismutase against adriamycin- induced acute cardiac toxicity in transgenic mice. J. Clin. Invest. 98, 1253-1260. doi: 10.1172/JCI118909
194. Yin, F., Wang, Y. Y., Du, J. H., Li, C., Lu, Z. Z., Han, C., et al. (2006). Noncanonical cAMP pathway and p38 MAPK mediate beta2-adrenergic receptor-induced IL-6 production in neonatal mouse cardiac fibroblasts. J. Mol. Cell. Cardiol. 40, 384-393. doi: 10.1016/j.yjmcc.2005.12.005
195. Yoshida, N., Haga, K., and Haga, T. (2003). Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in beta-tubulin. Eur. J. Biochem. 270, 1154-1163. doi: 10.1046/j.1432-1033.2003.03465.x
196. Zheng, M., Zhu, W., Han, Q., and Xiao, R. P. (2005). Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling. Pharmacol. Ther. 108, 257-268. doi: 10.1016/j.pharmthera.2005.04.006
197. Zhong, L., and Mostoslavsky, R. (2011). Fine tuning our cellular factories: sirtuins in mitochondrial biology. Cell. Metab. 13, 621-626. doi: 10.1016/j.cmet.2011.05.004
198. Zweier, J. L., Kuppusamy, P., Williams, R., Rayburn, B. K., Smith, D., Weisfeldt, M. L., et al. (1989). Measurement and characterization of postischemic free radical generation in the isolated perfused heart. J. Biol. Chem. 264, 18890-18895.