GRK2 blockade with βaRKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility

Cell Communication and Signaling

Volumn 11, Issue 1, 2013, Pages

  Salazar, Norma C ^a   Vallejos, Ximena ^a   Siryk, Ashley ^a   Rengo, Giuseppe ^b   Cannavo, Alessandro ^b   Liccardo, Daniela ^b   De Lucia, Claudio ^b   Gao, Erhe ^c   Leosco, Dario ^b   Koch, Walter J ^c   Lymperopoulos, Anastasios ^a  

^a NOVA SOUTHEASTERN UNIVERSITY   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac 2 adrenergic receptor; GRK2 inhibition; GRK5; Post myocardial infarction survival; Pro contractile signaling

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR KINASE CT; BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR KINASE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOPRENALINE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IVD; PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ADRBK1 PROTEIN, MOUSE; BARKCT PROTEIN, RECOMBINANT; BETA 1 ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOKINE; G PROTEIN COUPLED RECEPTOR KINASE 5; GPRK5 PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PDE4D PROTEIN, MOUSE; PEPTIDE FRAGMENT; PROTEIN BCL 2; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART FAILURE; HEART INFARCTION; HEART MUSCLE CONTRACTILITY; HEMODYNAMICS; IMMUNOPRECIPITATION; IN VIVO STUDY; INFLAMMATION; KNOCKOUT MOUSE; MALE; MOUSE; NICK END LABELING; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGENY; PROTEIN BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TRANSTHORACIC ECHOCARDIOGRAPHY; UPREGULATION; WESTERN BLOTTING; WOUND HEALING; ANIMAL; BLOOD; DRUG ANTAGONISM; GENETICS; HEART; HEART CONTRACTION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; ANTAGONISTS AND INHIBITORS;

MUS; MUS MUSCULUS;

ANIMALS; APOPTOSIS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYTOKINES; G-PROTEIN-COUPLED RECEPTOR KINASE 2; G-PROTEIN-COUPLED RECEPTOR KINASE 5; HEART; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; NF-KAPPA B; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT PROTEINS;

EID: 84883539947     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-11-64     Document Type: Article

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