The nature of antioxidant defense mechanisms: A lesson from transgenic studies

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 5, 1998, Pages 1219-1228

  Ho, Ye Shih ^a   Magnenat, Jean Luc ^b   Gargano, Mary ^a   Cao, Jin ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Adriamycin; Catalase; Gene knockout mice; Glutathione peroxidase; Ischemia reperfusion; Paraquat; Superoxide dismutase

Indexed keywords

ANTIOXIDANT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DOXORUBICIN; GLUTATHIONE PEROXIDASE; OXIDIZING AGENT; PARAQUAT; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; BRAIN EDEMA; BRAIN INJURY; CANCER; CONFERENCE PAPER; DEGENERATIVE DISEASE; EMBRYO DEATH; FEMALE; GENETIC ENGINEERING; HYPEROXIA; KNOCKOUT MOUSE; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SURVIVAL; TISSUE INJURY; TRANSGENIC ANIMAL;

ANIMALIA; MUS MUSCULUS;

EID: 0031761127     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106s51219     Document Type: Conference Paper

References (70)

1. Freeman BA, Crapo JD. Biology of disease: free radicals and tissue injury. Lab Invest 47:412-426 (1982).
2. Forman HJ, Fisher AB. Antioxidant defense. In: Oxygen and Living Process: An Interdisciplinary Approach (Gibert DL, ed). New York:Springer-Verlag, 1982;235-249.
3. Cross CE, moderator. Oxygen radicals and human disease. Ann Intern Med 107:526-545 (1987).
4. Weisiger RA, Fridovich I. Superoxide dismutase: organelle specificity. J Biol Chem 248:3582-3592 (1973).
5. Friduvich I. Superoxide dismutase. Annu Rev Biochcm 44:147-159: (1975).
6. Marklund SL. Human copper-containing Superoxide dismutase of high molecular weight. Proc Natl Acad Sci USA 79:7634-7638 (1982).
7. Marklund SL, Holme E, Hellner L. Superoxide dismutase in extracellular fluids. Clin Chim Acta 126:41-51 (1982).
8. Marklund SL, Bjelle A, Elmqvist LG. Superoxide dismutase isoenzymes of the synovial fluid in rheumatoid and reactive arthritides. Ann Rheum Dis 45:847-851 (1986).
9. Frampton J, Conkie D, Chambers I, McBain W, Dexter M, Harrison PR. Changes in minor transcripts from the alpha 1 and beta major globin and glutathione peroxide genes during erythropoiesis. Nucleic Acids Res 15:3671-3688 (1987).
10. Takahashi K, Avissar N, Whitin J, Cohen H. Purification and characterization of human plasma glutathione peroxidase: a selenocysteine distinct from the known cellular enzyme. Arch Biochem Biophys 256:677-686 (1987).
11. Avissar N, Finkelstein JB, Horowitz S, Willey JC, Coy E, Frampton MW, Watkins RH, Khullar P, Xu Y-L, Cohen HJ. Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells. Am J Physiol 270 (Lung Cell Mol Physiol 14):L173-L182 (1996).
12. Ursini F, Maiorino M, Valente M, Ferri L, Gregolin C. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on pnosphatidylcholine hydroperoxides. Biochim Biophys Acta 710:197-211 (1982).
13. Thomas JP, Maiorino M, Ursini F, Girotti AW. Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides. J Biol Chem 265:454-461 (1990).
14. Roveri A, Casasco A, Maiorino M, Dalan P, Calligaro A, Ursini F. Phospholipid hydroperoxide glutathione peroxidase of rat testis. Gonadotropin dependence and immunocytochemical identification. J Biol Chem 267:6142-6146 (1992).
15. Chu F-F, Doroshow JH, Esworthy RS. Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. J Biol Chem 268:2571-2576 (1993).
16. Chu F-F, Esworthy RS. The expression of an intestinal form of glutathione peroxidase (GSHPx-GI) in rat intestinal epithelium. Arch Biochem Biophys 323:288-294 (1995).
17. Burk RF, Hill KE. Regulation of selenoproteins. Annu Rev Nutr 13:65-81 (1993).
18. Gladyshev VN, Jeang KT, Stadtman TC. Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proc Natl Acad Sci USA 93:6146-6151 (1996).
19. Epstein CJ, Avraham, KB, Lovett M, Smith S, Elroy-Stein O, Rotman G, Bry C, Groner Y. Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc Natl Acad Sci USA 84:8044-8048 (1987).
20. Chan PH, Yang GY, Chen SF, Carlson E, Epstein CJ. Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-superoxide dismutase. Ann Neurol 29:482-486 (1991).
21. Kinouchi H, Epstein CJ, Mizui T, Carlson E, Chen SF, Chan PH. Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn Superoxide dismutase. Proc Natl Acad Sci USA 88:11158-11162 (1991).
22. Przedborski S, Kostic V, Jackson-Lewis V, Naini AB, Simonetti S, Fahn S, Carlson E, Epstein CJ, Cadet JL. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine-induced neurotoxicity. J Neurosci 12:1658-1667 (1992).
23. White CW, Avraham KB, Shanley PF, Groner Y. Transgenic mice with expression of elevated levels of copper-zinc superoxide dismutase in the lungs are resistant to pulmonary oxygen toxicity.J Clin Invest 87:2162-2168 (1991).
24. Kubisch HM, Wang J, Luche R, Carlson E, Bray TM, Epstein CJ, Phillips JP. Transgenic copper/zinc Superoxide dismutase modulates susceptibility to type I diabetes. Proc Natl Acad Sci USA 91:9956-9959 (1994).
25. Chua BHL. East Tennessee State University, personal communication.
26. Avraham KB, Schickler M, Sapoznikov D, Yarom R, Groner Y. Down's syndrome: abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase. Cell 54:823-829 (1988).
27. Paled-Kamar M, Lotem J, Wirguin I, Weiner L, Hermalin A, Groner Y. Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn Superoxide dismutase. Proc Natl Acad Sci USA 94:3883-3887 (1997).
28. Paled-Kamar M, Lotem J, Okon E, Sachs L, Groner Y. Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome. EMBO J 14:4985-4993 (1995).
29. Schickler M, Knobler H, Avraham KB, Elroy-Stein O, Groner Y. Diminished serotonin uptake in platelets of transgenic mice with increased Cu/Zn-superoxide dismutase activity. EMBO J 8:1385-1392 (1989).
30. Minc-Golomb D, Knobler H, Groner Y. Gene dosage of CuZnSOD and Down's syndrome: diminished prostaglandin synthesis in human trisomy 21, transfected cells and transgenic mice. EMBO J 10:2119-2124 (1991).
31. Bar-Peled O, Korkotian E, Segal M, Groner Y. Constitutive overexpression of Cu/Zn Superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn Superoxide dismutase neurons. Proc Natl Acad Sci USA 93:8530-8535 (1996).
32. Yim MB, Chock, PB, Stadtman ER. Copper, zinc Superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide. Proc Natl Acad Sci USA 87:5006-5010 (1990).
33. Ischiropoulos H, Zhu L, Chen L, Tsai M, Mattin JC, Smith CD, Beckman JS. Peroxynitrite-mediated tyrosine nitration catalyzed by Superoxide dismutase. Arch Biochem Biophys 298:431-437 (1992).
34. Oberly TD, Coursin DB, Cihla HP, Oberley LW, El-Sayyad N, Ho Y-S. Immunolocalization of manganese Superoxide dismutase in normal and transgenic mice expressing the human enzyme. Histochem J 25:267-279 (1993).
35. Ho Y-S, Vincent R, Dey MS, Slot JW, Crapo JD, Transgenic models for the study of lung antioxidant defense. Enhanced lung manganese-containing Superoxide dismutase activity gives only minimal protection to B6C3 hybrid mice exposed to hyperoxia. Am J Respir Cell Mol Biol 18:538-547 (1998).
36. Yen H-C, Oberley TD, Vichitbandha S, Ho Y-S, St. Clair DK. The protective role of manganese Superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest 98:1253-1260 (1996).
37. Chua BHL, East Tennessee University, personal communication.
38. Wispe JR, Warner BB, Clark JC, Dey CR, Neuman J, Glasser SW, Crapo JD, Chang L-Y, Whitsett JA. Human Mn-superoxide dismutase in pulmonary epithelia cells of transgenic mice confers protection from oxygen injury. J Biol Chem 267:23937-23941 (1992).
39. 2 toxicity. Proc Natl Acad Sci USA 89:9715-9719 (1992).
40. Oury TD, Piantadosi CA, Crapo JD. Cold-induced brain edema in mice: involvement of extracellular Superoxide dismutase and nitric oxide. J Biol Chem 268:15394-15398 (1993).
41. Chen EP, Bittner HB, Davis RD, Folz RJ, Van Trigt P. Extracellular Superoxide dismutase transgene overexpression preserves postischemic myocardial function in isolated murine hearts. Circulation 94:II412-II417 (1996).
42. Kang YJ, Chen Y, Epstein PN. Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic mice. J Biol Chem 271:12610-12616 (1996).
43. Ho Y-S, Oberley TD, Gargano M. Increased pulmonary glutathione peroxidase activity provides no protection to mice exposed to hyperoxia [Abstract], Am J Respir Crit Care Med 151:A649 (1995).
44. Yoshida T, Watanabe M, Engleman DT, Engleman RM, Schley J, Maulik N, Ho Y-S, Oberley TD, Das DK. Transgenic mice overexpressing glutathione peroxidase are resistant to myocardial ischemia reperfusion injury. J Mol Cell Cardiol 28:1759-1767 (1996).
45. Reddy VN, Lin L-R, Ho Y-S, Magnenat J-L, Ibaraki N, Giblin FJ, Dang L. Peroxide induced damage in lenses of transgenic mice with deficient and elevated levels of glutathione peroxidase. Ophthalmologica 211:192-200 (1997).
46. Cheng W-H, Ho Y-S, Valentine BA, Ross DA, Combs Jr GF, Lei XG. Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice. J Nutr 128:1070-1076 (1998).
47. Mirochnitchenko O, Palnitkar U, Philbert M, Inouye M. Thermosensitive phenotype of transgenic mice overproducing human glutathione peroxidases. Proc Natl Acad Sci USA 92:8120-8124 (1995).
48. Lu YP, Lou YR, Yen P, Newmark HL, Mirochnitchenko OI, Inouye M, Huang MT. Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and Superoxide dismutase. Cancer Res 57:1468-1474 (1997).
49. Weisbrot M, Mirochnitchenko O, Reuhl K, Inouye M. Focal cerebral ischemia/reperfusion in transgenic mice overexpressing glutachione peroxidases [Abstract]. FASEB J 11:A282 (1997).
50. Ho Y-S, Gargano M, Cao J, Bronson RT, Heimler I, Hutz R. Reduced fertility in female mice lacking copper-zinc Superoxide dismutase. J Biol Chem 273:7765-7769 (1998).
51. Tybulewicz VLJ, Crawford CE, Jackson PK, Bronson RT, Mulligan R. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153-1163 (1991).
52. Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA 90:8424-8428 (1993).
53. Bradley A. Production and analysis of chimaeric mice. In: Teratocarcinomas and Embryonic Stem Cells: A Practical Approach (Robertson EJ, ed). Oxford:IRL Press, 1987; 113-151.
54. Danciger E, Dafni N, Bernstein Y, Laver-Rudich Z, Neer A, Groner Y. Human Cu/Zn Superoxide dismutase gene family: Molecular structure and characterization of four Cu/Zn superoxide dismutase-related pseudogenes. Proc Natl Acad Sci USA 83:3619-3623 (1986).
55. Marklund SL. Extracellular Superoxide dismutase and other Superoxide dismutase isozymes in tissues from nine mammalian species. Biochem J 222:649-655 (1984).
56. Das DP. University of Connecticut School of Medicine, personal communication.
57. Reaume AG, Elliott JL, Huffman EK, Kowall NW, Ferrante RJ, Siwek DF, Wilcox HM, Flood DG, Beal MF, Brown RH, et al. Motor neurons in Cu/Zn Superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat Genet 13:43-47 (1996).
58. Kondo T, Reaume AG, Huang T-T, Carlson E, Murakami K, Chen SF, Huffman EK, Scott RW, Epstein CJ, Chan PH. Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci 17:4180-4189 (1997).
59. Freeman BA, Crapo JD Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J Biol Chem 256:10986-10992 (1981).
60. Turrens JF, Freeman BA, Levitt JG, Crapo JD. The effect of hyperoxia on Superoxide production by lung submitochondrial particles. Arch Biochem Biophys 217:401-410 (1982).
61. Li Y, Huang T-T, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese Superoxide dismutase. Nat Genet 11:376-381 (1995).
62. Lebovitz RM, Zhang H, Vogel H, Cartwright Jr J, Dionne L, Lu N, Huang S, Matzuk MM. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial Superoxide dismutase-deficient mice. Proc Natl Acad Sci USA 93:9782-9787 (1996).
63. Phillips JP, Campbell SD, Michaud D, Charbonneau M, Hilliker AJ. Null mutation of copper/zinc Superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. Proc Natl Acad Sci USA 86:2761-2765 (1989).
64. Ho Y-S, Magnenat J-L, Bronson RT, Cao J, Gargano M, Sugawara M, Funk CD. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem 272:16644-16651 (1997).
65. Makino N, Mochizuki Y, Bannai S, Sugita Y. Kinetic studies on the removal of extracellular hydrogen peroxide by cultured fibroblasts. J Biol Chem 269:1020-1025 (1994).
66. 2 stress. Exp Eye Res 62:521-540 (1996).
67. 2 by the mouse lens. Exp Eye Res 64:477-485 (1997).
68. Yoshida T, Maulik N, Engelman RM, Ho Y-S, Magnenat J-L, Rousou JA, Flack JE, Deatron D, Das DK. Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury. Circulation 96 (Suppl II):II-216-II-220 (1997).
69. Bedwal RS, Bahuguna A. Zinc, copper and selenium in reproduction. Experientia (Basel) 50:626-640 (1994).
70. XG Lei. Cornell University, personal communication.