Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers

Journal of the American Heart Association

Volumn 2, Issue 3, 2013, Pages

  Venkatasubramanian, Sowmya ^a   Noh, Radzi Mohd ^a   Daga, Shruti ^b   Langrish, Jeremy P ^a   Joshi, Nikhil V ^a   Mills, Nicholas L ^a   Hoffmann, Ethan ^c   Jacobson, Eric W ^c   Vlasuk, George P ^c   Waterhouse, Brian R ^c   Lang, Ninian N ^a   Newby, David E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GLAXOSMITHKLINE   (United States)

Author keywords

Cigarette smokers; Endothelium; Forearm plethysmography; Platelet activation; SIRT1; Sirtuins; Vascular

Indexed keywords

ACETYLCHOLINE; BRADYKININ; CHOLESTEROL; ENZYME ACTIVATOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITROPRUSSIDE SODIUM; PLACEBO; SRT 2104; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; SIRT1 PROTEIN, HUMAN; SIRTUIN; SIRTUIN 1; SRT2104;

APPLICATION SITE EXCORIATION; ARTICLE; BACKACHE; BLURRED VISION; BURNING SENSATION; CARDIOVASCULAR EFFECT; CARPAL TUNNEL SYNDROME; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CONTUSION; CROSSOVER PROCEDURE; DECREASED APPETITE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG ERUPTION; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DYSMENORRHEA; EYE PAIN; FATIGUE; FEMALE; FIBRINOLYSIS; FLATULENCE; FLU LIKE SYNDROME; FOREARM BLOOD FLOW; HEMORRHOID; HERPETIC STOMATITIS; HUMAN; HUMAN EXPERIMENT; HYPERBILIRUBINEMIA; HYPESTHESIA; LACERATION; MALE; MONOCYTE; MOTION SICKNESS; MOUTH ULCER; MUSCULOSKELETAL PAIN; MYALGIA; NORMAL HUMAN; OROPHARYNX PAIN; PARESTHESIA; PERIPHERAL EDEMA; PHLEBITIS; PRESYNCOPE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT INFECTION; RHINITIS; RHINOPHARYNGITIS; RHINORRHEA; SCIATICA; SIDE EFFECT; SMOKING; SWELLING; THORAX PAIN; THROMBOCYTE ACTIVATION; TRIACYLGLYCEROL BLOOD LEVEL; UPPER ABDOMINAL PAIN; UPPER RESPIRATORY TRACT INFECTION; ADOLESCENT; ADULT; AGED; BLOOD VESSEL; CARDIOVASCULAR SYSTEM; CIGARETTE SMOKERS; CONTROLLED CLINICAL TRIAL; ENDOTHELIUM; FOREARM PLETHYSMOGRAPHY; MIDDLE AGED; PATHOPHYSIOLOGY; RISK FACTOR; SIRT1; VASCULAR; VASCULAR ENDOTHELIUM; YOUNG ADULT; DRUG EFFECTS;

CIGARETTE SMOKERS; ENDOTHELIUM; FOREARM PLETHYSMOGRAPHY; PLATELET ACTIVATION; SIRT1; SIRTUINS; VASCULAR;

ADOLESCENT; ADULT; AGED; BLOOD VESSELS; CARDIOVASCULAR SYSTEM; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; SIRTUIN 1; SMOKING; YOUNG ADULT;

EID: 84889654527     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000042     Document Type: Article

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